Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T20973 | Target Info | |||
| Target Name | Cyclin-dependent kinase 5 (CDK5) | ||||
| Synonyms |
Tau protein kinase II catalytic subunit; TPKII catalytic subunit; Serine/threonine-protein kinase PSSALRE; Serine/threonine protein kinase PSSALRE; Proline-directed protein kinase F(A) (PDPK F(A)); Proline-directed protein kinase 33 kDa subunit; PDPK; Cyclin-dependent-like kinase 5; Cyclin-dependent kinase 5 (CDK5); Cell division protein kinase 5; CDKN5
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| Target Type | Patented-recorded Target | ||||
| Gene Name | CDK5 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 55 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
AR-A014418
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|
Patented | Compound Info | ||
| Synonyms |
487021-52-3; GSK-3beta Inhibitor VIII; 1-(4-methoxybenzyl)-3-(5-nitrothiazol-2-yl)urea; 1-[(4-methoxyphenyl)methyl]-3-(5-nitro-1,3-thiazol-2-yl)urea; A Inhibitor VIII; N-(4-METHOXYBENZYL)-N'-(5-NITRO-1,3-THIAZOL-2-YL)UREA; UNII-87KSH90Q6D; AR-AO 14418; SN 4521; AR-A 014418; CHEMBL259850; 87KSH90Q6D; N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea; AK175829; C12H12N4O4S; N-(4-Methoxybenzyl)-N& -(5-nitro-1,3-thiazol-2-yl)urea; AR 014418; GSK 3be
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| Activity |
IC50 = 100000 nM
|
[1] | |||
| Compound Name |
6-O-Cyclohexylmethyl Guanine
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Investigative | Compound Info | ||
| Synonyms |
6-(Cyclohexylmethoxy)-9H-purin-2-amine; nu2058; 161058-83-9; 6-(cyclohexylmethoxy)-9H-purin-2-amine; 6-O-CYCLOHEXYLMETHYL GUANINE; 2-amino-6-[(cyclohexylmethyl)oxy]purine; NU 2058; 2-amino-6-cyclohexylmethoxypurine; NU-2058; O6-Cyclohexylmethylguanine; CHEMBL269881; 1e1v; 1h1p; O-Cyclohexylmethylguanine; AC1Q4XUD; 9H-Purin-2-amine, 6-(cyclohexylmethoxy)-; O6-Cyclohexylmethyl guanine; AC1L1IG4; MLS001074898; SCHEMBL3462331; BDBM5485; CTK8D6642; CTK0E6580; EX-A790; AOB6207; MolPort-033-437-778; MolPort-003-958-993; MolPort-044-561-861; HMS3372K06; HMS3262L18; HMS2233F06
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| Activity |
IC50 = 97000 nM
|
[2] | |||
| Compound Name |
AM7
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Investigative | Compound Info | ||
| Synonyms |
pyrimidone, 22; AM 7; AM-7
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
3-(3,4-Dimethoxyphenyl)-1,5,7-triazatricyclo[7.3.0.02,6]dodeca-2(6),3,9,11-tetraen-8-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL453402; BDBM50267041; 1-(3,4-Dimethoxyphenyl)-3,4-dihydro-5H-dipyrrolo [1,2-a:20,30-e]pyrazin-5-one
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(3,4-Dichlorophenyl)-5-oxa-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),3,9,11-tetraen-8-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL478517; BDBM50267080; 1-(3,4-Dichlorophenyl)furo[2,3-e]pyrrolo [1,2-a]pyrazin-5(4H)-one
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(3,4-Dimethoxyphenyl)-5-oxa-1,7-diazatricyclo[7.3.0.02,6]dodeca-2(6),3,9,11-tetraen-8-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL478704; BDBM50267081; 1-(3,4-dimethoxyphenyl)furo[2,3-e]pyrrolo[1,2-a]pyrazin-5(4H)-one
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(3,4-Dimethoxy-phenyl)-furo[2,3-b]pyrrolizin-8-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL286423; BDBM50240447; 3-(3,4-dimethoxyphenyl)-8H-furo[2,3-b]pyrrolizin-8-one
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(4-Chlorophenyl)-1,5,7-triazatricyclo[7.3.0.02,6]dodeca-2(6),3,9,11-tetraen-8-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL516901; BDBM50267040; 1-(4-Chlorophenyl)-3,4-dihydro-5H-dipyrrolo [1,2-a:20,30-e]pyrazin-5-one
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-(3-(8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1081198; SCHEMBL5480112; BDBM50312153
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| Activity |
IC50 = 50000 nM
|
[5] | |||
| Compound Name |
3-(3-(Benzyloxy)-4-methoxyphenyl)pyrrolo[2,3-b]pyrrolizin-8(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL507162; BDBM50267108
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(4-Chlorophenyl)pyrrolo[2,3-b]pyrrolizin-8(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL476236; CTK2G8703; DTXSID00464128; BDBM50267107; Pyrrolo[2,3-b]pyrrolizin-8(1H)-one, 3-(4-chlorophenyl)-
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-(4-Methoxyphenyl)furo[2,3-e]pyrrolo [1,2-a]pyrazin-5(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL478516; BDBM50267079
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-(4-Methylphenyl)furo[2,3-e]pyrrolo[1,2-a] pyrazin-5(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL517669; BDBM50267078
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-(4-Bromophenyl)furo[2,3-e]pyrrolo[1,2-a] pyrazin-5(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL477954; BDBM50267076
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-(4-Fluorophenyl)furo[2,3-e]pyrrolo[1,2-a] pyrazin-5(4H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL517818; BDBM50267077
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
3-(3,4-Dimethoxyphenyl)pyrrolo[2,3-b]pyrrolizin-8(1H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL35864; CTK1J2753; DTXSID60463516; BDBM50240446; Pyrrolo[2,3-b]pyrrolizin-8(1H)-one, 3-(3,4-dimethoxyphenyl)-; 3-(3,4-Dimethoxy-phenyl)-1H-1,3b-diaza-cyclopenta[a]pentalen-7-one
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
5-Chloro-1-trimethylsilanyl-3,3a,4,5-tetrahydro-2H-cyclopenta[c]acridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3749137; CHEMBL3651155; BDBM153480; 5-chloro-1-trimethylsilyl-3,3a,4,5-tetrahydrocyclopenta[c]acridin-2-one; US8999955, 5-chloro-1-trimethylsilanyl-3,3a,4,5-tetrahydro-2H-cyclopenta[c]acridin-2-one
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| Activity |
IC50 = 63000 nM
|
[6] | |||
| Compound Name |
3-N-[4-(4-Methoxyphenyl)pyrimidin-2-yl]benzene-1,3-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098016; BDBM50262022
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| Activity |
IC50 = 81000 nM
|
[7] | |||
| Compound Name |
2,6,9-Trisubstituted purine deriv. 8
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL133740; BDBM7513; 2-{[9-(propan-2-yl)-6-(1,2,3,6-tetrahydropyridin-1-yl)-9H-purin-2-yl]amino}ethan-1-ol
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(4-methoxyphenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391119; BDBM50435040
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2,6,9-Trisubstituted purine deriv. 25
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Investigative | Compound Info | ||
| Synonyms |
BDBM7530; CHEMBL3085250; [(2R)-1-[9-benzyl-6-(benzylamino)-9H-purin-2-yl]pyrrolidin-2-yl]methanol; 2-[(2R)-2-(Hydroxymethyl)pyrrolizino]-9,N-dibenzyl-9H-purine-6-amine
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
CID 71578744
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391101; BDBM50435025; N-[4-[5-[(3-cyanophenyl)methylsulfanyl]-1,3,4-oxadiazol-2-yl]pyridin-2-yl]acetamide
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(3,5-difluorophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391117; BDBM50435038
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[[4-(4-Methoxyphenyl)phenyl]methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391131; SCHEMBL14604069; BDBM50435029
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[[4-(3,5-Difluorophenyl)phenyl]methylsulfanyl]-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391124; SCHEMBL14604425; BDBM50435018
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-[4-[5-[[4-(2-Cyanophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazol-2-yl]pyridin-2-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391102; BDBM50435024
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Compound Name |
2,6,9-Trisubstituted purine deriv. 6
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL129973; BDBM7511; 2-({9-methyl-6-[methyl(prop-2-en-1-yl)amino]-9H-purin-2-yl}amino)ethan-1-ol
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
3-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391132; SCHEMBL14604396; BDBM50435031
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
5-[3-Fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yl]oxy]phenyl]-2-(4-fluorophenylamino)-3-methylpyrimidin-4(3H)-one
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Investigative | Compound Info | ||
| Synonyms |
AMG-51; pyrimidone, 51; AMG51; CHEMBL453737; SCHEMBL2868963; AMG-51;AMG 51; BDBM24769; SYN1111; C34H33F2N5O5; BCP21618; ZINC43178754; NCGC00263201-01; NCGC00263201-02; AS-16255
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
2-[(4-Phenylphenyl)methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391099; SCHEMBL14604409; BDBM50435027; AKOS000905896
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2,6,9-Trisubstituted purine deriv. 7
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL336176; BDBM7512; 2-({6-[methyl(prop-2-en-1-yl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)ethan-1-ol
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
6-Chloro-2-iodo-9-isopropyl-9H-purine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL337291; 6-chloro-2-iodo-9-propan-2-ylpurine; 2,6,9-Trisubstituted purine deriv. 4b; BDBM7504; SCHEMBL2314138; CTK0J8514; DTXSID50424878; 2-Iodo-6-chloro-9-isopropyl-9H-purine; 6-chloro-2-iodo-9-(propan-2-yl)-9H-purine; 9H-Purine, 6-chloro-2-iodo-9-(1-methylethyl)-
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
N-[4-(5-Benzylsulfanyl-1,3,4-oxadiazol-2-yl)pyridin-2-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391100; BDBM50435026
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(2-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391129; BDBM50435023
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[4-[[5-(1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]-5-methoxybenzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391118; SCHEMBL14603900; BDBM50435039
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-[[4-(2-Nitrophenyl)phenyl]methylsulfanyl]-5-pyridin-4-yl-1,3,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391133; BDBM50435032
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
4-[4-[(5-Pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2390958; SCHEMBL14604141; BDBM50435030
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N,9-Dibenzyl-2-iodopurin-6-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL133477; 2,6,9-Trisubstituted purine deriv. 5f; BDBM7510; N,9-dibenzyl-2-iodo-9H-purin-6-amine
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]-5-methoxybenzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391125; SCHEMBL14604165; BDBM50435019
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(3-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391120; BDBM50435033
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2-(1,3-Benzodioxol-5-yl)-5-[[4-(2-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391122; BDBM50435035
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2,6,9-Trisubstituted purine deriv. 5d
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL132948; BDBM7508; N-benzyl-9-cyclopentyl-2-iodo-9H-purin-6-amine
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(4-methoxyphenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391126; SCHEMBL14604054; BDBM50435020
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
2,6,9-Trisubstituted purine deriv. 5e
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL335938; BDBM7509; N-benzyl-9-cyclohexyl-2-iodo-9H-purin-6-amine; 2-Iodo-N-benzyl-9-cyclohexyl-9H-purine-6-amine
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
6-Chloro-9-cyclopentyl-9H-purin-2-ylamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL335743; SCHEMBL6473284; 6-chloro-9-cyclopentylpurin-2-amine; BDBM50093398; 9-Cyclopentyl-6-chloro-9H-purine-2-amine
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| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
5-Fluoro-2-[4-[(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)sulfanylmethyl]phenyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391098; BDBM50435028
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
N-(2-((3-(Dimethylamino)propyl)(methyl)amino)-5-(trifluoromethyl)phenyl)-2-fluoro-5-((3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yl)oxy)benzamide
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Investigative | Compound Info | ||
| Synonyms |
2-MT-63; 2-(Methylamino)triazine 63; CHEMBL373882; SCHEMBL1264383; BDBM15000
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| Activity |
IC50 = 100000 nM
|
[10] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[[4-(3-nitrophenyl)phenyl]methylsulfanyl]-1,3,4-oxadiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391128; SCHEMBL14603927; BDBM50435021
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
10-Bromo-11H-indolo[3,2-c]quinoline-6-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3589661; BDBM50097868
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
3-[4-[[5-(1,3-Benzodioxol-5-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391121; BDBM50435034
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| Activity |
IC50 ~ 100000 nM
|
[9] | |||
| Compound Name |
3-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391130; SCHEMBL14603849; BDBM50435022
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-[(4-phenylphenyl)methylsulfanyl]-1,3,4-oxadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391123; SCHEMBL14604095; BDBM50435036
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Compound Name |
4(3H)-Pyrimidinone,2-[(4-fluorophenyl)amino]-5-[5-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinolinyl]oxy]-2-pyridinyl]-3-methyl-
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Investigative | Compound Info | ||
| Synonyms |
pyrimidone, 62; CHEMBL447602; SCHEMBL13511902; BDBM24772; ZINC43202030
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
(S)-5-(2-(2-Aminopyrimidin-5-yl)ethynyl)-N-(2-(3-(dimethylamino)piperidin-1-yl)-5-(trifluoromethyl)phenyl)-2-fluorobenzamide
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Investigative | Compound Info | ||
| Synonyms |
alkynylpyrimidine amide 6l; CHEMBL386637; SCHEMBL2973659; BDBM14961
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| Activity |
IC50 ~ 100000 nM
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[12] | |||
| Compound Name |
4-[4-[[5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]sulfanylmethyl]phenyl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2391127; SCHEMBL14603718; BDBM50435037
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| Activity |
IC50 ~ 100000 nM
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[9] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
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| REF 1 | Pharmacological inhibitors of glycogen synthase kinase 3. Trends Pharmacol Sci. 2004 Sep;25(9):471-80. | ||||
| REF 2 | Cyclin-Dependent Kinase (CDK) Inhibitors: Structure-Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines. J Med Chem. 2017 Mar 9;60(5):1746-1767. | ||||
| REF 3 | Design, synthesis, and biological evaluation of potent c-Met inhibitors. J Med Chem. 2008 Sep 25;51(18):5766-79. | ||||
| REF 4 | Synthesis of new dipyrrolo- and furopyrrolopyrazinones related to tripentones and their biological evaluation as potential kinases (CDKs1-5, GSK-3) inhibitors. Eur J Med Chem. 2009 Feb;44(2):708-16. | ||||
| REF 5 | Imidazo[1,2-a]pyrazine diaryl ureas: inhibitors of the receptor tyrosine kinase EphB4. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6991-5. | ||||
| REF 6 | US patent application no. 8999955B2, Tetrahydrocyclopenta[c]acridine derivatives as kinase inhibitors and biological | ||||
| REF 7 | Synthesis and evaluation of the NSCLC anti-cancer activity and physical properties of 4-aryl-N-phenylpyrimidin-2-amines. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4749-4754. | ||||
| REF 8 | 3D-QSAR CoMFA on cyclin-dependent kinase inhibitors. J Med Chem. 2000 Nov 2;43(22):4098-108. | ||||
| REF 9 | Structure-based optimization of oxadiazole-based GSK-3 inhibitors. Eur J Med Chem. 2013 Mar;61:26-40. | ||||
| REF 10 | Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor. J Med Chem. 2007 Feb 22;50(4):611-26. | ||||
| REF 11 | 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. J Med Chem. 2015 Apr 9;58(7):3131-43. | ||||
| REF 12 | Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase. J Med Chem. 2007 Feb 22;50(4):627-40. | ||||
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