Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T19368 | Target Info | |||
| Target Name | Endothelial lipase (LIPG) | ||||
| Synonyms |
Endothelial cell-derived lipase; EL; EDL
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| Target Type | Clinical trial Target | ||||
| Gene Name | LIPG | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 14 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Nonylphenylboronic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952301; (2-nonylphenyl)boronic acid; BDBM50364288
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| Activity |
IC50 = 50000 nM
|
[1] | |||
| Compound Name |
1-Methyl-3-(2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl)-1-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL512951; BDBM50254394
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
2-Methyl-N-phenyl-5-(piperidin-1-ylsulfonyl)furan-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL468911; Oprea1_244338; HMS1662L14; ZINC118139; BDBM50254397; CCG-239379; MCULE-2161200640; BRD-K13559272-001-01-4
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(2-Methyl-4-(morpholinosulfonyl)phenyl)-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL506964; BDBM50253986
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(2-Methyl-5-(piperidin-1-ylsulfonyl)-1H-pyrrol-3-yl)-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL462478; BDBM50253975
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(2-Methyl-6-(piperidin-1-ylsulfonyl)pyridin-3-yl)-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL461187; BDBM50254043
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(1-Methyl-3-(piperidin-1-ylsulfonyl)-1H-pyrazol-5-yl)-3-phenylurea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL462694; BDBM50253977
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(2,4-Dimethyl-5-(piperidin-1-ylsulfonyl)furan-3-yl)-3-phenylurea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL460141; BDBM50253973
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(1,2-Dimethyl-5-(piperidin-1-ylsulfonyl)-1H-pyrrol-3-yl)-3-phenylurea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL518672; BDBM50253976
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-Benzyl-3-(2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL468271; BDBM50254342
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
1-(4-Chlorophenyl)-1-methyl-3-(2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL468910; BDBM50254395
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
US8987314, Reference 2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672589; SCHEMBL15464707; BDBM151203; 2-methyl-2-(6-phenyl-1,3-benzothiazol-2-yl)-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]propanamide
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| Activity |
IC50 ~ 62000 nM
|
[3] | |||
| Compound Name |
US8987314, Reference 3
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3672590; SCHEMBL15470660; BDBM151204
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| Activity |
IC50 ~ 62000 nM
|
[3] | |||
| Compound Name |
3-[3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]phenyl]propanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1952314; BDBM50364302
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| Activity |
IC50 = 95000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design and synthesis of boronic acid inhibitors of endothelial lipase. Bioorg Med Chem Lett. 2012 Feb 1;22(3):1397-401. | ||||
| REF 2 | Discovery of potent, selective sulfonylfuran urea endothelial lipase inhibitors. Bioorg Med Chem Lett. 2009 Jan 1;19(1):27-30. | ||||
| REF 3 | US patent application no. 8987314B2, Amide, urea or sulfone amide linked benzothiazole inhibitors of endothelial lipase | ||||
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