Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T18784 | Target Info | |||
| Target Name | Lysine-specific demethylase 7A (KDM7A) | ||||
| Synonyms |
Lysine-specific demethylase 7; KIAA1718; KDM7; JmjC domain-containing histone demethylation protein 1D; JHDM1D
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| Target Type | Literature-reported Target | ||||
| Gene Name | KDM7A | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 10 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Amiodarone
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Approved | Compound Info | ||
| Synonyms |
Amidorone; Aminodarone; Amiobeta; Amiodarex; Amiodarona; Amiodarons; Amiodaronum; Amiohexal; Amjodaronum; Ancar; Aratac;Arycor; Braxan; Corbionax; Cordarex; Cordarone; Kordaron; Labaz; Ortacrone; Pacerone; Rytmarone; Sedacoron; Sedacorone; Tachydaron; ASTA Medica Brand of Amiodarone Hydrochloride; Alphapharm Brand of Amiodarone Hydrochloride; Amiodarone Base; Armstrong Brand of Amiodarone Hydrochloride; Berenguer Infale Brand of Amiodarone Hydrochloride; Betapharm Brand of Amiodarone Hydrochloride; Cordarone Intravenous; G Gam Brand of Amiodarone Hydrochloride; Hexal Brand of Amiodarone Hydrochloride; Leurquin Brand of Amiodarone Hydrochloride; Pharma Investi Brand of Amiodarone Hydrochloride; Sanofi Winthrop Brand of Amiodarone Hydrochloride; Wyeth Brand of Amiodarone Hydrochloride; Ethylaminoethoxy)benzoyl]benzofuran; L 3428; L3428; SKF 33134A; Amio-Aqueous IV; Amiodarona [INN-Spanish]; Amiodaronum [INN-Latin]; Aratac (TN); Arycor (TN); Atlansil (TN); Cordarone (TN); L-3428; Pacerone (TN); Pms-Amiodarone; SKF 33134-A; Amiodarone (USAN/INN); Amiodarone [USAN:BAN:INN]; Ketone, 2-butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl; Ketone, 2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl (7CI,8CI); (2-Butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diidophenyl)methanone; (2-butyl-1-benzofuran-3-yl)(4-{[2-(diethylamino)ethyl]oxy}-3,5-diiodophenyl)methanone; (2-butyl-1-benzofuran-3-yl)-[4-(2-diethylaminoethyloxy)-3,5-diiodophenyl]methanone; (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone; (2-butylbenzofuran-3-yl)-[4-(2-diethylaminoethoxy)-3,5-diiodo-phenyl]-methanone; (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine; 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran; 2-Butyl-3-(3,5-diiodo-4-(beta-diethylaminoethoxy)benzoyl)benzofuran; 2-Butyl-3-(4'-beta-N-diethylaminoethoxy-3',5'-diiodobenzoyl)benzofuran; 2-Butyl-3-[3,5-diiodo-4-(2-di; 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone; 2-Butyl-3-benzofuranyl p-((2-diethylamino)ethoxy)-m,m-diiodophenyl ketone; 2-Butyl-3-benzofuranyl p-[(2-diethylamino)ethoxy]-m,m-diiodophenyl ketone; 2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran
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| Activity |
IC50 = 80000 nM
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[1] | |||
| Compound Name |
Chembl4129540
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Investigative | Compound Info | ||
| Activity |
IC50 = 50000 nM
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[1] | |||
| Compound Name |
Chembl4129830
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273477
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| Activity |
IC50 = 68000 nM
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[1] | |||
| Compound Name |
Chembl4129980
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273474
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| Activity |
IC50 = 76000 nM
|
[1] | |||
| Compound Name |
Chembl4130224
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273478
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| Activity |
IC50 = 86000 nM
|
[1] | |||
| Compound Name |
Chembl4128152
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273476
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| Activity |
IC50 = 88000 nM
|
[1] | |||
| Compound Name |
Chembl4127094
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Investigative | Compound Info | ||
| Synonyms |
BDBM50270479
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| Activity |
IC50 = 102000 nM
|
[1] | |||
| Compound Name |
Chembl4127792
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273473
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| Activity |
IC50 = 104000 nM
|
[1] | |||
| Compound Name |
Chembl4126406
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273469
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| Activity |
IC50 = 108000 nM
|
[1] | |||
| Compound Name |
Chembl4127515
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273471
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| Activity |
IC50 = 151000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(carboxymethylamino)-2-oxoacetic acid
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Investigative | Compound Info | ||
| Synonyms |
N-Oxalylglycine; 5262-39-5; Oxalylglycine; Oxaloglycine; 2-((Carboxymethyl)amino)-2-oxoacetic acid; UNII-VVW38EB8YS; N-(carboxycarbonyl)glycine; N-OXALYOLGLYCINE; VVW38EB8YS; 2-oxo-3-azaglutaric acid; CHEMBL90852; Glycine, N-(carboxycarbonyl)-; CHEBI:44482; OGA; C4H5NO5; 4idz; 4nrp; 2xml; 3hqr; N-oxalyl glycine, 1a; 2oq6; 1h2k; AC1MIVD0; Glycine,N-(carboxycarbonyl)-; SCHEMBL435820; BDBM26106; CTK8F0807; DTXSID20200601; MolPort-000-141-021; ZINC1534133; N-Oxalylglycine, > 4958AE
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| Activity |
IC50 > 250000 nM
|
[2] | |||
| Compound Name |
Chembl4126951
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273475
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| Activity |
IC50 = 295000 nM
|
[1] | |||
| Compound Name |
Chembl4128613
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273470
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| Activity |
IC50 = 326000 nM
|
[1] | |||
| Compound Name |
Chembl4126135
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Investigative | Compound Info | ||
| Synonyms |
BDBM50270475
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| Activity |
IC50 = 534000 nM
|
[1] | |||
| Compound Name |
Chembl4126240
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Investigative | Compound Info | ||
| Activity |
IC50 = 2232000 nM
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[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases. Bioorg Med Chem. 2018 Jul 15;26(11):2984-2991. | ||||
| REF 2 | Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J Med Chem. 2013 Sep 26;56(18):7222-31. | ||||
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