Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T18299 | Target Info | |||
| Target Name | CaM-kinase II (CAMK2) | ||||
| Synonyms |
Calcium/calmodulin-dependent protein kinase type II; CaMK-II; CaM kinase II; CAMK
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| Target Type | Clinical trial Target | ||||
| Gene Name | CAMK2A; CAMK2B; CAMK2D; CAMK2G | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 12 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Minaprine
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Approved | Compound Info | ||
| Synonyms |
Brantur; Cantor; Minaprina; Minaprinum; Minaprine dihydrochloride; AGR 1240; CB 30038; Cantor (TN); Minaprina [INN-Spanish]; Minaprinum [INN-Latin]; Minaprine (USAN/INN); Minaprine [USAN:BAN:INN]; N-(4-Methyl-6-phenyl-3-pyridazinyl)-4-morpholineethanamine; 3-(morpholinoethyl)amino-4-methyl-6-phenylpyridazine; 4-(2-((4-Methyl-6-phenyl-3-pyridazinyl)amino)ethyl)morpholine; 4-Methyl-3-(2-morpholinoethylamino)-6-phenylpyridazin; 4-methyl-N-(2-morpholin-4-ylethyl)-6-phenylpyridazin-3-amine
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
JNJ-7706621
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Investigative | Compound Info | ||
| Synonyms |
JNJ-7706621; 443797-96-4; JNJ7706621; 4-((5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl)amino)benzenesulfonamide; UNII-74GK72DON8; RWJ-387252; 4-[[5-amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide; CHEMBL191003; 74GK72DON8; 4-[[5-Amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-yl]amino]benzenesulfonamide; JNJ 7706621; 4-(5-amino-1-(2,6-difluorobenzoyl)-1H-1,2,4-triazol-3-ylamino)benzenesulfonamide
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[[5-Cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino]-4-methyl-N-(1,2-oxazol-3-yl)benzamide
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Investigative | Compound Info | ||
| Synonyms |
3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-4-methyl-N-(1,2-oxazol-3-yl)benzamide; CHEMBL383172; 5-Cyanopyrimidine Derivative 3b; SCHEMBL16576397; BDBM16326; 3-{[5-cyano-6-(cyclopentylamino)pyrimidin-4-yl]amino}-N-isoxazol-3-yl-4-methylbenzamide
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
N-Cyclopropyl-2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5-yl)methylamino)benzamide
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Investigative | Compound Info | ||
| Synonyms |
BMS-605541; CHEMBL377734; BMS 605541; SCHEMBL2861987; BDBM50189603; AKOS034831603
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
R-K-K-Y-K-I-R-R-K-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL262895; BDBM50074642
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| Activity |
IC50 = 57400 nM
|
[5] | |||
| Compound Name |
3-(1-Methyl-1H-indole-3-yl)-4-[1-(1-benzylpyrrolidine-3-yl)-1H-indole-3-yl]-1H-pyrrole-2,5-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL291975; SCHEMBL6421778; BDBM50128283; 3-[1-(1-Benzyl-pyrrolidin-3-yl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-pyrrole-2,5-dione
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| Activity |
IC50 = 59000 nM
|
[6] | |||
| Compound Name |
N-(6-Phenylpyridazine-3-yl)-3-methyl-6-imino-1,6-dihydropyridazine-1-undecanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL117443; SCHEMBL2739508; BDBM50469776
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-(6-Phenylpyridazine-3-yl)-3-imino-2,3,5,6-tetrahydrobenzo[h]cinnoline-2-undecanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL115531; SCHEMBL2739447; BDBM50469777
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-[[1-(2,6-Difluoro-3-methylbenzoyl)-5-methyl-1,2,4-triazol-3-yl]amino]benzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL363607
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
8-Bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-1,2,3-triazol-4-ylmethyl)amino]quinoline-3-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
Cyanoquinoline, 51; BMCL193485 Compound 8; CHEMBL230232; SCHEMBL4961707; BDBM21925; 8-bromo-4-(3-chloro-4-fluoroanilino)-6-(2H-triazol-4-ylmethylamino)quinoline-3-carbonitrile
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
11-(6-Imino-3-phenylpyridazin-1-yl)-N-(6-phenylpyridazin-3-yl)undecanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL116963; SCHEMBL2739490; BDBM50469778; N-(6-Phenylpyridazine-3-yl)-3-phenyl-6-imino-1,6-dihydropyridazine-1-undecanamide
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
R-K-K-Y-K-L-R-R-K-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386668; BDBM50074636
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| Activity |
IC50 = 132000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 22 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
R-K-K-Y-K-S-R-R-K-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL267348; BDBM50074657
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-K-M-R-R-K-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL265891; BDBM50074637
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-K-F-R-R-K-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL409544; BDBM50074644
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-(Ach)-K-(Ach)-R-R-K-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL430273; BDBM50074647
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-(Ach)-K-Y-R-R-K-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL411670; BDBM50074656
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-(Ach)-(Ach)-(Ach)-R-R-K-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL407521; BDBM50074633
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|
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-K-A-R-R-K-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL264293; BDBM50074643
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-K-E-R-R-K-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL269727; BDBM50074641
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-K-N-R-R-K-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL262286; BDBM50074649
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-K-D-R-R-K-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL405953; BDBM50074654
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-K-(Ach)-R-R-K-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL415435; BDBM50074646
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|
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-K-K-R-R-K-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216528; BDBM50074652
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|
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-(Ach)-(Ach)-R-R-K-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL268790; BDBM50074648
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|
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-K-P-R-R-K-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425624; BDBM50074635
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-K-V-R-R-K-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL412772; BDBM50074650
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
(2S)-6-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]hexanoyl]amino]-3-hydroxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]hexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1791266; BDBM50369485
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-K-Q-R-R-K-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL264533; BDBM50074655
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-(Ach)-Y-R-R-K-NH2
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL385812; BDBM50074653
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-Y-K-G-R-R-K-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL262494; BDBM50074651
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| Activity |
IC50 > 200000 nM
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[5] | |||
| Compound Name |
MLCK inhibitor peptide 18
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL443574; Myosin Light Chain Kinase Inhibitor Peptide 18; GTPL9351; R-K-K-Y-K-Y-R-R-K-NH2; BDBM50074638; AKOS024456829; H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
R-K-K-(Ach)-(Ach)-Y-R-R-K-NH2
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL264267; BDBM50074634
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| Activity |
IC50 > 200000 nM
|
[5] | |||
| Compound Name |
10-Chloro-6-hydroxybenzo [c]quinolizinium chloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL175225; SCHEMBL2081163; SCHEMBL2081165
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| Activity |
IC50 = 760000 nM
|
[8] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | An aminopyridazine-based inhibitor of a pro-apoptotic protein kinase attenuates hypoxia-ischemia induced acute brain injury. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3465-70. | ||||
| REF 2 | 1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities. J Med Chem. 2005 Jun 30;48(13):4208-11. | ||||
| REF 3 | 5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase. J Med Chem. 2005 Oct 6;48(20):6261-70. | ||||
| REF 4 | Discovery and evaluation of N-cyclopropyl- 2,4-difluoro-5-((2-(pyridin-2-ylamino)thiazol-5- ylmethyl)amino)benzamide (BMS-605541), a selective and orally efficacious inhibitor of vascular endothelial growth factor receptor-2. J Med Chem. 2006 Jun 29;49(13):3766-9. | ||||
| REF 5 | Identification of novel classes of protein kinase inhibitors using combinatorial peptide chemistry based on functional genomics knowledge. J Med Chem. 1999 Mar 11;42(5):910-9. | ||||
| REF 6 | Acyclic N-(azacycloalkyl)bisindolylmaleimides: isozyme selective inhibitors of PKCbeta. Bioorg Med Chem Lett. 2003 Jun 2;13(11):1857-9. | ||||
| REF 7 | Inhibitors of tumor progression loci-2 (Tpl2) kinase and tumor necrosis factor alpha (TNF-alpha) production: selectivity and in vivo antiinflammatory activity of novel 8-substituted-4-anilino-6-aminoquinoline-3-carbonitriles. J Med Chem. 2007 Sep 20;50(19):4728-45. | ||||
| REF 8 | Benzo[c]quinoliziniums: A new family of inhibitors for protein kinase CK II. Bioorg Med Chem Lett. 1997 Apr 22;7(8):961-4. | ||||
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