Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17863 | Target Info | |||
| Target Name | Pepsinogen-5 (PGA5) | ||||
| Synonyms |
Pepsin A-5
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| Target Type | Literature-reported Target | ||||
| Gene Name | PGA5 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-Carbamimidoyl-2-[2-(2-Chlorophenyl)-5-[4-(4-Ethanoylphenoxy)phenyl]pyrrol-1-Yl]ethanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL253237; Acylguanidine, 7c; SCHEMBL4492598; BDBM16753; 2-[2-[4-(4-acetylphenoxy)phenyl]-5-(2-chlorophenyl)pyrrol-1-yl]-N-(diaminomethylidene)acetamide; Q27453455; N-{2-[2-[4-(4-acetyl-phenoxy)-phenyl]-5-(2-chloro-phenyl)-pyrrol-1-yl]-acetyl}-guanidine; 2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl]-1H-pyrrol-1-yl]-N-(diaminomethylidene)acetamide; 2-{2-[4-(4-acetylphenoxy)phenyl]-5-(2-chlorophenyl)-1H-pyrrol-1-yl}-N-carbamimidoylacetamide
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
Acylguanidine, 10b
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL403819; SCHEMBL4485912; BDBM16754; 2-[2-(1-adamantyl)-5-phenylpyrrol-1-yl]-N-[N'-(3-hydroxypropyl)carbamimidoyl]acetamide
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| Activity |
IC50 ~ 50000 nM
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[1] | |||
| Compound Name |
N-[Amino(imino)methyl]-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217068; 1H-Pyrrole-1-acetamide,N-(aminoiminomethyl)-2,5-diphenyl-; Acylguanidine, 7a; SCHEMBL4472723; SCHEMBL8269481; BDBM16751; N-(diaminomethylidene)-2-(2,5-diphenylpyrrol-1-yl)acetamide; ZINC14962105; DB06930; n-[2-(2,5-diphenyl-pyrrol-1-yl)-acetyl]guanidine; Q27095835; N-carbamimidoyl-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide; (N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-acetamide); N-(diaminomethylidene)-2-(2,5-diphenyl-1H-pyrrol-1-yl)acetamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
N-[2-(2-Adamantan-1-yl-5-phenyl-pyrrol-1-yl)-acetyl]-guanidine
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Investigative | Compound Info | ||
| Synonyms |
Acylguanidine, 7b; CHEMBL402330; SCHEMBL4489564; SCHEMBL8269634; BDBM16752; 2-[2-(1-adamantyl)-5-phenylpyrrol-1-yl]-N-(diaminomethylidene)acetamide; 2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-(diaminomethylidene)acetamide
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Acylguanidine, 10d
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL401587; BDBM16755
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-(4-Amino-piperidin-1-yl)-2-benzyl-N-[1-(1-cyclohexylmethyl-2,3-dihydroxy-5-pyridin-2-yl-pentylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-4-oxo-butyramide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL94762; BDBM50045683
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
CI-992
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Terminated | Compound Info | ||
| Synonyms |
CI-992; CHEMBL34894; 135704-06-2; CTK4B9950; N-[2-(2-Amino-thiazol-4-yl)-1-(1-cyclohexylmethyl-2,3-dihydroxy-5-methyl-hexylcarbamoyl)-ethyl]-2-(morpholine-4-sulfonylamino)-3-phenyl-propionamide; L-Alaninamide,N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-(9CI); BDBM50006844
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| Activity |
IC50 = 202000 nM
|
[3] | |||
| Compound Name |
2-Benzyl-N-[1-(1-cyclohexylmethyl-2,3,4,5,6-pentahydroxy-hexylcarbamoyl)-2-(1H-imidazol-4-yl)-ethyl]-3-(2-methyl-propane-2-sulfonyl)-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL357253; BDBM50008520
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| Activity |
IC50 > 1000000 nM
|
[4] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Acylguanidines as small-molecule beta-secretase inhibitors. J Med Chem. 2006 Oct 19;49(21):6158-61. | ||||
| REF 2 | Renin inhibitors containing a pyridyl amino diol derived C-terminus. J Med Chem. 1993 Sep 17;36(19):2788-800. | ||||
| REF 3 | Structure-activity relationships of a series of 2-amino-4-thiazole-containing renin inhibitors. J Med Chem. 1992 Jul 10;35(14):2562-72. | ||||
| REF 4 | Renin inhibitory pentols showing improved enteral bioavailability. J Med Chem. 1992 Feb 7;35(3):559-67. | ||||
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