Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17228 | Target Info | |||
| Target Name | Poly [ADP-ribose] polymerase 3 (PARP3) | ||||
| Synonyms |
pADPRT-3; hPARP-3; Protein mono-ADP-ribosyltransferase PARP3; Poly[ADP-ribose] synthase 3; PARP-3; NAD(+) ADP-ribosyltransferase 3; IRT1; DNA ADP-ribosyltransferase PARP3; ARTD3; ADPRTL3; ADPRT3; ADPRT-3; ADP-ribosyltransferase diphtheria toxin-like 3
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| Target Type | Patented-recorded Target | ||||
| Gene Name | PARP3 | ||||
| Biochemical Class | Glycosyltransferases | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 12 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1,2-Dihydro-2-(4-isopropylphenyl)-4(3H)-quinazolinone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3594136; Oprea1_576221; 2-[4-(propan-2-yl)phenyl]-1,2,3,4-tetrahydroquinazolin-4-one; BDBM50104287; AKOS001314013; MCULE-7496308930; Z48978364; 2-(4-Isopropylphenyl)-2,3-dihydroquinazolin-4(1H)-one; 2-(4-Isopropylphenyl)-1,2,3,4-tetrahydroquinazoline-4-one
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| Activity |
IC50 = 50000 nM
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[1] | |||
| Compound Name |
4-(4-Formyl-phenoxy)-benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4287655; 4-(4-Formylphenoxy)-benzamide; 4-(4-formylphenoxy)benzamide; SCHEMBL754740; BDBM50468581; ZINC20297191; A1-11748
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| Activity |
IC50 = 86000 nM
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[2] | |||
| Compound Name |
4-(4-Carbamoylphenoxy)benzamide
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Investigative | Compound Info | ||
| Synonyms |
4,4'-oxydibenzamide; OUL35; 4,4'-Oxybis[benzamide]; MLS000736992; 4-(4-aminocarbonylphenoxy)benzamide; NSC39047; Oprea1_001354; IFLab1_001185; OUL 35; SCHEMBL3137816; CHEMBL1438938; CTK5B8808; DTXSID10284793; BDBM199181; HMS1415F19; HMS2754A23; ZINC235625; NSC-39047; AKOS001482413; MCULE-8450176580; IDI1_009052; OUL35, >=98% (HPLC); SMR000393949; EU-0000374; SR-01000391101; SR-01000391101-1; 4-[(4-Carbamoylcyclohexyl)oxy]cyclohexane-1-carboxamide (OUL35)
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
4-Methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
p-Anisamide; p-Methoxybenzamide; 4-Methoxy benzamide; Benzamide, 4-methoxy-; 4-methoxy-benzamide; UNII-Z85FX3977E; CHEMBL449635; Z85FX3977E; MFCD00007995; 4-Methoxybenzamide, 97%; P-methyoxybenzamide; EINECS 222-319-6; BRN 1862847; ACMC-1CJJO; 4-Methoxybenzamide, 98%; Oprea1_456315; 4-10-00-00433 (Beilstein Handbook Reference); KSC225C6N; SCHEMBL201761; SCHEMBL12015238; CTK1C5166; KS-00000FKR; DTXSID40879434; ZINC161203; ACT03272; NSC11139; ANW-27812; BDBM50340090; NSC-11139; STL482885; AKOS000266484; AB00908; CS-W022205; GS-6794; MCULE-3713623573; VZ29332; AC-17055; AK114264; SC-65292; AB0016899; DB-006861; FT-0600843; M1679; ST50824264; 24M939; W-2595; W-106742; Q20059730; Z33546492
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
3-(4-Oxo-3,4-Dihydroquinazolin-2-Yl)-N-[(1r)-1-(Pyridin-2-Yl)ethyl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092538; BDBM103555; ZINC7979429; ME0354; Q27455857
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N-[3-Chloranyl-4-[[4-(4-Methoxyphenyl)oxan-4-Yl]methylcarbamoyl]phenyl]furan-2-Carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752386; SCHEMBL15057674; BDBM50136755; Q27464764; N-[3-chloro-4-[[4-(4-methoxyphenyl)oxan-4-yl]methylcarbamoyl]phenyl]furan-2-carboxamide
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Compound Name |
4-[(2-Fluorophenyl)methoxy]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4208737; OUL35 derivative 32; SCHEMBL20883219; 4-[(2-fluorobenzyl)oxy]benzamide; ZINC7509736; BDBM50452662; STL506080; AKOS017030557; MCULE-5507437194; Z26312097
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
N-[(1R)-2,3-Dihydro-1H-inden-1-yl]-3-(4-oxo-3H-quinazolin-2-yl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092540; BDBM50444036; ZINC32843533
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
N-[(1S)-2,3-Dihydro-1H-inden-1-yl]-3-(4-oxo-3H-quinazolin-2-yl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3092541; BDBM50444035; ZINC32843534
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| Activity |
IC50 ~ 100000 nM
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[3] | |||
| Compound Name |
4-(4-Carbamoylphenoxy)benzoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4287262; BDBM50468579; ZINC20297208; AKOS009229962; MCULE-8977258216; NE43435; EN300-70101; Z1222331858
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
1-[3-[4-(2-Chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]cyclobutyl]-2-oxidanylidene-3~{H}-benzimidazole-5-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4095003; SCHEMBL20302234; SCHEMBL20333643; SCHEMBL20333645; BDBM50250875
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| Activity |
IC50 ~ 100000 nM
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[5] | |||
| Compound Name |
N-{4-[(2-Chlorophenyl)(Pyrimidin-4-Yl)carbamoyl]phenyl}-4-Methoxybenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752492; BDBM50136772; Q27456886; 8IR
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| Activity |
IC50 ~ 100000 nM
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[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics. Bioorg Med Chem. 2015 Aug 1;23(15):4139-4149. | ||||
| REF 2 | 4-(Phenoxy) and 4-(benzyloxy)benzamides as potent and selective inhibitors of mono-ADP-ribosyltransferase PARP10/ARTD10. Eur J Med Chem. 2018 Aug 5;156:93-102. | ||||
| REF 3 | Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. J Med Chem. 2013 Dec 12;56(23):9556-68. | ||||
| REF 4 | Development and structural analysis of adenosine site binding tankyrase inhibitors. Bioorg Med Chem Lett. 2016 Jan 15;26(2):328-333. | ||||
| REF 5 | Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. J Med Chem. 2017 Dec 28;60(24):10013-10025. | ||||
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