Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17221 | Target Info | |||
| Target Name | Glutathione S-transferase A1 (GSTA1) | ||||
| Synonyms |
GTH1; GSTA1-1; GST-epsilon; GST class-alpha member 1; GST HA subunit 1; Androst-5-ene-3,17-dione isomerase; 13-hydroperoxyoctadecadienoate peroxidase
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| Target Type | Literature-reported Target | ||||
| Gene Name | GSTA1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
N-[2-[(1-Methylpyrrol-2-yl)sulfonylmethyl]phenyl]-1-(4-nitrophenyl)methanimine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165141; BDBM50395590
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| Activity |
Ki = 71000 nM
|
[1] | |||
| Compound Name |
1-Methyl-2-[((2-nitrobenzyl)sulfonyl)]-1H-pyrrole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2165146; BDBM50395591
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| Activity |
Ki = 135000 nM
|
[1] | |||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-Amino-4-[2-benzylsulfanyl-1-(2-carboxy-ethylcarbamoyl)-ethylcarbamoyl]-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL58451; BDBM50043759
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| Activity |
Ki = 360000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Synthesis and study of 2-(pyrrolesulfonylmethyl)-N-arylimines: a new class of inhibitors for human glutathione transferase A1-1. J Med Chem. 2012 Aug 9;55(15):6802-13. | ||||
| REF 2 | Isozyme-specific glutathione-S-transferase inhibitors: design and synthesis. J Med Chem. 1994 Jan 7;37(1):189-94. | ||||
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