Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T17140 | Target Info | |||
| Target Name | P2X purinoceptor 3 (P2RX3) | ||||
| Synonyms |
P2X3 receptor; P2X3; P2RX3; ATP-gated ion channel P2X(3)
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | P2RX3 | ||||
| Biochemical Class | ATP-gated P2X receptor cation channel | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
MRS 2219
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MRS2219; MRS-2220
Click to Show/Hide
|
||||
| Activity |
IC50 = 58300 nM
|
[1] | |||
| Compound Name |
adenosine diphosphate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Adenosine diphosphate; 58-64-0; ADP; Adenosine 5'-(trihydrogen diphosphate); adenosine pyrophosphate; adenosine 5'-pyrophosphate; ADP (nucleotide); adenosine-diphosphate; 5'-Adenylphosphoric acid; 5'-Adp; Adenosindiphosphorsaeure; Adenosine 5'-pyrophosphoric acid; Adenosine-5'-diphosphat; Adenosine 5'-diphosphoric acid; Adenosine diphosphoric acid; Ado-5'-P-P; UNII-61D2G4IYVH; H3adp; BRN 0067722; CHEBI:16761; EINECS 200-392-5; 61D2G4IYVH; CHEMBL14830
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1H-Benzoimidazole-2-carboxylic acid[(R)-1-((1S,2R,3S)-1-cyclo-hexylmethyl-3-cyclopropyl-2,3-dihydroxy-propylcarbamoyl)-2-thiazol-4-yl-ethyl]-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Ro 0437626; CHEMBL190141; RO-0437626; SCHEMBL16507547; CTK4B9123; DTXSID20470221; BDBM50168286; ZINC14209607; AKOS024456978; NCGC00378583-01; J-006525
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Dids
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
DIDS sodium salt; UNII-1VFRQ7416A; 1VFRQ7416A; Disodium 4,4'-diisothiocyano-2,2'-stilbenedisulfonate; 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonic Acid Disodium Salt; CHEMBL133930; NSC-344481; NSC 344481; 4,4'-diisothiocyanatostilbene-2,2'-disulfonic acid disodium salt; SPECTRUM1505164; Disodium 4,4'-Diisothiocyanato-2,2'-stilbenedisulfonate; MDL-101114ZA; AKOS015904177; CCG-214537; NCGC00096047-01; B7675; 4 4'-DIISOTHIOCYANATO-2 2'-STILBENEDISU&; J-013551; Disodium 4,4'-diisothiocyanato-2,2'-stilbenedisulfonate, (E)-; 4,4'-Diisothiocyanato-2,2'-stilbenzenedisulfonic acid disodium salt; 4,4'-Diisothiocyanato-2.2'-stilbenedisulfonic acid disodium salt; 4,4'-diisothiocyanatostilbene-2,2'-disul-fonic acid disodium salt; 4,4'-Diisothiocyano-2,2'-stilbenedisulfonic Acid, Disodium Salt; Sodium 6,6'-(ethene-1,2-diyl)bis(3-isothiocyanatobenzenesulfonate); sodium (E)-6,6'-(ethene-1,2-diyl)bis(3-isothiocyanatobenzenesulfonate); 2,2'-(1,2-Ethenediyl)bis(5-isothiocyanato-, disodium salt, benzenesulfonic acid; 2,2'-(Ethene-1,2-diyl)bis(5-isothiocyanatobenzenesulfonic acid sodium) salt
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Purine and pyrimidine (P2) receptors as drug targets. J Med Chem. 2002 Sep 12;45(19):4057-93. | ||||
| REF 2 | Discovery and synthesis of a novel and selective drug-like P2X(1) antagonist. Bioorg Med Chem Lett. 2005 Jul 1;15(13):3292-5. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.