Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16769 | Target Info | |||
| Target Name | X-linked inhibitor of apoptosis protein (XIAP) | ||||
| Synonyms |
hILP; hIAP3; hIAP-3; Xlinked IAP; X-linked IAP; RING-type E3 ubiquitin transferase XIAP; Inhibitor of apoptosis protein 3; ILP; IAPlike protein; IAP3; IAP-like protein; IAP-3; E3 ubiquitinprotein ligase XIAP; E3 ubiquitin-protein ligase XIAP; Baculoviral IAP repeatcontaining protein 4; Baculoviral IAP repeat-containing protein 4; BIRC4; API3
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| Target Type | Clinical trial Target | ||||
| Gene Name | XIAP | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 217 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
L-Phenylalanine
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Approved | Compound Info | ||
| Synonyms |
Endophenyl; Fenilalanina; Phe; Phenylalanine; Phenylalaninum; Fenilalanina [Spanish]; Phenylalaninum [Latin]; Antibiotic FN 1636; CB 3208; NCI9959; Alpha-Aminohydrocinnamic acid; Beta-Phenylalanine; L-Antibiotic FN 1636; L-PHENYLALININE; N-Formylmelphalan; Phenylalanine (VAN); H-Phe-OH; L-Phenylalanine (JP15); Phenylalanine (USP/INN); Phenylalanine [USAN:INN:JAN]; Beta-Phenyl-L-alanine; N-Formyl-L-sarcolysin; N-Formyl-L-p-sarcolysin; L-PHENYL ALANINE (SEE ALSO 22839-47-0, ASPARTAME; L-3-(p-(Bis(2-chloroethyl)amino)phenyl)-N-formylalanine; L-Phenylalanine, 4-(bis(2-chloroethyl)amino)-N-formyl-(9CI); (2S)-2-amino-3-phenylpropanoic acid; (L)-Phenylalanine; (S)-(-)-Phenylalanine; (S)-2-Amino-3-phenylpropanoic acid; (S)-2-Amino-3-phenylpropionic acid; (S)-Phenylalanine; (S)-alpha-Amino-benzenepropanoic acid; (S)-alpha-Amino-beta-phenylpropionic acid; (S)-alpha-Aminohydrocinnamic acid; 1F9436B3-8B0D-4AC6-A004-4249B0BDA436; 3-Phenyl-L-alanine; 3-Phenylalanine; 3-[4-[bis(2-chloroethyl)amino]phenyl]-2-formamidopropanoic acid
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| Activity |
IC50 = 80200 nM
|
[1] | |||
| Compound Name |
KAEMPFEROL
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Investigative | Compound Info | ||
| Synonyms |
kaempferol; 520-18-3; Kaempherol; Kempferol; Trifolitin; Populnetin; Robigenin; Rhamnolutein; Pelargidenolon; Rhamnolutin; Swartziol; Indigo Yellow; Kampherol; Nimbecetin; Kampferol; Campherol; Kaemferol; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one; 5,7,4'-Trihydroxyflavonol; Pelargidenolon 1497; 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one; C.I. 75640; CCRIS 41; NSC 407289; 3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one; 4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2-(4-hydroxyphe
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-8-fluoro-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4108407; BDBM237596; US9394263, 16
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Nvp-cgm097
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Investigative | Compound Info | ||
| Synonyms |
CGM097; CGM-097; CGM 097; NVP-CGM-097; NVP CGM097; UNII-4UF6MSL0ZH; 4UF6MSL0ZH; C38H47ClN4O4; SCHEMBL2391192; SCHEMBL2391196; CHEMBL3601398; SCHEMBL18458199; KS-00000TSY; BDBM162123; BCP18308; EX-A1059; MFCD28144684; s7875; NVP-CGM097 (CGM-097); AKOS030526402; ZINC253387855; CCG-270337; CS-3138; NCGC00390552-01; AC-32967; AS-75288; HY-15954; W5747; J3.509.326E; A16326; US9051279, 106; Q27454942
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-(pyridin-3-yl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089693; SCHEMBL11987417; BDBM50314468
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| Activity |
Ki = 50000 nM
|
[5] | |||
| Compound Name |
(3S,6S,10As)-N-[(S)-[1-[4-[4-[4-[4-[(S)-[[(3S,6S,10aS)-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carbonyl]amino]-phenylmethyl]triazol-1-yl]butyl]phenyl]butyl]triazol-4-yl]-phenylmethyl]-6-[[(2S)-2-acetamido-3-(1H-indol-3-yl)propanoyl]amino]-5-oxo-2,3,6,7,8,9,10,10a-octahydro-1H-pyrrolo[1,2-a]azocine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1774155; BDBM50343514
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(2S)-N-[(3S,4S)-1-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-5-(2-methoxyacetyl)-4-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3934552; SCHEMBL15629726; BDBM242796; US9422331, 17
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| Activity |
IC50 = 50260 nM
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[7] | |||
| Compound Name |
1-(6-Methylindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600725; SCHEMBL15837631; BDBM155955; US9018214, 6; 1-(6-methyl-2,3-dihydroindol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone
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| Activity |
IC50 = 51000 nM
|
[8] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-((S)-2-(5-methyl-7-phenylthiazolo[5,4-d]pyrimidin-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093356; SCHEMBL11987460; BDBM50314479
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| Activity |
Ki = 51000 nM
|
[5] | |||
| Compound Name |
1-(6-Fluoroindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600727; SCHEMBL15837634; BDBM155959; US9018214, 10; 1-(6-fluoro-2,3-dihydroindol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone
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| Activity |
IC50 = 51000 nM
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[8] | |||
| Compound Name |
(1S)-N-(2,6-Difluorophenyl)-2-[(2S,3R)-3-methoxy-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-1,3-dihydroisoindole-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3981335; SCHEMBL15605770; BDBM242854; US9422332, 32
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| Activity |
IC50 = 51740 nM
|
[9] | |||
| Compound Name |
Methanoic acid;(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]-N-[(2S)-1-oxidanylidene-1-(2-phenylhydrazinyl)propan-2-yl]butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1626340; MLS-0391056.0001; BDBM44283; cid_44176334
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| Activity |
Ki = 51790 nM
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[10] | |||
| Compound Name |
(2S)-N-[(3S,4S)-5-Acetyl-1-[(5-bromo-2-methoxyphenyl)methyl]-7-cyano-4-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3931439; SCHEMBL15629626; BDBM242812; US9422331, 36
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| Activity |
IC50 = 53050 nM
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[7] | |||
| Compound Name |
(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3906278; SCHEMBL15594372; BDBM237657; US9394263, 69
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| Activity |
IC50 ~ 53100 nM
|
[3] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-5-[(2-methylsulfonyl-1,3-dihydroisoindol-4-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3979396; SCHEMBL15594290; BDBM237648; US9394263, 60
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| Activity |
IC50 = 53210 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S,9S,12S,18S,24S,27S)-9,24-Dibenzyl-18-[[(2S)-2-(methylamino)propanoyl]amino]-2,8,11,17,23,26-hexaoxo-1,7,10,16,22,25-hexazatricyclo[25.3.0.012,16]triacontan-3-yl]-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1095992; BDBM50316636
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| Activity |
IC50 = 53900 nM
|
[11] | |||
| Compound Name |
(2S,3S)-2-Amino-N-((S)-1-((6-bromo-2-methoxynaphthalen-1-yl)methyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl)-3-hydroxybutanamide hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431763; SCHEMBL15414480
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| Activity |
IC50 ~ 54000 nM
|
[12] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-1-[(4-methylnaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431757; SCHEMBL15414494
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| Activity |
IC50 ~ 54000 nM
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[12] | |||
| Compound Name |
(2S)-N-[(3S)-1-Benzyl-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(methylamino)propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431770; SCHEMBL15414926
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| Activity |
IC50 ~ 54000 nM
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[12] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-1-(naphthalen-1-ylmethyl)-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431756; SCHEMBL15415150
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| Activity |
IC50 ~ 54000 nM
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[12] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-2-oxo-1-(2-phenylethyl)-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431771
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| Activity |
IC50 ~ 54000 nM
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[12] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-1-[(2-methylnaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431758; SCHEMBL15413924
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| Activity |
IC50 ~ 54000 nM
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[12] | |||
| Compound Name |
Smac peptido-mimetic 12d
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL362027; BDBM13157; (2S)-1-[(2S)-2-[(2S)-2-aminopentanamido]-3-methylbutanoyl]-N-benzylpyrrolidine-2-carboxamide
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| Activity |
Ki = 54000 nM
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[13] | |||
| Compound Name |
(2S)-N-[(3S)-1-[(2-Methoxynaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(methylamino)propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431759; SCHEMBL15413758
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| Activity |
IC50 ~ 54000 nM
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[12] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-1-(naphthalen-2-ylmethyl)-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431772; SCHEMBL15415124
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| Activity |
IC50 ~ 54000 nM
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[12] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutyl)-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436323; SCHEMBL16718106
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| Activity |
IC50 ~ 54000 nM
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[14] | |||
| Compound Name |
(2R)-N-[(3S)-1-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(methylamino)propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431761; SCHEMBL15414320
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| Activity |
IC50 ~ 54000 nM
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[12] | |||
| Compound Name |
(2S)-N-[(3S)-1-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(ethylamino)propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431764; SCHEMBL15414927
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| Activity |
IC50 ~ 54000 nM
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[12] | |||
| Compound Name |
(2S)-N-[(3S)-1-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-oxo-4,5-dihydro-3H-1-benzazepin-3-yl]-2-(methylamino)propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431760; SCHEMBL15414601
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| Activity |
IC50 ~ 54000 nM
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[12] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-1-methyl-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436322; SCHEMBL18066601
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| Activity |
IC50 ~ 54000 nM
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[14] | |||
| Compound Name |
(S)-N-[(S)-9-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocyclohepten-7-yl]-2-methylamino-propionamide trifluoroacetate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431765; SCHEMBL15565612
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| Activity |
IC50 ~ 54000 nM
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[12] | |||
| Compound Name |
(2S)-N-(5-Benzyl-1,1,4-trioxo-2,3-dihydro-1lambda6,5-benzothiazepin-3-yl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3937541; SCHEMBL15594350; BDBM237586; US9394263, 6
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| Activity |
IC50 ~ 54200 nM
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[3] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[1,1,4-trioxo-5-(4-phenylbutyl)-2,3-dihydro-1lambda6,5-benzothiazepin-3-yl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3900675; SCHEMBL15594411; BDBM237587; US9394263, 7
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| Activity |
IC50 ~ 54200 nM
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[3] | |||
| Compound Name |
(S)-2-Amino-N-((S)-3-methyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[D]azepin-1-YL)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431769; SCHEMBL4943515; DTXSID40657698; BDBM50441355; MFCD22371872; ZINC72191267; AKOS015924545; W-3725; (1S)-1alpha-(L-Alanylamino)-3-methyl-1,2,4,5-tetrahydro-3H-3-benzoazepine-2-one; N-[(1S)-3-Methyl-2-oxo-2,3,4,5-tetrahydro-1H-3-benzazepin-1-yl]-L-alaninamide
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| Activity |
IC50 ~ 54200 nM
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[12] | |||
| Compound Name |
(2S)-N-(5-Benzyl-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl)-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3983818; SCHEMBL15594344; BDBM237585; US9394263, 5
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| Activity |
IC50 ~ 54200 nM
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[3] | |||
| Compound Name |
4-Acetyl-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3911442; SCHEMBL15594342; BDBM237608; US9394263, 22h
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| Activity |
IC50 ~ 54800 nM
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[3] | |||
| Compound Name |
(2S)-N-(2-Benzoylphenyl)-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2,3-dihydroindole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926247; SCHEMBL16482924; BDBM238833; US9403768, 5
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| Activity |
IC50 ~ 54800 nM
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[15] | |||
| Compound Name |
(2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-8,9-difluoro-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3960805; SCHEMBL15594405; BDBM237589; US9394263, 9
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| Activity |
IC50 ~ 54800 nM
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[3] | |||
| Compound Name |
(2S)-N-[(3S,4S)-1-(1,2-Benzoxazol-3-ylmethyl)-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436220; CHEMBL3040594; SCHEMBL15629733; BDBM50441815
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| Activity |
IC50 ~ 54800 nM
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[7] | |||
| Compound Name |
1-Acetyl-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-3,4-dihydro-2H-1,5-benzothiazepin-9-yl]piperidine-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3981426; SCHEMBL17347420; BDBM237609; US9394263, 23
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| Activity |
IC50 ~ 54800 nM
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[3] | |||
| Compound Name |
3-Cyano-N-ethyl-4-[4-[[(2S,3S)-2-methyl-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]indazol-1-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3906624; SCHEMBL15594475; BDBM237668; US9394263, 81
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| Activity |
IC50 ~ 54800 nM
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[3] | |||
| Compound Name |
(2S)-2-Amino-N-[(3R)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]propanamide
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Investigative | Compound Info | ||
| Synonyms |
US9394263, 21; CHEMBL3955650; SCHEMBL15594363; BDBM237599
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| Activity |
IC50 ~ 54800 nM
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[3] | |||
| Compound Name |
(2S)-N-[(3S,4S)-7-Cyano-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(ethylamino)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3985856; SCHEMBL15629616; BDBM242806; US9422331, 28
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-N-[(3S,4S)-1-[(2-Methoxynaphthalen-1-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436218; SCHEMBL15621666
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(3S)-5-Benzyl-1-(3-methylbutanoyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436324; SCHEMBL16718676
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,3'-oxetane]-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3960145; SCHEMBL17347449; BDBM237565; US9394263, 1k
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S,4S)-1-[(7-Chloro-2-oxochromen-4-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3970030; SCHEMBL17001165; BDBM242815; US9422331, 40
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-N-[(2S,3S)-5-[[2-Cyano-1-(2-cyanophenyl)indol-4-yl]methyl]-2-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899943; SCHEMBL15594381; BDBM237664; US9394263, 77
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(1S)-N-(2,6-Difluorophenyl)-2-[(2S,3S)-2-[[(2S)-2-(methylamino)propanoyl]amino]-3-phenylbutanoyl]-1,3-dihydroisoindole-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961175; SCHEMBL15605749; BDBM242858; US9422332, 40
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(2S)-1-[(2S)-2-[[(2S)-2-(Methylamino)propanoyl]amino]-2-phenylacetyl]-N-(2-phenylphenyl)-2,3-dihydroindole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3970346; SCHEMBL16482997; BDBM238837; US9403768, 9
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[15] | |||
| Compound Name |
(2S)-N-[(3S,4S)-1-[(7-Methoxy-2-oxochromen-4-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3959682; SCHEMBL15629724; BDBM242792; US9422331, 12
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-N-[(3S)-5-(1,2-Benzoxazol-3-ylmethyl)-4-oxo-9-(trifluoromethyl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3965608; SCHEMBL15594465; BDBM237675; US9394263, 90
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(4-Bromonaphthalen-1-yl)methyl]-9-[4-(3-hydroxypropyl)piperazine-1-carbonyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3956026; SCHEMBL15565142; BDBM237644; US9394263, 56
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
4-Methoxy-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3942520; SCHEMBL15594340; BDBM237606; US9394263, 22f
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(S)-1-[(S)-3-Methyl-2-((S)-2-methylamino-propionylamino)-butyryl]-2,3-dihydro-1H-indole-2-carboxylic acid (2,6-difluoro-phenyl)-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926075; SCHEMBL16484028; BDBM238840; US9403768, 12
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[15] | |||
| Compound Name |
(2S)-N-[(3S,4S)-5-(4-Acetylbenzoyl)-1-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3950467; SCHEMBL15629700; BDBM242785; US9422331, 3
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-N-[(3S)-1-Acetyl-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436320; SCHEMBL18066531
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
(3S)-5-[(2-Methoxynaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3935349; SCHEMBL15594270; BDBM237637; US9394263, 49
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3903864; SCHEMBL15594264; BDBM237636; US9394263, 48
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
3-[[6-Methoxy-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carbonyl]amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3898307; SCHEMBL17347468; BDBM237622; US9394263, 34
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
N-[(3R)-3-[[(2S)-2-(Methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]-6-oxoheptanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3940451; SCHEMBL15594367; BDBM237612; US9394263, 26
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
N-(2-Hydroxyethyl)-6-methoxy-N-methyl-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3917199; SCHEMBL17347494; BDBM237621; US9394263, 33
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(2-Methoxynaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3896116; SCHEMBL15594358; BDBM237616; US9394263, 29b
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(4-Bromonaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3955727; SCHEMBL15594355; BDBM237615; US9394263, 29a
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)-6-fluoroindazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3946301; SCHEMBL15594373; BDBM237658; US9394263, 71
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
6-Methoxy-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3948518; SCHEMBL15594406; BDBM237620; US9394263, 32
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-(2-Methoxyphenyl)-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]-2-phenylacetyl]-2,3-dihydroindole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3927285; SCHEMBL16482998; BDBM238838; US9403768, 10
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[15] | |||
| Compound Name |
(2S)-N-[(3S,4S)-1-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-methyl-5-(oxane-4-carbonyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3963534; SCHEMBL15629622; BDBM242803; US9422331, 24
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-N-Benzyl-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2,3-dihydroindole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3931660; SCHEMBL16463734; BDBM238831; US9403768, 3
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[15] | |||
| Compound Name |
3-[[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carbonyl]amino]propanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3905054; SCHEMBL15594468; BDBM237638; US9394263, 50
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952123; BDBM237679; US9394263, 70
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(1S)-N-(2,6-Difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3898167; SCHEMBL15605750; BDBM242861; US9422332, 25
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(1R)-6-Chloro-N-(2,6-difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3892690; SCHEMBL15605810; BDBM242868; US9422332, 46
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(2S)-N-[(3R)-9-[[2-(2-Methoxyethoxy)acetyl]amino]-5-(naphthalen-1-ylmethyl)-3,4-dihydro-2H-1,5-benzothiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3919201; SCHEMBL17347419; BDBM237600; US9394263, 22
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(2-Methoxynaphthalen-1-yl)methyl]-1-(3-methylbutanoyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436328; SCHEMBL16718740
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
Methyl 6-methoxy-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3910969; SCHEMBL15594369; BDBM237619; US9394263, 31
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-1'-methylsulfonyl-4-oxospiro[3H-1,5-benzoxazepine-2,4'-piperidine]-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3901230; SCHEMBL17347563; BDBM237560; US9394263, 1e
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[3] | |||
| Compound Name |
N-[(3R)-3-[[(2S)-2-(Methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]pyridine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3905534; SCHEMBL15594324; BDBM237605; US9394263, 22e
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(1-methylindazol-3-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436221; SCHEMBL15621720
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
(1S)-N-(2,6-Difluorophenyl)-2-[(2S)-3,3-dimethyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3903660; SCHEMBL15605744; BDBM242863; US9422332, 38
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-1-(quinolin-4-ylmethyl)-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3923222; SCHEMBL15621883; BDBM242795; US9422331, 16
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436219; SCHEMBL15621846
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(2S,3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-2-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3889914; SCHEMBL17347499; BDBM237661; US9394263, 74
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutanoyl)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436327; SCHEMBL16718421
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(3S)-5-(1,2-Benzoxazol-3-ylmethyl)-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431753; SCHEMBL17332783
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[12] | |||
| Compound Name |
(2S)-N-[(3R)-5-[[2-(Difluoromethoxy)naphthalen-1-yl]methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3978353; SCHEMBL15594398; BDBM237671; US9394263, 86
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431754
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[12] | |||
| Compound Name |
(2S)-N-[(3S,4S)-5-Acetyl-4-methyl-1-[(3-methylquinolin-4-yl)methyl]-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908839; SCHEMBL15629725; BDBM242799; US9422331, 20
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutanoyl)-4-oxo-5-(2-phenylethyl)-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436325; SCHEMBL16718589
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(1-methylindazol-3-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436221; CHEMBL3040493; SCHEMBL15629631; BDBM50441814
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3935639; SCHEMBL17347490; BDBM237561; US9394263, 1f
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(1-Ethyl-2-oxo-3H-indol-4-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3948020; SCHEMBL15565449; BDBM237651; US9394263, 63
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S,3R)-2-Amino-N-[(3S)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-8-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-3-hydroxybutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4110409; SCHEMBL15594448; BDBM237625; US9394263, 37
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S,4S)-7-Cyano-1-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3960618; SCHEMBL15629530; BDBM242824; US9422331, 53
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
5-[[(3S)-9-[2-Hydroxyethyl(methyl)carbamoyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]-6-methoxynaphthalene-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3942830; SCHEMBL15594311; BDBM237641; US9394263, 53
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S,4S)-1-[(5-Chloro-2-methoxyphenyl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961346; SCHEMBL15629627; BDBM242818; US9422331, 43
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(4-Chlorophenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926445; SCHEMBL15565708; BDBM237635; US9394263, 47
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(oxetan-3-ylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3902270; SCHEMBL15564865; BDBM237654; US9394263, 66
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S,4S)-1-[(2-Methoxynaphthalen-1-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436218; CHEMBL3040491; SCHEMBL15629523; BDBM50441809
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(6-Fluoro-1-methyl-2-oxoquinolin-4-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3950374; SCHEMBL15564442; BDBM237649; US9394263, 61
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(1S)-N-(2,6-Difluorophenyl)-6-fluoro-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3917880; SCHEMBL15605767; BDBM242831; US9422332, 6
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(1R)-N-(2,6-Difluorophenyl)-6-fluoro-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3938605; SCHEMBL15605807; BDBM242871; US9422332, 43
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
3,4,5-Trimethoxy-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3934042; SCHEMBL15594426; BDBM237611; US9394263, 25
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(S)-N-[(S)-1-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-5-(3-methyl-butyryl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl]-2-methylamino-propionamide hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436329; SCHEMBL16718665
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(3S,4S)-1-[(6-Bromo-1,2-benzoxazol-3-yl)methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952658; SCHEMBL15629628; BDBM242816; US9422331, 41
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-1-[(2S)-2-[[(2S)-2-(Methylamino)propanoyl]amino]-2-phenylacetyl]-2,3-dihydroindole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952181; SCHEMBL16463718; BDBM238835; US9403768, 7
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[15] | |||
| Compound Name |
(2S)-N-[(5-Fluoro-2-methylphenyl)methyl]-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2,3-dihydroindole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953890; SCHEMBL16465437; BDBM238832; US9403768, 4
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[15] | |||
| Compound Name |
(1S)-N-(2,6-Difluorophenyl)-2-[(2S,3S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]pentanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926243; SCHEMBL15605745; BDBM242860; US9422332, 15
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(3S)-5-[(6-Carboxy-2-methoxynaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3972444; SCHEMBL15594473; BDBM237640; US9394263, 52
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(2-hydroxyethylamino)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3949246; SCHEMBL17347567; BDBM237670; US9394263, 83
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-4-oxo-5-[[2-(2,2,2-trifluoroethoxy)naphthalen-1-yl]methyl]spiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3944732; SCHEMBL15594441; BDBM237575; US9394263, 1w
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2,2-dimethyl-4-oxo-3H-1,5-benzothiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3958572; SCHEMBL15594397; BDBM237584; US9394263, 4
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-5-[(2-methylnaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3925367; SCHEMBL15564440; BDBM237632; US9394263, 44
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(1R)-N-(2,6-Difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-1,3-dihydroisoindole-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3903428; SCHEMBL15605804; BDBM242835; US9422332, 18
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(2S)-N-[(2S,3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2,8-dimethyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3926190; SCHEMBL15594325; BDBM237627; US9394263, 39
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S,4S)-5-Acetyl-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3984795; SCHEMBL15621713; BDBM242801; US9422331, 22
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(3-methylquinolin-4-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3932171; SCHEMBL15629606; BDBM242793; US9422331, 14
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-1-(2-methylsulfonylacetyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436215; SCHEMBL16718304
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
6-Methoxy-N,N-dimethyl-5-[[(3S)-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]naphthalene-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3911797; SCHEMBL15594414; BDBM237623; US9394263, 35
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-(1,2-Benzoxazol-3-ylmethyl)-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2431753; CHEMBL3040818; SCHEMBL15594476; BDBM50441336
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,1'-cyclopentane]-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3927629; SCHEMBL17347487; BDBM237558; US9394263, 1c
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(3-Chlorophenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3898381; SCHEMBL15565569; BDBM237634; US9394263, 46
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-1-Acetyl-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436214; SCHEMBL16718254
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
3-Methyl-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3891127; SCHEMBL15594321; BDBM237601; US9394263, 22a
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
N-[(3R)-3-[[(2S)-2-(Methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]-5-oxohexanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3984921; SCHEMBL15594424; BDBM237610; US9394263, 24
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-9-fluoro-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3965707; SCHEMBL15594425; BDBM237591; US9394263, 11
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(1S)-N-(2-Fluoro-6-methylphenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-1,3-dihydroisoindole-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3932790; SCHEMBL15605772; BDBM242844; US9422332, 47
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(3S)-5-[(4-Bromonaphthalen-1-yl)methyl]-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepine-9-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3943916; SCHEMBL15594327; BDBM237642; US9394263, 54
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-1-[(2S)-2-[[(2S)-2-(Methylamino)propanoyl]amino]-2-phenylacetyl]-N-phenyl-2,3-dihydroindole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3899158; SCHEMBL16482996; BDBM238836; US9403768, 8
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[15] | |||
| Compound Name |
(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3967129; SCHEMBL15565875; BDBM237646; US9394263, 58
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-1-(4-nitrobenzoyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436207; SCHEMBL16718111
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-4-oxo-5-propan-2-ylspiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3977386; SCHEMBL15594436; BDBM237574; US9394263, 1v
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[3] | |||
| Compound Name |
(2S,3S)-2-Amino-N-[(3S)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-8-methyl-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-3-hydroxybutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953832; SCHEMBL15594417; BDBM237626; US9394263, 38
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S,3S)-2-Amino-N-[(3R)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-3-hydroxybutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3938120; SCHEMBL17343093; BDBM237570; US9394263, 1p
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[3] | |||
| Compound Name |
(1S)-7-Chloro-N-(2,6-difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3952988; SCHEMBL15605805; BDBM242867; US9422332, 45
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(2S,3S)-2-Amino-N-[(3S)-5-[(6-bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-3-hydroxybutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3943405; SCHEMBL17343092; BDBM237569; US9394263, 1o
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[3] | |||
| Compound Name |
(1S)-N-(2,6-Difluorophenyl)-2-[(2S,3R)-3-hydroxy-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-1,3-dihydroisoindole-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3911343; SCHEMBL15605741; BDBM242855; US9422332, 33
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(1S)-N-(2,6-Difluorophenyl)-2-[(2S,3R)-3-methoxy-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3940670; SCHEMBL15605782; BDBM242864; US9422332, 39
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(2S)-2-Amino-N-[(3S)-4-oxo-5-propan-2-ylspiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3953461; SCHEMBL17343094; BDBM237573; US9394263, 1u
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[3] | |||
| Compound Name |
(1S)-N-(2,6-Dichlorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3912676; SCHEMBL15605819; BDBM242865; US9422332, 36
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(1R)-2-[(2S)-3-Methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-N-naphthalen-1-yl-1,3-dihydroisoindole-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3894477; SCHEMBL15605808; BDBM242837; US9422332, 22
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
3-Cyano-4-[4-[[(2S,3S)-2-methyl-3-[[(2S)-2-(methylamino)propanoyl]amino]-4-oxo-2,3-dihydro-1,5-benzoxazepin-5-yl]methyl]indazol-1-yl]benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3891098; SCHEMBL15594380; BDBM237667; US9394263, 80
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(1R)-7-Chloro-N-(2,6-difluorophenyl)-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3978633; SCHEMBL15605815; BDBM242866; US9422332, 44
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(S)-2-Methylamino-N-((S)-1-naphthalen-1-ylmethyl-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b][1,4]diazepin-3-yl)-propionamide hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436228; SCHEMBL18066562
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
(1R)-N-(2,6-Difluorophenyl)-7-fluoro-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3961690; SCHEMBL15605775; BDBM242869; US9422332, 41
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(2S)-N-[(3S,4S)-1-(1,2-Benzoxazol-3-ylmethyl)-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436220
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
N-[(3R)-3-[[(2S)-2-(Methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908665; SCHEMBL15594357; BDBM237614; US9394263, 28
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(1S)-2-[(2S)-2-Cyclopentyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(2,6-difluorophenyl)-3,4-dihydro-1H-isoquinoline-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3935144; SCHEMBL15605746; BDBM242862; US9422332, 37
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(2-Chlorophenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3949640; SCHEMBL15564330; BDBM237633; US9394263, 45
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-1-[(2S)-3-Methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2,3-dihydroindole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3915200; SCHEMBL17052780; BDBM238830; US9403768, 2
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[15] | |||
| Compound Name |
(2S)-N-(2,6-Difluorophenyl)-3,3-dimethyl-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-2H-indole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3898503; SCHEMBL16482849; BDBM238829; US9403768, 1
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[15] | |||
| Compound Name |
(2S)-N-[(5-Fluoro-2-methylphenyl)methyl]-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]-2-phenylacetyl]-2,3-dihydroindole-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3918215; SCHEMBL16464939; BDBM238834; US9403768, 6
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[15] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(4-Bromonaphthalen-1-yl)methyl]-9-[4-(2-hydroxyethyl)piperazine-1-carbonyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3965099; SCHEMBL15565424; BDBM237643; US9394263, 55
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
1-Methyl-N-[(3R)-3-[[(2S)-2-(methylamino)propanoyl]amino]-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-9-yl]piperidine-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3933545; SCHEMBL15594318; BDBM237604; US9394263, 22d
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S,4S)-4-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436219; CHEMBL3040492; SCHEMBL15629633; BDBM50441808
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(2-hydroxyethylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3893188; SCHEMBL15565678; BDBM237597; US9394263, 17
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[[6-Bromo-1-(2-cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(ethylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3955541; SCHEMBL15594477; BDBM237659; US9394263, 72
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(1S)-N-(2,6-Difluorophenyl)-7-fluoro-2-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-3,4-dihydro-1H-isoquinoline-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3907080; SCHEMBL15605785; BDBM242870; US9422332, 42
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
N-[(3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-9-fluoro-4-oxospiro[3H-1,5-benzoxazepine-2,4'-oxane]-3-yl]-2-(methylamino)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908732; BDBM237593; US9394263, 13
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(2S,3R)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,3'-oxolane]-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3900944; SCHEMBL15594433; BDBM237577; BDBM237578; US9394263, 1y; US9394263, 1z
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[3] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutanoyl)-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436321; SCHEMBL16718345
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(3S,4S)-1-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436222; SCHEMBL15621790
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(2-hydroxyethylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3948318; SCHEMBL15594253; BDBM237656; US9394263, 68
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-(2-methoxyethyl)-2-methyl-4-oxo-3H-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3930947; SCHEMBL17347492; BDBM237567; US9394263, 1m
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(2-Methoxyphenyl)methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3924128; SCHEMBL15594362; BDBM237617; US9394263, 29c
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
4-({[(S)-9-(6-Bromo-2-methoxy-naphthalen-1-ylmethyl)-7-((S)-2-methylamino-propionylamino)-8-oxo-6,7,8,9-tetrahydro-5-oxa-9-aza-benzocycloheptene-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3933065; SCHEMBL15564827; BDBM237639; US9394263, 51
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxo-7-(trifluoromethyl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3912876; SCHEMBL15594464; BDBM237630; US9394263, 42
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3R)-9-Amino-5-(naphthalen-1-ylmethyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3909777; SCHEMBL15565777; BDBM237613; US9394263, 27
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
2-[(2S)-3-Methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-N-phenyl-1,3-dihydroisoindole-1-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3908353; SCHEMBL15605768; BDBM242845; US9422332, 16
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[9] | |||
| Compound Name |
(2S)-N-[(3S,4S)-1-[[1-(2-Cyanophenyl)indazol-3-yl]methyl]-4-methyl-5-(2-methylsulfonylacetyl)-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436222; CHEMBL3040460; SCHEMBL15629632; BDBM50441813
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-1-(3-methylbutanoyl)-5-(1-naphthalen-1-ylethyl)-4-oxo-2,3-dihydro-1,5-benzodiazepin-3-yl]propanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2436326; SCHEMBL16718150
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[14] | |||
| Compound Name |
(2S)-N-[(3S,4S)-5-Acetyl-1-[[1-(2-cyanophenyl)indazol-3-yl]methyl]-4-methyl-2-oxo-3,4-dihydro-1,5-benzodiazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3933238; SCHEMBL15621865; BDBM242798; US9422331, 19
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[7] | |||
| Compound Name |
(2S)-2-Amino-N-[(3S)-5-[[1-(2-cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3911286; SCHEMBL15594285; BDBM237652; US9394263, 64
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[[1-(2-Cyanophenyl)indazol-4-yl]methyl]-4-oxo-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-[(2-hydroxy-2-methylpropyl)amino]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3933732; SCHEMBL15594450; BDBM237655; US9394263, 67
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-4-oxospiro[3H-1,5-benzoxazepine-2,1'-cyclohexane]-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3921114; SCHEMBL15594346; BDBM237555; US9394263, 1
Click to Show/Hide
|
||||
| Activity |
IC50 = 54800 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(2S,3S)-5-[(6-Bromo-2-methoxynaphthalen-1-yl)methyl]-2-methyl-4-oxo-7-(trifluoromethyl)-2,3-dihydro-1,5-benzoxazepin-3-yl]-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3940874; SCHEMBL15594467; BDBM237631; US9394263, 43
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 54800 nM
|
[3] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-(2-oxo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-6-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3890929; SCHEMBL13734507; BDBM184587; US9155743, 16
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[16] | |||
| Compound Name |
(2S)-N-(1,3-Dimethyl-2-oxo-4H-pyrido[3,2-d]pyrimidin-6-yl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3894597; SCHEMBL13732110; BDBM184591; US9155743, 20
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[16] | |||
| Compound Name |
(S)-N-((S)-2-((S)-2-(4-(3-Chlorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093708; SCHEMBL11987418; BDBM50314471
Click to Show/Hide
|
||||
| Activity |
Ki = 55000 nM
|
[5] | |||
| Compound Name |
(2S)-N-(1,3-Dimethyl-2-oxobenzimidazol-5-yl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3920196; SCHEMBL15474185; BDBM184588; US9155743, 17
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[16] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-[(3S)-3-methyl-2-oxo-3,4-dihydro-1H-pyrido[2,3-b]pyrazin-6-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3922505; SCHEMBL13734315; BDBM184586; US9155743, 15
Click to Show/Hide
|
||||
| Activity |
IC50 = 55000 nM
|
[16] | |||
| Compound Name |
(2R)-N-Benzhydryl-1-[(2S)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1619777; BDBM50348196
Click to Show/Hide
|
||||
| Activity |
Ki ~ 56000 nM
|
[17] | |||
| Compound Name |
(2S)-N-Benzhydryl-1-[(2S)-3-methyl-2-[[(2R)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1800337; BDBM50348197
Click to Show/Hide
|
||||
| Activity |
Ki ~ 56000 nM
|
[17] | |||
| Compound Name |
(2S)-N-Benzhydryl-1-[(2R)-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1625398; BDBM50348220
Click to Show/Hide
|
||||
| Activity |
Ki ~ 56000 nM
|
[17] | |||
| Compound Name |
Formic acid;(2S)-1-[(2S)-2-[[(2S)-2-(methylamino)propanoyl]amino]butanoyl]-N-(6-methylquinolin-5-yl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1622682; MLS-0391030.0001; BDBM44334; cid_44182261
Click to Show/Hide
|
||||
| Activity |
Ki = 56130 nM
|
[17] | |||
| Compound Name |
(S)-N-((S)-2-((S)-2-(4-(4-Chlorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091484; SCHEMBL11987420; BDBM50314472
Click to Show/Hide
|
||||
| Activity |
Ki = 58000 nM
|
[5] | |||
| Compound Name |
1-(6-Isopropylindoline-1-yl)-2-((3R)-3-methylpiperazine-1-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3600726; SCHEMBL15837638; BDBM155962; US9018214, 13; 2-[(3R)-3-methylpiperazin-1-yl]-1-(6-propan-2-yl-2,3-dihydroindol-1-yl)ethanone
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[8] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-(pyridin-4-yl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089694; SCHEMBL11987421; BDBM50314469
Click to Show/Hide
|
||||
| Activity |
Ki = 60000 nM
|
[5] | |||
| Compound Name |
(2S)-N-[(1S)-1-(Anilinocarbamoyl)-2-methyl-propyl]-3-methyl-2-[[(2S)-2-(methylamino)propanoyl]amino]butyramide;formic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1625435; MLS-0391058.0001; BDBM44285; cid_44176338
Click to Show/Hide
|
||||
| Activity |
Ki = 65620 nM
|
[10] | |||
| Compound Name |
(5S,8S,10Ar)-N-benzhydryl-5-[[(2S)-3-(1H-indol-3-yl)-2-(methylamino)propanoyl]amino]-3-(3-methylbutanoyl)-6-oxo-1,2,4,5,8,9,10,10a-octahydropyrrolo[1,2-a][1,5]diazocine-8-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2158052; SCHEMBL12851758; BDBM50393506
Click to Show/Hide
|
||||
| Activity |
Ki = 67300 nM
|
[18] | |||
| Compound Name |
Smac peptido-mimetic 12a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL181182; BDBM13154; (2S)-1-[(2S)-2-(2-aminoacetamido)-3-methylbutanoyl]-N-(2-phenylethyl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
||||
| Activity |
Ki = 68000 nM
|
[13] | |||
| Compound Name |
(S)-N-((S)-3,3-Dimethyl-1-((S)-2-(4-(naphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-1-oxobutan-2-yl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091762; SCHEMBL13576685; BDBM50314447
Click to Show/Hide
|
||||
| Activity |
Ki = 68000 nM
|
[5] | |||
| Compound Name |
N-{(1s)-1-Cyclohexyl-2-[(2s)-2-(4-Naphthalen-1-Yl-1,3-Thiazol-2-Yl)pyrrolidin-1-Yl]-2-Oxoethyl}-N~2~-Methyl-L-Alaninamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091044; SCHEMBL13576665; BDBM50314448; Q27455387
Click to Show/Hide
|
||||
| Activity |
Ki = 68000 nM
|
[5] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(7-phenylthiazolo[5,4-c]pyridin-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092761; SCHEMBL11987440; BDBM50314477
Click to Show/Hide
|
||||
| Activity |
Ki = 73000 nM
|
[5] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-(quinolin-4-yl)thiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089398; SCHEMBL13576748; BDBM50314452
Click to Show/Hide
|
||||
| Activity |
Ki = 75000 nM
|
[5] | |||
| Compound Name |
2-((R)-3-Methyl-piperazin-1-yl)-1-(6-phenylamino-2,3-dihydro-indol-1-yl)-ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696487; SCHEMBL15811900; BDBM155952; US9018214, 3; 1-(6-anilino-2,3-dihydroindol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[8] | |||
| Compound Name |
(3S,8As)-6-[[(2S)-2-aminopropanoyl]amino]-5-oxo-N-phenyl-2,3,6,7,8,8a-hexahydro-1H-indolizine-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL538075
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
(S)-N-((S)-2-((S)-2-(4-(Benzofuran-3-yl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093692; SCHEMBL13576671; BDBM50314454
Click to Show/Hide
|
||||
| Activity |
Ki = 100000 nM
|
[5] | |||
| Compound Name |
(2S,4S)-1-[(2S)-2-[2-(Dimethylamino)propanoylamino]-3,3-dimethylbutanoyl]-4-phenoxy-N-(1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL434901
Click to Show/Hide
|
||||
| Activity |
EC50 ~ 100000 nM
|
[20] | |||
| Compound Name |
Afzelin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
kaempferol-3-rhamnoside; Kaempferin; Kaempferol 3-rhamnoside; UNII-5M86W1YH7O; 5M86W1YH7O; CHEMBL240528; kaempferol 3-O-alpha-L-rhamnopyranoside; Kaempferol 3-O-alpha-L-rhamnoside; KAEMPEEROL-3-O-GLUCORHAMNOSIDE; kaempferol-3-O-alpha-L-rhamnoside; kaempferol 3-O-rhamnoside; kaempferol-3-o-alpha-l-rhamnopyranoside; Afzeloside; kaempferol-3-o-beta-rhamnoside; MEGxp0_000339; SCHEMBL1689477; kaempherol 3-O-alpha-rhamnoside; ACon1_000149; DTXSID50197459; HY-N1441; Afzelin, >=90% (LC/MS-UV); BDBM50213414; MFCD00210589; ZINC15657732; AKOS032962059; MCULE-1968715677; afzelin; kaempherol 3-O-alpha-rhamnoside; CS-0016878; W1662; A13891; C16911; Q3334749; 5,7-dihydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-3-yl alpha-L-rhamnoside
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Smac AVPI Mimetic 3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL508177; SCHEMBL12724577; BDBM13203; (3S,6S,8aR)-6-[(2S)-2-aminopropanamido]-N-benzyl-5-oxo-octahydroindolizine-3-carboxamide; (3S,8abeta)-N-Benzyl-5-oxo-6beta-(alanylamino)octahydroindolizine-3beta-carboxamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
(3S,8Ar)-6-[[(2S)-2-aminopropanoyl]amino]-N-benzyl-5-oxo-2,3,6,7,8,8a-hexahydro-1H-indolizine-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558170
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
(3S,8As)-6-[[(2S)-2-aminopentanoyl]amino]-N-benzyl-5-oxo-2,3,6,7,8,8a-hexahydro-1H-indolizine-3-carboxamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537185
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[19] | |||
| Compound Name |
(3S,6S,8As)-6-[[(2S)-2-aminopentanoyl]amino]-N-benzyl-1,2,3,5,6,7,8,8a-octahydroindolizine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445214
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[21] | |||
| Compound Name |
(S)-N-(6-Amino-2-pyridyl)-2-aminopropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
compound 4 [PMID: 26218264]; CHEMBL3600720; GTPL8734; BDBM50109043; (2S)-2-amino-N-(6-aminopyridin-2-yl)propanamide; Q27076704
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[22] | |||
| Compound Name |
N,N-Dimethyl-1-[2-[(3R)-3-methylpiperazin-1-yl]acetyl]-2,3-dihydroindole-6-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696491; SCHEMBL15812125; BDBM155966; US9018214, 17
Click to Show/Hide
|
||||
| Activity |
IC50 = 110000 nM
|
[8] | |||
| Compound Name |
(S)-N-((S)-2-((S)-2-(4-(Benzo[d]isoxazol-3-yl)thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1094001; SCHEMBL13576714; BDBM50314455
Click to Show/Hide
|
||||
| Activity |
Ki = 120000 nM
|
[5] | |||
| Compound Name |
1-(5-Fluoro-2,3-dihydroindol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696488; SCHEMBL15837633; BDBM155958; US9018214, 9
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[8] | |||
| Compound Name |
(S)-N-((S)-3,3-Dimethyl-1-oxo-1-((S)-2-(4-(quinolin-4-yl)thiazol-2-yl)pyrrolidin-1-yl)butan-2-yl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1093691; BDBM50314453
Click to Show/Hide
|
||||
| Activity |
Ki = 130000 nM
|
[5] | |||
| Compound Name |
(S)-N-((S)-2-((S)-2-(4-(4-Fluoronaphthalen-1-yl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxo-1-(tetrahydro-2H-pyran-4-yl)ethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089024; SCHEMBL13576660; BDBM50314451
Click to Show/Hide
|
||||
| Activity |
Ki = 140000 nM
|
[5] | |||
| Compound Name |
(S)-N-((S)-2-((S)-2-(4-Benzylbenzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092174; SCHEMBL11987413; BDBM50314466
Click to Show/Hide
|
||||
| Activity |
Ki = 150000 nM
|
[5] | |||
| Compound Name |
1-(4-Chloro-3,3-dimethyl-2H-indol-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696492; SCHEMBL15837641; BDBM155968; US9018214, 19
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[8] | |||
| Compound Name |
(2S)-N-((1S)-2-((2S)-2-(4-(2-Chlorophenyl)benzo[d]thiazol-2-yl)pyrrolidin-1-yl)-1-cyclohexyl-2-oxoethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089695; SCHEMBL11987422; BDBM50314470
Click to Show/Hide
|
||||
| Activity |
Ki = 160000 nM
|
[5] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-((S)-2-(4-isopropylbenzo[d]thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092173; SCHEMBL11987415; BDBM50314465
Click to Show/Hide
|
||||
| Activity |
Ki = 190000 nM
|
[5] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(4-phenylthiazol-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1089012; SCHEMBL13576682; BDBM50314446
Click to Show/Hide
|
||||
| Activity |
Ki = 190000 nM
|
[5] | |||
| Compound Name |
(2S)-2-(Methylamino)-N-(2-oxo-3,4-dihydro-1H-pyrido[3,2-d]pyrimidin-6-yl)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3892789; SCHEMBL13826404; BDBM184613; US9155743, 44
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[16] | |||
| Compound Name |
(2S)-N-(3-Benzyl-2-oxo-1H-imidazo[4,5-b]pyridin-5-yl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3917272; SCHEMBL13826401; BDBM184612; US9155743, 43
Click to Show/Hide
|
||||
| Activity |
IC50 = 200000 nM
|
[16] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-(2,3-Dihydropyrrolo[2,3-b]pyridin-1-yl)-2-[(3R)-3-methylpiperazin-1-yl]ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3696504; SCHEMBL13735661; BDBM155985; US9018214, 36
Click to Show/Hide
|
||||
| Activity |
IC50 = 240000 nM
|
[8] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-oxo-2-((S)-2-(7-phenylthiazolo[5,4-d]pyrimidin-2-yl)pyrrolidin-1-yl)ethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1091442; SCHEMBL11987443; BDBM50314478
Click to Show/Hide
|
||||
| Activity |
Ki = 260000 nM
|
[5] | |||
| Compound Name |
(S)-N-((S)-1-Cyclohexyl-2-((S)-2-(4-methylbenzo[d]thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1092172; SCHEMBL11987412; BDBM50314464
Click to Show/Hide
|
||||
| Activity |
Ki = 940000 nM
|
[5] | |||
| Compound Name |
L-Alanyl-L-valinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL181785; SCHEMBL564352; ZINC2560954; BDBM50109042; (2S)-2-[[(2S)-2-aminopropanoyl]amino]-3-methylbutanamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 1200000 nM
|
[22] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Exploration of carboxy pyrazole derivatives: Synthesis, alkaline phosphatase, nucleotide pyrophosphatase/phosphodiesterase and nucleoside triphosphate diphosphohydrolase inhibition studies with potential anticancer profile. Eur J Med Chem. 2018 Aug 5;156:461-478. | ||||
| REF 2 | In silico discovery of acylated flavonol monorhamnosides from Eriobotrya japonica as natural, small-molecular weight inhibitors of XIAP BIR3. Bioorg Med Chem. 2011 Jan 15;19(2):1002-9. | ||||
| REF 3 | US patent application no. 9394263B2, Substituted hetero-azepinones | ||||
| REF 4 | Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. J Med Chem. 2015 Aug 27;58(16):6348-58. | ||||
| REF 5 | Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2229-33. | ||||
| REF 6 | Potent bivalent Smac mimetics: effect of the linker on binding to inhibitor of apoptosis proteins (IAPs) and anticancer activity. J Med Chem. 2011 May 12;54(9):3306-18. | ||||
| REF 7 | US patent application no. 9422331B2, 2-oxo-2,3,4,5-tetrahydro-1 H-benzo[B]diazepines and their use in the treatment of cancer | ||||
| REF 8 | US patent application no. 9018214B2, Bicyclic heterocycle compounds and their uses in therapy | ||||
| REF 9 | US patent application no. 9422332B2, Azaheterocycles as BIR2 and/or BIR3 inhibitors | ||||
| REF 10 | Design, synthesis and evaluation of inhibitor of apoptosis protein (IAP) antagonists that are highly selective for the BIR2 domain of XIAP. Bioorg Med Chem Lett. 2013 Jul 15;23(14):4253-7. | ||||
| REF 11 | Cyclopeptide Smac mimetics as antagonists of IAP proteins. Bioorg Med Chem Lett. 2010 May 15;20(10):3043-6. | ||||
| REF 12 | Benzazepinones and benzoxazepinones as antagonists of inhibitor of apoptosis proteins (IAPs) selective for the second baculovirus IAP repeat (BIR2) domain. J Med Chem. 2013 Oct 24;56(20):7772-87. | ||||
| REF 13 | Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics. Bioorg Med Chem Lett. 2005 Feb 1;15(3):793-7. | ||||
| REF 14 | Optimization of benzodiazepinones as selective inhibitors of the X-linked inhibitor of apoptosis protein (XIAP) second baculovirus IAP repeat (BIR2) domain. J Med Chem. 2013 Oct 24;56(20):7788-803. | ||||
| REF 15 | US patent application no. 9403768B2, Indolines | ||||
| REF 16 | US patent application no. 9155743B2, Bicyclic heterocycle compounds and their uses in therapy | ||||
| REF 17 | Design, synthesis and evaluation of monovalent Smac mimetics that bind to the BIR2 domain of the anti-apoptotic protein XIAP. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4332-6. | ||||
| REF 18 | A potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatment. J Med Chem. 2011 Apr 28;54(8):2714-26. | ||||
| REF 19 | Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site. J Med Chem. 2004 Aug 12;47(17):4147-50. | ||||
| REF 20 | Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. J Med Chem. 2004 Aug 26;47(18):4417-26. | ||||
| REF 21 | Structure-based design, synthesis, evaluation, and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP). J Med Chem. 2008 Nov 27;51(22):7169-80. | ||||
| REF 22 | Fragment-Based Drug Discovery Targeting Inhibitor of Apoptosis Proteins: Discovery of a Non-Alanine Lead Series with Dual Activity Against cIAP1 and XIAP. J Med Chem. 2015 Aug 27;58(16):6574-88. | ||||
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