Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16555 | Target Info | |||
| Target Name | P2Y purinoceptor 14 (P2RY14) | ||||
| Synonyms |
UDP-glucose receptor; P2Y14; KIAA0001; GPR105; G-protein coupled receptor 105
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| Target Type | Literature-reported Target | ||||
| Gene Name | P2RY14 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Uridine-5'-Diphosphate
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Investigative | Compound Info | ||
| Synonyms |
Uridine 5'-diphosphate; URIDINE DIPHOSPHATE; 58-98-0; Uridine 5'-(trihydrogen diphosphate); uridine-5'-diphosphate; UDP; UNII-5G0F599A1Y; 5'-UDP; Uridine 5'-pyrophosphate; EINECS 200-409-6; Uridine 5'-pyrophosphoric acid; CHEMBL130266; CHEBI:17659; 5G0F599A1Y; uridine-diphosphate; ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate; [(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate; Uridine Pyrophosp
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| Activity |
EC50 = 160000 nM
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[1] | |||
| Compound Name |
Chembl4206162
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456177
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| Activity |
IC50 ~ 50000 nM
|
[2] | |||
| Compound Name |
Chembl4205258
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456180
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| Activity |
IC50 = 53000 nM
|
[2] | |||
| Compound Name |
Chembl4208103
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456175
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| Activity |
IC50 = 54700 nM
|
[2] | |||
| Compound Name |
Chembl4205655
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456195
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| Activity |
IC50 = 67200 nM
|
[2] | |||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Uridine 5'-diphosphoric acid beta-(3-fluoro-3-deoxy-alpha-D-glucopyranosyl) ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL594064; MRS-2825; BDBM50304033
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| Activity |
EC50 = 361000 nM
|
[1] | |||
| Compound Name |
Uridine-5'-diphosphate-4-deoxy-4-fluoro-alpha-D-galactose
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593125; UDP-4-fluoro-4-deoxy-alpha-D-glucose; BDBM50304034; DB04097; URIDINE-5''-DIPHOSPHATE-4-DEOXY-4-FLUORO-ALPHA-D-GALACTOSE
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| Activity |
EC50 = 567000 nM
|
[1] | |||
| Compound Name |
[[(2R,3S,4R,5R)-5-(2,4-Dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3R,4S,5S,6S)-6-(fluoromethyl)-3,4,5-trihydroxyoxan-2-yl] hydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593126; BDBM50304035
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| Activity |
EC50 = 905000 nM
|
[1] | |||
| Compound Name |
Uridine-5'-Diphosphate-2-Deoxy-2-Fluoro-alpha-D-Glucose
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL593830; URIDINE-5'-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GALACTOSE; BDBM50304032; DB03488; Q27466809; URIDINE-5''-DIPHOSPHATE-2-DEOXY-2-FLUORO-ALPHA-D-GLUCOSE; Uridine 5'-(trihydrogen diphosphate) P'-(2-deoxy-2-fluoro-; A-D-glucopyranosyl) ester
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| Activity |
EC50 = 2500000 nM
|
[1] | |||
| Compound Name |
Cyclohexyl [[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] hydrogen phosphate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1199733; BDBM50097952
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| Activity |
EC50 = 5160000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Molecular modeling of the human P2Y14 receptor: A template for structure-based design of selective agonist ligands. Bioorg Med Chem. 2015 Jul 15;23(14):4056-64. | ||||
| REF 2 | Structure-Guided Modification of Heterocyclic Antagonists of the P2Y 14 Receptor. J Med Chem. 2018 Jun 14;61(11):4860-4882. | ||||
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