Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T16514 | Target Info | |||
| Target Name | Fatty acid synthase (FASN) | ||||
| Synonyms |
Yeast fatty acid synthase; Fatty-acyl-CoA synthase; Fatty acyl-CoA synthetase enzyme; FAS
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| Target Type | Successful Target | ||||
| Gene Name | FASN | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 53 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Rabeprazole
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|
Approved | Compound Info | ||
| Synonyms |
Dexrabeprazole; Eraloc; Rebeprazole sodium; CL23619; LY307640; Aciphex (TN); Eraloc (TN); Pariet (TN); Rabeprazole (INN); Rabeprazole [BAN:INN]; Rabeprazole [INN:BAN]; Rablet (TN); 2-(((4-(3-Methoxypropoxy)-3-methyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole; 2-((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methylsulfinyl)-1H-benzimidazole; 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)-1H-benzimidazole; 2-[[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl]-1H-benzimidazole
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
B-Lactams
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Approved | Compound Info | ||
| Synonyms |
Luteolin; luteolin; 491-70-3; Luteolol; 2-(3,4-Dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one; Luteoline; Digitoflavone; Flacitran; Weld Lake; Cyanidenon 1470; Salifazide; Yama kariyasu; 5,7,3',4'-Tetrahydroxyflavone; UNII-KUX1ZNC9J2; CI Natural Yellow 2; 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-; 7-Tetrahydroxyflavone; CCRIS 3790; EINECS 207-741-0; KUX1ZNC9J2; CHEMBL151; BRN 0292084; 2-(3,4-dihydroxyphenyl)-5,7-dihydroxychromen-4-one
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| Activity |
IC50 = 62500 nM
|
[2] | |||
| Compound Name |
EPICATECHIN
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Phase 2 | Compound Info | ||
| Synonyms |
(-)-Epicatechin; Epicatechin; 490-46-0; L-Epicatechin; (-)-Epicatechol; l-Acacatechin; (2R,3R)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol; Epicatechol; l-Epicatechol; (-)epicatechin; (2R,3R)-(-)-Epicatechin; UNII-34PHS7TU43; epi-Catechin; epi-Catechol; CCRIS 7097; EINECS 207-710-1; NSC 81161; Epicatechol, (-)-; CHEBI:90; 34PHS7TU43; PFTAWBLQPZVEMU-UKRRQHHQSA-N; (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol; (-)-(2R:3R)-5,7,3',4'-Tetrahydroxyflavan-3-ol; AK105372; C15H14O6
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
PMID26394986-Compound-44
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|
Patented | Compound Info | ||
| Activity |
IC50 = 51970 nM
|
[3] | |||
| Compound Name |
(L-)-S-adenosyl-L-homocysteine
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Investigative | Compound Info | ||
| Synonyms |
S-Adenosyl-L-homocysteine; S-adenosylhomocysteine; S-adenosyl-L-homocysteine; 979-92-0; AdoHcy; S-(5'-adenosyl)-L-homocysteine; adenosylhomocysteine; Formycinylhomocysteine; Adenosyl-L-homocysteine; S-(5'-deoxyadenosin-5'-yl)-L-homocysteine; 2-S-adenosyl-L-homocysteine; 5'-Deoxy-S-adenosyl-L-homocysteine; S-adenosyl-homocysteine; S-Adenosyl Homocysteine; L-S-Adenosylhomocysteine; L-Homocysteine, S-(5'-deoxyadenosin-5'-yl)-; adenosylhomo-cys; adenosyl-homo-cys; UNII-8K31Q2S66S; (S)-5'-(S)-(3-Amino-3-carboxypropyl)-5'-thioadenosine; BRN 5166233; SAH; S-Adenosylhomocysteine; S-Adenosyl-L-Homocysteine
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| Activity |
Ki = 150000 nM
|
[4] | |||
| Compound Name |
N-[3-[4-(4-Cyanophenyl)-4-fluoropiperidine-1-carbonyl]-2,4-dimethylphenyl]-6-(propan-2-ylamino)pyridine-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3661728; SCHEMBL12488848; BDBM137058; US8871790, 126
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[2-Cyclobutyl-5-[5-(methoxymethyl)-1H-1,2,4-triazol-3-yl]-4-methylbenzoyl]piperidin-4-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3661795; SCHEMBL12489410; BDBM137127; US8871790, 195
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[5-[3-(2-Methoxyethoxy)-4-methyl-1H-pyrazol-5-yl]-2,4-dimethylbenzoyl]azetidin-3-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3934120; SCHEMBL15601659; BDBM244666; US9428502, 276
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|
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
N-[2-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-5-methylpyridin-4-yl]-6-(propan-2-ylamino)pyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666551; SCHEMBL12488804; BDBM137269; US8871790, 349
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-[5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]pyridazin-3-yl]-3-(2-methylpropyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666511; SCHEMBL13277548; BDBM137228; US8871790, 305
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
5-(4-(4-Cyanophenyl)piperidine-1-carbonyl)-2-cyclobutyl-4-methylbenzoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
5-[4-(4-cyanophenyl)piperidine-1-carbonyl]-2-cyclobutyl-4-methylbenzoic acid; CHEMBL3661834; SCHEMBL12488147; BDBM137166; US8871790, 234
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-(1-(4-Cyclobutyl-5-(5-ethyl-4H-1,2,4-triazol-3-yl)-2-methylbenzoyl)piperidin-4-yl)benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
US8871790, 164; US8871790, 258; CHEMBL3661762; SCHEMBL12489045; BDBM137092; US8871790, 160; 4-[1-[4-cyclobutyl-5-(5-ethyl-1H-1,2,4-triazol-3-yl)-2-methylbenzoyl]piperidin-4-yl]benzonitrile
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[2-Chloro-3-(3,4,6,7-tetrahydropyrano[3,4-d]imidazol-2-yl)benzoyl]piperidin-4-yl]benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3661705; SCHEMBL13276699; BDBM137035; US8871790, 101
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
3-[5-(6-Cyanospiro[1H-2-benzofuran-3,4'-piperidine]-1'-carbonyl)-2-methylphenyl]-1-methyl-1-(oxolan-3-ylmethyl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666578; SCHEMBL13277194; BDBM137296; US8871790, 381
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[5-[3-(Cyclopropylmethoxy)-4-methyl-1H-pyrazol-5-yl]-2,4-dimethylbenzoyl]azetidin-3-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3921231; SCHEMBL15601690; BDBM244667; US9428502, 277
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
1-(3-(4-(4-Cyanophenyl)piperidine-1-carbonyl)-1-methyl-1H-pyrazol-5-yl)-3-isobutylurea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666553; SCHEMBL12488228; BDBM137271; US8871790, 351; 1-[5-[4-(4-cyanophenyl)piperidine-1-carbonyl]-2-methylpyrazol-3-yl]-3-(2-methylpropyl)urea
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[2-Methyl-4-methylsulfonyl-5-(5-methyl-1H-1,2,4-triazol-3-yl)benzoyl]piperidin-4-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3671586; SCHEMBL13455309; BDBM137407; US8871790, 494
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-2-methyl-N-[(1-methylpiperidin-4-yl)methyl]benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666480; SCHEMBL12686841; BDBM137197; US8871790, 265
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[3-[5-(2-Methoxyethyl)-1H-1,2,4-triazol-3-yl]-2-methylbenzoyl]piperidin-4-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666670; SCHEMBL13455293; BDBM137389; US8871790, 476
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[2,3-Dimethyl-5-(3,4,6,7-tetrahydropyrano[3,4-d]imidazol-2-yl)benzoyl]piperidin-4-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3661704; SCHEMBL13281515; BDBM137034; US8871790, 100
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[2-Methyl-3-(6-pyrrolidin-1-yl-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl]piperidin-4-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322375; BDBM50426442
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|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-2-methyl-N-(oxolan-3-ylmethyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666481; SCHEMBL13276776; BDBM137198; US8871790, 266
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
Cnc(=O)C1=C(C=C(C)C(=C1)C(=O)N1ccc(CC1)C1=CC=CC2=C1OC=C2)C1ccc1
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3976321; SCHEMBL16928765; BDBM244507; US9428502, 116
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|
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
4-[1-[3-Methyl-5-(6-pyrrolidin-1-yl-3H-imidazo[4,5-c]pyridin-2-yl)benzoyl]piperidin-4-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2322373; BDBM50426444
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|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
3-[5-(6-Cyanospiro[1H-2-benzofuran-3,4'-piperidine]-1'-carbonyl)-2-methylphenyl]-1-(2-methoxyethyl)-1-methylurea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666558; SCHEMBL13455224; BDBM137276; US8871790, 356
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[3-(1H-Imidazol-2-ylamino)-4-methylbenzoyl]piperidin-4-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666499; SCHEMBL13277169; BDBM137216; US8871790, 286
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-[5-[7-(4-Cyanophenyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyridin-3-yl]-2-methylphenyl]pyrrolidine-1-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666571; SCHEMBL13277252; BDBM137289; US8871790, 373
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-[2-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-5-methylpyridin-4-yl]-3-(oxolan-3-yl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666579; SCHEMBL12686990; BDBM137297; US8871790, 382
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-[6-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-3-methylpyridin-2-yl]-3-(oxolan-3-yl)urea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666580; SCHEMBL13276936; BDBM137298; DS-020382; US8871790, 383
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[5-[5-(Methoxymethyl)-1H-1,2,4-triazol-3-yl]-4-methyl-2-propan-2-ylbenzoyl]piperidin-4-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3661796; SCHEMBL12489295; BDBM137128; US8871790, 196
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-[5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]pyridazin-3-yl]-3-(2-methoxyethyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666509; SCHEMBL13276988; BDBM137226; US8871790, 302
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-[5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-1-methylpyrazol-3-yl]-6-(2-methylpropylamino)pyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666581; SCHEMBL13277296; BDBM137299; US8871790, 384
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-2-methyl-N-(piperidin-4-ylmethyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666479; SCHEMBL12686977; BDBM137196; US8871790, 264
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[3-[5-(Methoxymethyl)-1H-1,2,4-triazol-3-yl]benzoyl]piperidin-4-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3661731; SCHEMBL12489245; BDBM137061; US8871790, 129
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[3-(3,5-Dimethyl-1H-pyrazol-4-yl)benzoyl]azetidin-3-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3936191; SCHEMBL15555544; BDBM244659; US9428502, 269
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
N-[5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-2-methylpyrazol-3-yl]-6-(2-methylpropylamino)pyridine-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666587; SCHEMBL13277040; BDBM137305; US8871790, 391
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
N-[4-[4-(4-Cyanophenyl)piperidine-1-carbonyl]pyridin-2-yl]pyrrolidine-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3661727; SCHEMBL12489432; BDBM137057; US8871790, 125
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-Amino-4-[(2S,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethanesulfinyl]-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL46902; SCHEMBL2038207; BDBM50142502; S-(5'-Adenosyl)homocysteine S-oxide
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| Activity |
Ki = 50000 nM
|
[4] | |||
| Compound Name |
4-[1-[3-(1H-Imidazo[4,5-b]pyridin-2-ylamino)-4-methylbenzoyl]piperidin-4-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666498; SCHEMBL13276890; BDBM137215; US8871790, 285
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
1-[5-[4-(4-Cyanophenyl)piperidine-1-carbonyl]-2-methylpyrazol-3-yl]-3-propan-2-ylurea
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666586; SCHEMBL12686915; BDBM137304; US8871790, 390
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[2,4-Dimethyl-5-[5-(oxetan-3-ylmethyl)-1H-1,2,4-triazol-3-yl]benzoyl]piperidin-4-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3661743; SCHEMBL12489094; BDBM137073; US8871790, 141
Click to Show/Hide
|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
4-[1-[3-[[5-(Dimethylamino)-1H-imidazo[4,5-b]pyridin-2-yl]amino]-4-methylbenzoyl]piperidin-4-yl]benzonitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666500; SCHEMBL13276608; BDBM137217; US8871790, 287
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
[3-(2,5-Dimethyl-1H-imidazol-4-yl)-4-methylphenyl]-[4-([1,2,4]triazolo[4,3-a]pyridin-7-yl)piperidin-1-yl]methanone
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3964640; SCHEMBL15556293; BDBM244432; US9428502, 41
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
Schembl21318035
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3666583; SCHEMBL13276548
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|
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-Cyclobutyl-5-(4-imidazo[1,2-a]pyridin-7-ylpiperidine-1-carbonyl)-N,4-dimethylbenzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3905739; SCHEMBL15601619; BDBM244497; US9428502, 106
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
Albaspidin PB
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706853; 4-[(5-butanoyl-2,6-dihydroxy-3,3-dimethyl-4-oxocyclohexa-1,5-dien-1-yl)methyl]-3,5-dihydroxy-6,6-dimethyl-2-propanoylcyclohexa-2,4-dien-1-one
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| Activity |
IC50 = 56100 nM
|
[2] | |||
| Compound Name |
Albaspidin PP
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Investigative | Compound Info | ||
| Synonyms |
albaspidin P-P; CHEMBL484218
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| Activity |
IC50 = 60200 nM
|
[2] | |||
| Compound Name |
Albaspidin AP
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3706849; MFCD20527285; AKOS030573554; ZINC103540111; ZINC137945855; FT-0689309; N2439
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| Activity |
IC50 = 71700 nM
|
[2] | |||
| Compound Name |
Egonol
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Investigative | Compound Info | ||
| Synonyms |
3-[2-(1,3-benzodioxol-5-yl)-7-methoxy-1-benzofuran-5-yl]propan-1-ol; 2-(1,3-Benzodioxol-5-yl)-7-methoxy-5-benzofuranpropanol; CHEMBL470981; Isolated from leaves of Styrax ferrugineus; 5-Benzofuranpropanol, 2-(1,3-benzodioxol-5-yl)-7-methoxy-; 3-(2-(benzo[d][1,3]dioxol-5-yl)-7-methoxybenzofuran-5-yl)propan-1-ol; 3-[2-(2H-1,3-benzodioxol-5-yl)-7-methoxy-1-benzofuran-5-yl]propan-1-ol; 5-(3''-Hydroxypropyl)-7-methoxy-2-(3',4'-methylenedioxyphenyl)benzofuran; SCHEMBL4183989; CTK1G9757; DTXSID70967474; ZINC6483721; BDBM50327911; Q27137901; 2-(1,3-Benzodioxol-5-yl)-7-methoxy-5-benzofuranpropanol, 9CI; 5-Benzofuranpropanol, 7-methoxy-2-[3,4-(methylenedioxy)phenyl]-; 3-(2-Benzo[1,3]dioxol-5-yl-7-methoxy-benzofuran-5-yl)-propan-1-ol; 3-[2-(1,3-Benzodioxol-5-yl)-7-methoxy-1-benzofuran-5-yl]-1-propanol #; 3-[2-(1,3-benzodioxol-5-yl)-7-methoxy-benzofuran-5-yl]propan-1-ol; 5-(2-Hydroxypropyl)-7-methoxy-2-(3,4-methylenedioxyphenyl)benzofuran; 5-(3-Hydroxypropyl)-7-methoxy-2-(3,4-methylenedioxyphenyl)benzofuran
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| Activity |
IC50 = 91070 nM
|
[3] | |||
| Compound Name |
Lansoprazole
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Investigative | Compound Info | ||
| Synonyms |
Prevacid; Bamalite; Monolitum; Ogastro; Lansoprazol; Agopton; Limpidex; Lanzor; Opiren; Prevacid SoluTab; Lanzopral; Takepron; Zoton; Lanproton; Lansopep; Lasoprol; Mesactol; Aprazol; Blason; Ketian; Lancid; Lanston; Prezal; Ulpax; AG-1749; Pro Ulco; Lansoprazolum; (R)-Lansoprazole; Compraz; Ilsatec; Prosogan; Suprecid; Dakar; Promp; Zoprol; Prevacid Iv; Lanzol-30; AG 1749; Lansoprazol [INN-Spanish]; Lansoprazolum [INN-Latin]; Lansox; Lanzo; A-65006; Prevacid 24HR; TAK-390MR; MLS000069705; Ogast; MFCD00866873; C16H14F3N3O2S; NCGC00015615-02; SMR000058469; DSSTox_CID_3200; MLS-0003247.0001; Prevacid NapraPAC; DSSTox_RID_76922; DSSTox_GSID_23200; Prevacid I.V.; TAK 390MR; Lansophed; Lansoprazole [USAN:BAN:INN]; Lanzol; Lanzul; PrevOnco; Prevacid (TN); HSDB 7204; SR-01000000169; A 65006; BRN 4333393; Lanfast; Lapraz; ABT-006; Lansoprazole,(S); Lansoprazole [USAN:USP:INN:BAN]; LANSAPRAZOLE; CG-4801; PubChem16834; Spectrum_001580; CPD000058469; Prevacid Delayed Release; Opera_ID_1676; Prestwick0_001072; Prestwick1_001072; Prestwick2_001072; Prestwick3_001072; Spectrum2_000444; Spectrum3_000295; Spectrum4_000856; Spectrum5_001521; Lopac-L-8533; CHEMBL480; L 8533; cid_3883; Lopac0_000709; SCHEMBL22365; BSPBio_001084; BSPBio_001830; KBioGR_001491; KBioSS_002060; MLS000759405; MLS001074170; MLS001424235; BIDD:GT0006; DivK1c_000920; SPECTRUM1503926; SPBio_000488; SPBio_002992; BPBio1_001194; GTPL7208; DTXSID4023200; BDBM47032; CTK8F0500; HMS502N22; KBio1_000920; KBio2_002060; KBio2_004628; KBio2_007196; KBio3_001330; KS-00000VHO; Lansoprazole (JP17/USP/INN); Levolansoprazole;(-)-Lansoprazole; NINDS_000920; HMS1571G06; HMS1922M04; HMS2052F05; HMS2093M07; HMS2098G06; HMS2234B10; HMS3262M19; HMS3264E12; HMS3269D15; HMS3371E21; HMS3394F05; HMS3413J05; HMS3654J17; HMS3677J05; HMS3715G06; Pharmakon1600-01503926; Pharmakon1600-01504282; ACT03358; BCP22331; BCP34129; EBD14854; Tox21_110184; Tox21_301023; Tox21_500709; BBL029072; BDBM50070208; CCG-39952; CL0035; NSC758638; NSC758710; s1354; STK621169; AKOS005554811; Tox21_110184_1; AC-1233; CS-1847; DB00448; KS-1075; Lansoprazole, >=98% (TLC), powder; LP00709; MCULE-8446262134; NC00411; NSC-758638; NSC-758710; SB19127; SDCCGSBI-0050687.P004; IDI1_000920; NCGC00015615-01; NCGC00015615-03; NCGC00015615-04; NCGC00015615-05; NCGC00015615-06; NCGC00015615-07; NCGC00015615-08; NCGC00015615-09; NCGC00015615-10; NCGC00015615-11; NCGC00015615-12; NCGC00015615-14; NCGC00015615-15; NCGC00023826-03; NCGC00023826-04; NCGC00023826-05; NCGC00023826-06; NCGC00023826-07; NCGC00254925-01; NCGC00261394-01; NCGC00381720-13; AK308448; HY-13662; SC-15158; SBI-0050687.P003; AB0005100; AB00052388; EU-0100709; FT-0610894; FT-0670721; FT-0670722; L0233; ST51015040; SW197226-4; D00355; AB00052388-17; AB00052388_18; AB00052388_19; 577L453; A800764; Q254296; J-007154; SR-01000000169-2; SR-01000000169-6; SR-01000000169-9; BRD-A49172652-001-05-7; BRD-A49172652-001-13-1; F2173-0222
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| Activity |
IC50 = 93000 nM
|
[1] | |||
| Compound Name |
3-Hydroxyflavone
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Investigative | Compound Info | ||
| Synonyms |
Flavonol; 3-Hydroxy-2-phenyl-4H-chromen-4-one; Flavon-3-ol; 3-Hydroxy-2-phenylchromone; 4H-1-Benzopyran-4-one, 3-hydroxy-2-phenyl-; FLAVONE, 3-HYDROXY-; 3-hydroxy-2-phenylchromen-4-one; UNII-ZTG9LSS5QH; MFCD00006832; ZTG9LSS5QH; NSC57653; CHEMBL294009; 3-hydroxy-2-phenyl-4H-1-benzopyran-4-one; NSC-57653; F0013-0884; flavonols; FLAVONE,3-HYDROXY-; NSC58585; SR-01000401360; EINECS 209-416-9; NSC 57653; NSC 58585; 3-hydroxyflavon; HSDB 7572; 3-hydroxy-2-phenyl-chromen-4-one; Spectrum_000328; SpecPlus_000831; Spectrum2_001392; Spectrum3_001432; Spectrum4_001845; Spectrum5_000350; ACMC-209m0e; Oprea1_038914; Oprea1_692205; SCHEMBL20246; 3-Hydroxyflavone, >=98%; 4-Hydroxy-3-oxylatoflavylium; BSPBio_003164; KBioGR_002250; KBioSS_000808; MLS002207277; BIDD:ER0553; DivK1c_006927; SPECTRUM1501012; SPBio_001404; MEGxp0_001695; DTXSID4060365; ACon1_000167; CTK3J2720; KBio1_001871; KBio2_000808; KBio2_003376; KBio2_005944; KBio3_002384; ZINC57675; HMS3740M15; KUC106685N; KS-00000VN5; WLN: T66 BO EVJ CR& DQ; ANW-32796; BDBM50187668; CCG-38858; NCI-57653; s4790; SBB000767; AKOS000599906; MCULE-8535739842; SDCCGMLS-0066736.P001; NCGC00095653-01; NCGC00095653-02; NCGC00095653-03; 3-Hydroxy-2-phenyl-4H-chromen-4-one #; AK163706; AS-19638; SMR000112317; ST086622; SY048803; KSC-11-207-16; DB-053103; HY-107825; CS-0030701; EU-0001678; FT-0615841; Y2009; VU0053575-3; C01495; H-5000; 3-Hydroxy-2-phenyl-4H-1-benzopyran-4-one, 9CI; Q5919049; SR-01000401360-1; SR-01000401360-2; BRD-K55150756-001-05-7; B48D3495-6D21-4742-8A87-D3DE07DC9554
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(10E,12Z)-Octadeca-10,12-dienoic acid
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Investigative | Compound Info | ||
| Synonyms |
10E,12Z-octadecadienoic acid; 10-TRANS-12-CIS-OCTADECADIENOIC ACID; UNII-N151ZM4M27; trans-10,cis-12-conjugated linoleic acid; (10E,12Z)-10,12-Octadecadienoic acid; (10E,12Z)-octadecadienoic acid; 10-trans-12-cis-CLA; 10E, 12Z-Linoleic acid; trans-10,cis-12 conjugated linoleic acid; CHEMBL1093743; 10-trans-12-cis-linoleic acid; C18:2, n-6,8 cis,trans; N151ZM4M27; 10,12-trans,cis-octadecanoic acid; 10,12-Octadecadienoicacid, (10E,12Z)- (9CI); (E,Z)-octadeca-10,12-dienoic acid; trans-10, cis-12-octadecadienoic acid; 10-trans-12-cis-conjugated linoleic acid; t10c12 CLA; C18:2n-6,8; trans-10, cis-12 conjugate linoleic acid; 10E12Z-CLA; Conjugated Linoleic Acid (10E,12Z); 10,12-Octadecadienoic acid, (Z,E)-; SCHEMBL1810737; DTXSID0040628; SCHEMBL14357949; HMS3649F05; BDBM50394662; LMFA01030125; ZINC12504490; DB04746; trans,cis-octadeca-10,12-dienoic acid; 420C566; Q419936; SR-01000946649; SR-01000946649-1; BRD-K26222048-001-01-7; Conjugated (10E,12Z)-Linoleic acid, analytical standard; UNII-G199I91G4B component GKJZMAHZJGSBKD-NMMTYZSQSA-N
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| Activity |
IC50 = 100000 nM
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[8] | |||
| Compound Name |
2-Amino-4-[(2S,3S,4R,5R)-5-(6-amino-purin-9-yl)-3,4-dihydroxy-tetrahydro-furan-2-ylmethanesulfonyl]-butyric acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL47994; S-adenosylhomocysteine sulfoxide; SCHEMBL8427663; BDBM50142505
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| Activity |
Ki = 100000 nM
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[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 8 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Orlistat
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Approved | Compound Info | ||
| Synonyms |
orlistat; 96829-58-2; Tetrahydrolipstatin; Xenical; Alli; Orlipastat; (-)-Tetrahydrolipstatin; Orlipastatum; Orlipastatum [INN-Latin]; THLP; Ro-18-0647; UNII-95M8R751W8; C29H53NO5; Ro 18-0647/002; N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester; (2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl (2S)-2-formamido-4-methylpentanoate; Orlistat (Alli, Xenical); MLS002207022; [(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate; CHEMBL175247; Alli; GlaxoSmithKline brand of orlistat; Roche brand of orlistat; Alli (TN); Hoffmann-La Roche brand of orlistat; KS-1183; Orlistat [USAN:INN]; R-212; Xenical (TN); Orlistat (USAN/INN); Ro 18-0647/008; Alli, Xenical, Tetrahydrolipstatin, Orlistat; N-Formyl-L-leucine, ester with (3S,4S)-3-hexyl-4-((2S)-2-hydroxytridecyl)-2-oxetanone; L-Leucine, N-formyl-, (1S)-1-(((2S,3S)-3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester; L-Leucine,N-formyl-, (1S)-1-(((2S,3S)-3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl ester; 1-((3-hexyl-4-oxo-2-oxetanyl)methyl)dodecyl-2-formamido-4-methylvalerate; TETRAHYDROLIPSTATIN
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| Activity |
IC50 = 203000 nM
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[1] | |||
| Compound Name |
METHYLTHIOADENOSINE
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Terminated | Compound Info | ||
| Synonyms |
5'-Deoxy-5'-methylthioadenosine; 2457-80-9; Methylthioadenosine; 5'-S-methyl-5'-thioadenosine; 5'-Deoxy-5'-(methylthio)adenosine; 5'-DEOXY-5'-METHYLTHIOADENOSINE; (2R,3R,4S,5S)-2-(6-Amino-9H-purin-9-yl)-5-((methylthio)methyl)tetrahydrofuran-3,4-diol; Thiomethyladenosine; Vitamin L2; ADENOSINE, 5'-S-METHYL-5'-THIO-; 5'-S-Methylthioadenosine; MTA; S-methyl-5'-thioadenosine; Vitamin L(sub 2); UNII-634Z2VK3UQ; 5'-Deoxy(methylthio)adenosine; 5'-Deoxy-5'-Methylthioadenosine
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| Activity |
Ki = 1500000 nM
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[4] | |||
| Compound Name |
L-methionine
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Investigative | Compound Info | ||
| Synonyms |
Acimethin; Cymethion
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| Activity |
Ki > 150000000 nM
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[4] | |||
| Compound Name |
5'-Deoxy-5'-methylsulphonyladenosine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL296716; BDBM50142506; (2R,3R,4S,5S)-2-(6-Amino-purin-9-yl)-5-methanesulfonylmethyl-tetrahydro-furan-3,4-diol
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| Activity |
Ki = 220000 nM
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[4] | |||
| Compound Name |
Methylthioadenosine sulfoxide
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Investigative | Compound Info | ||
| Synonyms |
5'-Deoxy-5'-S-adenosylmethyl sulfoxide; CHEMBL294920; 5'-Deoxy-5'-(methylsulfinyl)adenosine; (2R,3R,4S,5S)-2-(6-aminopurin-9-yl)-5-(methylsulfinylmethyl)oxolane-3,4-diol; Adenosine, 5'-deoxy-5'-(methylsulfinyl)-; Methyl-adenosyl-sulfoxyd; SCHEMBL6761157; CTK4H1373; DTXSID50955455; 5'-deoxy-5'-methylsulfinyladenosine; BDBM50142504; 5'-deoxy-5'-(methanesulfinyl)adenosine; 5'-deoxy-5'-(methanesulphinyl)adenosine; Adenosine,5'-deoxy-5'-(methylsulfinyl)- (7CI,8CI,9CI); 9-[5-Deoxy-5-(methanesulfinyl)pentofuranosyl]-9H-purin-6-amine
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| Activity |
Ki = 500000 nM
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[4] | |||
| Compound Name |
(+)-Epicatechin
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Investigative | Compound Info | ||
| Synonyms |
ent-Epicatechin; (2S,3S)-2-(3,4-dihydroxyphenyl)chroman-3,5,7-triol; UNII-LD6B6TT8Q5; LD6B6TT8Q5; d-Epicatechin; CHEMBL129482; (+)-epicatechol; (2S,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol; (+)-3 3' 4' 5 7-Pentahydroxyflavan; (-) epicatechine; (2S,3S)-3,3',4',5,7-pentahydroxyflavan; Epicatechin, (+)-; (2S,3S)-epicatechin; SCHEMBL862089; Ethyl dichlorophosphorylcarbamate; ZINC119978; BDBM50135167; SB18952; N2101; C09728; (2S,3S)-3',4',5,7-tetrahydroxyflavan-3-ol; cis-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol; 99182E3E-BCCB-48BB-89BF-7DDC933D48FF; Q27145771; (2S,3S)-2-(3,4-dihydroxyphenyl)chromane-3,5,7-triol; (2S,3S)-2-(3,4-Dihydroxy-phenyl)-chroman-3,5,7-triol; (2S,3S)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol; 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2S-cis)-
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| Activity |
IC50 > 1000000 nM
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[3] | |||
| Compound Name |
5'-(Dimethylsulfonio)-5'-deoxyadenosine iodide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL540135
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| Activity |
Ki = 2500000 nM
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[4] | |||
| Compound Name |
Methylmethionine iodide
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Investigative | Compound Info | ||
| Synonyms |
UNII-7O2D9U053L; 7O2D9U053L; [(3S)-3-Amino-3-carboxypropyl](dimethyl)-sulfonium iodide; (S)-(3-Amino-3-carboxypropyl)dimethylsulfonium iodide; METHIONINE-S-METHYLSULFONIUM IODIDE CRYSTALLINE; CHEMBL540394; MLS006012027; MFCD00050272; AKOS015907820; VZ32472; SMR004703560; Q27268629; [(3S)-3-amino-3-carboxypropyl]-dimethylsulfanium;iodide; Sulfonium, (3-amino-3-carboxypropyl)dimethyl-, iodide, (S)-
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| Activity |
Ki = 140000000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Repositioning proton pump inhibitors as anticancer drugs by targeting the thioesterase domain of human fatty acid synthase. J Med Chem. 2015 Jan 22;58(2):778-84. | ||||
| REF 2 | Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4738-42. | ||||
| REF 3 | Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana. Bioorg Med Chem Lett. 2010 Oct 15;20(20):6045-7. | ||||
| REF 4 | Synthesis and evaluation of analogues of S-adenosyl-L-methionine, as inhibitors of the E. coli cyclopropane fatty acid synthase. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1661-4. | ||||
| REF 5 | US patent application no. 8871790B2, Heterocyclic modulators of lipid synthesis | ||||
| REF 6 | US patent application no. 9428502B2, Heterocyclic modulators of lipid synthesis | ||||
| REF 7 | Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation. ACS Med Chem Lett. 2012 Dec 2;4(1):113-7. | ||||
| REF 8 | The lipogenesis pathway as a cancer target. J Med Chem. 2011 Aug 25;54(16):5615-38. | ||||
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