Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15855 | Target Info | |||
| Target Name | Dipeptidyl peptidase 8 (DPP-8) | ||||
| Synonyms |
Prolyl dipeptidase DPP8; MSTP141; MSTP135; MSTP097; Dipeptidyl peptidase VIII; Dipeptidyl peptidase IV-related protein 1; DPRP1; DPRP-1; DPP VIII; DP8
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| Target Type | Clinical trial Target | ||||
| Gene Name | DPP8 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 650 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sitagliptin
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|
Approved | Compound Info | ||
| Synonyms |
486460-32-6; Januvia; Xelevia; Sitagliptan; MK-0431; UNII-QFP0P1DV7Z; Tesavel; QFP0P1DV7Z; (3R)-3-AMINO-1-[3-(TRIFLUOROMETHYL)-5H,6H,7H,8H-[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7-YL]-4-(2,4,5-TRIFLUOROPHENYL)BUTAN-1-ONE; (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-AMINE; CHEBI:40237; (R)-3-AMINO-1-(3-(TRIFLUOROMETHYL)-5,6-DIHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL)-4-(2,4,5-TRIFLUOROPHENYL)BUTAN-1-ONE; Janumet; Sitagliptin phosphate; Januvia (TN); Sitagliptin (PropINN); Januvia (merck & Co); (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; (3R)-3-amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; (3R)-3-amino-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; Sitagliptin/atovastatin
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Linagliptin
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Approved | Compound Info | ||
| Synonyms |
Ondero; BI 1356; BI-1356; Ondero (TN); BI-1356-BS; (R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Alogliptin
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Approved | Compound Info | ||
| Synonyms |
850649-61-5; UNII-JHC049LO86; alogliptina; 2-({6-[(3r)-3-Aminopiperidin-1-Yl]-3-Methyl-2,4-Dioxo-3,4-Dihydropyrimidin-1(2h)-Yl}methyl)benzonitrile; SYR-322; JHC049LO86; (R)-2-((6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile; CHEBI:72323; AK322010; 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile; vipidia; Alogliptin [INN]; Alogliptin (SYR-322); alogliptinum; alogliptine; HSDB 8203; UNII-JHC049LO86
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
MK-3102
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Phase 3 | Compound Info | ||
| Synonyms |
Omarigliptin
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| Activity |
IC50 ~ 67000 nM
|
[3] | |||
| Compound Name |
Pyrimidine derivative 33
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Patented | Compound Info | ||
| Synonyms |
PMID25482888-Compound-67
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
US8470836, 6
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Patented | Compound Info | ||
| Synonyms |
SCHEMBL13099347; CHEMBL3644787; BDBM97579; US8470836, 6
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| Activity |
IC50 ~ 127000 nM
|
[5] | |||
| Compound Name |
TAK-100
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Discontinued in Phase 1 | Compound Info | ||
| Synonyms |
CHEMBL1672127
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| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(S)-pyrrolidin-1-yl(pyrrolidin-2-yl)methanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL403882; L-Prolin-pyrrolidid; (S)-1-prolylpyrrolidine; 1-(L-Prolyl)pyrrolidine; (S)-pyrrolidin-1-yl(pyrrolidin-2-yl)methanone; 41721-00-0; SCHEMBL1383434; HDLWINONZUFKQV-QMMMGPOBSA-N; ZINC11754367; BDBM50228295; AKOS022180332; AJ-60015; Pyrrolidine, 1-[(2S)-2-pyrrolidinylcarbonyl
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| Activity |
IC50 = 50000 nM
|
[7] | |||
| Compound Name |
N4-(4-chlorobenzyl)-2,4-diaminobutanoylpiperidine
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Investigative | Compound Info | ||
| Synonyms |
DNVZYSMOLXCOLY-HNNXBMFYSA-N; UAMC00039; CHEMBL98869; SCHEMBL6824340; GTPL6538; ZINC13561228; BDBM50146972; NCGC00379239-01; 1-[(S)-2-Amino-4-[(4-chlorobenzyl)amino]butyryl]piperidine; (S)-4-(4-chlorobenzylamino)-2-amino-1-(piperidin-1-yl)butan-1-one; (2S)-2-amino-4-[(4-chlorophenyl)methylamino]-1-piperidin-1-ylbutan-1-one; 2-(S)-Amino-4-(4-chloro-benzylamino)-1-piperidin-1-yl-butan-1-one
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| Activity |
IC50 = 142000 nM
|
[1] | |||
| Compound Name |
(2R,3S,5R)-2-(2-Chloro-5-fluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425074; BDBM50440340
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| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
CID 44123747
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1819090; SCHEMBL162310; BDBM50351402
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| Activity |
IC50 ~ 50000 nM
|
[9] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylpivalamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683101; BDBM50338467
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| Activity |
IC50 = 50000 nM
|
[10] | |||
| Compound Name |
2-({2-[(3R)-3-Aminopiperidin-1-yl]-6-fluoro-7-(morpholin-4-yl)-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL227356; SCHEMBL3426116; quinazolinone-based inhibitor 1m; BDBM16284
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-methyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL251404; BDBM50222487
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| Activity |
IC50 = 50000 nM
|
[12] | |||
| Compound Name |
(2S,3S)-2-Amino-3-methyl-1-(5-nitroisoindolin-2-yl)pentan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL510322; BDBM50243081
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| Activity |
IC50 ~ 50000 nM
|
[13] | |||
| Compound Name |
(1S,2R,5S)-5-(9-Methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3804994
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| Activity |
IC50 = 50000 nM
|
[14] | |||
| Compound Name |
1-[6-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyridin-3-yl]-4-phenylmethoxypyridin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011535; BDBM50379790
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| Activity |
IC50 ~ 50000 nM
|
[15] | |||
| Compound Name |
[5-(2-Chlorophenyl)-3-methylbenzimidazol-4-yl]methanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL270365; SCHEMBL3144437; BDBM50375236
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| Activity |
IC50 = 50000 nM
|
[16] | |||
| Compound Name |
2-[4-[[[(4R)-3-[3-Amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetic acid;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL183060
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| Activity |
IC50 ~ 50000 nM
|
[17] | |||
| Compound Name |
2-({2-[(3R)-3-Aminopiperidin-1-yl]-6-chloro-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL389074; SCHEMBL3427609; quinazolinone-based inhibitor 1d; BDBM16275; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-6-chloro-4-oxoquinazolin-3-yl]methyl]benzonitrile
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
2-({2-[(3R)-3-Aminopiperidin-1-yl]-6-methoxy-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL227670; SCHEMBL3427450; quinazolinone-based inhibitor 1i; BDBM16280; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-6-methoxy-4-oxoquinazolin-3-yl]methyl]benzonitrile
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| Activity |
IC50 ~ 50000 nM
|
[11] | |||
| Compound Name |
[5-(2,4-Dichlorophenyl)-3-ethylbenzimidazol-4-yl]methanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL257308; SCHEMBL3145087; BDBM50375233
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| Activity |
IC50 = 50000 nM
|
[16] | |||
| Compound Name |
(S)-3-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethylamino)-N-(3,4-dimethoxyphenyl)-3-methylbutanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL217198; BDBM50201584
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| Activity |
IC50 ~ 50000 nM
|
[18] | |||
| Compound Name |
(3R)-3-Amino-1-{2-cyclopropyl-4H,5H,6H,7H-pyrido[3,4-d][1,3]oxazol-5-yl}-4-(2,5-difluorophenyl)butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
oxazolopiperidine 77; CHEMBL197082; BDBM11975
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| Activity |
IC50 = 51000 nM
|
[19] | |||
| Compound Name |
(2S,3As,6aS)-1-[(3R)-3-amino-4-(4-fluorophenyl)butanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330066; BDBM50098989
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| Activity |
IC50 = 51600 nM
|
[20] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(3-tert-butyl-1,2,4-oxadiazol-5-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL565633; SCHEMBL8273925; BDBM50302956
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| Activity |
IC50 = 52000 nM
|
[21] | |||
| Compound Name |
(2S,3S)-3-Amino-N,N-diethyl-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL364939
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| Activity |
IC50 = 52000 nM
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[22] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-[4-(trifluoromethyl)phenyl]propanoyl]pyrrolidine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093924; BDBM50443752
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| Activity |
IC50 = 52120 nM
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[23] | |||
| Compound Name |
(2s,3s)-3-Amino-4-[(3s)-3-Fluoropyrrolidin-1-Yl]-N,N-Dimethyl-4-Oxo-2-(trans-4-[1,2,4]triazolo[1,5-A]pyridin-5-Ylcyclohexyl)butanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL237566; CHEMBL400841; EXYL)BUTANAMIDE; SCHEMBL13412170; BDBM50221979; BDBM50221980; DB07135; Q27096050
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| Activity |
IC50 = 53000 nM
|
[24] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-(2-hydroxyethyl)-3-methyl-1,4-diazepan-2-one
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Investigative | Compound Info | ||
| Synonyms |
1-substituted diazepanone 9f; CHEMBL231117; BDBM15535
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| Activity |
IC50 = 53000 nM
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[25] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(pyridin-2-ylmethyl)-1,4-diazepan-2-one
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Investigative | Compound Info | ||
| Synonyms |
Diazepanone Analog 25; CHEMBL216178; BDBM13527
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| Activity |
IC50 = 53000 nM
|
[26] | |||
| Compound Name |
N-[(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-7-yl]acetamide;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL556494
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| Activity |
IC50 = 53000 nM
|
[27] | |||
| Compound Name |
(2R)-1-[2-[2-[3-(3,4-Dimethoxyphenyl)-2-oxoimidazolidin-1-yl]ethylamino]acetyl]pyrrolidine-2-carbonitrile;oxalic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1202080
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| Activity |
IC50 = 53000 nM
|
[28] | |||
| Compound Name |
(3R,4R)-1-Pyrazino[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL231196
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| Activity |
IC50 = 54000 nM
|
[29] | |||
| Compound Name |
(3R,4R)-1-Pyridin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL230341
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| Activity |
IC50 = 54000 nM
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[29] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(1-isobutyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL400278; BDBM50222472
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| Activity |
IC50 = 54000 nM
|
[12] | |||
| Compound Name |
(R)-3-Amino-1-(3-cyclopropyl-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL390239; BDBM50210647
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| Activity |
IC50 = 54000 nM
|
[30] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-tert-butyl-3-methyl-1,4-diazepan-2-one
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Investigative | Compound Info | ||
| Synonyms |
1-substituted diazepanone 9j; CHEMBL230283; SCHEMBL5492305; BDBM15539
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| Activity |
IC50 = 55000 nM
|
[25] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-[3-(5-cyclopropyl-1,2,4-oxadiazol-3-yl)phenyl]phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL370033
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| Activity |
IC50 = 55000 nM
|
[31] | |||
| Compound Name |
(3R)-3-Amino-1-(4-ethyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL250204; BDBM50222468
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| Activity |
IC50 = 55000 nM
|
[12] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-2,4-difluoro-N-methylbenzenesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682983; BDBM50338449
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| Activity |
IC50 = 55000 nM
|
[10] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-1,3-thiazole-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735129; BDBM50134189
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| Activity |
IC50 = 55000 nM
|
[32] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-thiophen-3-ylpropanoyl]pyrrolidine-2-carbonitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127980; BDBM50449227
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| Activity |
IC50 = 55700 nM
|
[33] | |||
| Compound Name |
cis-(R)-2-(2,5-Difluorophenyl)-1-(4-(piperidin-1-yl)cyclohexyl)ethanamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683116; CHEMBL1683117; BDBM50338410; BDBM50338411; trans-(R)-2-(2,5-difluorophenyl)-1-(4-(piperidin-1-yl)cyclohexyl)ethanamine
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| Activity |
IC50 = 56000 nM
|
[10] | |||
| Compound Name |
Bis(4-acetamidophenyl) 1-(pyrrolidine-2-carbonyl)pyrrolidin-2-ylphosphonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL439382; BDBM50225436
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| Activity |
IC50 = 56000 nM
|
[34] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(1,1,2,2,2-pentafluoroethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
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Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 54; CHEMBL369894; BDBM11952
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| Activity |
IC50 = 56000 nM
|
[19] | |||
| Compound Name |
N-[[(2S,3As,7aS)-1-[(3R)-3-amino-4-(2,4,5-trifluorophenyl)butanoyl]-2,3,3a,4,5,6,7,7a-octahydroindol-2-yl]methyl]-1,1,1-trifluoromethanesulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3357782; BDBM50037682
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| Activity |
IC50 = 56330 nM
|
[35] | |||
| Compound Name |
(2S,3S)-2-Amino-3-methyl-1-(5H-pyrrolo[3,4-b]pyridin-6(7H)-yl)pentan-1-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL453199; BDBM50243083
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| Activity |
IC50 = 56900 nM
|
[13] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3-chloro-4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364093
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[31] | |||
| Compound Name |
(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]pentanoyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4078112; BDBM50242265
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[36] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-pyrimidin-5-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192449
Click to Show/Hide
|
||||
| Activity |
IC50 = 57000 nM
|
[31] | |||
| Compound Name |
(2S,4S)-1-[(2S)-2-Amino-3-(4-nitrophenyl)propanoyl]-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3093906; BDBM50443734
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 58000 nM
|
[23] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1-cyclopropyl-3-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-substituted diazepanone 9i; CHEMBL230282; BDBM15538
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[25] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(tetrazol-1-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195739
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[31] | |||
| Compound Name |
trans-(R)-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidin-3-yl carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683122; BDBM50338416
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[10] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-2-methyl-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 58; CHEMBL197301; BDBM11956
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[19] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(1-ethyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251405; BDBM50222486
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[12] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,3-dimethyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-substituted diazepanone 9e; CHEMBL231011; BDBM15534
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[25] | |||
| Compound Name |
3-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)piperidin-1-yl)cyclohexanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683145; BDBM50338439
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[10] | |||
| Compound Name |
(3R,7R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-methyl diazepanone 15a; CHEMBL230496; SCHEMBL4708250; BDBM15545
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[25] | |||
| Compound Name |
4-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL427257
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[25] | |||
| Compound Name |
(3R)-3-Amino-1-(1,4-dimethyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250202; SCHEMBL8312244; BDBM50222485
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[12] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,3,5-trimethyl-1,2-oxazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683108; BDBM50338474
Click to Show/Hide
|
||||
| Activity |
IC50 = 58000 nM
|
[10] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(11-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805400
Click to Show/Hide
|
||||
| Activity |
IC50 = 59000 nM
|
[14] | |||
| Compound Name |
(2S,3S)-2-(4-Acetamidophenyl)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245970
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[37] | |||
| Compound Name |
(2R,3S,5R)-5-(2-Cyclopentylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736085; SCHEMBL14845416
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[32] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(3-methylsulfonyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735917
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[32] | |||
| Compound Name |
(3R,4R)-1-Pyrimidin-4-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230984
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[29] | |||
| Compound Name |
1-[3-(Aminomethyl)-4-(4-methylphenyl)-2-(2-methylpropyl)quinolin-6-yl]piperazine-2,5-dione;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL3897109; CHEMBL3142227
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 60000 nM
|
[38] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methylsulfanylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192365
Click to Show/Hide
|
||||
| Activity |
IC50 = 61000 nM
|
[31] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682975; BDBM50338441
Click to Show/Hide
|
||||
| Activity |
IC50 = 61000 nM
|
[10] | |||
| Compound Name |
(R)-3-Amino-1-(2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399499; SCHEMBL5228197; BDBM50221447
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[39] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(4-fluorophenyl)-1-methyl-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 57; CHEMBL193802; BDBM11955
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[19] | |||
| Compound Name |
N-[5-[[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-methylsulfamoyl]-4-methyl-1,3-thiazol-2-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683089; BDBM50338455
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[10] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-1H-imidazole-5-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736137
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[32] | |||
| Compound Name |
(3-Methyl-5-phenylbenzimidazol-4-yl)methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL255769; SCHEMBL3154092; BDBM50375248; ZINC29125126
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[16] | |||
| Compound Name |
(1S,2R,5S)-2-(2,5-Difluorophenyl)-5-(11-methyl-1,5,8,12-tetrazatricyclo[7.3.0.03,7]dodeca-2,7,9,11-tetraen-5-yl)cyclohexan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805226
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[14] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(pyrazol-2-ium-1-carbonyl)phenyl]butan-1-one;2,2,2-trifluoroacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552788
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[31] | |||
| Compound Name |
(R)-7-(3-Amino-4-(2,4,5-trifluorophenyl)butanoyl)-N-tert-butyl-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233891; SCHEMBL5494170; BDBM50210671
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[30] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-(trifluoromethyl)-4H,5H,6H,7H-pyrido[3,4-d][1,3]thiazol-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
thiazolopiperidine 73; CHEMBL363375; BDBM11971
Click to Show/Hide
|
||||
| Activity |
IC50 = 63000 nM
|
[19] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-(1,4-dimethyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250006; BDBM50222481
Click to Show/Hide
|
||||
| Activity |
IC50 = 64000 nM
|
[12] | |||
| Compound Name |
(R)-2-(2,5-Difluorophenyl)-1-(4-(pyridin-4-yl)phenyl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL471936; BDBM50243711
Click to Show/Hide
|
||||
| Activity |
IC50 = 64000 nM
|
[40] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[4-(trifluoromethyl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192980
Click to Show/Hide
|
||||
| Activity |
IC50 = 64000 nM
|
[31] | |||
| Compound Name |
(1S,2R,5R)-2-(2,5-Difluorophenyl)-5-(4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)cyclohexan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806164
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[14] | |||
| Compound Name |
(3R)-3-Amino-1-(2-cyclopropyl-1,4-dimethyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400911; CHEMBL1204389; BDBM50222476; BDBM50371230
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[12] | |||
| Compound Name |
4-[[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-methylsulfamoyl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682982; BDBM50338448; trans-4-(N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylsulfamoyl)benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[10] | |||
| Compound Name |
(2S,4R)-4-(4-Chlorobenzylamino)-2-amino-1-(piperidin-1-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215824; BDBM50191166
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[41] | |||
| Compound Name |
(R)-3-Amino-4-(4-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL242811; BDBM50210645
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[30] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridin-6-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 62; CHEMBL371521; BDBM11961
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[19] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-2-(trifluoromethyl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682976; BDBM50338442
Click to Show/Hide
|
||||
| Activity |
IC50 = 65000 nM
|
[10] | |||
| Compound Name |
(3R,4R)-1-Pyrido[2,3-b]pyrazin-3-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231194
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[29] | |||
| Compound Name |
5-Aminomethyl-4-(2,4-dichlorophenyl)-6-methyl-pyridine-2-carboxylic acid cyanomethyl-amide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688431; SCHEMBL12807244; BDBM50339103
Click to Show/Hide
|
||||
| Activity |
Ki = 66000 nM
|
[42] | |||
| Compound Name |
(3R)-3-Amino-1-[5,5-dimethyl-3-(trifluoromethyl)-6,8-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536765
Click to Show/Hide
|
||||
| Activity |
IC50 = 66000 nM
|
[43] | |||
| Compound Name |
(S)-2-(1-Hydroxy-2-methylpropan-2-ylamino)-1-(2-(5-methyl-1,2,4-oxadiazole-3-carbonyl)pyrrolidin-1-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL234911; BDBM50214722
Click to Show/Hide
|
||||
| Activity |
IC50 = 67300 nM
|
[44] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[1-methyl-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 47; CHEMBL195721; BDBM11945
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[19] | |||
| Compound Name |
cis-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683118; CHEMBL1683119; BDBM50338412; BDBM50338413; trans-1-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidine-3-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[10] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251205; BDBM50222475
Click to Show/Hide
|
||||
| Activity |
IC50 = 68000 nM
|
[12] | |||
| Compound Name |
(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]butanoyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4086264; BDBM50242264
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[36] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537400
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[45] | |||
| Compound Name |
Sitagliptin Analog 13
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SCHEMBL725863; Triazolopiperazine Analogue 25; CHEMBL216186; BDBM11160; 4-Desfluoro Sitagliptin; Sitagliptin EP Impurity B
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[30] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-3-cyano-N-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682977; BDBM50338443; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-3-cyano-N-methylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 69000 nM
|
[10] | |||
| Compound Name |
4-Amino-N-[4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682979; BDBM50338445; trans-4-amino-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 69000 nM
|
[10] | |||
| Compound Name |
1-((2S,4S)-2-(5-Tert-butyl-1,2,4-oxadiazole-3-carbonyl)-4-fluoropyrrolidin-1-yl)-2-(1-hydroxy-2-methylpropan-2-ylamino)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL391929; BDBM50214724
Click to Show/Hide
|
||||
| Activity |
IC50 = 69900 nM
|
[44] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylthiadiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683105; BDBM50338471
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[10] | |||
| Compound Name |
(3R,7S)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,7-dimethyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
7-methyl diazepanone 15b; CHEMBL394836; BDBM15546
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[25] | |||
| Compound Name |
(3R)-3-Amino-1-(4-benzyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250284; SCHEMBL8311484; BDBM50222470
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[12] | |||
| Compound Name |
(3R)-3-Amino-1-[(5R,8R)-5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536311
Click to Show/Hide
|
||||
| Activity |
IC50 = 70000 nM
|
[43] | |||
| Compound Name |
Diphenyl 1-((2S,3S)-2-amino-3-methylpentanoyl)pyrrolidin-2-ylphosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL427850; BDBM50225427
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[34] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,5-dimethyl-1H-pyrazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683086; BDBM50338452
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[10] | |||
| Compound Name |
1-[[(S)-2-Pyrrolidinyl]carbonyl]-2-pyrrolidinylphosphonic acid diphenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1182947; BDBM50393202
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[34] | |||
| Compound Name |
(R)-3-Amino-1-((R)-8-(cyclopropylmethyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400752; BDBM50221451
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[39] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[1-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 49; CHEMBL196010; BDBM11947
Click to Show/Hide
|
||||
| Activity |
IC50 = 71000 nM
|
[19] | |||
| Compound Name |
3-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)piperidin-1-yl)cyclohexanecarboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683144; BDBM50338438
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[10] | |||
| Compound Name |
(3R)-3-Amino-1-[8-prop-2-enyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537000
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[43] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(1,1,2,2,2-pentafluoroethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 53; CHEMBL370269; BDBM11951
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[19] | |||
| Compound Name |
(3R)-3-Amino-1-(6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557187
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[45] | |||
| Compound Name |
(R)-3-Amino-1-((S)-2-(5-(3-methyloxetan-3-yl)-1,2,4-oxadiazol-3-yl)pyrrolidin-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL565600; SCHEMBL8272829; BDBM50302972
Click to Show/Hide
|
||||
| Activity |
IC50 = 72000 nM
|
[21] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-methoxyphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195443
Click to Show/Hide
|
||||
| Activity |
IC50 = 74000 nM
|
[31] | |||
| Compound Name |
(R)-3-Amino-4-(2-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388475; BDBM50210663
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[40] | |||
| Compound Name |
(3R)-3-Amino-1-[(6R)-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL553787
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[43] | |||
| Compound Name |
4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]-N-(4,4,4-trifluorobutyl)cyclohexan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683124; BDBM50338418; trans-4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)-N-(4,4,4-trifluorobutyl)cyclohexanamine
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[10] | |||
| Compound Name |
1-Pentanone, 2-amino-3-methyl-1-(1-piperidinyl)-, (2S,3S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL83418; 1-(L-Ile-)Piperidine; SCHEMBL16578291; BDBM50243497; ZINC11959236; (2S,3S)-2-amino-3-methyl-1-(piperidin-1-yl)pentan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[7] | |||
| Compound Name |
(3R,4R)-1-Pyrazin-2-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230985
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[29] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-4-(1,3-oxazol-5-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682984; BDBM50338450
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[10] | |||
| Compound Name |
(3R,7S)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-methyl-7-(trifluoromethyl)-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230603
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[25] | |||
| Compound Name |
trans-4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)-N-benzyl-N-ethylcyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683127; BDBM50338421
Click to Show/Hide
|
||||
| Activity |
IC50 = 76000 nM
|
[10] | |||
| Compound Name |
(2S,3As,6aS)-1-[(3R)-3-amino-4-(2-methylphenyl)butanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3330064; BDBM50098991
Click to Show/Hide
|
||||
| Activity |
IC50 = 76720 nM
|
[20] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-ethyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398492; BDBM50222488
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[12] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-methylphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191514
Click to Show/Hide
|
||||
| Activity |
IC50 = 77000 nM
|
[31] | |||
| Compound Name |
(1S,2R,5R)-5-(11-Methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)cyclohexan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3804854
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[14] | |||
| Compound Name |
(1S,2R,5S)-2-(2,5-Difluorophenyl)-5-(4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)cyclohexan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806026
Click to Show/Hide
|
||||
| Activity |
IC50 = 79000 nM
|
[14] | |||
| Compound Name |
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(pyrazin-2-ylmethyl)-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217702
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[26] | |||
| Compound Name |
6-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2-methyl-3H-pyrido[3,2-d]pyrimidin-4-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231395
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[29] | |||
| Compound Name |
[3-Methyl-5-(2-methylphenyl)benzimidazol-4-yl]methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL256625; SCHEMBL3143924; BDBM50375235
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[16] | |||
| Compound Name |
(3R)-3-Amino-1-(2-tert-butyl-1,4-dimethyl-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250283; BDBM50222474
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[12] | |||
| Compound Name |
(3R)-3-Amino-1-[3-(1,1,2,2,2-pentafluoroethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558585
Click to Show/Hide
|
||||
| Activity |
IC50 = 80000 nM
|
[45] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]acetamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245971
Click to Show/Hide
|
||||
| Activity |
IC50 = 82000 nM
|
[37] | |||
| Compound Name |
4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Diazepanone Analog 22; 1,4-diazepan-2-one 2c; CHEMBL216643; BDBM13523
Click to Show/Hide
|
||||
| Activity |
IC50 = 82000 nM
|
[26] | |||
| Compound Name |
IP5Pms7gwy
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-IP5PMS7GWY; CHEMBL389151; SCHEMBL12323237; BDBM50210665; Sitagliptin phosphate impurity C [EP]; 5-Desfluoro Sitagliptin; Sitagliptin EP Impurity C
Click to Show/Hide
|
||||
| Activity |
IC50 = 83000 nM
|
[30] | |||
| Compound Name |
2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-5-((E)-2-pyridin-3-ylvinyl)-6H-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650429; SCHEMBL3388711; BDBM50335798
Click to Show/Hide
|
||||
| Activity |
IC50 = 84000 nM
|
[46] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-phenylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191933
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[31] | |||
| Compound Name |
(3R)-3-Amino-1-(4-cyclopropyl-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248810; BDBM50222469
Click to Show/Hide
|
||||
| Activity |
IC50 = 85000 nM
|
[12] | |||
| Compound Name |
(R)-3-Amino-1-(3-(difluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390240; SCHEMBL18104703; BDBM50210649
Click to Show/Hide
|
||||
| Activity |
IC50 = 86000 nM
|
[30] | |||
| Compound Name |
Diphenyl 1-((S)-2,4-diaminobutanoyl)pyrrolidin-2-ylphosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL392139; BDBM50225429
Click to Show/Hide
|
||||
| Activity |
IC50 = 86000 nM
|
[34] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-[(2,5-dichlorophenyl)methyl]-3-methylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650444; SCHEMBL391986; BDBM50335783; ZINC66102414; 6-[3(R)-Amino-piperidin-1-yl]-1-(2,5-di-chloro-benzyl)-3-methyl-1H-pyrimidine-2,4-dione; 6-[3-(R)-Aminopiperidin-1-yl]-1-(2,5-dichlorobenzyl)-3-methyl-1H-pyrimidine-2,4-dione; 6-[3 (R)-Amino-piperidin-1-yl]-1-(2,5-di-chloro-benzyl)-3-methyl-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 = 86000 nM
|
[46] | |||
| Compound Name |
(R)-3-Amino-1-((R)-8-(cyclopropyl(hydroxy)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400722; BDBM50221446
Click to Show/Hide
|
||||
| Activity |
IC50 = 86000 nM
|
[39] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189881
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[37] | |||
| Compound Name |
(R)-4-((R)-3-Amino-4-(2-fluorophenyl)butanoyl)-3-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452805; BDBM50243966
Click to Show/Hide
|
||||
| Activity |
IC50 = 87000 nM
|
[40] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237336; SCHEMBL5251423; BDBM50221977; (2S,3S)-2-amino-3-(4''-fluorobiphenyl-4-yl)-1-((S)-3-fluoropyrrolidin-1-yl)butan-1-one; (2S,3S)-2-amino-3-(4''-fluoro-biphenyl-4-yl)-1-((S)-3-fluoro-pyrrolidin-1-yl)-butan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 88000 nM
|
[24] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]ethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734828; BDBM50134192
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[32] | |||
| Compound Name |
(3R,6R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-6-methyl-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-methyl diazepanone 14f; CHEMBL230495; BDBM15550
Click to Show/Hide
|
||||
| Activity |
IC50 = 89000 nM
|
[25] | |||
| Compound Name |
(3R)-3-Amino-1-(2-benzoyldiazepan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539611
Click to Show/Hide
|
||||
| Activity |
IC50 = 89120 nM
|
[47] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]cyclopropanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734999; BDBM50134194
Click to Show/Hide
|
||||
| Activity |
IC50 = 91000 nM
|
[32] | |||
| Compound Name |
(2r,3s,5r)-2-(2,5-Difluorophenyl)-5-(7h-Pyrrolo[3',4':3,4]pyrazolo[1,5-A]pyrimidin-8(9h)-Yl)oxan-3-Amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806216; Q27456333
Click to Show/Hide
|
||||
| Activity |
IC50 = 91000 nM
|
[14] | |||
| Compound Name |
4-[(3R,5S,6R)-5-Amino-6-(2,4,5-trifluorophenyl)oxan-3-yl]-9-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9-trien-11-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806310
Click to Show/Hide
|
||||
| Activity |
IC50 = 92000 nM
|
[14] | |||
| Compound Name |
(3R,6R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3,6-dimethyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-methyl diazepanone 14b; CHEMBL397241; BDBM15544
Click to Show/Hide
|
||||
| Activity |
IC50 = 93000 nM
|
[25] | |||
| Compound Name |
(2S,3S)-2-((1r,4S)-4-([1,2,4]Triazolo[1,5-a]pyridin-5-yl)cyclohexyl)-3-amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxobutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237783; CHEMBL237997; SCHEMBL13412169; BDBM50221968; BDBM50221975
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[24] | |||
| Compound Name |
(S)-2-Amino-3-(4-hydroxyphenyl)-1-(pyrrolidin-1-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL511346; SCHEMBL14390395; BDBM50243456; (2S)-1-Pyrrolizino-2-amino-3-(4-hydroxyphenyl)-1-propanone
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[7] | |||
| Compound Name |
(R)-2-(2,5-Difluorophenyl)-1-(1-(methylsulfonyl)piperidin-4-yl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683130; BDBM50338424
Click to Show/Hide
|
||||
| Activity |
IC50 = 95000 nM
|
[10] | |||
| Compound Name |
(R)-3-Amino-1-((S)-8-methyl-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251376; BDBM50221455
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(R)-3-Amino-4-(2-chloro-4,5-difluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233058; BDBM50210643
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
CID 53312239
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329699; SCHEMBL12518740; BDBM50101332
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2R,3R)-7-Fluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552071
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
N-[4-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL193887
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
2-((2-(3-(R)-Aminopiperidin-1-yl)-5-bromo-6-oxopyrimidin-1(6H)-yl)methyl)-4-fluorobenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650434; SCHEMBL3394117; BDBM50335793; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-bromo-6-oxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2R,3R)-6,8-Difluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL558253
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(3R,4R)-1-(3-Methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231497
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(2R,3S,5R)-5-(9-Methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3806021
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[14] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-2-(4-imidazo[1,2-a]pyridin-6-ylphenyl)-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378673
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
2-[[3-Methyl-2-oxo-7-(piperidin-4-ylamino)imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329690; BDBM50102859
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxo-4-piperidin-1-ylbutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190923
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-(4,4,4-trifluorobutyl)acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683112; BDBM50338405; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-(4,4,4-trifluorobutyl)acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329627; SCHEMBL12518747; BDBM50102865
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(3R)-3-Amino-1-[(6S)-6-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557990
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
2-[2-(3-(r)-Aminopiperidin-1-yl)-5-ethynyl-6-oxo-6h-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650422; SCHEMBL3392460; BDBM50335757; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-ethynyl-6-oxopyrimidin-1-yl]methyl]benzonitrile; 2-[2-(3-(R)-Amino-piperidin-1-yl)-5-ethynyl-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(3R,4R)-1-(2-Cyclopropyl-3-methylimidazo[4,5-b]pyridin-5-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389804
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(11-methyl-1,4,8,12-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),7,9,11-tetraen-4-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805294
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[14] | |||
| Compound Name |
(3S)-1-[(2S,3S)-2-Amino-3-(4-fluorophenyl)-1-oxobutanyl]-3-fluoropyrrolidine trifluoroacetic acid salt
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365575; SCHEMBL5364475
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoroazetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364355
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(2-methylphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372472
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(2-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209710
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1,4-dimethylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425039
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-(cyclopropylmethyl)pyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL383323
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
[3-Benzyl-5-(2-chlorophenyl)benzimidazol-4-yl]methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403156; SCHEMBL3139405; BDBM50375242
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-[[2-[(3R)-3-Aminopiperidin-1-yl]-4,5-dimethyl-6-oxopyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650409; SCHEMBL3392381; BDBM50335770; 2-[2-(3-(r)-aminopiperidin-1-yl)-4,5-dimethyl-6-oxo-6h-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-morpholin-4-yl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371347
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(2R,3R,5S)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425081; BDBM50440350
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(S)-1-((2S,4R)-4-(2-(Isoindolin-2-yl)-2-oxoethyl)-5-oxopyrrolidine-2-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243403; SCHEMBL3395715; BDBM50326376
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(3R)-3-Amino-1-[(8R)-8-[cyclopropyl(hydroxy)methyl]-2-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[1,5-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404210; BDBM50221440
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
4-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191906
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(8-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210621
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
(2S,3S)-3-Amino-N-ethyl-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189067
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2-(trifluoromethyl)phenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397744; BDBM50210644
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-3-[(6-bromoquinolin-2-yl)methyl]-1-but-2-ynylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425888; BDBM50440465
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-chloroquinolin-2-yl)methyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425889; BDBM50440464
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4213950
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454658
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[52] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[4-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220301; alpha-amino acid pyrrolidide 17; BDBM11655
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(R)-1-((R)-8-((1H-1,2,4-Triazol-1-yl)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400068; BDBM50221444
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(R)-3-Amino-4-(2-chlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388431; BDBM50210661
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-(hydroxymethyl)-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203169
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[6-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230342
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-ethylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683110; BDBM50338476
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,4S)-1-{(2S,4S)-4-[2-(5-Chloro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl}-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243127; SCHEMBL16509426; BDBM50326391
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438992
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-3-chloro-4-fluoro-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203267
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
(2R,3S,5R)-5-(1-Cyclopropylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736190; SCHEMBL14845407
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
(R)-3-Amino-4-(3,4-dichlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL388433; BDBM50210656
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
2-[2-(3-(R)-Aminopiperidin-1-yl)-5-furan-3-yl-4-methyl-6-oxo-6H-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650419; SCHEMBL3391376; BDBM50335760; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-(furan-3-yl)-4-methyl-6-oxopyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
alpha-Amino acid pyrrolidide 29
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219278; BDBM11667
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2S,3S)-2-Amino-1-((S)-3-fluoropyrrolidin-1-yl)-3-(4-(pyridin-4-yl)phenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL442673; BDBM50243712
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
Chembl4207996
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454652
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[52] | |||
| Compound Name |
(2S,3R)-2-Amino-1-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)-3-methylpentan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3800132
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-[4-(4-Chlorophenyl)-3,6-dihydropyridin-1(2h)-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243061; SCHEMBL3399417; BDBM50326386
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(2S,4S)-1-(2-((1,1-Dimethyl-3-oxo-3-(1-pyrrolidinyl)propyl)amino)acetyl)-4-fluoro-2-pyrrolidinecarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
DBPR-108; DBPR108; UNII-E329HG23ZT; E329HG23ZT; CHEMBL1082462; SCHEMBL2401277; BDBM50320120; ZINC43207516; CS-3825; NCGC00485889-01; HY-12528; Q27276810
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
7-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-chlorophenyl)methyl]-3-methylimidazo[4,5-b]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329636; SCHEMBL12518750; BDBM50102839
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1,6-dimethylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL206252
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
2-[[2-(3-Aminopiperidin-1-yl)-8-methoxy-4-oxoquinazolin-3-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390776; SCHEMBL3422073
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluoro-phenyl)-1-[3-(4-fluoro-benzyl)-2-trifluoromethyl-1,4,6,7-tetrahydro-imidazo[4,5-c]pyridin-5-yl]-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400761; BDBM50222479
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
N-[3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]-1,1,1-trifluoromethanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192117
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2R,3S,5R)-5-[11-(Trifluoromethyl)-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl]-2-(2,4,5-trifluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805502
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[14] | |||
| Compound Name |
Unii-625uxd6cji
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
625UXD6CJI; CHEMBL1650435; 2-[[6-[(3R)-3-aminopiperidin-1-yl]-2,4-dioxopyrimidin-1-yl]methyl]benzonitrile; N-Demethylated alogliptin; Alogliptin metabolite M-I; SCHEMBL390872; BDBM50335792; ZINC36377313
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-(3-fluoroazetidin-1-yl)-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378597
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
3-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329634; SCHEMBL12518770; BDBM50102842
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
2-[[6-[(3R)-3-Amino-3-methylpiperidin-1-yl]-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650449; SCHEMBL387156; BDBM50335778
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
US9051329, Example 5
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687980; SCHEMBL14554341; BDBM162380
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[55] | |||
| Compound Name |
Chembl4215849
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454649
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[52] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-(4-pyrazolo[1,5-a]pyrimidin-5-ylphenyl)butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210459
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191327
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-phenylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362973
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-(hydroxymethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233684; BDBM50210670
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-[(2,4-difluorophenyl)sulfonylamino]cyclohexyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246170
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
2-[(3R)-3-Aminopiperidino]-3-(2-cyanobenzyl)-6-fluoroquinazoline-4(3H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425483; SCHEMBL3425219; quinazolinone-based inhibitor 1c; BDBM16274; 2-({2-[(3R)-3-aminopiperidin-1-yl]-6-fluoro-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375414; alpha-amino acid pyrrolidide 13; BDBM11651
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(2R,3R)-6,7,8-trifluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL562530
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-chloro-5-fluorophenyl)methyl]-3-methylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650441; SCHEMBL2087382; BDBM50335786; ZINC66102717; 6-[3 (R)-Amino-piperidin-1-yl]-1-(2-chloro-5-fluoro-benzyl)-3-methyl-1H-pyrimidine-2,4-dione; 6-[3(R)-Amino-piperidin-1-yl]-1-(2-chloro-5-fluoro-benzyl)-3-methyl-1H-pyrimidine-2,4-dione; 6-[3-(R)-Aminopiperidin-1-yl]-1-(2-chloro-5-fluorobenzyl)-3-methyl-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2S,3S)-2-Amino-3-phenyl-1-(1,3-thiazolidin-3-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
thiazolidide 4; CHEMBL192983; BDBM11466
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2R,3R)-8-Fluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560669
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-oxo-4-(1,3-thiazolidin-3-yl)butan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL377724
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(3-propan-2-ylsulfonyl-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735694
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MK-0626; CHEMBL537869
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
CID 53311141
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329638; SCHEMBL12518869; BDBM50102847
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
CID 53311071
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329639; SCHEMBL12518871; BDBM50102846
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-ethylmethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683095; BDBM50338461
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S)-1-({(2S,4S)-4-[2-[4-(4-Fluorophenyl)piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243028; SCHEMBL3393509; BDBM50326384
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(3-(trifluoromethyl)phenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243227; BDBM50210659
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
Ethyl 2-[5-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-2-oxopyridin-1-yl]acetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL382674
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
Methyl (2S,3S)-3-amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372004
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(2R,3S,5R)-2-(2,4-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425072; BDBM50440342
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(2R,3R)-7-(trifluoromethyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552479
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[3-(trifluoromethyl)-[1,2,4]triazolo[4,3-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228311
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(2R,3S,5R)-5-(2-Cyclopropyl-5,5-dimethyl-7H-pyrrolo[3,4-d]pyrimidin-6-yl)-2-(2,5-difluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425065; BDBM50440348
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-({2-[(3R)-3-Aminopiperidin-1-yl]-6,7-dimethoxy-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227089; quinazolinone-based inhibitor 1k; BDBM16282; ZINC6716416
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2R,3R)-6-Fluoro-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL537962
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[3-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230449
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-5-methylhexan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219371
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(5-azidoisoindolin-2-yl)-3-methylpentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL487432; BDBM50243082
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220021; alpha-amino acid pyrrolidide 15; BDBM11653
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(2H-tetrazol-5-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195378
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
N-[4-[5-[(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-4-oxobutan-2-yl]-1,2,4-oxadiazol-3-yl]-3-chlorophenyl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375146
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-[3-(tetrazol-1-yl)phenyl]phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191473
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(2R,3R)-7-Ethylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560192
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2S,3S)-3-{3-[4-(Methylsulfonyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-oxo-1-pyrrolidin-1-ylbutan-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374936; alpha-amino acid pyrrolidide 20; BDBM11658; DB07067; (2S,3S)-2-amino-3-[3-(4-methanesulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one; Q27095982
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362976
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S,3S)-3-Amino-2-(4''-fluorobiphenyl-4-yl)-4-((S)-3-fluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxobutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237119; SCHEMBL5251559; BDBM50221967
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-bromophenyl)methyl]-3-methylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650439; SCHEMBL389898; BDBM50335788; ZINC66102000; 6-[3 (R)-Amino-piperidin-1-yl]-1-(2-bromo-benzyl)-3-methyl-1H-pyrimidine-2,4-dione; 6-[3(R)-Amino-piperidin-1-yl]-1-(2-bromo-benzyl)-3-methyl-1H-pyrimidine-2,4-dione; 6-[3-(R)-Aminopiperidin-1-yl]-1-(2-bromobenzyl)-3-methyl-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(pyrrolo[3,4-c]pyrazol-5(1H,4H,6H)-yl)tetrahydro-2H-pyran-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425070; SCHEMBL13958054; SCHEMBL18927988; BDBM50440351; ACN-037554
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
2-[3-[2-[2-Cyano-(S)-pyrrolidin-1-yl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,3-dihydroisoindole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(2S)-cyanopyrrolidine 4; CHEMBL201644; SCHEMBL1069325; BDBM11719; (2S)-Cyanopyrrolidine analogue 21d
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
DPP-4 ligand 3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL427261; BDBM15561
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
Trelagliptin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
SYR-472; Trelagliptin(SYR-472); UNII-Q836OWG55H; Q836OWG55H; CHEMBL1650443; 865759-25-7 (free base); C18H20FN5O2; Trelagliptin [USAN:INN]; Trelagliptin (USAN); Trelagliptin(syr472); SCHEMBL175726; DTXSID00235678; EX-A470; AOB87180; KS-00000TD0; 2763AH; BDBM50335784; MFCD22572746; s7513; ZINC34505198; AKOS026674097; CCG-268122; CS-1041; DB15323; SB16717; NCGC00378845-01; AC-30279; AS-75009; HY-15408; A3889; D10178; W-5952; Q27287099
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-ethyl-3,5-dimethyl-1,2-oxazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683092; BDBM50338458
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3-fluoroazetidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210974
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
(2S)-1-[(2S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243248
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(benzenesulfonamido)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245772
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,5-dimethyl-1,2-oxazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683088; BDBM50338454; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N,5-dimethylisoxazole-4-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
trans-(R)-2-(2,5-Difluorophenyl)-1-(4-(3,3-difluoropyrrolidin-1-yl)cyclohexyl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683113; CHEMBL1683114; BDBM50338406; BDBM50338407; cis-(R)-2-(2,5-difluorophenyl)-1-(4-(3,3-difluoropyrrolidin-1-yl)cyclohexyl)ethanamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3-chlorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192781
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S)-1-[(2S,4S)-4-[2-(5,7-Dihydro-4H-thieno[2,3-c]pyridin-6-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242993; BDBM50326381
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(2S,3S)-2-Amino-3-methyl-1-(4-methylisoindolin-2-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469892; BDBM50242853
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-methoxy-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL380496
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
(3R)-3-Amino-1-[8-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536999
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-4-cyano-N-methylbenzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682978; BDBM50338444; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-4-cyano-N-methylbenzenesulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,4R)-4-(4-Chlorobenzylamino)-2-amino-5-methyl-1-(piperidin-1-yl)heptan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214580; BDBM50191167
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
(2R,3R)-3-(3-(2,4-Dichlorophenyl)-1,2,4-oxadiazol-5-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL519591; BDBM50243916
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-fluoroquinolin-2-yl)methyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425890; BDBM50440463
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxobenzimidazol-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329633; BDBM50102852
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S)-1-[(2S,4S)-5-Oxo-4-[2-oxo-2-[2-(trifluoromethyl)-6,8-dihydro-5H-imidazo[1,2-a]pyrazin-7-yl]ethyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242994; SCHEMBL16509428; BDBM50326382
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4,4-difluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243153; SCHEMBL3395679; BDBM50326392
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,3,5-trimethyl-1,2-oxazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683091; BDBM50338457
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(2-methoxyphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365953
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
2[2-(3-(R)-Aminopiperidin-1-yl)-5-bromo-4-methyl-6-oxo-6Hpyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650406; SCHEMBL3387907; BDBM50335773; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-bromo-4-methyl-6-oxopyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
4-[[5-(Aminomethyl)-2-methyl-4-(4-methylphenyl)-6-(2-methylpropyl)pyridine-3-carbonyl]oxymethyl]benzoic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4100667; SCHEMBL5451591; BDBM50253949
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[56] | |||
| Compound Name |
(2R,3R)-8-Methylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549645
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
2-[[2-[(3R)-3-Aminopiperidin-1-yl]-6-oxopyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650403; SCHEMBL3393516; BDBM50335776; 2-[2-(3-(R)-Amino-piperidin-1-yl)-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile; 2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-6H-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-fluoro-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL424687
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(trifluoromethyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL194489
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[5-(2,4-dichlorophenyl)-1,2,4-oxadiazol-3-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220404
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
US9051329, Example 2
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687978; SCHEMBL14554395; BDBM162377
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[55] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(1,3-thiazol-2-yl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192396
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
trans-4-(((4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)(methyl)amino)methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683125; BDBM50338419
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-benzylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683111; BDBM50338404
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
7-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-cyanophenyl)methyl]-3-methyl-2-oxoimidazo[4,5-b]pyridine-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329700; BDBM50102843
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(3R)-3-Amino-1-[8-ethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556606
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
2-[[7-[(3S)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329694; BDBM50102849
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
2-(3,4-Difluorophenyl)-1,2,3,4-tetrahydroisoquinoline
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
isoquinoline derivative 10; CHEMBL180664; BDBM12187; AKOS027557967
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[57] | |||
| Compound Name |
alpha-Amino acid pyrrolidide 21
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218911; BDBM11659
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(3R)-1-(4-(4-Fluorobenzyl)-1-methyl-2-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250285; SCHEMBL8311489; BDBM50222484
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[12] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-methoxyquinolin-2-yl)methyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425892; BDBM50440461
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[2-(3-(r)-Aminopiperidin-1-yl)-5-fluoro-6-oxo-6h-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650404; SCHEMBL204350; BDBM50335777; 2- [2-(3-(R)-Amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-fluoro-6-oxopyrimidin-1-yl]methyl]benzonitrile; 2-[2-(3-(R)-Amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
3-[3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370072
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-1H,4H,5H,6H,7H-pyrazolo[4,3-b]pyridin-4-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 65; CHEMBL364461; BDBM11963
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-3,5-dimethyl-N-(4,4,4-trifluorobutyl)-1,2-oxazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683094; BDBM50338460
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-[[2-(3-Aminopiperidin-1-yl)-8-chloro-4-oxoquinazolin-3-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL387552; SCHEMBL3425436
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[2-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL426335; alpha-amino acid pyrrolidide 10; BDBM11648
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-5-phenyl-6H-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650414; SCHEMBL3391384; BDBM50335765; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-6-oxo-5-phenylpyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1H-pyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL381145
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-(5-Trifluoromethyl-1,3-dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242966; SCHEMBL3395102; BDBM50326379
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(1,1,2,2,2-pentafluoroethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 55; CHEMBL366166; BDBM11953
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(1,1-dioxo-1,3-thiazolidin-3-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365967
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(2S)-1-(2-{[4-(6-Fluoro-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-methyl-4-oxobutan-2-yl]amino}acetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL380902; BDBM11717; (2S)-Cyanopyrrolidine analogue 21b
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[58] | |||
| Compound Name |
(3R)-3-Amino-1-[3-(trifluoromethyl)-8-[[2-(trifluoromethyl)phenyl]methyl]-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536090
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
(2S,3S)-2-Amino-4-cyclopropyl-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3-(4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375442
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
2-({2-[(3R)-3-Aminopiperidin-1-yl]-6,8-dichloro-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390529; SCHEMBL3424625; quinazolinone-based inhibitor 1g; BDBM16278; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-6,8-dichloro-4-oxoquinazolin-3-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-3-(1H-benzimidazol-2-ylmethyl)-1-but-2-ynylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425885; BDBM50440468
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-3-benzyl-1-but-2-ynylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425883; BDBM50440470
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(4-bromophenyl)-1-((S)-3-fluoropyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472124; SCHEMBL5150617; BDBM50243710; (2S,3S)-2-amino-3-(4-bromophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-pyrazolo[1,5-a]pyrimidin-5-ylphenyl)butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL208957
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-6-fluoro-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL205872
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
2-[[6-[(3R)-3-Aminopiperidin-1-yl]-9-methyl-8-oxopurin-7-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329632; BDBM50102853
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
2-[2-(3-(R)-Aminopiperidin-1-yl)-5-furan-3-yl-6-oxo-6H-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650418; SCHEMBL3389575; BDBM50335761; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-(furan-3-yl)-6-oxopyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2,4-difluorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374032; alpha-amino acid pyrrolidide 23; BDBM11661
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(4-(3-chloropyridin-4-yl)phenyl)-1-((S)-3-fluoropyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512895; BDBM50243714
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(3R)-3-Amino-1-(1-methyl-4-(trifluoromethyl)-6,7-dihydro-1H-imidazo[4,5-c]pyridin-5(4H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400954; BDBM50222477
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(2,5-difluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL278729
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2R,3S,5R)-5-(1-Cyclopentylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3645492; SCHEMBL14845408; BDBM107101; US8592371, 3
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210999
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
(2S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]propan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL189645
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL206501
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195755
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
N-[4-[5-[(2S,3S)-3-Amino-4-[(3R)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]-1,2,4-oxadiazol-3-yl]-3-chlorophenyl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218776
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,1-dimethylpyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683109; BDBM50338475
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(3S)-2-[(2S)-2-Amino-3-(1H-indol-3-yl)propanoyl]-3,4-dihydro-1H-isoquinoline-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL180000
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[57] | |||
| Compound Name |
(2R,3R)-2-Amino-N,N-dimethyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole-7-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL560729
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-(4-fluoropiperidin-1-yl)-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202634
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
trans-4-((4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)(methyl)amino)-4-oxobutanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683103; BDBM50338469
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,4S)-4-[[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]amino]-1-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090635; BDBM50242274
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[36] | |||
| Compound Name |
CID 53312243
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329697; SCHEMBL13719893; BDBM50101396
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(3-methylsulfonylphenyl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370677
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-(4-methylsulfonylphenyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL194437
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2r)-4-[(8r)-8-Methyl-2-(Trifluoromethyl)-5,6-Dihydro[1,2,4]triazolo[1,5-A]pyrazin-7(8h)-Yl]-4-Oxo-1-(2,4,5-Trifluorophenyl)butan-2-Amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250787; SCHEMBL21068050; BDBM50221443; DB07081; Q27095996
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
2-[(3S,5S)-5-[(2S)-2-Cyanopyrrolidine-1-carbonyl]-2-oxopyrrolidin-3-yl]-N-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243093; SCHEMBL3395680; BDBM50326389; 2-[(3s,5s)-5-{[(2s)-2-cyanopyrrolidin-1-yl]carbonyl}-2-oxopyrrolidin-3-yl]-n-phenylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-5-methoxy-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329695; BDBM50102848
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
2-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-3H-isoindol-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425066; BDBM50440347
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2S,4R)-4-(4-Chlorobenzylamino)-2-amino-5-methyl-1-(piperidin-1-yl)hexan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL373665; BDBM50191169
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-5-vinyl-6H-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650426; SCHEMBL3390501; BDBM50335753; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-ethenyl-6-oxopyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[46] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-2-oxo-3H-imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329626; SCHEMBL12518746; BDBM50102856
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
2-({2-[(3R)-3-Aminopiperidin-1-yl]-7-fluoro-6-methoxy-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375508; SCHEMBL3425298; quinazolinone-based inhibitor 1j; BDBM16281; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-7-fluoro-6-methoxy-4-oxoquinazolin-3-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(3R,4R)-1-Isoquinolin-1-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231091
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-methyl-1,2,4-oxadiazol-5-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL507719; BDBM50243866
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[3-(trifluoromethyl)-4H,5H,6H,7H-pyrido[4,3-c][1,2]oxazol-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
isoxazolopiperidine 59; CHEMBL363606; BDBM11957
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
4'-[(1r)-1-Amino-2-(2,5-Difluorophenyl)ethyl]biphenyl-3-Carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452289; BDBM50244011; DB07181; Q27096098; 4''-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]biphenyl-3-carboxamide; 4''-[(R)-1-Amino-2-(2,5-difluoro-phenyl)-ethyl]-biphenyl-3-carboxylic acid amide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(3R)-1-(8-((1H-Imidazol-1-yl)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250147; BDBM50221449
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(2R,3S,5S)-5-(9-Methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805235
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[14] | |||
| Compound Name |
2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-4-phenyl-6H-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650412; SCHEMBL3390969; BDBM50335767; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-6-oxo-4-phenylpyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
alpha-Amino acid pyrrolidide 28
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216835; BDBM11666
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-((1r,4S)-4-(5,6,7,8-tetrahydro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)cyclohexyl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235198; CHEMBL235199; BDBM50221969; BDBM50221976
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
CID 53312238
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329701; SCHEMBL12518737; BDBM50102841
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S,3R)-2-Amino-3-methyl-1-(5-(trifluoromethyl)isoindolin-2-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL488225; BDBM50243131
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
2-[(3R)-3-Aminopiperidin-1-yl]-3-[(2-chloro-5-fluorophenyl)methyl]-5-methyl-4-oxoimidazo[4,5-c]quinoline-7-carboxylic acid;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2147070
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[59] | |||
| Compound Name |
(R)-3-Amino-4-(3-fluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL232262; BDBM50210662
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-difluorophenyl)-1-(3-isobutyl-2-(trifluoromethyl)-6,7-dihydro-3H-imidazo[4,5-c]pyridin-5(4H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429829; BDBM50222478
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-ethylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL206792
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
(3R,4R)-1-Pteridin-7-yl-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231195
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191823
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(R)-3-Amino-4-(3-chlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL243230; BDBM50210650
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
(3s,5s)-3-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-(1,3-thiazolidin-3-ylcarbonyl)pyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243154; SCHEMBL3395728; BDBM50326393; (3S,5S)-3-[2-(1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-(1,3-thiazolidine-3-carbonyl)pyrrolidin-2-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-4-hydroxybutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365567
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
2-[2-(3-(R)-Aminopiperidin-1-yl)-5-(2-fluorophenyl)-6-oxo-6Hpyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650416; SCHEMBL3390926; BDBM50335763; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-(2-fluorophenyl)-6-oxopyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2R,3R,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425082; BDBM50440335
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(1S,2R,5S)-5-(3-(Trifluoromethyl)-5,6-dihydroimidazo[1,2-a]pyrazin-7(8H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL234635; BDBM50210527
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxo-5-(trifluoromethyl)imidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329698; SCHEMBL12518805; BDBM50101385
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
CID 53311222
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329692; SCHEMBL12518751; BDBM50102851
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-5-hydroxypentan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220357
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(3R)-3-Amino-1-[8-[[3,5-bis(trifluoromethyl)phenyl]methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536312
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
(2S,3S)-3-Amino-2-(4-(1,8a-dihydro-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl)-4-((S)-3-fluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxobutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459357; BDBM50276598
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
(2s)-1-({(2s,4s)-5-Oxo-4-[2-oxo-2-(pyrrolidin-1-yl)ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243091; SCHEMBL3393495; BDBM50326387
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-2-((1s,4R)-4-(2,6-dimethoxypyrimidin-4-yl)cyclohexyl)-N,N-dimethyl-4-oxobutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL235004; CHEMBL235223; BDBM50221973; BDBM50221983
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
(R)-3-Amino-1-(2-cyclopropyl-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248936; SCHEMBL5230936; BDBM50221441
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(R)-3-Amino-1-(5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248743; BDBM50221450
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425063; BDBM50440349
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(R)-2-((2-(3-Aminopiperidin-1-yl)-5-fluoro-6-oxopyrimidin-1 (6H)-yl)methyl)-4-fluorobenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650432; SCHEMBL3392432; BDBM50335795; 2-((2-(3-(R)-Aminopiperidin-1-yl)-5-fluoro-6-oxopyrimidin-1(6H)-yl)methyl)-4-fluorobenzonitrile; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-fluoro-6-oxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2R,3S,5R)-5-(2-Cyclopropyl-7,7-dimethyl-5H-pyrrolo[3,4-d]pyrimidin-6-yl)-2-(2,5-difluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425064; BDBM50440352
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2R,3R)-7-Methoxy-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550598
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(2-chlorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191769
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL377221
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(2-chloro-4-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195862
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
alpha-Amino acid pyrrolidide 18
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218882; BDBM11656
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3-(2-chloro-4-(methylsulfonyl)phenyl)-1,2,4-oxadiazol-5-yl)-1-((S)-3-fluoropyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL488469; BDBM50243917
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-5-morpholin-4-yl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329703; BDBM50102866
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2R,3S,5R)-2-(2-Chlorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425071; BDBM50440343
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
Chembl4208513
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454657
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[52] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-benzyl-3,5-dimethyl-1,2-oxazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683093; BDBM50338459
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,3S)-3-Amino-N,N-dimethyl-4-oxo-4-pyrrolidin-1-yl-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL378048
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(1,3,4-oxadiazol-2-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195667
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
[6-Bromo-5-(2-chlorophenyl)-3-methylbenzimidazol-4-yl]methanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257653; SCHEMBL3141016; BDBM50375240
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
2-({2-[(3R)-3-Aminopiperidin-1-yl]-7-chloro-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL228004; quinazolinone-based inhibitor 1e; BDBM16276
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(R)-1-(4-(1-Amino-2-(2,5-difluorophenyl)ethyl)piperidin-1-yl)ethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683129; BDBM50338423
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,3S)-2-Amino-3-methyl-1-(5-(trifluoromethyl)isoindolin-2-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469679; BDBM50243078
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
Imigliptin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
UNII-68UX3YT8DK; 68UX3YT8DK; CHEMBL3329696; SCHEMBL12517256; BDBM50102854; Q27264277
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxo-5-pyrrolidin-1-ylimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329702; BDBM50102868
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-3-(benzo[f]quinolin-3-ylmethyl)-1-but-2-ynylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425887; BDBM50440466
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
2-[7-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-8-yl]-N,N-dimethylacetamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL556979
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopyrrolidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329641; SCHEMBL13719188; BDBM50102844
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-2,2,2-trifluoroethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735461; BDBM50134193
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
(3R)-3-Amino-1-[8-[(4-methoxyphenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539352
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
(2S)-N-Tert-butyl-1-[(2S,4S)-4-[2-(1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243215; BDBM50326396
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
US9051329, Example 1
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687977; SCHEMBL14554328; US9051329, Example 4; BDBM162376
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[55] | |||
| Compound Name |
(2S)-1-({(2S,4S)-5-Oxo-4-[2-oxo-2-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]ethyl]pyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243027; SCHEMBL16509425; BDBM50326383
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3-phenyl-1,2,4-oxadiazol-5-yl)-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
alpha-amino acid pyrrolidide 8; CHEMBL216854; BDBM11646
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
trans-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-benzylmethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683096; BDBM50338462
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(4-chloroquinolin-2-yl)methyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425895; BDBM50440472
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(3R)-3-Amino-1-[8-(pyridin-2-ylmethyl)-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557176
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
(2R,3S,5R)-5-(11-Methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)-2-(2,4,5-trifluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805751
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[14] | |||
| Compound Name |
4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]-N-benzyl-N-(4,4,4-trifluorobutyl)cyclohexan-1-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683128; BDBM50338422; trans-4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)-N-benzyl-N-(4,4,4-trifluorobutyl)cyclohexanamine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(5-tert-butylisoindolin-2-yl)-3-methylpentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL469678; BDBM50243077
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-[2-(trifluoromethylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736188
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
(S)-N-(2-(2-Cyanopyrrolidin-1-yl)-2-oxoethyl)-1-naphthamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243374; SCHEMBL715747; BDBM50326374; N-[2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl]naphthalene-1-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
2-[2-(3-(R)-Aminopiperidin-1-yl)-6-oxo-5-(1H-pyrrol-3-yl)-6Hpyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650420; SCHEMBL3389584; BDBM50335759; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-6-oxo-5-(1H-pyrrol-3-yl)pyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(4-bromo-2-chlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL374703; alpha-amino acid pyrrolidide 25; BDBM11663
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(R)-3-Amino-1-((R)-8-(cyclopropylfluoromethyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249945; BDBM50221445
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(2,4-difluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363584
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-4-(trifluoromethoxy)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682980; BDBM50338446
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
3-[2-(2-Cyanopyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-N-(1-methyl-1-phenylethyl)butyramide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL202711; BDBM11720; (2S)-Cyanopyrrolidine analogue 21e; 3-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-3-methyl-N-(2-phenylpropan-2-yl)butanamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[58] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]cyclohexyl]-3-fluoro-N-methylbenzamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246374
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
2-[2-(3-(R)-Aminopyrimidin-1-yl)-5-bromo-6-oxo-6H-pyrimidin-1-ylmethyl]thiophene-3-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650430; SCHEMBL8235171; BDBM50335797
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(4-chloro-2-fluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370734
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209064
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191067
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3,5-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195270
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
cis-(R)-2-(2,5-Difluorophenyl)-1-(4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)cyclohexyl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1681802; CHEMBL1683115; BDBM50338408; BDBM50338409
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-(4-pyridin-1-ium-1-ylphenyl)phenyl]butanamide;2,2,2-trifluoroacetate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552503
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
2-[[7-(3-Aminoazetidin-1-yl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329640; SCHEMBL12518748; BDBM50102845
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
4-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329635; SCHEMBL12517523; BDBM50102840
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S,3S,5R)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425079; BDBM50440333
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(3R)-3-Amino-1-(2-benzoyldiazinan-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL535180
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[62] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-4-(thiadiazol-4-yl)benzenesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1682985; BDBM50338451
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
7-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2-methylpyrimido[1,2-b]pyridazin-4-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231397
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
2-[2-(3-(R)-Aminopiperidin-1-yl)-5-methoxy-6-oxo-6H-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650411; SCHEMBL3390992; BDBM50335768; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-methoxy-6-oxopyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-(2,2,2-trifluoroethyl)-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 50; CHEMBL194979; BDBM11948
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(7-fluoroquinolin-2-yl)methyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425894; BDBM50440459
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2R,3R)-7-Methyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL562953
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2S,3R)-2-Amino-3-[4-(4-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]-4-(tetrazol-1-yl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL359581
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylpyridine-3-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683090; BDBM50338456; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylpyridine-3-sulfonamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-propan-2-ylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735865
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
US9051329, Example 7
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687982; SCHEMBL14554312; BDBM162382
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[55] | |||
| Compound Name |
(3R)-3-Amino-1-[8-benzyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL539350
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
(11R,12R)-11-(2,4,5-Trifluorophenyl)-1,5,8-triazatricyclo[7.4.0.02,7]trideca-2(7),3,5,8-tetraen-12-amine;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL552068
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
4-{5-[(2S,3S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butan-2-yl]-1,2,4-oxadiazol-3-yl}benzene-1-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219602; alpha-amino acid pyrrolidide 19; BDBM11657
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2S)-1-[(2S,4S)-4-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243216; BDBM50326397
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
trans-3-(((4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)(methyl)amino)methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683126; BDBM50338420
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-[[4-(trifluoromethoxy)phenyl]sulfonylamino]cyclohexyl]butanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397854
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S)-1-(2-{[4-(6,8-Difluoro-1,2,3,4-tetrahydroisoquinolin-2-yl)-2-methyl-4-oxobutan-2-yl]amino}acetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425756; BDBM11718; (2S)-Cyanopyrrolidine analogue 21c
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[58] | |||
| Compound Name |
(2S)-1-[3-Amino-4-(2-fluorophenyl)butanoyl]-N-[4-(2H-tetrazol-5-yl)butyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL184346
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
1-[6-[(3R)-3-Aminopyrrolidin-1-yl]pyridin-3-yl]-4-phenylmethoxypyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2011537; SCHEMBL14222785; BDBM50379784
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(2R,3R)-7-Methylsulfonyl-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559940
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2S)-1-({(2S,4S)-4-[2-(1,3-Dihydro-2H-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243402; SCHEMBL3393551; BDBM50326375
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(2S)-2-Amino-4-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-1-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)butane-1,4-dione;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3800436
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[54] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[2-(trifluoromethyl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425375
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2R,3R)-1-(2,5-Difluorophenyl)-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)butan-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL520067; BDBM50243914
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(3R)-3-Amino-1-[8-[(4-fluorophenyl)-hydroxymethyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536536
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
(1S,2R,5R)-5-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-2-(2,4,5-trifluorophenyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL232191; SCHEMBL13938022; BDBM50210526
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[60] | |||
| Compound Name |
N-[4-[5-[(2S,3S)-3-Amino-4-oxo-4-pyrrolidin-1-ylbutan-2-yl]-1,2,4-oxadiazol-3-yl]-3-chlorophenyl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386812
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-chloro-4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216855; alpha-amino acid pyrrolidide 26; BDBM11664
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220249; alpha-amino acid pyrrolidide 16; BDBM11654
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(3S,5S)-3-[2-(1,3-Dihydroisoindol-2-yl)-2-oxoethyl]-5-(pyrrolidine-1-carbonyl)pyrrolidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243183; SCHEMBL16502392; BDBM50326394
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-3-bromo-1,6-dimethylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203323
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-piperidin-1-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362930
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S)-2-[4-[[[(2S)-1-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445949
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[61] | |||
| Compound Name |
6-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]-2-methyl-[1,2,4]triazolo[4,3-b]pyridazin-3-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390241
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2,4-dichlorophenyl)-1H-1,2,4-triazol-5-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218306
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(R)-3-Amino-4-(perfluorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL397743; BDBM50210654
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1,3-bis(but-2-ynyl)pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425882; BDBM50440471
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methyl-1,2-oxazole-5-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683106; BDBM50338472; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylisoxazole-5-carboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Ethyl 4-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363175
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2R,3S,5R)-5-(2-Cyclopropylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)-2-(2,5-difluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735329; SCHEMBL14845410
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-(4,4,4-trifluorobutyl)methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683097; BDBM50338463
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Ethyl 2-[5-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-2-oxopyridin-1-yl]-2,2-difluoroacetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438258
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
2-({2-[(3r)-3-Aminopiperidin-1-Yl]-5-Bromo-6-Oxopyrimidin-1(6h)-Yl}methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1235761; SCHEMBL3385972; BDBM50335774; Q27465145; 2-((2-(3-(R)-Aminopiperidin-1-yl)-5-bromo-6-oxopyrimidin-1(6H)-yl)methyl)benzonitrile; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-bromo-6-oxopyrimidin-1-yl]methyl]benzonitrile; 2-[2-(3-(R)-Amino-piperidin-1-yl)-5-bromo-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3-fluoroazetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL363115
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(2R,3S,5R)-5-[9-(Trifluoromethyl)-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl]-2-(2,4,5-trifluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805937
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[14] | |||
| Compound Name |
(R)-1-(4-Bromophenyl)-2-(2,5-difluorophenyl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL504506; BDBM50243709
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(azetidin-1-yl)-2-[4-(4-fluorophenyl)phenyl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370509
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3-(2,4-dichlorophenyl)-1,2,4-oxadiazol-5-yl)-1-((S)-3-fluoropyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL487630; BDBM50243915
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2S,3S)-2-[4-[Acetyl(methyl)amino]cyclohexyl]-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428747
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzenesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL366031
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S,4S)-4-(4-Chlorobenzylamino)-2-amino-1-(piperidin-1-yl)hexan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215244; BDBM50191170
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
2-[2-(3-(R)-Aminopiperidin-1-yl)-5-iodo-6-oxo-6H-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650408; SCHEMBL3388751; BDBM50335771; ZINC66111793; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-iodo-6-oxopyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
[(2R)-1-[(2S)-3-Methyl-2-(pyridine-3-carbonylamino)butanoyl]pyrrolidin-2-yl]boronic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2333024; BDBM50431227
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[63] | |||
| Compound Name |
7-(Aminomethyl)-6-(2-Chlorophenyl)-1-Methyl-1h-Benzimidazole-5-Carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL272114; SCHEMBL3135076; BDBM50375237; DB07239; Q27096464; 1-Methyl-6-(2-chlorophenyl)-7-(aminomethyl)-1H-benzoimidazole-5-carbonitrile; 7-aminomethyl-6-(2-chloro-phenyl)-1-methyl-1h-benzoimidazole-5-carbonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[4,3-a]pyridin-6-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL207348
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
(3R)-3-Amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
pyrazolopiperidine 48; CHEMBL191805; BDBM11946
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
(R)-3-Amino-4-(2,5-dichlorophenyl)-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL232648; BDBM50210664
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
2-[2-(3-(R)-Aminopiperidin-1-yl)-5-(3-hydroxyprop-1-ynyl)-6-oxo-6H-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650424; SCHEMBL3388743; BDBM50335755; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-(3-hydroxyprop-1-ynyl)-6-oxopyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219369; alpha-amino acid pyrrolidide 11; BDBM11649
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
US9051329, Example 8
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687983; SCHEMBL14554317; BDBM162383
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[55] | |||
| Compound Name |
N-[(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-7-yl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL561793
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL435320
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methylsulfonylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370079
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-methyl-4,6-dihydropyrrolo[3,4-d][1,3]oxazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425068; BDBM50440345
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2s,4s)-1-({(2s,4s)-4-[2-(1,3-Dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)-4-fluoropyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243126; SCHEMBL3393518; BDBM50326390
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(3R,4R)-1-([1,2,4]Triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231496
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(2-chloro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-4-cyclopropyl-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376498
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
4-(Aminomethyl)-5-(2-chlorophenyl)-3-methyl-1H-benzimidazol-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257852; SCHEMBL3149740; BDBM50375238
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
4-[(3R,5S,6R)-5-Amino-6-(2,4,5-trifluorophenyl)oxan-3-yl]-11-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1(12),2(6),10-trien-9-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805154
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[14] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-ethylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735281; SCHEMBL18792879
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
(2S,4S)-4-(4-Chlorobenzylamino)-2-amino-5-phenyl-1-(piperidin-1-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL214630; BDBM50191164
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[41] | |||
| Compound Name |
2-[4-[Amino-[2-[(4R)-4-cyano-1,3-thiazolidin-3-yl]-2-oxoethyl]amino]piperidin-1-yl]-N-(5-chloropyridin-2-yl)acetamide;trihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3216684
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[64] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylpyridine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683104; BDBM50338470; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylnicotinamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-[(3R)-4-[(3R)-3-Amino-4-(2,5-difluorophenyl)butanoyl]-3-methyl-2-oxo-1,4-diazepan-1-yl]acetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1-substituted diazepanone 9c; CHEMBL231010; BDBM15531
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
Chembl4205581
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454656
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[52] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3-fluoro-4-phenylphenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL365996
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-bromophenyl)methyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650438; SCHEMBL390434; BDBM50335789; ZINC66103839; 6-[3-(R)-Aminopiperidin-1-yl]-1-(2-bromobenzyl)-1H-pyrimidine-2,4-dione; 6-[3 (R)-Amino-piperidin-1-yl]-1-(2-bromo-benzyl)-1H-pyrimidine-2,4-dione; 6-[3(R)-Amino-piperidin-1-yl]-1-(2-bromo-benzyl)-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
CID 16035093
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL407296; BDBM50375031; (2S,4S,5S)-2-N-(cyanomethyl)-2-N-ethyl-4-N,4-N,5-trimethylpyrrolidine-2,4-dicarboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
(2S,3S)-2-Amino-3-{3-[2-(difluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
alpha-amino acid pyrrolidide 9; CHEMBL216774; BDBM11647
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2S)-1-(2-{[2-Methyl-4-oxo-4-(1,2,3,4-tetrahydroisoquinolin-2-yl)butan-2-yl]amino}acetyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL201424; SCHEMBL1064193; BDBM11716; (2S)-Cyanopyrrolidine analogue 21a
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[58] | |||
| Compound Name |
(3R,6R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-ethyl-6-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-methyl diazepanone 14d; CHEMBL397242; BDBM15548
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-5-methyl-1,4-diazepan-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-methyl diazepanone 13b; 5-methyl diazepanone 13a; CHEMBL397010; SCHEMBL5038119; BDBM15541
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[25] | |||
| Compound Name |
(2R,3R)-3-(3-(2-Chloro-4-(methylsulfonyl)phenyl)-1,2,4-oxadiazol-5-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL527198; BDBM50243918
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-2-(4-imidazo[1,2-b]pyridazin-6-ylphenyl)-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL379702
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[2-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219370; alpha-amino acid pyrrolidide 12; BDBM11650
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-N-methylacetamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246169
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
CID 53311226
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329628; SCHEMBL12517238; BDBM50102864
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(4-chlorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190454
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S)-1-[(2S,4S)-4-[2-(3,4-Dihydro-1H-isoquinolin-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242967; SCHEMBL3399176; BDBM50326380
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
N-[3-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]phenyl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL263326
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S)-1-[{(2S,4S)-5-Oxo-4-(2-oxo-2-(piperidin-1-yl)ethyl)pyrrolidine-2-yl}carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243092; BDBM50326388
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
CID 53311144
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329625; SCHEMBL12517499; BDBM50102858; 2-[[7-[(3R)-3-aminopiperidin-1-yl]-3,3-dimethyl-2-oxopyrrolo[3,2-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S)-1-[(2S,4S)-4-[2-(5-Fluoro-1,3-dihydroisoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidine-2-carbonyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242940; SCHEMBL3399137; BDBM50326378
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
Ethyl N-[5-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-3-fluoro-1-methyl-2-oxopyridin-4-yl]carbamate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438265
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
3,4-Dihydro-1H-isoquinolin-2-yl-[(2S)-pyrrolidin-2-yl]methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL179996; ZINC11754398
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[57] | |||
| Compound Name |
(R)-3-Amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(4-(trifluoromethyl)phenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245181; BDBM50210667
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[30] | |||
| Compound Name |
6-(4-{(1S,2S)-2-Amino-1-[(dimethylamino)carbonyl]-3-[(3S)-3-fluoropyrrolidin-1-YL]-3-oxopropyl}phenyl)-1H-[1,2,4]triazolo[1,5-A]pyridin-4-ium
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237337; SCHEMBL14591260; BDBM50221972; DB08504; Q27097704
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-3-bromo-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL383651
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-2-((1r,4S)-4-(4-fluorophenyl)cyclohexyl)-N,N-dimethyl-4-oxobutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237972; CHEMBL238190; SCHEMBL13412168; BDBM50221974; BDBM50221978
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(pyrrolidin-1-yl)-3-{3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375875; alpha-amino acid pyrrolidide 14; BDBM11652
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
Chembl4204176
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454650
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[52] | |||
| Compound Name |
(2R,3S,5R)-2-(4-Chloro-2,5-difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425073; BDBM50440341
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-[2-(3-(r)-Aminopiperidin-1-yl)-5-chloro-6-oxo-6h-pyrimidin-1-ylmethyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650405; SCHEMBL3392462; BDBM50335775; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-chloro-6-oxopyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(3R)-3-Amino-1-[(5S,8S)-5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557219
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
(2s,3s)-3-Amino-4-(3,3-Difluoropyrrolidin-1-Yl)-N,N-Dimethyl-4-Oxo-2-(trans-4-[1,2,4]triazolo[1,5-A]pyridin-6-Ylcyclohexyl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL238191; CHEMBL437557; SCHEMBL2898742; BDBM50221970; BDBM50221981; DB07092; Q27096007
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[24] | |||
| Compound Name |
2-[(3-Methyl-2-oxo-7-piperazin-1-ylimidazo[4,5-b]pyridin-1-yl)methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329689; SCHEMBL12518806; BDBM50102861
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-[4-(Pyridine-4-yl)-piperazin-1-yl]-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1243060; SCHEMBL3398698; BDBM50326385
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
2-(S)-Amino-4-(2-chloro-benzylamino)-1-piperidin-1-yl-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL98762; SCHEMBL7062524; BDBM50146971
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-pyridin-4-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL371846
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2S)-2-Amino-2-phenyl-1-(1,2,3,4-tetrahydroisoquinolin-2-yl)ethan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
isoquinoline derivative 9; CHEMBL361758; BDBM12186
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[57] | |||
| Compound Name |
(3R)-3-Amino-1-[(8S)-8-methyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL557542
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[4-(trifluoromethyl)pyridin-2-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL389602
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-(4-fluorophenyl)pyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL206172
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
2-[5-(Aminomethyl)-6-(2,2-dimethylpropyl)-2-methyl-4-(4-methylphenyl)pyridin-3-yl]acetic acid;dihydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3215607
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[6] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-pyridin-2-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191858
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]phenyl]-N,4-dimethylbenzamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL396168
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL206383
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]methanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734769; BDBM50134191
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(1-methyl-6-oxopyridin-3-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209162
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
CID 16035094
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL259198; BDBM50375032; (2S,4S,5S)-2-N-(cyanomethyl)-2-N,4-N,4-N,5-tetramethylpyrrolidine-2,4-dicarboxamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[65] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-1-pyridin-4-ylmethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3735433; BDBM50134195
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-(quinolin-2-ylmethyl)pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425886; BDBM50440467
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2S,3S)-2-[4-[Acetyl(methyl)amino]phenyl]-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL246168
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(4,7,8,10,12-pentazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3805353
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[14] | |||
| Compound Name |
2-((2-(3-(R)-Aminopiperidin-1-yl)-5-chloro-6-oxopyrimidin-1(6H)-yl)methyl)-4-fluorobenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650433; SCHEMBL3392451; BDBM50335794; ZINC66112264; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-chloro-6-oxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]-4-fluoro-N-methylbenzamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437379
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(3R)-3-Amino-1-[(8S)-8-[(4-fluorophenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL559371
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]propanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3736135; BDBM50135020
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
2-[[7-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-sulfanylideneimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329629; SCHEMBL12518780; BDBM50102863
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-pyridin-3-ylphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL195205
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
2-({2-[(3r)-3-Aminopiperidin-1-Yl]-4-Oxoquinazolin-3(4h)-Yl}methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227954; quinazolinone-based inhibitor 1a; SCHEMBL21067637; BDBM16272; ZINC6716417; DB08588; Q27097790; 2-[(3R)-3-Aminopiperidino]-3-(2-cyanobenzyl)quinazoline-4(3H)-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-[3-(1H-1,2,4-triazol-5-yl)phenyl]phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL190979
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(9-methyl-4,7,8,12-tetrazatricyclo[6.4.0.02,6]dodeca-1,6,9,11-tetraen-4-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3804950
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[14] | |||
| Compound Name |
(2S,3R,5S)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425077; BDBM50440338
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
2-[[2-[(3R)-3-Aminopiperidin-1-yl]-6-oxo-5-prop-1-ynylpyrimidin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650423; SCHEMBL3390429; BDBM50335756; 2-[2-(3-(r)-aminopiperidin-1-yl)-5-prop-1-ynyl-6-oxo-6h-pyrimidin-1-ylmethyl]benzonitrile; 2-[2-(3-(R)-Amino-piperidin-1-yl)-5-prop-1-ynyl-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2S,3S)-2-Amino-4-cyclopropyl-3-[3-(2-fluoro-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL375745; SCHEMBL2896776
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2s)-1-({(2s,4s)-4-[2-(5-Chloro-1,3-dihydro-2h-isoindol-2-yl)-2-oxoethyl]-5-oxopyrrolidin-2-yl}carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1242939; SCHEMBL3395629; BDBM50326377
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[51] | |||
| Compound Name |
4-[[[(2S)-1-[3-Amino-4-(3,4-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]benzoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL182223
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-[4-([1,2,4]triazolo[1,5-a]pyridin-7-yl)phenyl]butanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL210829
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
2-[[9-[(3R)-3-Aminopiperidin-1-yl]-3-methyl-2-oxoimidazo[4,5-b]quinolin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329631; SCHEMBL13719091; BDBM50102855
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,3,4,5,6-pentafluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL183289
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(2-fluorophenyl)phenyl]-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL370240
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
2-({2-[(3R)-3-Aminopiperidin-1-yl]-6-bromo-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227676; SCHEMBL3426274; quinazolinone-based inhibitor 1h; BDBM16279; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-6-bromo-4-oxoquinazolin-3-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-(5-methyl-[1,2,4]triazolo[1,5-a]pyridin-6-yl)phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL209111
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[49] | |||
| Compound Name |
N-[5-[(3R,5S,6R)-5-Amino-6-(2,5-difluorophenyl)oxan-3-yl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]cyclopropanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734964; BDBM50134186
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(3,4-difluorophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL366173
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
2-({2-[(3R)-3-Aminopiperidin-1-yl]-5-fluoro-4-oxo-3,4-dihydroquinazolin-3-yl}methyl)benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227464; SCHEMBL3423480; quinazolinone-based inhibitor 1b; BDBM16273; 2-[[2-[(3R)-3-aminopiperidin-1-yl]-5-fluoro-4-oxoquinazolin-3-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
N-[4-[(2S,3S)-3-Amino-1-(dimethylamino)-4-[(3S)-3-fluoropyrrolidin-1-yl]-1,4-dioxobutan-2-yl]phenyl]-4-fluoro-N-methylbenzamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL245969
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(3R)-3-Amino-1-[5,8-dimethyl-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL536089
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
cis-N-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683098; CHEMBL1683099; BDBM50338464; BDBM50338465; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
3-Amino-N-[4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683102; BDBM50338468; trans-3-amino-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylpropanamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
5-[4-[(2S,3S)-3-Amino-4-oxo-4-pyrrolidin-1-ylbutan-2-yl]phenyl]-1-methylpyridin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203379
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[50] | |||
| Compound Name |
(2S,3S)-2-Amino-4-cyclopropyl-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[3-(2-methyl-4-methylsulfonylphenyl)-1,2,4-oxadiazol-5-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219434
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(3R,4R)-1-(3-Ethyl-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-(2,4,5-trifluorophenyl)piperidin-3-amine;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390080
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,2-dimethylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683100; BDBM50338466; trans-N-(4-((R)-1-amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)-N-methylisobutyramide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
2-[[7-(1,4-Diazepan-1-yl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329691; SCHEMBL12518739; BDBM50102857
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-N,N-dimethyl-2-[4-[methyl-(4-methylphenyl)sulfonylamino]phenyl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429653
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[37] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[4-(2,4-dichlorophenyl)-1,3-oxazol-2-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL218254
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(3R)-1-(8-((1H-Pyrazol-1-yl)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250351; BDBM50221442
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
(1S,2R,5S)-5-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-A]pyrazin-7(8H)-YL]-2-(2,4,5-trifluorophenyl)cyclohexanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233360; SCHEMBL3904882; BDBM50212927; CHEMBL233360 (15); DB07072; Q27095987
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[66] | |||
| Compound Name |
(3R)-3-Amino-1-[8-[(2-fluorophenyl)methyl]-3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL540888
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[43] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(2R,3R)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL549913
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2R,3S,5R)-5-(4,6-Dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)-2-(2,4,5-trifluorophenyl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425075; BDBM50440334
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
(2R,3S,5R)-2-(2,5-Difluorophenyl)-5-(2-propylsulfonyl-4,6-dihydropyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3734912
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[32] | |||
| Compound Name |
(2S,3S)-3-Amino-2-[4-(4-fluorophenyl)phenyl]-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutanamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191208
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[22] | |||
| Compound Name |
(2S,3S,5S)-2-(2,5-Difluorophenyl)-5-(4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-5-yl)oxan-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425080; BDBM50440336
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[8] | |||
| Compound Name |
7-[(3R,4R)-3-Amino-4-(2,4,5-trifluorophenyl)piperidin-1-yl]pyrimido[1,2-b]pyridazin-2-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231396
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
Ethyl 3-[4-[(2S,3S)-3-amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]phenyl]benzoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL192425
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
2-({2-[(3r)-3-Aminopiperidin-1-Yl]-5-Methyl-6,9-Dioxo-5,6,7,9-Tetrahydro-1h-Imidazo[1,2-A]purin-1-Yl}methyl)-4-Fluorobenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687984; SCHEMBL14554320; Q27456296; 6AJ
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[55] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-(pyrimidin-2-ylmethyl)pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425884; BDBM50440469
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-bromo-5-fluorophenyl)methyl]-3-methylpyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1650440; SCHEMBL389715; BDBM50335787; ZINC34576251; 6-[3 (R)-Amino-piperidin-1-yl]-1-(2-bromo-5-fluoro-benzyl)-3-methyl-1H-pyrimidine-2,4-dione; 6-[3(R)-Amino-piperidin-1-yl]-1-(2-bromo-5-fluoro-benzyl)-3-methyl-1H-pyrimidine-2,4-dione; 6-[3-(R)-Aminopiperidin-1-yl]-1-(2-bromo-5-fluorobenzyl)-3-methyl-1H-pyrimidine-2,4-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[46] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[3-(3,5-dichlorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-yl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL219382; alpha-amino acid pyrrolidide 22; BDBM11660
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
(2R,3R)-2-Amino-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazole-7-carboxylic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL563383
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-[4-fluoro-2-(trifluoromethyl)phenyl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191652
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(3R,4R)-1-[2-(trifluoromethyl)-[1,2,4]triazolo[1,5-b]pyridazin-6-yl]-4-(2,4,5-trifluorophenyl)piperidin-3-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231293
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[29] | |||
| Compound Name |
(2S,3S)-2-Amino-1-[(3S)-3-fluoropyrrolidin-1-yl]-3-(4-methoxyphenyl)butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL369888
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
Methyl 2-[4-[[[(4R)-3-[3-amino-4-(2-fluorophenyl)butanoyl]-1,3-thiazolidine-4-carbonyl]amino]methyl]phenyl]acetate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL186482
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(2S,3S)-2-Amino-3-(4-bromophenyl)-1-[(3S)-3-fluoropyrrolidin-1-yl]butan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL191354
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[31] | |||
| Compound Name |
Chembl4212894
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50454653
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[52] | |||
| Compound Name |
US9051329, Example 3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3687979; SCHEMBL14554368; BDBM162378
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[55] | |||
| Compound Name |
2-[[7-(3-Aminoazepan-1-yl)-3-methyl-2-oxoimidazo[4,5-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329688; SCHEMBL12517557; BDBM50102867
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
trans-(R)-1-(4-((R)-1-Amino-2-(2,5-difluorophenyl)ethyl)cyclohexyl)piperidine-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683121; BDBM50338415
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
7-[(3R)-3-Aminopiperidin-1-yl]-1-[(2-fluorophenyl)methyl]-3-methylimidazo[4,5-b]pyridin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329637; SCHEMBL12518867; BDBM50102838
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(R)-1-(4-(3-Chloropyridin-4-yl)phenyl)-2-(2,5-difluorophenyl)ethanamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL472123; BDBM50243713
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[40] | |||
| Compound Name |
N-[4-[5-[(2S,3S)-3-Amino-4-[(3S)-3-fluoropyrrolidin-1-yl]-4-oxobutan-2-yl]-1,2,4-oxadiazol-3-yl]-3-chlorophenyl]methanesulfonamide;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL387333
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
CID 53311140
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329624; SCHEMBL12518870; BDBM50102860; 2-[[7-[(3R)-3-aminopiperidin-1-yl]-2-oxo-[1,3]oxazolo[5,4-b]pyridin-1-yl]methyl]benzonitrile
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
(3R)-1-(8-((1H-1,2,4-Triazol-1-yl)methyl)-2-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[1,5-a]pyrazin-7(8H)-yl)-3-amino-4-(2,4,5-trifluorophenyl)butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250353; SCHEMBL8340200; BDBM50221453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[39] | |||
| Compound Name |
2,2,2-Trifluoroacetic acid;(2R,3R)-8-(trifluoromethyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a]benzimidazol-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL550801
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[27] | |||
| Compound Name |
(2S,3S)-2-Amino-3-[5-(2,4-dichlorophenyl)-1,3,4-oxadiazol-2-yl]-1-pyrrolidin-1-ylbutan-1-one;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL220402
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[53] | |||
| Compound Name |
N-[(3R)-1-[1-[(2-Cyanophenyl)methyl]-3-methyl-2-oxoimidazo[4,5-b]pyridin-7-yl]piperidin-3-yl]acetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3329693; BDBM50102850
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[48] | |||
| Compound Name |
N-[4-[(1R)-1-Amino-2-(2,5-difluorophenyl)ethyl]cyclohexyl]-N,1-dimethylimidazole-4-sulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1683087; BDBM50338453
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
6-[(3R)-3-Aminopiperidin-1-yl]-1-but-2-ynyl-3-[(6-methylquinolin-2-yl)methyl]pyrimidine-2,4-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2425891; BDBM50440462
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(2R)-2-[4-[[[(2S)-1-[3-Amino-4-(2,5-difluorophenyl)butanoyl]pyrrolidine-2-carbonyl]amino]methyl]phenoxy]-3-methylbutanoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364102
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
5-(Aminomethyl)-N-cyclopropyl-4-(4-fluorophenyl)-6-methylpicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688415; SCHEMBL12807260; BDBM50339095
Click to Show/Hide
|
||||
| Activity |
Ki = 106000 nM
|
[42] | |||
| Compound Name |
Pyrrolidine, 1-(N-phenylalanyl)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
H-PHE-PYRROLIDIDE; L-Phenylalanine pyrrolidide; 1-[(2S)-2-AMINO-1-OXO-3-PHENYLPROPYL]PYRROLIDINE; (S)-2-amino-3-phenyl-1-(pyrrolidin-1-yl)propan-1-one; (2S)-2-amino-3-phenyl-1-pyrrolidin-1-ylpropan-1-one; CHEMBL453918; FC 191; 1-(N-Phenylalanyl)pyrrolidine; BRN 0010916; 1-(L-Phe-)Pyrrolidine; (S)-1-(2-Amino-1-oxo-3-phenylpropyl)pyrrolidine; H-Phe-Pyrrolidide, AldrichCPR; SCHEMBL1619160; (2S)-2-Amino-3-phenyl-1-(1-pyrrolidinyl)-1-propanone; CTK8F3041; DTXSID10238832; ZINC2567636; 7223AH; BDBM50243410; MFCD00672358; AKOS010390661; AS-46927; K-9988
Click to Show/Hide
|
||||
| Activity |
IC50 = 115000 nM
|
[7] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-pyridin-2-ylpropanoyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127983; BDBM50449226
Click to Show/Hide
|
||||
| Activity |
IC50 = 125100 nM
|
[33] | |||
| Compound Name |
(2S)-2-Amino-1-(2-diphenoxyphosphorylpyrrolidin-1-yl)-3-methyl-butan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL236586; Compound 10.10; BDBM98050; CTK5J7986; diphenyl[1-(l-valyl)pyrrolidin-2-yl]phosphonate
Click to Show/Hide
|
||||
| Activity |
IC50 = 126000 nM
|
[34] | |||
| Compound Name |
1-Isoleucylazetidine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461496; CTK0A1560; DTXSID80442363; BDBM50243496; (2S,3S)-2-amino-1-(azetidin-1-yl)-3-methylpentan-1-one; Azetidine, 1-[(2S,3S)-2-amino-3-methyl-1-oxopentyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 = 127000 nM
|
[7] | |||
| Compound Name |
(2S,3S)-2-Amino-1-(3-hydroxypyrrolidin-1-yl)-3-methylpentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL503809; BDBM50243553; AKOS012240510
Click to Show/Hide
|
||||
| Activity |
IC50 = 130000 nM
|
[7] | |||
| Compound Name |
(5-(Aminomethyl)-4-(4-fluorophenyl)-6-methylpyridin-2-yl)(pyrrolidin-1-yl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688416; SCHEMBL12807262; BDBM50339096
Click to Show/Hide
|
||||
| Activity |
Ki = 137000 nM
|
[42] | |||
| Compound Name |
(2S)-2,6-Diamino-1-(3-hydroxypyrrolidin-1-yl)hexan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL461911; BDBM50243602
Click to Show/Hide
|
||||
| Activity |
IC50 = 139000 nM
|
[7] | |||
| Compound Name |
(2S,4S)-4-(4-Chlorobenzylamino)-2-amino-1-(piperidin-1-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215299; BDBM50191168
Click to Show/Hide
|
||||
| Activity |
IC50 = 148000 nM
|
[41] | |||
| Compound Name |
(S)-1-((3R,4R)-1-(4-(1-Methyl-1H-pyrazol-5-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248793; BDBM50226067
Click to Show/Hide
|
||||
| Activity |
IC50 = 148000 nM
|
[67] | |||
| Compound Name |
5-(Aminomethyl)-4-(2,4-difluorophenyl)-6-methyl-N-(5-methylisoxazol-3-yl)picolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688423; SCHEMBL12807259; BDBM50339099
Click to Show/Hide
|
||||
| Activity |
Ki = 179000 nM
|
[42] | |||
| Compound Name |
5-(Aminomethyl)-N-cyclopropyl-4-(2,4-difluorophenyl)-6-methylpicolinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1688419; SCHEMBL12807261; BDBM50339098
Click to Show/Hide
|
||||
| Activity |
Ki = 182000 nM
|
[42] | |||
| Compound Name |
(S)-1-((3R,4R)-1-(4-(1,2,3-Thiadiazol-4-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249407; BDBM50226069
Click to Show/Hide
|
||||
| Activity |
IC50 = 190000 nM
|
[67] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 32 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
US8470836, 5
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
SCHEMBL3111337; CHEMBL3644786; BDBM97578; US8470836, 5
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
US8470836, 8
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
SCHEMBL13099353; CHEMBL3644788; BDBM97581; US8470836, 8
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
US8470836, 2
Click to Show/Hide
|
Patented | Compound Info | ||
| Synonyms |
SCHEMBL3101345; CHEMBL3644783; BDBM97575; US8470836, 2
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
(1R)-2-((3R,4R)-1-(2-Methyl-4-(1H-1,2,4-triazol-1-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)cyclopentanecarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250620; BDBM50226076
Click to Show/Hide
|
||||
| Activity |
IC50 = 203000 nM
|
[67] | |||
| Compound Name |
(S)-2-Amino-1-(pyrrolidine-1-yl)-3-(1H-indole-3-yl)propane-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452029; CTK1B8962; DTXSID20444841; BDBM50243409; ZINC11754554; MCULE-6977406476; (2S)-2-amino-3-(1H-indol-3-yl)-1-pyrrolidin-1-ylpropan-1-one; (S)-2-amino-3-(1H-indol-3-yl)-1-(pyrrolidin-1-yl)propan-1-one; Pyrrolidine, 1-[(2S)-2-amino-3-(1H-indol-3-yl)-1-oxopropyl]-
Click to Show/Hide
|
||||
| Activity |
IC50 = 242000 nM
|
[7] | |||
| Compound Name |
(S)-1-((3R,4R)-1-(4-(2H-1,2,3-Triazol-2-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400338; BDBM50226075
Click to Show/Hide
|
||||
| Activity |
IC50 = 247000 nM
|
[67] | |||
| Compound Name |
1-((3R,4R)-3-Amino-4-((2R)-2-cyanocyclopentanecarbonyl)pyrrolidin-1-yl)-2,3-dihydro-1H-indene-5-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249408; BDBM50226078
Click to Show/Hide
|
||||
| Activity |
IC50 = 258000 nM
|
[67] | |||
| Compound Name |
(2S)-1-[(2S)-2-Amino-3-(furan-3-yl)propanoyl]pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3127979; BDBM50449223
Click to Show/Hide
|
||||
| Activity |
IC50 > 288200 nM
|
[33] | |||
| Compound Name |
Chembl4162340
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50283545
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[68] | |||
| Compound Name |
(S)-2,6-Diamino-1-(3,4-dihydroquinolin-1(2H)-yl)hexan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL449318; BDBM50243606
Click to Show/Hide
|
||||
| Activity |
IC50 = 312000 nM
|
[7] | |||
| Compound Name |
(S)-1-((3R,4R)-1-(4-(1H-Pyrazol-5-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249203; BDBM50226099
Click to Show/Hide
|
||||
| Activity |
IC50 = 326000 nM
|
[67] | |||
| Compound Name |
(1R,3S)-2-((3R,4R)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)-3-fluorocyclopentanecarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249602; BDBM50226092
Click to Show/Hide
|
||||
| Activity |
IC50 = 332000 nM
|
[67] | |||
| Compound Name |
4-(((3R,4R)-3-Amino-4-((2R)-2-cyanocyclopentanecarbonyl)pyrrolidin-1-yl)methyl)-2,6-dimethylbenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399791; BDBM50226096
Click to Show/Hide
|
||||
| Activity |
IC50 = 346000 nM
|
[67] | |||
| Compound Name |
(S)-1-((3R,4R)-1-(4-(1-Methyl-1H-pyrazol-4-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249406; BDBM50226073
Click to Show/Hide
|
||||
| Activity |
IC50 = 363000 nM
|
[67] | |||
| Compound Name |
(6S)-1-[(2S)-2-Amino-4-[2-(2-methoxyethyl)-4-(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]-4-oxobutyl]-5,5-difluoro-6-hydroxypiperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3644790; SCHEMBL13099358; BDBM97583; US8470836, 10
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
(6S)-1-[(2S)-2-Amino-4-oxo-4-[2-thiophen-2-yl-4-(trifluoromethyl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-7-yl]butyl]-5,5-difluoro-6-hydroxypiperidin-2-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3644792; SCHEMBL13099364; BDBM97585; US8470836, 12
Click to Show/Hide
|
||||
| Activity |
IC50 > 400000 nM
|
[5] | |||
| Compound Name |
(S)-2-Amino-1-(pyrrolidin-1-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL443622; (2S)-2-amino-1-pyrrolidin-1-ylpropan-1-one; Pyrrolidine, 1-[(2S)-2-amino-1-oxopropyl]-; (2S)-2-amino-1-(pyrrolidin-1-yl)propan-1-one; l-alanine pyrrolidide; 1-(L-Ala-)Pyrrolidine; SCHEMBL389573; CTK1F4743; DTXSID20464286; BDBM50243406; ZINC11957328; AKOS010386702; MCULE-7219811454; NS-01098
Click to Show/Hide
|
||||
| Activity |
IC50 = 411000 nM
|
[7] | |||
| Compound Name |
4-(((3R,4R)-3-Amino-4-((2R)-2-cyanocyclopentanecarbonyl)pyrrolidin-1-yl)methyl)-2,6-diethylbenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429482; BDBM50226102
Click to Show/Hide
|
||||
| Activity |
IC50 = 417000 nM
|
[67] | |||
| Compound Name |
4-(((3R,4R)-3-Amino-4-((2R)-2-cyanocyclopentanecarbonyl)pyrrolidin-1-yl)methyl)-2-methylbenzonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429115; BDBM50226064
Click to Show/Hide
|
||||
| Activity |
IC50 = 460000 nM
|
[67] | |||
| Compound Name |
(S)-1-((3R,4R)-1-(4-(1H-1,2,4-Triazol-1-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399525; BDBM50226065
Click to Show/Hide
|
||||
| Activity |
IC50 = 461000 nM
|
[67] | |||
| Compound Name |
(S)-Benzyl 5-amino-6-(3,4-dihydroquinolin-1(2H)-yl)-6-oxohexylcarbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL512705; BDBM50243647
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
(2S,4R)-4-(4-Chlorobenzylamino)-2-amino-5-phenyl-1-(piperidin-1-yl)pentan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL213514; BDBM50191165
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[41] | |||
| Compound Name |
(S)-2-Amino-3-hydroxy-1-(pyrrolidin-1-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL459641; BDBM50243455; (2S)-1-Pyrrolizino-2-amino-3-hydroxy-1-propanone; (2S)-2-amino-3-hydroxy-1-pyrrolidin-1-ylpropan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
(2S)-2-Amino-1-(2-diphenoxyphosphorylpyrrolidin-1-yl)-3-hydroxy-propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL237673; Compound 10.8; BDBM98048
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[34] | |||
| Compound Name |
(S)-3-Amino-4-oxo-4-(pyrrolidin-1-yl)butanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL443373; BDBM50243452
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
(S)-2-Amino-3-(1H-imidazol-4-yl)-1-(pyrrolidin-1-yl)propan-1-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501521; SCHEMBL21794988; BDBM50243494; (2S)-1-Pyrrolizino-2-amino-3-(1H-imidazole-4-yl)-1-propanone; (2S)-2-amino-3-(1H-imidazol-5-yl)-1-pyrrolidin-1-ylpropan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[7] | |||
| Compound Name |
(S)-1-((3R,4R)-1-(4-Cyanobenzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248599; BDBM50226086
Click to Show/Hide
|
||||
| Activity |
IC50 = 560000 nM
|
[67] | |||
| Compound Name |
(1R)-2-((3R,4R)-1-(1-(4-(1H-1,2,4-Triazol-1-yl)phenyl)ethyl)-3-aminopyrrolidine-4-carbonyl)cyclopentanecarbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400532; BDBM50226093
Click to Show/Hide
|
||||
| Activity |
IC50 = 586000 nM
|
[67] | |||
| Compound Name |
1-Isoleucylhexahydro-1H-azepine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL446007; BDBM50243498; ZINC13529436; (2S,3S)-2-amino-1-(azepan-1-yl)-3-methylpentan-1-one
Click to Show/Hide
|
||||
| Activity |
IC50 = 612000 nM
|
[7] | |||
| Compound Name |
(S)-1-((3R,4R)-1-(4-(5-Methyl-1,3,4-oxadiazol-2-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399726; BDBM50226071
Click to Show/Hide
|
||||
| Activity |
IC50 = 704000 nM
|
[67] | |||
| Compound Name |
(S)-1-((3R,4R)-1-(4-(3-Methyl-1H-1,2,4-triazol-1-yl)benzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248794; BDBM50226066
Click to Show/Hide
|
||||
| Activity |
IC50 = 858000 nM
|
[67] | |||
| Compound Name |
(S)-1-((3R,4R)-1-(3-Cyano-4-fluorobenzyl)-3-aminopyrrolidine-4-carbonyl)pyrrolidine-2-carbonitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438520; BDBM50226084
Click to Show/Hide
|
||||
| Activity |
IC50 = 922000 nM
|
[67] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Crystal structure of Porphyromonas gingivalis dipeptidyl peptidase 4 and structure-activity relationships based on inhibitor profiling. Eur J Med Chem. 2017 Oct 20;139:482-491. | ||||
| REF 2 | Selective inhibitors of fibroblast activation protein (FAP) with a xanthine scaffold. Medchemcomm. 2014;5:1700-7. | ||||
| REF 3 | Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes. J Med Chem. 2014 Apr 24;57(8):3205-12. | ||||
| REF 4 | Highly potent dipeptidyl peptidase IV inhibitors derived from Alogliptin through pharmacophore hybridization and lead optimization. Eur J Med Chem. 2013 Oct;68:312-20. | ||||
| REF 5 | US patent application no. 8470836B2, Dipeptidyl peptidase-IV inhibiting compounds, methods of preparing the same, and pharmaceutical compositions containing the same as active agent | ||||
| REF 6 | Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor. J Med Chem. 2011 Feb 10;54(3):831-50. | ||||
| REF 7 | Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 1: identification of dipeptide derived leads. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4154-8. | ||||
| REF 8 | Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected]. Bioorg Med Chem Lett. 2013 Oct 1;23(19):5361-6. | ||||
| REF 9 | 2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): a potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A. Bioorg Med Chem. 2011 Sep 15;19(18):5490-9. | ||||
| REF 10 | Synthesis and evaluation of [(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]cyclohexanes and 4-[(1R)-1-amino-2-(2,5-difluorophenyl)ethyl]piperidines as DPP-4 inhibitors. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1880-6. | ||||
| REF 11 | Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. J Med Chem. 2007 May 17;50(10):2297-300. | ||||
| REF 12 | Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5853-7. | ||||
| REF 13 | Inhibitors of dipeptidyl peptidase 8 and dipeptidyl peptidase 9. Part 2: isoindoline containing inhibitors. Bioorg Med Chem Lett. 2008 Jul 15;18(14):4159-62. | ||||
| REF 14 | The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors. Bioorg Med Chem Lett. 2016 Jun 1;26(11):2622-6. | ||||
| REF 15 | An example of designed multiple ligands spanning protein classes: dual MCH-1R antagonists/DPPIV inhibitors. Bioorg Med Chem Lett. 2012 Apr 1;22(7):2464-9. | ||||
| REF 16 | Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2008 Apr 1;18(7):2362-7. | ||||
| REF 17 | Potent and selective proline derived dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5151-5. | ||||
| REF 18 | (2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3596-600. | ||||
| REF 19 | Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole. Bioorg Med Chem Lett. 2005 May 2;15(9):2253-8. | ||||
| REF 20 | Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors. Eur J Med Chem. 2014 Oct 30;86:242-56. | ||||
| REF 21 | The design of potent and selective inhibitors of DPP-4: optimization of ADME properties by amide replacements. Bioorg Med Chem Lett. 2009 Nov 15;19(22):6340-5. | ||||
| REF 22 | Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2005 Jun 15;15(12):3048-52. | ||||
| REF 23 | Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem. 2013 Dec 1;21(23):7418-29. | ||||
| REF 24 | 4-arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5806-11. | ||||
| REF 25 | Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2007 Apr 1;17(7):1903-7. | ||||
| REF 26 | (3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorg Med Chem Lett. 2007 Jan 1;17(1):49-52. | ||||
| REF 27 | Aminopiperidine-fused imidazoles as dipeptidyl peptidase-IV inhibitors. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4097-101. | ||||
| REF 28 | Synthesis and evaluation of structurally constrained imidazolidin derivatives as potent dipeptidyl peptidase IV inhibitors. Eur J Med Chem. 2009 Aug;44(8):3318-22. | ||||
| REF 29 | Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4579-83. | ||||
| REF 30 | Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: close analogs of JANUVIA (sitagliptin phosphate). Bioorg Med Chem Lett. 2007 Jun 15;17(12):3373-7. | ||||
| REF 31 | Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors. Bioorg Med Chem Lett. 2005 May 16;15(10):2533-6. | ||||
| REF 32 | Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin. Bioorg Med Chem Lett. 2015 Dec 15;25(24):5767-71. | ||||
| REF 33 | Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors. Eur J Med Chem. 2014 Mar 21;75:111-22. | ||||
| REF 34 | Irreversible inhibition of dipeptidyl peptidase 8 by dipeptide-derived diaryl phosphonates. J Med Chem. 2007 Nov 15;50(23):5568-70. | ||||
| REF 35 | (R)-3-amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: design, synthesis, biological evaluation, and molecular modeling. Bioorg Med Chem. 2014 Dec 1;22(23):6684-6693. | ||||
| REF 36 | Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome. Bioorg Med Chem Lett. 2017 Jun 1;27(11):2313-2318. | ||||
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| REF 38 | Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554. Bioorg Med Chem. 2011 Aug 1;19(15):4482-98. | ||||
| REF 39 | Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5934-9. | ||||
| REF 40 | Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design. Bioorg Med Chem Lett. 2008 Jul 1;18(13):3706-10. | ||||
| REF 41 | Synthesis and dipeptidyl peptidase inhibition of N-(4-substituted-2,4-diaminobutanoyl)piperidines. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4777-9. | ||||
| REF 42 | Design, Synthesis, and in Vitro Evaluation of Novel Aminomethyl-pyridines as DPP-4 Inhibitors. ACS Med Chem Lett. 2010 Oct 5;1(9):530-5. | ||||
| REF 43 | Discovery of potent and selective dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing subsituted triazolopiperazines. J Med Chem. 2008 Feb 14;51(3):589-602. | ||||
| REF 44 | Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones. Bioorg Med Chem Lett. 2007 Aug 1;17(15):4167-72. | ||||
| REF 45 | (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2005 Jan 13;48(1):141-51. | ||||
| REF 46 | Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV. J Med Chem. 2011 Jan 27;54(2):510-24. | ||||
| REF 47 | Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors. Bioorg Med Chem Lett. 2007 May 1;17(9):2622-8. | ||||
| REF 48 | Discovery of Imigliptin, a Novel Selective DPP-4 Inhibitor for the Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2014 Jun 16;5(8):921-6. | ||||
| REF 49 | (2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]-pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. J Med Chem. 2006 Jun 15;49(12):3614-27. | ||||
| REF 50 | Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1346-9. | ||||
| REF 51 | Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein. J Med Chem. 2010 Sep 23;53(18):6572-83. | ||||
| REF 52 | Surrogating and redirection of pyrazolo[1,5-a]pyrimidin-7(4H)-one core, a novel class of potent and selective DPP-4 inhibitors. Bioorg Med Chem. 2018 Feb 15;26(4):903-912. | ||||
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| REF 54 | Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation. Medchemcomm. 2016;7:433-8. | ||||
| REF 55 | Discovery of Novel Tricyclic Heterocycles as Potent and Selective DPP-4 Inhibitors for the Treatment of Type 2 Diabetes. ACS Med Chem Lett. 2016 Mar 12;7(5):498-501. | ||||
| REF 56 | Design of potent dipeptidyl peptidase IV (DPP-4) inhibitors by employing a strategy to form a salt bridge with Lys554. Bioorg Med Chem Lett. 2017 Aug 1;27(15):3565-3571. | ||||
| REF 57 | Novel isoindoline compounds for potent and selective inhibition of prolyl dipeptidase DPP8. Bioorg Med Chem Lett. 2005 Feb 1;15(3):687-91. | ||||
| REF 58 | 2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioava... J Med Chem. 2006 Jan 12;49(1):373-80. | ||||
| REF 59 | Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors. Bioorg Med Chem. 2012 Oct 1;20(19):5864-83. | ||||
| REF 60 | Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin. Bioorg Med Chem Lett. 2007 Jun 15;17(12):3384-7. | ||||
| REF 61 | Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes. Bioorg Med Chem. 2009 Mar 1;17(5):1783-802. | ||||
| REF 62 | Docking-based 3D-QSAR study for selectivity of DPP4, DPP8, and DPP9 inhibitors. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3716-21. | ||||
| REF 63 | Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase. J Med Chem. 2013 May 9;56(9):3467-77. | ||||
| REF 64 | Novel N-substituted 4-hydrazino piperidine derivative as a dipeptidyl peptidase IV inhibitor. Bioorg Med Chem Lett. 2009 Sep 1;19(17):5021-5. | ||||
| REF 65 | Discovery of long-acting N-(cyanomethyl)-N-alkyl-L-prolinamide inhibitors of dipeptidyl peptidase IV. Bioorg Med Chem. 2008 Jan 1;16(1):190-208. | ||||
| REF 66 | Modeling assisted rational design of novel, potent, and selective pyrrolopyrimidine DPP-4 inhibitors. Bioorg Med Chem Lett. 2007 Jul 15;17(14):3877-9. | ||||
| REF 67 | Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6707-13. | ||||
| REF 68 | Rapid generation of a novel DPP-4 inhibitor with long-acting properties: SAR study and PK/PD evaluation. Eur J Med Chem. 2017 Dec 1;141:519-529. | ||||
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