Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15700 | Target Info | |||
| Target Name | Caspase-8 (CASP8) | ||||
| Synonyms |
MORT1-associated CED-3 homolog; MCH5; MACH; ICE-like apoptotic protease 5; FLICE; FADD-like ICE; FADD-homologous ICE/CED-3-like protease; CASP-8; CAP4; Apoptotic protease Mch-5; Apoptotic cysteine protease
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| Target Type | Patented-recorded Target | ||||
| Gene Name | CASP8 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 100 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
isatin sulfonamide 34
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|
Clinical trial | Compound Info | ||
| Synonyms |
CHEMBL439753; Isatin Sulfonamide 34; JMC522188 Compound 2; Pyrrolidine Isatin Analogue 2; GTPL6515; SCHEMBL2264739; BDBM10323; PKOUAUWPBMZQCH-FQEVSTJZSA-N; isatin sulfonamide 34 [PMID: 11384246]; (S)-1-Benzyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl}isatin; (s)-1-benzyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]-isatin; 5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl-1-(phenylmethyl)indole-2,3-dione; (S)-1-benzyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
5-(pyrrolidin-1-ylsulfonyl)indoline-2,3-dione; 220510-17-8; 5-(Pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione; Isatin Sulfonamide 20; 5-pyrrolidinylsulfonylisatin; AC1N3S5K; 5-pyrrolidin-1-ylsulfonyl-1H-indole-2,3-dione; SCHEMBL2486952; CHEMBL305545; BDBM10309; DTXSID80399500; QKCWUYHXHMXOLG-UHFFFAOYSA-N; ZINC2944777; 5-[1-(pyrrolidinyl)sulfonyl]isatin; 2991AJ; AKOS024262065; AJ-44312; 5-(Pyrrolizinosulfonyl)indoline-2,3-dione; AX8291337; FT-0734877; 5-(Pyrrolidin-1-ylsulfonyl)-1H-indole-2,3-dione
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
casp 4 inhib
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Investigative | Compound Info | ||
| Synonyms |
5-nitro-isatin 1 [PMID: 11384246]
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-1-(4-Methoxybenzyl)-5-(2-((pyridin-3-yloxy)methyl)azetidin-1-ylsulfonyl)indoline-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762350; BDBM50340530
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
5-(2-(Pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
IST-1; Pyridine Analogue 20; CHEMBL197535; SCHEMBL13914678; BDBM10348; 5-{[(2S)-2-[(pyridin-3-yloxy)methyl]pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Isatin sulfonamide, 16a
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL476022; BDBM29581
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-tert-butylphenyl)phenyl]sulfonylpyrrolidine-2-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3741594; BDBM50499737
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| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-[1-[(4-Hydroxyphenyl)methyl]-2-oxo-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226881; SCHEMBL14236089; BDBM50216417
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-[1-(3,4-Dichlorobenzyl)-2-oxo-5-(thiomorpholinosulfonyl)indolin-3-ylidene]malononitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL490851; BDBM29580; CTK4A8757; DTXSID50655221; ZINC49878620; FT-0666552; isatin Michael acceptor (IMA) analogue, 13c
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Nsci
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Investigative | Compound Info | ||
| Synonyms |
Pyridine Analogue 21c; CHEMBL372322; SCHEMBL17835785; BDBM10351; DTXSID20469079; NSCI, >=97% (HPLC), solid; ZINC13676501; NCGC00485490-01
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-1-(6-Fluoropyridin-2-yl-methyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 18i; CHEMBL371687; SCHEMBL4152413; BDBM10347; (S)-1-(6-Fluoropyridin-2-yl-methyl)-5-(2-phenoxymethyl-azetidine--1-sulfonyl)-1H-indole-2,3-dione; 1-[(6-fluoropyridin-2-yl)methyl]-5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonylindole-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[1-(Hydroxy-benzyl-2-oxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1,2-dihydro-indol-3-yl-idene]-malononitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL427283; SCHEMBL14236093; BDBM50216422
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(S)-5-(2-((2,4-Difluorophenoxy)methyl)azetidin-1-ylsulfonyl)-1-((1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)indoline-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762366; BDBM50340546
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-Methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL293034; (s)-1-methyl-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin; (S)-1-Methyl-5-{1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl}isatin; Isatin Sulfonamide 31; SCHEMBL4156846; Pyrrolidine Isatin Analogue 11a; BDBM10320; DB08213; Q27097439; (S)-1-methyl-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione; 1-Methyl-5-[[(2S)-2-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(s)-1-(6-Fluoropyridin-3-yl-methyl)-5-(2-phenoxymethylpyrrolidine-1-sulfonyl)-1h-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200653; SCHEMBL4156239; Pyrrolidine Isatin Analogue 11g; BDBM10335; 1-[(6-fluoropyridin-3-yl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Isatin Michael acceptor (IMA) analogue, 19b
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477659; BDBM29586
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(S)-5-(2-Phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 17; CHEMBL200767; SCHEMBL4156166; BDBM10338; 5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonyl-1H-indole-2,3-dione; 5-{[(2S)-2-(phenoxymethyl)azetidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione
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|
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[1-[(4-Bromophenyl)methyl]-2-oxo-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL387556; BDBM50216418
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-[2-Oxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1,2-dihydro-indol-3-yl-idene]-malononitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL376760; SCHEMBL13915007; BDBM50216423
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|
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Isatin Michael acceptor (IMA) analogue, 12c
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521972; BDBM29577
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(S)-1-(4-(2-(2-(2-Fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)azetidin-1-ylsulfonyl)indoline-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762348; BDBM50340528
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-{1-Benzyl-2-oxo-5-[2-(pyridine-3-yloxymethyl)-pyrrolidine-1-sulfonyl]-1,2-dihydro-indol-3-yl-idene}-malononitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226828; SCHEMBL14236097; BDBM50216415
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Isatin Michael acceptor (IMA) analogue, 11b
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL521801; BDBM29573
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-(4-Bromo-benzyl)-5-[2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227036; SCHEMBL17835790; BDBM50216416; 1-[(4-bromophenyl)methyl]-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)methyl)-5-(2(2,4-difluorophenoxymethyl)-pyrrolidine-1-sulfonyl)isatin
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL456799; SCHEMBL2264192; BDBM50273338
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 18c; CHEMBL200813; SCHEMBL4153093; BDBM10341; 1-[(4-methoxyphenyl)methyl]-5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonylindole-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
5-(2-((Methyl(phenyl)amino)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL62187; BDBM50297258; 5-{2-[(Methyl-phenyl-amino)-methyl]-pyrrolidine-1-sulfonyl}-1H-indole-2,3-dione
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
(S)-2-(1-(4-(2-(2-Fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762359; BDBM50340539
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-2-[(2-isoquinolin-1-yloxyacetyl)amino]-4-methylpentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL100578; BDBM50119225
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|
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
(S)-2-(1-(4-(2-Fluoroethoxy)benzyl)-2-oxo-5-(2-((pyridin-3-yloxy)methyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762360; BDBM50340540
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-[(1-Benzyl-2-oxo-5-(thiomorpholinosulfonyl)indolin-3-ylidene]malononitrile
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL523131; BDBM29578; DTXSID80655219; ZINC40423296; FT-0662844; isatin Michael acceptor (IMA) analogue, 13a; [1-Benzyl-2-oxo-5-(thiomorpholine-4-sulfonyl)-1,2-dihydro-3H-indol-3-ylidene]propanedinitrile
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-Benzyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
Pyridine Analogue 21b; CHEMBL197549; BDBM10350
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(4-Methylthiobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
Pyridine Analogue 21d; CHEMBL198755; BDBM10352
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-1-(4-Methoxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL200677; 1-[(4-methoxyphenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione; SCHEMBL4152857; Pyrrolidine Isatin Analogue 11b; BDBM10330; 1-(4-Methoxybenzyl)-5-[[2alpha-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-(4-Bromo-benzyl)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL376112; BDBM50216414
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| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(S)-1-(4-(2-(2-(2-Fluoroethoxy)ethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762352; BDBM50340532
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-[(2-quinolin-4-yloxyacetyl)amino]pentanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL100927; BDBM50119251
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| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
(S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 18h; CHEMBL196855; SCHEMBL4158993; BDBM10346; (S)-1-(2-Fluoropyridin-4-yl-methyl)-5-(2-phenoxymethyl-azetidine1-sulfonyl)-1H-indole-2,3-dione; 1-[(2-fluoropyridin-4-yl)methyl]-5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonylindole-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
1-Benzyl-5-thiomorpholinosulfonyl Isatin
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Investigative | Compound Info | ||
| Synonyms |
isatin sulfonamide, 10a; CHEMBL482841; BDBM29571; DTXSID20655218; ZINC40414015; FT-0663055; J-003100; 1-Benzyl-5-(thiomorpholine-4-sulfonyl)-1H-indole-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(S)-1-((1-(2-Fluoroethyl)-1H-[1,2,3]-triazol-4-yl)methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)isatin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL456798; SCHEMBL2258519; BDBM50273337
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(S)-1-(2-Fluorobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 18f; CHEMBL200493; SCHEMBL4150262; BDBM10344; 1-[(2-fluorophenyl)methyl]-5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonylindole-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 18d; CHEMBL382084; SCHEMBL4149360; BDBM10342; 1-[(4-methylsulfanylphenyl)methyl]-5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonylindole-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-1-(2-Fluoro-pyridin-4-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL373012; SCHEMBL4143079; Pyrrolidine Isatin Analogue 11h; BDBM10336; 1-[(2-fluoropyridin-4-yl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Isatin Michael acceptor (IMA) analogue, 19c
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL478694; BDBM29587
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(S)-5-(2-((2,4-Difluorophenoxy)methyl)pyrrolidin-1-ylsulfonyl)-1-(4-(2-fluoroethoxy)benzyl)indoline-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762365; BDBM50340545
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|
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-[(4-Methoxybenzyl)-2-oxo-5-(thiomorpholinosulfonyl)indolin-3-ylidene]malononitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL490850; BDBM29579; CTK4A8756; DTXSID90655220; ZINC40423157; FT-0671173; isatin Michael acceptor (IMA) analogue, 13b
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Isatin Michael acceptor (IMA) analogue, 12a
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492060; BDBM29575
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|
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| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(S)-2-(1-(4-(2-Fluoroethoxy)benzyl)-2-oxo-5-(2-((pyridin-3-yloxy)methyl)azetidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762356; BDBM50340536
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| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
2-[1-[(4-Methoxyphenyl)methyl]-2-oxo-5-[(2S)-2-(pyridin-3-yloxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL427284; BDBM50216419
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
5-(Morpholin-4-ylsulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
5-(MORPHOLINE-4-SULFONYL)-1H-INDOLE-2,3-DIONE; 5-morpholin-4-ylsulfonyl-1H-indole-2,3-dione; 5-(Morpholinosulfonyl)indoline-2,3-dione; Morpholine, 4-[(2,3-dihydro-2,3-dioxo-1H-indol-5-yl)sulfonyl]-; isatin sulfonamide, 6; CHEMBL484273; SCHEMBL6535504; BDBM29569; CTK0I8878; DTXSID30429023; ZINC6658375; 2989AJ; BBL021592; MFCD01029070; STK894305; AKOS000142453; MCULE-3087737533; SB35500; DA-38564; FT-0720445; K-6255; SR-01000597242; SR-01000597242-1; 5-(morpholine-4-sulfonyl)-2,3-dihydro-1H-indole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(S)-1-((1-(2-Fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-((pyridin-3-yloxy)methyl)azetidin-1-ylsulfonyl)indoline-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762362; BDBM50340542
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-(4-Fluorobenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1h-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Pyridine Analogue 21e; CHEMBL198682; BDBM10353
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-1-Benzyl-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 18b; CHEMBL200785; SCHEMBL4148275; BDBM10340; 1-benzyl-5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonylindole-2,3-dione; 1-benzyl-5-{[(2S)-2-(phenoxymethyl)azetidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-5-(2-((2,4-Difluorophenoxy)methyl)azetidin-1-ylsulfonyl)-1-(4-(2-fluoroethoxy)benzyl)indoline-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762364; BDBM50340544
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(S)-2-(1-(4-(2-(2-Fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)azetidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762355; BDBM50340535
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(S)-1-(4-(2-(2-Fluoroethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762351; BDBM50340531
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Isatin Michael acceptor (IMA) analogue, 18a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL516251; BDBM29582
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(2S)-N-[(3S)-2-Hydroxy-5-oxooxolan-3-yl]-4-methyl-2-(4-naphthalen-2-ylbutanoylamino)pentanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL100769; BDBM50119210
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[7] | |||
| Compound Name |
(S)-1-Methyl-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 18a; CHEMBL371709; SCHEMBL4142884; BDBM10339; 1-methyl-5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonylindole-2,3-dione; 1-methyl-5-{[(2S)-2-(phenoxymethyl)azetidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Isatin Michael acceptor (IMA) analogue, 11c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492059; BDBM29574
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
5-(2-(Pyridin-4-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Pyridine Analogue 23; CHEMBL197237; BDBM10354; 5-{[(2S)-2-[(pyridin-4-yloxy)methyl]pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-1-(6-Fluoropyridin-3-ylmethyl)-5-(2-phenoxymethylazetidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 18g; CHEMBL370012; SCHEMBL4152385; BDBM10345; (S)-1-(6-Fluoropyridin-3-ylmethyl)-5-(2-phenoxymethyl-azetidine1-sulfonyl)-1H-indole-2,3-dione; 1-[(6-fluoropyridin-3-yl)methyl]-5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-1-(4-Methylthiobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200220; SCHEMBL4154263; Pyrrolidine Isatin Analogue 11d; BDBM10332
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-1-((1-(2-Fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-(phenoxymethyl)azetidin-1-ylsulfonyl)indoline-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762361; BDBM50340541
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Isatin sulfonamide, 9c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL482634; BDBM29570
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Isatin Michael acceptor (IMA) analogue, 18b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476023; BDBM29583
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(S)-2-(1-(4-(2-Fluoroethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762358; BDBM50340538
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
Isatin Michael acceptor (IMA) analogue, 3
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL226779; SCHEMBL14236498; BDBM29588
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-[1-[(4-Bromophenyl)methyl]-2-oxo-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL436989; SCHEMBL14236091; BDBM50216424
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
Isatin Michael acceptor (IMA) analogue, 19a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL477047; BDBM29585
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
1-Methyl-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)--1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Pyridine Analogue 21a; CHEMBL371879; BDBM10349
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Acetic acid (S)-4-[2,3-dioxo-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-2,3-dihydroindol-1-yl-methyl]phenyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200476; Pyrrolidine Isatin Analogue 11e; BDBM10333; 1-(4-Acetoxybenzyl)-5-[[2alpha-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-1-(4-Hydroxybenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200927; SCHEMBL4143820; Pyrrolidine Isatin Analogue 11f; BDBM10334; 1-(4-Hydroxybenzyl)-5-[[2alpha-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione; 1-[(4-hydroxyphenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-2-(1-(4-Methoxybenzyl)-2-oxo-5-(2-((pyridin-3-yloxy)methyl)azetidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762357; BDBM50340537
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(S)-5-(2-Phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL62993; (s)-5-[1-[2-(phenoxymethyl)pyrrolidinyl]sulfonyl]isatin; (S)-5-{1-[2-(Phenoxymethyl)pyrrolidinyl]sulfonyl}isatin; Isatin Sulfonamide 29; Pyrrolidine Isatin Analogue 10; SCHEMBL2263591; BDBM10318; 5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonyl-1H-indole-2,3-dione; 5-[[2alpha-(Phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione; 5-{[(2S)-2-(Phenoxymethyl)pyrrolidin-1-yl]sulfonyl}-1H-indole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
Isatin Michael acceptor (IMA) analogue, 11a
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL519148; BDBM29572
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Isatin Michael acceptor (IMA) analogue, 18c
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL510809; BDBM29584
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
Isatin Michael acceptor (IMA) analogue, 12b
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL492061; BDBM29576
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[4] | |||
| Compound Name |
(S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-azetidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Azetidine Isatin Analogue 18e; CHEMBL200886; SCHEMBL4156891; BDBM10343; 1-[(4-fluorophenyl)methyl]-5-[(2S)-2-(phenoxymethyl)azetidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-((pyridin-3-yloxy)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762353; SCHEMBL17835822; BDBM50340533
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(S)-1-(6-Fluoro-pyridin-2-yl-methyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372994; SCHEMBL4140312; Pyrrolidine Isatin Analogue 11i; BDBM10337; 1-[(6-fluoropyridin-2-yl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-((pyridin-3-yloxy)methyl)azetidin-1-ylsulfonyl)indoline-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762349; BDBM50340529
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(S)-1-((1-(2-Fluoroethyl)-1H-1,2,3-triazol-4-yl)methyl)-5-(2-((pyridin-3-yloxy)methyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762363; BDBM50340543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
1-(4-Hydroxy-benzyl)-5-[2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL227035; SCHEMBL17835872; BDBM50216421
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(S)-1-(4-Fluorobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL372607; SCHEMBL2260281; Pyrrolidine Isatin Analogue 11c; BDBM10331; 1-[(4-fluorophenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
(S)-1-(4-(2-Fluoroethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL213759; WC-II-89; SCHEMBL15029245; BDBM50192784; (S)-1-(4-(2-fluoroethoxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin; 1-[4-(2-fluoroethoxy)-benzyl]-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-(4-phenylphenyl)sulfonylpyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740601; BDBM50499736
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
{(R)-1-[2-((S)-2-Hydroxy-5-oxo-tetrahydro-furan-3-yl)-acetyl]-3-methyl-butyl}-carbamic acid benzyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL319251; BDBM50119241
Click to Show/Hide
|
||||
| Activity |
IC50 = 50000 nM
|
[8] | |||
| Compound Name |
(S)-1-(4-(2-(2-Fluoroethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)azetidin-1-ylsulfonyl)indoline-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1762347; BDBM50340527
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-N-[(1S)-3-Amino-1-cyano-3-oxopropyl]-1-[4-(4-methoxyphenyl)phenyl]sulfonylpyrrolidine-2-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740153; BDBM50499738
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Compound Name |
2-[1-Methyl-2-oxo-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindol-3-ylidene]propanedinitrile
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL390932; BDBM50216420
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 50000 nM
|
[6] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-N-(furan-2-ylmethyl)-1,3-thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Bio5F2; Maybridge3_004143; Oprea1_701540; Burnham Institute Compound 3; BI-9C8; CHEMBL365119; BDBM10217; HMS1442M07; MCULE-3424746182; IDI1_015530
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[9] | |||
| Compound Name |
Phenyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3-thiazole-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Maybridge3_003881; Oprea1_135680; Burnham Institute Compound 4; BI-9C3; CHEMBL195568; SCHEMBL12204572; BDBM10218; HMS1442A09; MCULE-5811988770; IDI1_015268
Click to Show/Hide
|
||||
| Activity |
IC50 = 60000 nM
|
[9] | |||
| Compound Name |
[2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-1,3-thiazol-4-yl](thiophen-2-ylsulfanyl)methanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Oprea1_472683; Burnham Institute Compound 5; CHEMBL193538; BDBM10219; BI-9B11; HMS1665H02; MCULE-8815858593; BRD-A61097160-001-01-3
Click to Show/Hide
|
||||
| Activity |
IC50 = 62000 nM
|
[9] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-2-YL)-1,3-thiazole-4-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
2-(2,3-dihydro-1,4-benzodioxin-3-yl)-1,3-thiazole-4-carboxylic acid; Maybridge3_004185; Oprea1_735244; Burnham Institute Compound 6; BI-9C1; CHEMBL194183; SCHEMBL3875594; BDBM10220; CTK0H3955; DTXSID50384887; HMS1442O05; AKOS014686734; IDI1_015572; FT-0608390; 2-(2,3-Dihydro-benzo[1,4]dioxin-2-yl)-thiazole-4-carboxylic acid; 4-Thiazolecarboxylicacid, 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-
Click to Show/Hide
|
||||
| Activity |
IC50 = 75000 nM
|
[9] | |||
| Compound Name |
7-[3-(4-Chlorophenoxy)-2-hydroxypropyl]-3-methyl-8-sulfanyl-3,7-dihydro-1H-purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4067280; BAS 00458029; C15H15ClN4O4S; Oprea1_332725; Oprea1_378529; SCHEMBL22364491; BDBM50240928; STK834224; AKOS000578676; AKOS024304377; MCULE-5327391260; ST50230388; 7-(3-(4-CL-PHENOXY)-2-HO-PR)-8-MERCAPTO-3-METHYL-3,7-DIHYDRO-PURINE-2,6-DIONE
Click to Show/Hide
|
||||
| Activity |
IC50 = 76100 nM
|
[10] | |||
| Compound Name |
Isatin Sulfonamide 26
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
(s)-5-[1-[2-(anilinomethyl)pyrrolidinyl]sulfonyl]isatin; (S)-5-{1-[2-(Anilinomethyl)pyrrolidinyl]sulfonyl}isatin; SCHEMBL6535653; CHEMBL1907830; BDBM10315; 5-[[(2S)-2-(Anilinomethyl)pyrrolizino]sulfonyl]indoline-2,3-dione; 5-{[(2S)-2-[(phenylamino)methyl]pyrrolidine-1-]sulfonyl}-2,3-dihydro-1H-indole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
Ki = 80000 nM
|
[2] | |||
| Compound Name |
Planktocyclin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400366; cyclo(Pro-Gly-Leu-Val-Met-Phe-Gly-Val); BDBM50224807
Click to Show/Hide
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||||
| Activity |
IC50 = 93000 nM
|
[11] | |||
| Compound Name |
4-(Ethoxycarbonylmethoxy)-1-hydroxy-naphthalene-2-carboxylic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL479009; SCHEMBL7824970; ZINC402550; 4-(2-ethoxy-2-oxoethoxy)-1-hydroxynaphthalene-2-carboxylic acid; BDBM50270346; AKOS024325306; MCULE-9442446112; 1-hydroxy-4-ethoxycarbonylmethyloxy-2-naphthoic acid; 4-(2-Ethoxy-2-oxoethoxy)-1-hydroxy-2-naphthoic acid
Click to Show/Hide
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||||
| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
(3S)-4-[(2-Hydroxyphenyl)methylamino]-3-[[(2S)-2-[[(2S)-3-methyl-2-(naphthalene-2-carbonylamino)butanoyl]amino]propanoyl]amino]butanoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL597796; BDBM50308243
Click to Show/Hide
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||||
| Activity |
IC50 = 100000 nM
|
[13] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 25 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-N,N-dimethyl-1,3-thiazole-4-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Maybridge3_004099; Oprea1_776634; Burnham Institute Compound 7; BI-9C7; CHEMBL195076; BDBM10221; HMS1442K07; MCULE-2581910611; IDI1_015486
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
Ethyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4-methyl-1,3-thiazole-5-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Maybridge3_003925; Oprea1_019141; Burnham Institute Compound 9; BI-9C5; CHEMBL370604; BDBM10223; HMS1442C09; MCULE-8085095066; IDI1_015312
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
8-Mercaptocaffeine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CAFFEINE, 8-MERCAPTO-; 1H-Purine-2,6-dione, 3,7,8,9-tetrahydro-1,3,7-trimethyl-8-thioxo-; CHEMBL4092935; NSC11258; 8-Mercapto-1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione; 1,3,7-trimethyl-8-sulfanylidene-9H-purine-2,6-dione; SCHEMBL9123418; CTK4D7186; CTK8D6946; DTXSID90170761; BDBM50240932; NSC-11258; AKOS000291422; ZINC100316548; MCULE-4110501571; ST50274560; SR-01000418040; SR-01000418040-1; 1,3,7-trimethyl-8-sulfanyl-1,3,7-trihydropurine-2,6-dione
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[10] | |||
| Compound Name |
(4-Chlorophenyl) 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-1,3-thiazole-4-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Maybridge4_002244; Oprea1_801076; Burnham Institute Compound 8; BI-9C4; CHEMBL195577; BDBM10222; DTXSID40384891; HMS1527F22; CCG-250683; MCULE-9205334627; NCGC00176765-01; BRD-A55814806-001-01-9; 4-chlorophenyl 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3-thiazole-4-carboxylate
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
[2-(2,3-Dihydro-1,4-benzodioxin-3-yl)-1,3-thiazol-4-yl]-morpholin-4-ylmethanone
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BI-9C2; Oprea1_649863; Burnham Institute Compound 10; CHEMBL194103; SCHEMBL3537780; BDBM10224; 4-{[2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1,3-thiazol-4-yl]carbonyl}morpholine
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
1-Benzyl-3,7-dimethyl-8-sulfanylidene-9H-purine-2,6-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4074941; 1-benzyl-8-mercapto-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione; SCHEMBL17165784; ZINC7425816; BDBM50240931; AKOS000291420; MCULE-8278247595; VU0607699-1; F3260-0165
Click to Show/Hide
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||||
| Activity |
IC50 > 200000 nM
|
[10] | |||
| Compound Name |
1-Ethyl-8-mercapto-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL4093898; SCHEMBL17165772; BDBM50240930; AKOS024481695; MCULE-4439529883; VU0607990-1; F3260-0907; 1-ethyl-3,7-dimethyl-8-sulfanylidene-9H-purine-2,6-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[10] | |||
| Compound Name |
2-(2,3-Dihydro-1,4-benzodioxin-2-yl)-4-methyl-1,3-thiazole-5-carboxylic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Maybridge3_004013; Oprea1_459918; MLS000850593; Burnham Institute Compound 11; BI-9C6; CHEMBL193772; SCHEMBL3880831; BDBM10225; HMS1442G09; HMS2793O03; AKOS014686032; MCULE-3808231625; 2-(2,3-dihydro-1,4-benzodioxin-3-yl)-4-methyl-1,3-thiazole-5-carboxylic acid; IDI1_015400; SMR000456611
Click to Show/Hide
|
||||
| Activity |
IC50 > 200000 nM
|
[9] | |||
| Compound Name |
(S)-1-(4-(2-(4-Methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216071; SCHEMBL8263984; BDBM50200312
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(S)-1-(4-Iodobenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217457; SCHEMBL15029243; BDBM50200306
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(S)-1-(4-(2-(4-Methylphenylsulfonyloxy)ethoxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386510; BDBM50200310; 1-[4-[2-(Tosyloxy)ethoxy]benzyl]-5-[[2alpha-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
Click to Show/Hide
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||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(S)-5-(2-(Methoxymethyl)pyrrolidin-1-ylsulfonyl)-1-methylindoline-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216819; SCHEMBL15029242; BDBM50200302; (S)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]-1-methylisatin
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(S)-1-(4-Hydroxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)-sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217220; BDBM50200307
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(S)-5-[1-(2-Methoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217822; BDBM50200313
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(S)-5-[1-(2-Phenoxymethylpyrrolidinyl)sulfonyl]-1-(4-(tributylstannyl)benzyl)isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL386464; BDBM50200304
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
Caspase-3/7 Inhibitor I
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL60190; 5-[(S)-(+)-2-(Methoxymethyl)pyrrolidino]sulfonylisatin; Isatin Sulfonamide 16; SCHEMBL3681388; BDBM10305; DTXSID50431688; ZINC3871900; MFCD22581511; A14919; J-014451; (S)-5-[1-(2-Methoxymethyl)pyrrolidinylsulfonyl]isatin; 5-[[(2S)-2-(Methoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione; 5-{[(2S)-2-(Methoxymethyl)pyrrolidin-1-yl]sulfonyl}-1H-indole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(S)-1-(4-(2-Bromoethoxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL385930; BDBM50200315; 1-[4-(2-Bromoethoxy)benzyl]-5-[[2alpha-(phenoxymethyl)pyrrolizino]sulfonyl]indoline-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(S)-1-(4-(2-Bromoethoxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL216447; BDBM50200311
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(S)-1-(4-Iodobenzyl)-5-(2-phenoxymethyl-pyrrolidine-1-sulfonyl)isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL384023; SCHEMBL2259426; BDBM50200305; (S)-1-(4-iodobenzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin; 1-[(4-iodophenyl)methyl]-5-[(2S)-2-(phenoxymethyl)pyrrolidin-1-yl]sulfonylindole-2,3-dione
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(S)-1-(4-(Tert-butyldimethylsilyloxy)benzyl)-5-[1-(2-methoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL387041; BDBM50200308
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(S)-1-(4-(Tert-butyldimethylsilyloxy)benzyl)-5-[1-(2-phenoxymethylpyrrolidinyl)sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217821; BDBM50200314
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
(S)-1-(4-Methoxybenzyl)-5-[1-(2-methoxymethylpyrrolidinyl)-sulfonyl]isatin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217777; SCHEMBL8263985; BDBM50200303
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[14] | |||
| Compound Name |
Cys-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL429546; BDBM50022802
Click to Show/Hide
|
||||
| Activity |
EC50 = 4000000 nM
|
[15] | |||
| Compound Name |
Ala-Met-Val-Gly-Arg-Cys-Tyr-Arg-Pro-Cys-Trp-Glu-Val
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL438946; BDBM50022799
Click to Show/Hide
|
||||
| Activity |
EC50 = 25000000 nM
|
[15] | |||
| Compound Name |
Asp-Thr-Met-Arg-Ala-Met-Cys-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2371646; BDBM50022801
Click to Show/Hide
|
||||
| Activity |
EC50 = 25000000 nM
|
[15] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies. J Med Chem. 2005 Dec 1;48(24):7637-47. | ||||
| REF 2 | Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem. 2001 Jun 7;44(12):2015-26. | ||||
| REF 3 | Synthesis and evaluation of isatin analogs as caspase-3 inhibitors: introduction of a hydrophilic group increases potency in a whole cell assay. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2192-7. | ||||
| REF 4 | Synthesis and in vitro evaluation of sulfonamide isatin Michael acceptors as small molecule inhibitors of caspase-6. J Med Chem. 2009 Apr 23;52(8):2188-91. | ||||
| REF 5 | Development of a potent and selective cell penetrant Legumain inhibitor. Bioorg Med Chem Lett. 2015 Dec 1;25(23):5642-5. | ||||
| REF 6 | Isatin sulfonamide analogs containing a Michael addition acceptor: a new class of caspase 3/7 inhibitors. J Med Chem. 2007 Jul 26;50(15):3751-5. | ||||
| REF 7 | Acyl dipeptides as reversible caspase inhibitors. Part 1: initial lead optimization. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2969-71. | ||||
| REF 8 | Acyl dipeptides as reversible caspase inhibitors. Part 2: further optimization. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2973-5. | ||||
| REF 9 | Discovery of a novel class of reversible non-peptide caspase inhibitors via a structure-based approach. J Med Chem. 2005 Mar 10;48(5):1649-56. | ||||
| REF 10 | Blockade of Asparagine Endopeptidase Inhibits Cancer Metastasis. J Med Chem. 2017 Sep 14;60(17):7244-7255. | ||||
| REF 11 | Planktocyclin, a cyclooctapeptide protease inhibitor produced by the freshwater cyanobacterium Planktothrix rubescens. J Nat Prod. 2007 Oct;70(10):1611-5. | ||||
| REF 12 | Structure-based discovery of a novel non-peptidic small molecular inhibitor of caspase-3. Bioorg Med Chem. 2008 May 1;16(9):4854-9. | ||||
| REF 13 | Noncovalent tripeptidyl benzyl- and cyclohexyl-amine inhibitors of the cysteine protease caspase-1. J Med Chem. 2010 Mar 25;53(6):2651-5. | ||||
| REF 14 | 5-pyrrolidinylsulfonyl isatins as a potential tool for the molecular imaging of caspases in apoptosis. J Med Chem. 2006 Nov 16;49(23):6704-15. | ||||
| REF 15 | Melanin concentrating hormone analogues: contraction of the cyclic structure. 1. Agonist activity. J Med Chem. 1988 May;31(5):949-54. | ||||
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