Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15610 | Target Info | |||
| Target Name | Puromycin-sensitive aminopeptidase (NPEPPS) | ||||
| Synonyms |
NPEPPS
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | NPEPPS | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 8 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4161744
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50277150
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| Activity |
IC50 = 53000 nM
|
[1] | |||
| Compound Name |
Chembl4173240
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50277157
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| Activity |
IC50 = 53000 nM
|
[1] | |||
| Compound Name |
Methyl 4-anilino-2,6-bis(4-nitrophenyl)-1-phenyl-3,6-dihydro-2H-pyridine-5-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740158; BDBM50499704
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| Activity |
IC50 = 68810 nM
|
[2] | |||
| Compound Name |
Ethyl 4-anilino-2-(4-bromophenyl)-1-phenyl-6-thiophen-2-yl-3,6-dihydro-2H-pyridine-5-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3741344; BDBM50499713
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| Activity |
IC50 = 80970 nM
|
[2] | |||
| Compound Name |
Ethyl 4-anilino-1-phenyl-2,6-dipyridin-2-yl-3,6-dihydro-2H-pyridine-5-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3741701; BDBM50499701
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| Activity |
IC50 = 92510 nM
|
[2] | |||
| Compound Name |
Ethyl 4-oxo-1-phenyl-2,6-dipyridin-2-ylpiperidine-3-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3740862; BDBM50499703
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|
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| Activity |
IC50 = 92870 nM
|
[2] | |||
| Compound Name |
Ethyl 4-anilino-2-(4-chlorophenyl)-1-phenyl-6-pyridin-3-yl-3,6-dihydro-2H-pyridine-5-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3741419; BDBM50499711
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| Activity |
IC50 = 98190 nM
|
[2] | |||
| Compound Name |
Chembl4169814
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50277159
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Puromycin based inhibitors of aminopeptidases for the potential treatment of hematologic malignancies. Eur J Med Chem. 2017 Oct 20;139:325-336. | ||||
| REF 2 | Highly functionalized tetrahydropyridines are cytotoxic and selective inhibitors of human puromycin sensitive aminopeptidase. Eur J Med Chem. 2015 Dec 1;106:26-33. | ||||
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