Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T15497 | Target Info | |||
| Target Name | Prostaglandin E2 receptor EP1 (PTGER1) | ||||
| Synonyms |
Prostanoid EP1 receptor; Prostaglandin E2 receptor EP1 subtype; PGE2 receptor EP1 subtype; PGE receptor, EP1 subtype; PGE receptor EP1 subtype; EP1 receptor
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| Target Type | Clinical trial Target | ||||
| Gene Name | PTGER1 | ||||
| Biochemical Class | GPCR rhodopsin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 23 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-(2-cinnamylphenyl)acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
3-(2-cinnamylphenyl)acrylic acid; CHEMBL376282; SCHEMBL585953
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
3-(2-(4-methoxycinnamyl)phenyl)acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL219590; 3-(2-(4-methoxycinnamyl)phenyl)acrylic acid
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
8-aza-11-deoxyprostaglandin E1
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL42027; 8-aza-11-deoxyprostaglandin E1; BDBM50142481; 7-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
3-(2-(naphthalen-2-ylmethyl)phenyl)acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL423815; 3-(2-(naphthalen-2-ylmethyl)phenyl)acrylic acid; SCHEMBL7922112; SCHEMBL7922115; BDBM50097792; 2-(2-Naphthylmethyl)benzeneacrylic acid; (E)-3-(2-Naphthalen-2-ylmethyl-phenyl)-acrylic acid
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[1-[2-(N-Benzoyl-4-methylanilino)ethyl]piperidin-4-yl]oxyacetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3793911; BDBM50163296
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
7-{(R)-2-[(E)-3-Hydroxy-3-(3-phenoxy-phenyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL288978; SCHEMBL5733153; BDBM50142486; 7-[(2R)-2-[(E)-3-hydroxy-3-(3-phenoxyphenyl)prop-1-enyl]-5-oxopyrrolidin-1-yl]heptanoic acid
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| Activity |
Ki = 50000 nM
|
[2] | |||
| Compound Name |
Schembl20719106
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1770317; BDBM50384443; 5-(6-naphthalen-2-yl-2-oxo-1H-pyridin-3-yl)-5-propan-2-yl-1,3-oxazolidine-2,4-dione
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| Activity |
Ki ~ 50118.72 nM
|
[4] | |||
| Compound Name |
1-Benzyl-1-[2-[4-[(6-oxo-11,12-dihydrobenzo[c][1]benzazocin-5-yl)methyl]phenyl]phenyl]sulfonyl-3-(2-phenylethyl)urea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL91301; BDBM50081449
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| Activity |
Ki = 51000 nM
|
[5] | |||
| Compound Name |
(E)-3-[2-(3,4-Dichloro-benzyl)-phenyl]-acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL166351; SCHEMBL7922145; SCHEMBL7922149; (E)-3-[2-[(3,4-dichlorophenyl)methyl]phenyl]prop-2-enoic Acid; BDBM50097793; 2-(3,4-Dichlorobenzyl)benzeneacrylic acid
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| Activity |
Ki = 63000 nM
|
[6] | |||
| Compound Name |
(E)-3-{2-[(E)-3-(2-Hydroxy-3-methyl-phenyl)-allyl]-phenyl}-acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL180389; SCHEMBL7805023; SCHEMBL7805026; BDBM50159771; (E)-3-[2-[(E)-3-(2-hydroxy-3-methylphenyl)prop-2-enyl]phenyl]prop-2-enoic acid
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| Activity |
Ki = 68000 nM
|
[7] | |||
| Compound Name |
(E)-3-[2-[(E)-3-[4-[2-[4-[(1E,3E)-4-[4-(Dimethylamino)phenyl]buta-1,3-dienyl]-2,6-dimethylpyridin-1-ium-1-yl]ethoxy]-3-methoxyphenyl]prop-1-enyl]phenyl]prop-2-enoic acid;tetrafluoroborate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164612
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| Activity |
Ki = 68625 nM
|
[8] | |||
| Compound Name |
(E)-3-(2-{3-[2-(Phenylmethoxy)phenyl]phenyl}phenyl)prop-2-enoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL340501; SCHEMBL6986591; SCHEMBL6986593; BDBM50134521; 2''-(Benzyloxy)-1,1':3',1''-terbenzene-2-acrylic acid; (E)-3-(2- {3-[2-(Phenylmethoxy)phenyl]phenyl}phenyl)prop-2-enoic acid; (E)-3-[2-[3-(2-phenylmethoxyphenyl)phenyl]phenyl]prop-2-enoic acid; (E)-3-(2-Benzyloxy-[1,1'';3'',1'''']terphenyl-2''''-yl)-acrylic acid
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| Activity |
Ki = 72000 nM
|
[9] | |||
| Compound Name |
{2-[5-(2-Benzyloxy-phenyl)-thiophen-3-yl]-phenylamino}-acetic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL124675; BDBM50134513; N-[2-[5-[2-(Benzyloxy)phenyl]-3-thienyl]phenyl]glycine
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| Activity |
Ki = 85000 nM
|
[9] | |||
| Compound Name |
4''-(Benzyloxy)-1,1':3',1''-terbenzene-2-propionic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL127204; BDBM50134510; 3-(4''''-Benzyloxy-[1,1'';3'',1'''']terphenyl-2-yl)-propionic acid
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| Activity |
Ki ~ 97000 nM
|
[9] | |||
| Compound Name |
4-(2-((R)-2-((S)-3-Hydroxyoct-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL222715; SCHEMBL4936479; BDBM50156547; 4-(2-((R)-2-((S,E)-3-hydroxyoct-1-enyl)-5-oxopyrrolidin-1-yl)ethyl)benzoic acid; 4-[2-[(2R)-2-[(E,3S)-3-hydroxyoct-1-enyl]-5-oxopyrrolidin-1-yl]ethyl]benzoic acid; 4-[2-{(2R)-2-[(1E,3S)-3-hydroxy-oct-1-enyl]-5-oxopyrrolidin-1-yl}ethyl)benzoic acid
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| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
(E)-3-[2-(4-Methylsulfanyl-benzyl)-phenyl]-acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL165010; SCHEMBL7929810; SCHEMBL7929816; (E)-3-[2-[(4-methylsulfanylphenyl)methyl]phenyl]prop-2-enoic Acid; BDBM50097794; 2-[4-(Methylthio)benzyl]benzeneacrylic acid
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| Activity |
Ki ~ 100000 nM
|
[6] | |||
| Compound Name |
3-(2-((6-(Benzyloxy)naphthalen-2-yl)methyl)phenyl)acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL218263; SCHEMBL7929714; SCHEMBL7929719; BDBM50193924; (E)-3-[2-[(6-phenylmethoxynaphthalen-2-yl)methyl]phenyl]prop-2-enoic acid
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
N-(2-Thienylsulfonyl)-3'-(methylsulfonyl)biphenyl-2-propionamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL86820; BDBM50117682; Thiophene-2-sulfonic acid [3-(3''-methanesulfonyl-biphenyl-2-yl)-propionyl]-amide
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| Activity |
Ki ~ 100000 nM
|
[11] | |||
| Compound Name |
7-{(R)-2-[(E)-3-Hydroxy-4-(3-trifluoromethyl-phenyl)-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL440474; BDBM50142491
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
(E)-3-[2-(2,4-Dichloro-benzyl)-phenyl]-acrylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL350832; BDBM50097791; 2-(2,4-Dichlorobenzyl)benzeneacrylic acid
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| Activity |
Ki ~ 100000 nM
|
[6] | |||
| Compound Name |
3-(2-((6-(Benzyloxy)naphthalen-2-yl)methyl)phenyl)-N-(5-bromo-2-methoxyphenylsulfonyl)acrylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL217941; BDBM50193935
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|
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| Activity |
Ki ~ 100000 nM
|
[1] | |||
| Compound Name |
7-{(R)-2-[(E)-(S)-3-Hydroxy-4-(3-trifluoromethyl-phenyl)-but-1-enyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL45008; SCHEMBL10210123; BDBM50142482
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|
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| Activity |
Ki ~ 100000 nM
|
[2] | |||
| Compound Name |
3-(2-((E)-3-(4-(Benzyloxy)-3-methoxyphenyl)prop-1-enyl)phenyl)acrylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL180191; BDBM50159774
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|
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| Activity |
Ki = 151350 nM
|
[8] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 55 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Sodium;1-[1-(5-chloro-2-phenylmethoxyphenyl)ethyl]-5-methylpyrazole-3-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256785
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| Activity |
IC50 = 1584893192 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]pyrazol-3-yl]-2-pyridin-2-ylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL402326
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| Activity |
IC50 = 2.51E+15 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL402604; SCHEMBL4091451; N-[1-({5-Chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-yl]acetamide
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| Activity |
IC50 = 3.16E+15 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]pyrazol-3-yl]benzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL255485
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| Activity |
IC50 = 3.98E+15 nM
|
[12] | |||
| Compound Name |
1-[[5-Chloro-2-(2-methylpropoxy)phenyl]methyl]-5-methyl-N-morpholin-4-ylpyrazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL402202; SCHEMBL4098204
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| Activity |
IC50 = 3.98E+15 nM
|
[12] | |||
| Compound Name |
1-[[5-Chloro-2-(2-methylpropoxy)phenyl]methyl]-5-methyl-N-piperidin-1-ylpyrazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256532; SCHEMBL4098868
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| Activity |
IC50 = 5.01E+15 nM
|
[12] | |||
| Compound Name |
Methyl N-[1-[(5-chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL258439; SCHEMBL13693293; methyl[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1h-pyrazol-3-yl]carbamate
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| Activity |
IC50 = 5.01E+15 nM
|
[12] | |||
| Compound Name |
1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-N-(3-fluorophenyl)-5-methylpyrazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254958; SCHEMBL4089750
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|
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| Activity |
IC50 = 5.01E+15 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]pyrazol-3-yl]-2-phenylacetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL257969
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|
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| Activity |
IC50 = 6.31E+15 nM
|
[12] | |||
| Compound Name |
1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methyl-N-pyridin-2-ylpyrazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL257147; SCHEMBL4091192; 1-({5-Chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-N-2-pyridinyl-1H-pyrazole-3-carboxamide
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| Activity |
IC50 = 7.94E+15 nM
|
[12] | |||
| Compound Name |
1-[[5-Chloro-2-(2-methylpropoxy)phenyl]methyl]-5-methylpyrazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256737; SCHEMBL4085947
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| Activity |
IC50 = 7.94E+15 nM
|
[12] | |||
| Compound Name |
1-({5-Chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL437399; SCHEMBL4085523; 1-[(5-chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazole-3-carboxamide
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| Activity |
IC50 = 7.94E+15 nM
|
[12] | |||
| Compound Name |
1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methyl-N-propan-2-ylpyrazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL257970; SCHEMBL4093184
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|
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| Activity |
IC50 = 7.94E+15 nM
|
[12] | |||
| Compound Name |
1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-N,5-dimethylpyrazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL258171; SCHEMBL4092092
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|
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| Activity |
IC50 = 1.00E+16 nM
|
[12] | |||
| Compound Name |
1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methyl-N-(pyridin-4-ylmethyl)pyrazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256736; SCHEMBL4090215
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| Activity |
IC50 = 1.26E+16 nM
|
[12] | |||
| Compound Name |
Pyridin-2-ylmethyl N-[1-[(5-chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL253538; SCHEMBL13693193
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|
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| Activity |
IC50 = 1.26E+16 nM
|
[12] | |||
| Compound Name |
Ethyl N-[1-[(5-chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL258226; SCHEMBL13693294
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| Activity |
IC50 = 1.26E+16 nM
|
[12] | |||
| Compound Name |
1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-N-(4-fluorophenyl)-5-methylpyrazole-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL256579; SCHEMBL4085370
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|
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| Activity |
IC50 = 1.26E+16 nM
|
[12] | |||
| Compound Name |
[(3S)-Oxolan-3-yl] N-[1-[(5-chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL429321
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|
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| Activity |
IC50 = 1.26E+16 nM
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[12] | |||
| Compound Name |
Benzyl N-[1-[(5-chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254963; SCHEMBL13693298
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|
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| Activity |
IC50 = 1.26E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]-2-methyl-2-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254559; SCHEMBL4100809
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|
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| Activity |
IC50 = 1.58E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]oxane-4-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL403939; SCHEMBL4085958
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|
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| Activity |
IC50 = 1.58E+16 nM
|
[12] | |||
| Compound Name |
Oxan-4-yl N-[1-[[5-chloro-2-(2-methylpropoxy)phenyl]methyl]-5-methylpyrazol-3-yl]carbamate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL255701; SCHEMBL13693184
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|
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| Activity |
IC50 = 1.58E+16 nM
|
[12] | |||
| Compound Name |
(1,1,1-Trifluoro-2-methylpropan-2-yl) N-[1-[[5-chloro-2-(2-methylpropoxy)phenyl]methyl]-5-methylpyrazol-3-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL255876; SCHEMBL13693189
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|
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| Activity |
IC50 = 2.00E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]-2-pyridin-4-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404481; SCHEMBL4098153
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|
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| Activity |
IC50 = 2.00E+16 nM
|
[12] | |||
| Compound Name |
1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methyl-N-(pyridin-3-ylmethyl)pyrazole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254553; SCHEMBL4085489
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|
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| Activity |
IC50 = 2.00E+16 nM
|
[12] | |||
| Compound Name |
Propan-2-yl N-[1-[[5-chloro-2-(2-methylpropoxy)phenyl]methyl]-5-methylpyrazol-3-yl]carbamate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258183; SCHEMBL13693157
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|
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| Activity |
IC50 = 2.00E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]-2-pyridin-3-ylacetamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257544; SCHEMBL4095264
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|
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| Activity |
IC50 = 2.51E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]oxolane-3-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL403940; SCHEMBL4090838
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|
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| Activity |
IC50 = 2.51E+16 nM
|
[12] | |||
| Compound Name |
1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methyl-N-phenylpyrazole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404698; SCHEMBL4097555; BDBM50412223
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|
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| Activity |
IC50 = 2.51E+16 nM
|
[12] | |||
| Compound Name |
N-Benzyl-1-[(5-chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazole-3-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257146; SCHEMBL4096562
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|
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| Activity |
IC50 = 2.51E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]oxolane-2-carboxamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL256731; SCHEMBL13693375
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|
||||
| Activity |
IC50 = 2.51E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]-2,2-difluoro-2-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254558; SCHEMBL4103331
Click to Show/Hide
|
||||
| Activity |
IC50 = 2.51E+16 nM
|
[12] | |||
| Compound Name |
Tert-butyl N-[1-[[5-chloro-2-(2-methylpropoxy)phenyl]methyl]-5-methylpyrazol-3-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL402770; SCHEMBL13693156
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.16E+16 nM
|
[12] | |||
| Compound Name |
Propan-2-yl N-[1-[(5-chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL256092; SCHEMBL13693296; BDBM50373357
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.16E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[[5-Chloro-2-(2-methylpropoxy)phenyl]methyl]-5-methylpyrazol-3-yl]cyclohexanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258200; SCHEMBL4098878
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.16E+16 nM
|
[12] | |||
| Compound Name |
N-Benzyl-3-[2-(5-chloro-2-phenylmethoxyphenyl)-5-methylpyrrol-1-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL233140; SCHEMBL5628647; BDBM50423126; 3-{2-[5-Chloro-2-(benzyloxy)-phenyl]-5-methyl-pyrrol-1-yl}-N-(benzyl)-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.98E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[[5-Chloro-2-(2-methylpropoxy)phenyl]methyl]-5-methylpyrazol-3-yl]cyclopentanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258413; SCHEMBL4091442
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.98E+16 nM
|
[12] | |||
| Compound Name |
1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methyl-N-(pyridin-2-ylmethyl)pyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254554; SCHEMBL4091768
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.98E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]-2,2-difluoro-2-pyridin-2-ylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL403580; SCHEMBL4090543
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.98E+16 nM
|
[12] | |||
| Compound Name |
Tert-Butyl (1-(2-(benzyloxy)-5-chlorobenzyl)-5-methyl-1H-pyrazol-3-yl)carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258199; SCHEMBL13693152; DTXSID10474859; 5291AC; BDBM50373358; ZINC29043620
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.98E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]-2-methylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254152; SCHEMBL4092606
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.98E+16 nM
|
[12] | |||
| Compound Name |
2-Methylpropyl N-[1-[(5-chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]carbamate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL256560; SCHEMBL13693297
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.98E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]-2-pyridin-2-ylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL257138; SCHEMBL4101676
Click to Show/Hide
|
||||
| Activity |
IC50 = 5.01E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254990; SCHEMBL4095687; BDBM50412242
Click to Show/Hide
|
||||
| Activity |
IC50 = 6.31E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]-2-methyl-2-pyridin-2-ylpropanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL437796; SCHEMBL4101950
Click to Show/Hide
|
||||
| Activity |
IC50 = 6.31E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]cyclopentanecarboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254151; SCHEMBL4096166
Click to Show/Hide
|
||||
| Activity |
IC50 = 6.31E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]-2,6-difluorobenzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404026; SCHEMBL4095170
Click to Show/Hide
|
||||
| Activity |
IC50 = 7.94E+16 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]-2-phenylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL256933; SCHEMBL4095567; N-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-yl]-2-phenylacetamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 7.94E+16 nM
|
[12] | |||
| Compound Name |
1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-N-(2,6-difluorophenyl)-5-methylpyrazole-3-carboxamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404711; SCHEMBL4093941
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.00E+17 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]-3,3-dimethylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254150; SCHEMBL4089654; N-[1-({5-chloro-2-[(phenylmethyl)oxy]phenyl}methyl)-5-methyl-1H-pyrazol-3-yl]-3,3-dimethylbutanamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.00E+17 nM
|
[12] | |||
| Compound Name |
3-(2-(2-(Benzyloxy)-5-chlorophenyl)-5-methyl-1H-pyrrol-1-yl)benzoic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL377852; SCHEMBL5628867; BDBM50183185; 3-[2-(5-chloro-2-phenylmethoxyphenyl)-5-methylpyrrol-1-yl]benzoic acid; 3-{2-[5-Chloro-2-(benzyloxy)-phenyl]-5-methyl-pyrrol-1-yl}-benzoic acid; 3-{2-[5-Chloro-2-(benzyloxy)-phenyl]-5-methyl-pyrrol-1yl}-benzoic acid
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.26E+17 nM
|
[12] | |||
| Compound Name |
Sodium;1-[(5-bromo-2-phenylmethoxyphenyl)methyl]-5-methylpyrazole-3-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL258184
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.58E+17 nM
|
[12] | |||
| Compound Name |
N-[1-[(5-Chloro-2-phenylmethoxyphenyl)methyl]-5-methylpyrazol-3-yl]-2-cyclohexylacetamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404297; SCHEMBL4104407
Click to Show/Hide
|
||||
| Activity |
IC50 = 1.58E+17 nM
|
[12] | |||
| Compound Name |
4-[2-(5-Chloro-2-phenylmethoxyphenyl)-5-methylpyrrol-1-yl]-N-(pyridin-2-ylmethyl)benzamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL232117; SCHEMBL5627742; BDBM50423128; 4-{2-[5-Chloro-2-(benzyloxy)-phenyl]-5-methyl-pyrrol-1-yl}-N-(pyridin-2-ylmethyl)-benzamide
Click to Show/Hide
|
||||
| Activity |
IC50 = 3.98E+17 nM
|
[12] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Comparison between two classes of selective EP(3) antagonists and their biological activities. Bioorg Med Chem Lett. 2006 Nov 1;16(21):5639-42. | ||||
| REF 2 | Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization. Bioorg Med Chem Lett. 2004 Apr 5;14(7):1655-9. | ||||
| REF 3 | Piperidine derivatives as nonprostanoid IP receptor agonists. Bioorg Med Chem Lett. 2016 May 1;26(9):2360-4. | ||||
| REF 4 | Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists. ACS Med Chem Lett. 2010 May 14;1(7):316-20. | ||||
| REF 5 | New class of biphenylene dibenzazocinones as potent ligands for the human EP1 prostanoid receptor. Bioorg Med Chem Lett. 1999 Sep 20;9(18):2699-704. | ||||
| REF 6 | Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry. Bioorg Med Chem Lett. 2001 Mar 12;11(5):747-9. | ||||
| REF 7 | Structure-activity relationship studies on ortho-substituted cinnamic acids, a new class of selective EP(3) antagonists. Bioorg Med Chem Lett. 2005 Feb 1;15(3):527-30. | ||||
| REF 8 | Fluorescent Human EP3 Receptor Antagonists. ACS Med Chem Lett. 2012 Aug 8;3(9):774-9. | ||||
| REF 9 | Structure-activity relationship of triaryl propionic acid analogues on the human EP3 prostanoid receptor. Bioorg Med Chem Lett. 2003 Nov 3;13(21):3813-6. | ||||
| REF 10 | Lactams as EP4 prostanoid receptor agonists. 3. Discovery of N-ethylbenzoic acid 2-pyrrolidinones as subtype selective agents. J Med Chem. 2004 Dec 2;47(25):6124-7. | ||||
| REF 11 | Structure-activity relationship of biaryl acylsulfonamide analogues on the human EP(3) prostanoid receptor. Bioorg Med Chem Lett. 2002 Sep 16;12(18):2583-6. | ||||
| REF 12 | Non-acidic pyrazole EP1 receptor antagonists with in vivo analgesic efficacy. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3392-9. | ||||
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