Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T14908 | Target Info | |||
| Target Name | Ceramide glucosyltransferase (UGCG) | ||||
| Synonyms |
UGCG; UDP-glucose:N-acylsphingosine D-glucosyltransferase; UDP-glucose ceramideglucosyltransferase; Glucosylceramide synthase; GLCT-1
Click to Show/Hide
|
||||
| Target Type | Successful Target | ||||
| Gene Name | UGCG | ||||
| Biochemical Class | Hexosyltransferase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Migalastat
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
DDIG; D-Galactitol, 1,5-dideoxy-1,5-imino; (2R,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Dideoxy-1,5-iminogalactitol; 2-(Hydroxymethyl)-3,4,5-piperidinetriol hydrochloride
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Deoxynojirimycin
Click to Show/Hide
|
Phase 3 | Compound Info | ||
| Synonyms |
1-DEOXYNOJIRIMYCIN; 19130-96-2; DUVOGLUSTAT; deoxynojirimycin; Moranoline; (2R,3R,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; 1,5-Deoxy-1,5-imino-D-mannitol; Moranolin; UNII-FZ56898FLE; D-1-deoxynojirimycin; 1,5-Dideoxy-1,5-imino-D-glucitol; CHEMBL307429; C6H13NO4; FZ56898FLE; CHEBI:44369; 1-Deoxy-Nojirimycin; 5-Amino-1,5-dideoxy-D-glucopyranose; DNJ; AK151410; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5S)-; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R-(2alpha,3beta,4alpha,5beta))-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(2S,3S,4R,5S)-1-Butyl-2-(hydroxymethyl)piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1088291; N-Butyl-L-altro-1-deoxynojirimycin; BDBM50312530; ZINC11681341; 1-Butyl-2beta-(hydroxymethyl)piperidine-3alpha,4alpha,5beta-triol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N-[5-(Adamantan-1-yl-methoxy)-pentyl]-L-altro-1-deoxynojirimycin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1088292; BDBM50312531
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3S,4R,5S)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL179409; 1-Deoxy-L-altrostatin; L-altro-1-Deoxynojirimycin; SCHEMBL4619759; BDBM50163445; ZINC13612564; (2s,3s,4r,5s)-2-(hydroxymethyl)piperidin-3,4,5-triol; (2S,3S,4R,5S)-2-(hydroxymethyl)piperidine-3,4,5-triol; (2S,3S,4R,5S)-2-Hydroxymethyl-piperidine-3,4,5-triol
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-Octyl-2alpha-(hydroxymethyl)-5beta-(octyloxy)piperidine-3beta,4alpha-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3596248
Click to Show/Hide
|
||||
| Activity |
IC50 = 164000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 1 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Miglitol
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Diastabol; Glyset; Plumarol; Seibule; Glyset (TN); SK-983; Bay-m-1099; Miglitol (JAN/USAN/INN); (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
Click to Show/Hide
|
||||
| Activity |
IC50 > 1000000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Dual-action lipophilic iminosugar improves glycemic control in obese rodents by reduction of visceral glycosphingolipids and buffering of carbohydrate assimilation. J Med Chem. 2010 Jan 28;53(2):689-98. | ||||
| REF 2 | Beyond substrate analogues: new inhibitor chemotypes for glycosyltransferases. Medchemcomm. 2014;5:1106-25. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.