Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T13863 | Target Info | |||
| Target Name | Transmembrane protease serine 6 (TMPRSS6) | ||||
| Synonyms |
Matriptase-2
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|
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| Target Type | Literature-reported Target | ||||
| Gene Name | TMPRSS6 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 19 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-naphthalen-2-ylacetamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159394
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|
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| Activity |
Ki = 50000 nM
|
[1] | |||
| Compound Name |
(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,41S,44S,50S)-50-Benzyl-4-[(2S)-butan-2-yl]-25,34-bis[3-(diaminomethylideneamino)propyl]-28-[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-19-[(4-hydroxyphenyl)methyl]-3,6,12,18,21,24,27,30,33,36,39,43,49,52-tetradecaoxo-54,55-dithia-2,5,11,17,20,23,26,29,32,35,38,42,48,51-tetradecazapentacyclo[29.21.4.07,11.013,17.044,48]hexapentacontane-41-carboxylic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3623793; BDBM50125045
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|
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| Activity |
Ki ~ 50000 nM
|
[2] | |||
| Compound Name |
4-[3-[(3-Carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoic acid;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159303
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|
||||
| Activity |
Ki = 52000 nM
|
[1] | |||
| Compound Name |
2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-cyclohexylacetamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159395
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|
||||
| Activity |
Ki = 64000 nM
|
[1] | |||
| Compound Name |
2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-phenylacetamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159393
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|
||||
| Activity |
Ki = 65000 nM
|
[1] | |||
| Compound Name |
Tert-butyl 3-[3-[(3-carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoate;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159292
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|
||||
| Activity |
Ki = 65000 nM
|
[1] | |||
| Compound Name |
Tert-butyl 4-[4-[(3-carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoate;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159293
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|
||||
| Activity |
Ki = 70000 nM
|
[1] | |||
| Compound Name |
2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-(3,4-dimethoxyphenyl)acetamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159387
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|
||||
| Activity |
Ki = 82000 nM
|
[1] | |||
| Compound Name |
4-(N-Phenylsulfamoyl)Benzamidinium Chloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159365
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|
||||
| Activity |
Ki = 88000 nM
|
[1] | |||
| Compound Name |
2-[(4-Carbamimidoylphenyl)sulfonylamino]-N-(3,4-dimethoxyphenyl)acetamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159381
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|
||||
| Activity |
Ki = 115000 nM
|
[1] | |||
| Compound Name |
3-[(3-Carbamimidoylphenyl)sulfonylamino]-N-(3,4-dimethoxyphenyl)propanamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159388
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|
||||
| Activity |
Ki = 132000 nM
|
[1] | |||
| Compound Name |
Tert-butyl 4-[[2-[(3-carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoate;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159289
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|
||||
| Activity |
Ki = 137000 nM
|
[1] | |||
| Compound Name |
4-[[2-[(3-Carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoic acid;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159301
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|
||||
| Activity |
Ki = 139000 nM
|
[1] | |||
| Compound Name |
2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-propan-2-ylacetamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159396
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|
||||
| Activity |
Ki = 148000 nM
|
[1] | |||
| Compound Name |
2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-[(3,4-dimethoxyphenyl)methyl]acetamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159389
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|
||||
| Activity |
Ki = 155000 nM
|
[1] | |||
| Compound Name |
N-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)acetamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159281
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|
||||
| Activity |
Ki = 163000 nM
|
[1] | |||
| Compound Name |
N-(3-Carbamimidoylphenyl)-2-(naphthalen-1-ylsulfonylamino)acetamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159282
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|
||||
| Activity |
Ki = 163000 nM
|
[1] | |||
| Compound Name |
3-[(3-Carbamimidoylphenyl)sulfonylamino]-N-[(3,4-dimethoxyphenyl)methyl]propanamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159391
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|
||||
| Activity |
Ki = 187000 nM
|
[1] | |||
| Compound Name |
N-(3-Carbamimidoylphenyl)-2-[(3,4-dimethoxyphenyl)sulfonylamino]acetamide;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159397
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|
||||
| Activity |
Ki = 196000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 37 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-[[2-[(3-Carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoic acid;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159302
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|
||||
| Activity |
Ki = 207000 nM
|
[1] | |||
| Compound Name |
3-[3-[(3-Carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoic acid;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159304
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|
||||
| Activity |
Ki = 208000 nM
|
[1] | |||
| Compound Name |
4-[4-[(3-Carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoic acid;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159305
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|
||||
| Activity |
Ki = 217000 nM
|
[1] | |||
| Compound Name |
4-[(4-Methoxyphenyl)sulfamoyl]benzenecarboximidamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159366
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
4-[4-[(4-Carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoic acid;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159299
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-[(3-Methoxyphenyl)methylsulfamoyl]benzenecarboximidamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159379
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-[(3,4-Dimethoxyphenyl)methylsulfamoyl]benzenecarboximidamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159380
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
4-[(3-Carbamimidoylphenyl)sulfonylamino]-N-[(3,4-dimethoxyphenyl)methyl]butanamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159392
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
2-[(4-Carbamimidoylphenyl)sulfonylamino]-N-[(3,4-dimethoxyphenyl)methyl]acetamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159383
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-[[2-[(4-Carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoic acid;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159296
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
4-[(3-Methoxyphenyl)sulfamoyl]benzenecarboximidamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159367
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-[(3-Methoxyphenyl)sulfamoyl]benzenecarboximidamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159375
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
Tert-butyl 3-[[2-[(4-carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoate;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159284
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-[(4-Methoxyphenyl)sulfamoyl]benzenecarboximidamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159374
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
4-[(4-Methoxyphenyl)methylsulfamoyl]benzenecarboximidamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159370
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
4-[(3,4-Dimethoxyphenyl)sulfamoyl]benzenecarboximidamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159368
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-[(3,4-Dimethoxyphenyl)sulfamoyl]benzenecarboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159376
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
4-[3-[(4-Carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoic acid;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159297
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
4-[(4-Carbamimidoylphenyl)sulfonylamino]-N-(3,4-dimethoxyphenyl)butanamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159384
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
4-[[2-[(4-Carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoic acid;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159295
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-[(4-Carbamimidoylphenyl)sulfonylamino]-N-[(3,4-dimethoxyphenyl)methyl]propanamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159385
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
Tert-butyl 3-[4-[(4-carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoate;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159288
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-[(4-Methoxyphenyl)methylsulfamoyl]benzenecarboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159378
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
4-[(4-Carbamimidoylphenyl)sulfonylamino]-N-[(3,4-dimethoxyphenyl)methyl]butanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159386
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-[3-[(4-Carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoic acid;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159298
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
Tert-butyl 3-[4-[(3-carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159294
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-[(4-Carbamimidoylphenyl)sulfonylamino]-N-(3,4-dimethoxyphenyl)propanamide;hydrochloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159382
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-[4-[(4-Carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoic acid;2,2,2-trifluoroacetic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159300
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|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-(N-Phenylsulfamoyl)Benzamidinium Chloride
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159373
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
4-[(3-Methoxyphenyl)methylsulfamoyl]benzenecarboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159371
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
4-[(3-Carbamimidoylphenyl)sulfonylamino]-N-(3,4-dimethoxyphenyl)butanamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159390
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
Tert-butyl 4-[3-[(4-carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159285
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
4-(N-Benzylsulfamoyl)Benzamidinium Chloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159369
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
4-[(3,4-Dimethoxyphenyl)methylsulfamoyl]benzenecarboximidamide;hydrochloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159372
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-[4-[(3-Carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoic acid;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159361
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
Tert-butyl 3-[3-[(4-carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoate;2,2,2-trifluoroacetic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159286
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Compound Name |
3-(N-Benzylsulfamoyl)Benzamidinium Chloride
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2159377
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines. Bioorg Med Chem. 2012 Nov 1;20(21):6489-505. | ||||
| REF 2 | Improving the Selectivity of Engineered Protease Inhibitors: Optimizing the P2 Prime Residue Using a Versatile Cyclic Peptide Library. J Med Chem. 2015 Oct 22;58(20):8257-68. | ||||
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