Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T13075 | Target Info | |||
| Target Name | Casein kinase I alpha (CSNK1A1) | ||||
| Synonyms |
Casein kinase I isoform alpha; CKI-alpha; CK1
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| Target Type | Clinical trial Target | ||||
| Gene Name | CSNK1A1 | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 5 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3361128; BDBM50038423; ZINC16052822; (E)-2-(3,4-Dihydroxybenzylidene)benzofuran-3(2H)-one
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| Activity |
IC50 = 78800 nM
|
[1] | |||
| Compound Name |
N-(2-Aminoethyl)-5-chloronaphthalene-1-sulfonamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL219301; N-(2-aminoethyl)-5-chloro-1-naphthalenesulfonamide; Tocris-0366; CBiol_002054; BSPBio_001382; SCHEMBL2739414; CTK3D3017; DTXSID00274345; Bio1_000340; Bio1_000829; Bio1_001318; HMS1791F04; HMS1989F04; HMS3402F04; N-(2-AMINOETHYL)-5-CHLORO-NAPHTHALENE-1-SULFONAMIDE; ZINC2555126; BDBM50375645; SDCCGSBI-0633780.P001; NCGC00024555-01; NCGC00024555-02; NCGC00024555-03; NCGC00024555-04; NCGC00024555-05; NCGC00024555-06; 1-Naphthalenesulfonamide, N-(2-aminoethyl)-5-chloro-; BRD-K51215422-001-02-3; BRD-K51215422-003-01-1; Q27185988; 5-Chloro-naphthalene-1-sulfonic acid, (2-amino-ethyl)-amide
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| Activity |
Ki = 80000 nM
|
[2] | |||
| Compound Name |
2-Amino-7-methyl-4-[(4-methylphenyl)methylamino]-9H-pyrimido[4,5-b]indol-6-ol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4098682; BDBM50242512
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4276946
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Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
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Compound Info | |||
| Activity |
IC50 ~ 50000 nM
|
[5] | |||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-[(3-Hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea;methanesulfonic acid
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Investigative | Compound Info | ||
| Synonyms |
SCHEMBL2551860; CHEMBL3218297
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| Activity |
IC50 = 469800 nM
|
[6] | |||
| Compound Name |
4-Phenyl-[1]benzofuro[2,3-b]pyridine-3,6-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2163772; BDBM50395892
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| Activity |
Ki > 1000000 nM
|
[7] | |||
| Compound Name |
N-(4-Methoxybenzyl)benzofuro[2,3-b]pyridin-4-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1290072; BDBM50331612
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| Activity |
Ki > 1000000 nM
|
[8] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | In vitro and in vivo characterization of a benzofuran derivative, a potential anticancer agent, as a novel Aurora B kinase inhibitor. Eur J Med Chem. 2015 Jan 7;89:310-9. | ||||
| REF 2 | A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20523-8. | ||||
| REF 3 | Discovery of novel substituted benzo-anellated 4-benzylamino pyrrolopyrimidines as dual EGFR and VEGFR2 inhibitors. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2708-2712. | ||||
| REF 4 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
| REF 5 | Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat Chem Biol. 2008 Nov;4(11):691-9. | ||||
| REF 6 | Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). Medchemcomm. 2012 Jun 1;3(6):699-709. | ||||
| REF 7 | Multitargeted drug development: Discovery and profiling of dihydroxy substituted 1-aza-9-oxafluorenes as lead compounds targeting Alzheimer disease relevant kinases. Bioorg Med Chem Lett. 2012 Nov 15;22(22):6914-8. | ||||
| REF 8 | Discovery and selectivity-profiling of 4-benzylamino 1-aza-9-oxafluorene derivatives as lead structures for IGF-1R inhibitors. Bioorg Med Chem Lett. 2010 Dec 1;20(23):6915-9. | ||||
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