Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T12646 | Target Info | |||
| Target Name | Valosin-containing protein p97 (VCP) | ||||
| Synonyms |
Valosin-containing protein; Transitional endoplasmic reticulum ATPase; TER ATPase; 15S Mg(2+)-ATPase p97 subunit
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| Target Type | Clinical trial Target | ||||
| Gene Name | VCP | ||||
| Biochemical Class | Acid anhydride hydrolase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
4-Bromo-2-[(1R,2S)-1,2-dimethyl-3-methylidenecyclopentyl]-5-methylphenol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4099907; Allolaurinterol; CTK5J1595; BDBM50260459; 4-bromo-2-[(1R,2S)-1,2-dimethyl-3-methylene-cyclopentyl]-5-methyl-phenol; 4-Bromo-2-[(1R,2S)-1,2-dimethyl-3-methylenecyclopentyl]-5-methylphenol; Phenol, 4-bromo-2-[(1R,2S)-1,2-dimethyl-3-methylenecyclopentyl]-5-methyl-
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(4S,6S)-7-Hydroxy-3,6,9-trimethyl-4-(2-methylprop-1-enyl)-5,6-dihydro-4H-phenalene-1,2-dione
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Investigative | Compound Info | ||
| Synonyms |
elisabatin A; NSC704379; PEH-II; CHEMBL494655; CTK5J8515; BDBM50260460; NSC-704379; NCI60_037264
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Oxaspirol B
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3800252; BDBM50163869; J3.528.693D
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| Activity |
IC50 = 180000 nM
|
[2] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | ATP-competitive, marine derived natural products that target the DEAD box helicase, eIF4A. Bioorg Med Chem Lett. 2017 Sep 1;27(17):4082-4085. | ||||
| REF 2 | Oxaspirol B with p97 Inhibitory Activity and Other Oxaspirols from Lecythophora sp. FL1375 and FL1031, Endolichenic Fungi Inhabiting Parmotrema tinctorum and Cladonia evansii. J Nat Prod. 2016 Feb 26;79(2):340-52. | ||||
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