Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T12059 | Target Info | |||
| Target Name | Alpha-mannosidase (MANA) | ||||
| Synonyms |
Mannosidase alpha class 2
Click to Show/Hide
|
||||
| Target Type | Clinical trial Target | ||||
| Gene Name | MAN2B1; MAN2B2; MAN2C1 | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(3r,4r,5r)-3,4-Dihydroxy-5-({[(1r)-2-Hydroxy-1-Phenylethyl]amino}methyl)pyrrolidin-2-One
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476925; BDBM50263048; Q27460642; (3R,4R,5R)-3,4-dihydroxy-5-(((R)-2-hydroxy-1-phenylethylamino)methyl)pyrrolidin-2-one; GB6
Click to Show/Hide
|
||||
| Activity | Lysosomal alpha-mannosidase |
IC50 = 50000 nM
|
[1] | ||
| Compound Name |
(2R,3R,4S)-2-({[(1R)-2-Hydroxy-1-phenylethyl]amino}methyl)pyrrolidine-3,4-diol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL425723; SCHEMBL13808578; BDBM50168988; Q27120493
Click to Show/Hide
|
||||
| Activity | Lysosomal alpha-mannosidase |
IC50 = 50000 nM
|
[1] | ||
| Compound Name |
3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2S,3S,4R,5R)-
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL179130; Deoxy-L-allonojirimycin; Lopac-D-9305; CTK0A8432; DTXSID20424961; ZINC5600742; BDBM50163438; NCGC00015383-01; (2S,3S,4R,5R)-2-Hydroxymethyl-piperidine-3,4,5-triol
Click to Show/Hide
|
||||
| Activity | Epididymis-specific alpha-mannosidase |
IC50 = 59000 nM
|
[2] | ||
| Lysosomal alpha-mannosidase |
IC50 = 64000 nM
|
[2] | |||
| Compound Name |
(R)-2-(((2R,3R,4S)-3,4-Dihydroxypyrrolidin-2-yl)methylamino)-2-phenylethyl 4-bromobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476718; BDBM50263047
Click to Show/Hide
|
||||
| Activity | Lysosomal alpha-mannosidase |
IC50 = 75000 nM
|
[1] | ||
| Compound Name |
(R)-2-(((2R,3R,4R)-3,4-Dihydroxy-1-methyl-5-oxopyrrolidin-2-yl)methylamino)-2-phenylethyl 4-bromobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476343; BDBM50263091
Click to Show/Hide
|
||||
| Activity | Lysosomal alpha-mannosidase |
IC50 = 75000 nM
|
[1] | ||
| Compound Name |
(R)-2-(((2R,3R,4R)-3,4-Dihydroxy-5-oxopyrrolidin-2-yl)methylamino)-2-phenylethyl 4-bromobenzoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL476927; BDBM50263050
Click to Show/Hide
|
||||
| Activity | Lysosomal alpha-mannosidase |
IC50 = 75000 nM
|
[1] | ||
| Compound Name |
(3S,5R)-1-Decyl-4-(2-hydroxyethyl)piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344206; BDBM50030374
Click to Show/Hide
|
||||
| Activity | Lysosomal alpha-mannosidase |
IC50 = 112000 nM
|
[3] | ||
| Compound Name |
(3R,5S)-4-(2-Hydroxyethyl)-1-octylpiperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344205; BDBM50030343
Click to Show/Hide
|
||||
| Activity | Lysosomal alpha-mannosidase |
IC50 = 143000 nM
|
[3] | ||
| Compound Name |
(3R,5S)-1-Hexyl-4-(2-hydroxyethyl)piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344204; BDBM50030342
Click to Show/Hide
|
||||
| Activity | Lysosomal alpha-mannosidase |
IC50 = 183000 nM
|
[3] | ||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 5 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Miglitol
Click to Show/Hide
|
Approved | Compound Info | ||
| Synonyms |
Diastabol; Glyset; Plumarol; Seibule; Glyset (TN); SK-983; Bay-m-1099; Miglitol (JAN/USAN/INN); (2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol
Click to Show/Hide
|
||||
| Activity | Lysosomal alpha-mannosidase |
IC50 = 379000 nM
|
[3] | ||
| Compound Name |
(3S,5R)-1-Butyl-4-(2-hydroxyethyl)piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344203; BDBM50030340
Click to Show/Hide
|
||||
| Activity | Lysosomal alpha-mannosidase |
IC50 = 252000 nM
|
[3] | ||
| Compound Name |
1-Deoxymannojirimycin
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Deoxymannojirimycin; (2R,3R,4R,5R)-2-(hydroxymethyl)piperidine-3,4,5-triol; D-manno-Deoxynojirimycin; CHEMBL84844; 1-Deoxymannojirimycin hydrochloride; 3,4,5-Piperidinetriol, 2-(hydroxymethyl)-, (2R,3R,4R,5R)-; (2R,3R,4R,5R)-2-(Hydroxymethyl)-3,4,5-piperidinetriol; D-Deoxymannojirimycin; NSC625109; 2-HYDROXYMETHYL-PIPERIDINE-3,4,5-TRIOL; BSPBio_000991; SCHEMBL329674; Bio1_000480; Bio1_000969; Bio1_001458; HMS1792A13; HMS1990A13; ZINC3995890; BDBM50065259; AKOS006238598; DB03955; SMP2_000289; NCGC00015383-05; NCGC00025086-02; NCGC00025086-03; C10141; Q27094814; (2R,3R,4R,5R)-2-Hydroxymethyl-piperidine-3,4,5-triol; (2R,3R,4R,5R)-2-(Hydroxymethyl)piperidine-3,4,5-triol, 11
Click to Show/Hide
|
||||
| Activity | Epididymis-specific alpha-mannosidase |
IC50 = 560000 nM
|
[2] | ||
| Compound Name |
(3S,5R)-1,4-Bis(2-hydroxyethyl)piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344207; BDBM50030341
Click to Show/Hide
|
||||
| Activity | Lysosomal alpha-mannosidase |
IC50 = 873000 nM
|
[3] | ||
| Compound Name |
(3S,5R)-4-(2-Hydroxyethyl)piperidine-3,4,5-triol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3344202; BDBM50030339
Click to Show/Hide
|
||||
| Activity | Lysosomal alpha-mannosidase |
IC50 = 1826000 nM
|
[3] | ||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Functionalized pyrrolidine inhibitors of human type II alpha-mannosidases as anti-cancer agents: optimizing the fit to the active site. Bioorg Med Chem. 2008 Aug 1;16(15):7337-46. | ||||
| REF 2 | Biological properties of D- and L-1-deoxyazasugars. J Med Chem. 2005 Mar 24;48(6):2036-44. | ||||
| REF 3 | -Hydroxyethyl piperidine iminosugar and N-alkylated derivatives: a study of their activity as glycosidase inhibitors and as immunosuppressive agents. Bioorg Med Chem. 2014 Nov 1;22(21):5776-82. | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.