Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T11824 | Target Info | |||
| Target Name | Microtubule-associated protein tau phosphorylation (MAPT p) | ||||
| Synonyms |
tau phosphorylation; Paired helical filamenttau phosphorylation; Paired helical filament-tau phosphorylation; PHFtau; PHF-tau; Neurofibrillary tangle protein phosphorylation; MTBT1 phosphorylation; MAPTL phosphorylation
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| Target Type | Patented-recorded Target | ||||
| Gene Name | MAPT | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
1-[3,5-Bis(3,4-dihydroxyphenyl)-3,4-dihydropyrazol-2-yl]ethanone
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3663966; SCHEMBL16181207; BDBM170574; US9085549, 98
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| Activity |
IC50 = 78510 nM
|
[1] | |||
| Compound Name |
4-[2-(3,4-Dihydroxyphenyl)-1,3-oxazol-5-yl]benzene-1,2-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3663954; SCHEMBL12682332; BDBM170560; US9085549, 70
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| Activity |
IC50 = 117000 nM
|
[1] | |||
| Non Binders of This Target (in total, 4 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
EPICATECHIN
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Phase 2 | Compound Info | ||
| Synonyms |
(-)-Epicatechin; Epicatechin; 490-46-0; L-Epicatechin; (-)-Epicatechol; l-Acacatechin; (2R,3R)-2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol; Epicatechol; l-Epicatechol; (-)epicatechin; (2R,3R)-(-)-Epicatechin; UNII-34PHS7TU43; epi-Catechin; epi-Catechol; CCRIS 7097; EINECS 207-710-1; NSC 81161; Epicatechol, (-)-; CHEBI:90; 34PHS7TU43; PFTAWBLQPZVEMU-UKRRQHHQSA-N; (2R,3R)-2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol; (-)-(2R:3R)-5,7,3',4'-Tetrahydroxyflavan-3-ol; AK105372; C15H14O6
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| Activity |
IC50 >= 200000 nM
|
[2] | |||
| Compound Name |
4-[4-Bromo-5-(3,4-dihydroxyphenyl)thiophen-2-yl]benzene-1,2-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3663938; SCHEMBL12682339; BDBM170543; US9085549, 59
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| Activity |
IC50 = 211100 nM
|
[1] | |||
| Compound Name |
2,5-Bis(3,4-dihydroxyphenyl)-1,3,4-thiadiazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3663955; SCHEMBL12682322; BDBM170561; US9085549, 72
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| Activity |
IC50 = 290200 nM
|
[1] | |||
| Compound Name |
4-[5-(3,4-Dihydroxyphenyl)-1,3,4-oxadiazol-2-yl]benzene-1,2-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3663951; SCHEMBL12682336; BDBM170557; US9085549, 67
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| Activity |
IC50 = 3941000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | US patent application no. 9085549B2, Compounds for the treatment of neurodegenerative diseases | ||||
| REF 2 | Progress and developments in tau aggregation inhibitors for Alzheimer disease. J Med Chem. 2013 Jun 13;56(11):4135-55. | ||||
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