Target Poor or Non Binder(s) Information

Target General Information

Target ID

T11615

Target Info

Target Name

Cystine/glutamate transporter (SLC7A11)

Synonyms

XCT; X(c)-cystine transporter; X(c)- plasma membrane cystine transporter; Solute carrier family 7 member 11; Calcium channel blocker resistance protein CCBR1; Amino acid transport system xc-; Amino acid transport system XCT

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Target Type

Clinical trial Target

Gene Name

SLC7A11

Biochemical Class

Amino acid-polyamine-organocation

UniProt ID

Q9UPY5

Poor Binders of This Target (in total, 8 binders)

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Compound Name

L-cysteine

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Clinical trial

Compound Info

Synonyms

52-90-4; Cystein; Half-cystine; (R)-Cysteine; Thioserine; (R)-2-Amino-3-mercaptopropanoic acid; L-(+)-Cysteine; L-Cystein; (2R)-2-amino-3-sulfanylpropanoic acid; beta-Mercaptoalanine; Half cystine; FREE CYSTEINE; Cysteine, L-; L-Cys; L-Alanine, 3-mercapto-; L-Zystein; H-Cys-OH; Cisteinum [Latin]; L-2-Amino-3-mercaptopropionic acid; Cisteina [Spanish]; cisteina; Polycysteine; Cysteinum; Cisteinum; (R)-2-Amino-3-mercaptopropionic acid; L Cysteine; alpha-Amino-beta-thiolpropionic acid; L-2-Amino-3-mercaptopropanoic a

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Activity

Ki = 59000 nM

[1]

Compound Name

3-[3-Carboxy-5-[2-(2-naphthyl)ethyl]isoxazole-4-yl]-L-alanine

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Investigative

Compound Info

Synonyms

CHEMBL600474; BDBM50378670

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Activity

Ki = 52000 nM

[1]

Compound Name

Susalimod

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Investigative

Compound Info

Synonyms

2-hydroxy-5-[2-[4-[(3-methylpyridin-2-yl)sulfamoyl]phenyl]ethynyl]benzoic acid; UNII-I5MPG6F043; I5MPG6F043; CHEMBL1614646; Susalimod [INN]; SCHEMBL1229340; CTK8H0231; DTXSID80164336; ZINC538399; BDBM50355009; Q27280478; 5-((p-((3-Methyl-2-pyridyl)sulfamoyl)phenyl)ethynyl)salicylic acid; 2-Hydroxy-5-((4-(N-(3-methylpyridin-2-yl)sulfamoyl)phenyl)ethynyl)benzoic acid

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Activity

IC50 = 70000 nM

[2]

Compound Name

2-Hydroxy-5-[(E)-2-[4-(pyridin-2-ylsulfamoyl)phenyl]ethenyl]benzoic acid

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Investigative

Compound Info

Synonyms

CHEMBL1834956; BDBM50355004

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Activity

IC50 = 70000 nM

[2]

Compound Name

3-[2-[4-(Pyridin-2-ylsulfamoyl)phenyl]ethynyl]benzoic acid

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Investigative

Compound Info

Synonyms

CHEMBL1834959; BDBM50355007

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Activity

IC50 = 75000 nM

[2]

Compound Name

3-[3-Carboxy-5-[2-(1-naphthyl)ethyl]isoxazole-4-yl]-L-alanine

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Investigative

Compound Info

Synonyms

CHEMBL591770; BDBM50378669

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Activity

Ki = 117000 nM

[1]

Compound Name

2-Hydroxy-5-(phenylethynyl)benzoic acid

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Investigative

Compound Info

Synonyms

CHEMBL1834962; 2-hydroxy-5-(2-phenylethynyl)benzoic Acid; CTK7I6623; KS-00002ART; ZINC2525637; BDBM50355011; MFCD04039086; AKOS004116354; PS-7617; DS-016433; 2-HYDROXY-5-PHENYLETHYNYL-BENZOIC ACID; K-7520

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Activity

IC50 = 150000 nM

[2]

Compound Name

5-(Phenylazo)salicylic acid

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Investigative

Compound Info

Synonyms

2-Hydroxy-5-(phenyldiazenyl)benzoic acid; Benzoic acid, 2-hydroxy-5-(phenylazo)-; 2-hydroxy-5-phenyldiazenyl benzoic acid; Mesalamine Impurity I; CHEMBL1834961; UNII-0JGZ1HX6EX; 0JGZ1HX6EX; 2-hydroxy-5-phenyldiazenylbenzoic acid; 2-Hydroxy-5-(2-phenyldiazenyl)benzoic Acid; (E)-2-hydroxy-5-(phenyldiazenyl)benzoic acid; 2-hydroxy-5-[(E)-phenyldiazenyl]benzoic acid; Phenylazosalicylic Acid; Sodium 5-(phenylazo)salicylate; Salicylic acid, 5-(phenylazo)-; EINECS 221-569-3; EINECS 233-406-3; 2-Hydroxy-5-(phenylazo)benzoic Acid; 5-(Phenylazo)Salicylicacid; SCHEMBL137145; SCHEMBL15339774; CTK4G7218; DTXSID70877100; 5-[(E)-Phenylazo]salicylic acid; BCP26299; ZINC4787427; 3396AB; ANW-73288; BDBM50355010; NSC163392; STL139171; ZINC16982974; (3Z)-6-oxo-3-(phenylhydrazinylidene)cyclohexa-1,4-diene-1-carboxylic acid; AKOS005134022; AKOS024333040; AKOS025401127; ZINC100061734; FS-6631; MCULE-8484078877; NSC-163392; DB-020689; FT-0673722; Benzoic acid,2-hydroxy-5-(2-phenyldiazenyl)-; J-509654; 2-Hydroxy-5-(phenyldiazenyl)benzoic Acid (Phenylazosalicylic Acid)

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Activity

IC50 = 200000 nM

[2]

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Non Binders of This Target (in total, 9 non binders)

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Compound Name

Sulfapyridine

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Approved

Compound Info

Synonyms

Adiplon; Coccoclase; Dagenan; Eubasin; Eubasinum; Haptocil; Piridazol; Plurazol; Pyriamid; Pyridazol; Relbapiridina; Ronin;Septipulmon; Solfapiridina; Streptosilpyridine; Sulfapiridina; Sulfapyridinum; Sulfidin; Sulfidine; Sulphapyridin; Sulphapyridine; Thioseptal; Trianon; Solfapiridina [DCIT]; M and B 693; A-499; ALBB-006215; M + B 693; M&B 693; M+B 693; Sulfapiridina [INN-Spanish]; Sulfapyridine (TN); Sulfapyridinum [INN-Latin]; AO-801/41077453; N(1)-Pyridylsulfanilamide; N(sup1)-Pyridylsulfanilamide; N-2-Pyridylsulfanilamide; N1-2-Pyridylsulfanilamide; Sulfapyridine (USP/INN); Sulfapyridine [USAN:INN:BAN]; N'-2-Pyridylsulfanilide; N(1)-2-Pyridylsulfanilamide; N(sup 1)-2-Pyridylsulfanilamide; N1-(Pyridin-2-yl)sulfanilamide; Sulfanilamide, N1-2-pyridyl-(8CI); 2-(4-Aminobenzenesulfonamido)pyridine; 2-(p-Aminobenzenesulphonamido)pyridine; 2-Sulfanilamidopyridin; 2-Sulfanilamidopyridin [German]; 2-Sulfanilamidopyridine; 2-Sulfanilyl aminopyridine; 2-Sulfanilylaminopyridine; 2-Sulfapyridine; 4-(2-Pyridinylsulfonyl)aniline; 4-AMINO-N-2-PYRIDINYLBENZENESULFONAMIDE; 4-Amino-N,2-pyridinylbenzenesulfonamide; 4-Amino-N-2-pyridinyl-benzenesulfonamide; 4-Amino-N-[2-pyridyl]benzene sulfonamide; 4-[(2-Pyridylamino)sulfonyl]aniline; 4-amino-N-(pyridin-2-yl)benzenesulfonamide; 4-amino-N-pyridin-2-yl-benzenesulfonamide; 4-amino-N-pyridin-2-ylbenzenesulfonamide

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Activity

IC50 > 1000000 nM

[2]

Compound Name

3-Phenylethynyl-benzoic acid

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Investigative

Compound Info

Synonyms

3-(Phenylethynyl)Benzoic Acid; 3-(2-phenylethynyl)benzoic acid; CHEMBL1834963; NSC171754; SCHEMBL1927619; CTK7I8597; DTXSID70305832; ZINC1692877; BDBM50355012; MFCD06740205; AKOS004116391; NSC-171754; AS-38230; F2167-5392

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Activity

IC50 = 270000 nM

[2]

Compound Name

2-Hydroxy-5-[2-[4-(pyridin-2-ylsulfamoyl)phenyl]ethyl]benzoic acid

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Investigative

Compound Info

Synonyms

CHEMBL1834958; SCHEMBL8073603; BDBM50355006; 2-Hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]ethyl]benzoic acid

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Activity

IC50 = 700000 nM

[2]

Compound Name

Methyl 2-hydroxy-5-[(E)-2-[4-(pyridin-2-ylsulfamoyl)phenyl]ethenyl]benzoate

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Investigative

Compound Info

Synonyms

CHEMBL1834955; SCHEMBL8069397; BDBM50355003

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Activity

IC50 = 900000 nM

[2]

Compound Name

3-[2-[4-(Pyridin-2-ylsulfamoyl)phenyl]ethyl]benzoic acid

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Investigative

Compound Info

Synonyms

CHEMBL1834960; BDBM50355008

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Activity

IC50 = 920000 nM

[2]

Compound Name

(R)-4-Carboxyphenylglycine

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Investigative

Compound Info

Synonyms

(R)-4-(Amino(Carboxy)Methyl)Benzoic Acid; 4-[(R)-amino(carboxy)methyl]benzoic acid; Tocris-0321; Tocris-0322; SCHEMBL8258234; CHEMBL1402765; BDBM82251; ZINC1629225; AKOS006275274; NCGC00024533-01; NCGC00024534-01; SR-01000597635; (R)-alpha-Amino-alpha-(4-carboxyphenyl)acetic acid; J-006477; SR-01000597635-3

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Activity

IC50 > 1000000 nM

[2]

Compound Name

Mesalamine

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Investigative

Compound Info

Synonyms

5-Aminosalicylic acid; Mesalazine; 5-Amino-2-hydroxybenzoic acid; Asacol; Pentasa; Claversal; Canasa; 5-ASA; Salofalk; Rowasa; m-Aminosalicylic acid; Mesasal; Lialda; Benzoic acid, 5-amino-2-hydroxy-; Fisalamine; Lixacol; Apriso; p-Aminosalicylsaeure; Asacolitin; Mesalazina; Mesalazinum; sfRowasa; 5-amino-2-hydroxy-benzoic acid; Asacol HD; 5-Amino Salicylic Acid; SALICYLIC ACID, 5-AMINO-; MFCD00007877; 2-Hydroxy-5-aminobenzoic acid; 3-carboxy-4-hydroxyaniline; UNII-4Q81I59GXC; NSC 38877; MAX-002; MLS001424012; 4Q81I59GXC; NSC-38877; NCGC00016344-03; Mesalazinum [Latin]; SMR000145728; DSSTox_CID_4506; DSSTox_RID_77435; DSSTox_GSID_24506; 5-Aminosalicylic acid, 99%; Mesalazina [Spanish]; p-Aminosalicylsaeure [German]; Mesavancol; Delzicol; Mesavance; Mezavant; Iialda; Mesalazine MMX; Mezavant XL; Mesalamine (USP); Pentasa (TN); 5-Aminosalicylicacid; Salofalk Granu-Stix; Apriso (TN); Asacol (TN); Canasa (TN); Lialda (TN); Rowasa (TN); CCRIS 7334; SR-01000763486; Mesalamine [USAN:USP]; EINECS 201-919-1; BRN 2090421; AI3-15564; 5-Aminosalicylic Acid, Purified; HSDB 7512; AJG-501; SPD 476; SPD-476; SPD-480; Mesalamine (TN); Delzicol (TN); Sfrowasa (TN); Mesalazine [INN]; mesalamine (USAN); Mesalamine (Lialda); 5-aminosalicylic_acid; MD-0901; 5-Aminosalicyclic acid; 5-amino-salicylic acid; PubChem17623; Mesalazine; ACMC-1BKFR; Prestwick0_001069; Prestwick1_001069; Prestwick2_001069; Prestwick3_001069; WLN: ZR DQ CVQ; Z-206; CHEMBL704; Mesalazine (JP17/INN); EC 201-919-1; cid_4075; Oprea1_847633; SCHEMBL31297; 3amino-6-hydroxybenzoic acid; BSPBio_001058; KBioGR_002425; KBioSS_002431; 4-14-00-02058 (Beilstein Handbook Reference); KSC448C0L; MLS000758287; 5-Aminosalicylic acid, 95%; 5-Aminosalicylic acid, tablet; ARONIS23914; BIDD:GT0811; 3-amino-6-hydroxybenzoic acid; SPBio_002969; BPBio1_001164; GTPL2700; ZINC1688; 5-Amino 2-hydroxy benzoic acid; DTXSID5024506; SCHEMBL18038934; 5-Aminosalicylic acid, >=99%; BDBM60918; CTK3E8105; KBio2_002425; KBio2_004993; KBio2_007561; KBio3_002904; cMAP_000045; HMS1571E20; HMS2051M21; HMS2090I09; HMS2098E20; HMS3393M21; HMS3649K15; HMS3651M15; HMS3715E20; Pharmakon1600-01505993; BCP05326; KS-00000CC5; KS-000048PQ; NSC38877; Tox21_110384; Tox21_201610; Tox21_303125; 5-?Aminosalicylic Acid (Mesalazine); ANW-39326; BBL013046; NSC759301; s1681; SBB052617; STK301678; AKOS000118959; Tox21_110384_1; AC-2764; BCP9000175; CCG-100829; DB00244; HS-0100; LS11426; MCULE-5752745805; NC00079; NSC-759301; NCGC00016344-01; NCGC00016344-02; NCGC00016344-04; NCGC00016344-05; NCGC00016344-07; NCGC00090934-01; NCGC00090934-02; NCGC00257142-01; NCGC00259159-01; 5-amino-2-hydroxobenzoic acid monohydrate; AK-72925; BP-13074; BR-72925; HY-15027; SC-15695; SY002854; 5-Aminosalicylic acid, analytical standard; ST4109571; A0317; AB00374979; AM20060091; FT-0619950; SW197303-4; 1764-EP2272825A2; 1764-EP2275420A1; C07138; D00377; M-7246; 24215-EP2289518A1; 24215-EP2295053A1; 24215-EP2295409A1; 24215-EP2314574A1; 24215-EP2314590A1; 90701-EP2371811A2; AB00374979-09; AB00374979-10; AB00374979_11; AB00374979_12; Q412479; Q-201355; SR-01000763486-3; SR-01000763486-4; SR-01000763486-9; Z57127471; F1918-0003

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Activity

IC50 > 1000000 nM

[2]

Compound Name

Methyl 2-hydroxy-5-[[4-[(2-pyridinylamino)sulfonyl]phenyl]ethynyl]benzoate

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Investigative

Compound Info

Synonyms

CHEMBL1834953; SCHEMBL8067735; BDBM50355001; methyl 2-hydroxy-5-[2-[4-(pyridin-2-ylsulfamoyl)phenyl]ethynyl]benzoate

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Activity

IC50 > 1000000 nM

[2]

Compound Name

Methyl 2-hydroxy-5-[2-[4-(pyridin-2-ylsulfamoyl)phenyl]ethyl]benzoate

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Investigative

Compound Info

Synonyms

CHEMBL1834957; BDBM50355005

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Activity

IC50 > 1000000 nM

[2]

Click to Show/Hide the Information of All Non Binders

References

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REF 1

Isoxazole analogues bind the system xc- transporter: structure-activity relationship and pharmacophore model. Bioorg Med Chem. 2010 Jan 1;18(1):202-13.

REF 2

Inhibition of xc-transporter-mediated cystine uptake by sulfasalazine analogs. Bioorg Med Chem Lett. 2011 Oct 15;21(20):6184-7.

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