Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T10877 | Target Info | |||
| Target Name | Cyclic ADP-ribose hydrolase 1 (CD38) | ||||
| Synonyms |
cADPr hydrolase 1; T10; Cyclic ADPribose hydrolase 1; ADPribosyl cyclase 1; ADPRC 1; ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase 1; 2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-ADP-ribosyl cyclase
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| Target Type | Successful Target | ||||
| Gene Name | CD38 | ||||
| Biochemical Class | Glycosylase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 12 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Resveratrol
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Phase 3 | Compound Info | ||
| Synonyms |
Resveratrol; Resvida; KUC104385N; R 5010; SRT 501; Cis-resveratrol; PREVENTION 8 (RESVERATROL); RM-1812; SRT-501; Trans-resveratrol; CU-01000001503-3; KSC-10-164; Resveratrol-3-sulfate; Trans-3,4',5-trihydroxystilbene; Trans-3,4′,5-Trihydroxystilbene; Trans-1,2-(3,4',5-Trihydroxydiphenyl)ethylene; (E)-5-(2-(4-hydroxyphenyl)ethenyl)-1,3-benzenediol
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
SEN-196
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Phase 2 | Compound Info | ||
| Synonyms |
EX-527; SEN-0014196; SIRT1 inhibitors (Huntingtons disease), Elixir/Siena; Sirtuin-1 inhibitors (oral, Huntington's disease), Elixir/Siena
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide; CHEMBL112265; 352549-39-4; CBMicro_001045; Cambridge id 5870454; AC1N6ME3; Oprea1_743470; SCHEMBL251128; CTK1B0687; DTXSID20401358; MolPort-000-735-346; HMS1632P07; SMSF0008851; STL525366; BDBM50178767; carboxamido-1,2,3-tetrahydrocarbazole; AKOS004917884; CB02357; BIM-0000968.P001; SR-01000154363; SR-01000154363-1; 1H-Carbazole-1-carboxamide, 2,3,4,9-tetrahydro-
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
Piceatannol
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Investigative | Compound Info | ||
| Synonyms |
piceatannol; 10083-24-6; 3-Hydroxyresveratol; piceatanol; astringinin; 3,5,3',4'-Tetrahydroxystilbene; (E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol; 3,3',4'5-Tetrahydroxystilbene; 4-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol; 3,3',4,5'-Tetrahydroxystilbene; UNII-6KS3LS0D4F; NSC 365798; NSC-365798; NSC 622471; 6KS3LS0D4F; CHEMBL69863; 3,3',4,5'-Stilbenetetrol; 4-[(E)-2-(3,5-dihydroxyphenyl)vinyl]benzene-1,2-diol; 4339-71-3; CHEBI:28814; C14H12O4; NSC365798; NSC622471; 1,2-Benzenediol, 4-(2-(3,5-dihydroxyphenyl)ethenyl)-
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
Fisetinidin
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1275835; 3,3',4',7-Tetrahydroxyflavylium; BDBM50347143; 3,3',4',7-Tetrahydroxyflavylium chloride; 2-(3,4-dihydroxyphenyl)chromenylium-3,7-diol
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| Activity |
IC50 = 70300 nM
|
[1] | |||
| Compound Name |
Epicatechin
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Investigative | Compound Info | ||
| Synonyms |
L-Epicatechin; 2-(3,4-Dihydroxyphenyl)chroman-3,5,7-triol; DL-Catechin; (+/-)-Catechin; 2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol; Catechin (hydrate); 2-(3,4-dihydroxyphenyl)-3,4-dihydro-2H-chromene-3,5,7-triol; epi-Catechol; (+/-)-Epicatechin; (+)-Catechin;Cianidanol;Catechuic acid; (-)-3,5,7,3',4'-PENTAHYDROXYFLAVAN; l-Epicatechol; DL-Catechin; Racemic catechin; dl-Catechin; dl-Catechol; rac-Catechin; (2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol; Epicatechol, (-)-; 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-,(2R,3S)-rel-; 2-(3,4-Dihydroxyphenyl)chromane-3,5,7-triol; (2R,3R)-(-)-Epicatechin; catechins; Catachin; MFCD00075648; NSC 81161; NCGC00015215-02; EINECS 241-357-4; NSC 81162; 2-(3,4-Dihydroxyphenyl)-3,5,7-chromanetriol #; Prestwick3_000817; Epicatechin, (+/-)-; (-)-(2R:3R)-5,7,3',4'-Tetrahydroxyflavan-3-ol; (-)-CATECHINHYDRATE; SCHEMBL19411; BSPBio_000713; BPBio1_000785; CHEMBL206452; SCHEMBL10001669; DTXSID10859304; 2H-1-Benzopyran-3,5,7-triol, 2-(3,4-dihydroxyphenyl)-3,4-dihydro-, (2R,3R)-; HMS1664H16; 2H-1-Benzopyran-3,5,7-triol,2-(3,4-dihydroxyphenyl)-3,4-dihydro-; BDBM50479045; MFCD00066757; AKOS016009549; cis-(1)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-3,5,7-triol; (+)-3,3',4',5,7-Flavanpentol; MCULE-4219942050; NCGC00015215-03; NCGC00015215-04; NCGC00095270-01; NCGC00095270-02; AK-77017; AK105372; AK111290; BS-15212; SC-65140; SC-86438; DB-017858; DB-050100; AB00513926; FT-0604384; FT-0613995; FT-0614024; FT-0636422; (-)-cis-3,3',4',5,7-Pentahydroxyflavane; (?)-cis-3,3',4',5,7-Pentahydroxyflavane; C17590; BRD-A61899133-002-02-2; Q51617472; 714E3A52-14F7-4C41-BF5D-1DAA0C81FCC5
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| Activity |
IC50 ~ 100000 nM
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[1] | |||
| Compound Name |
2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
2-Chloro-5,6,7,8,9,10-hexahydro-cyclohepta[b]indole-6-carboxylic acid amide; CHEMBL446446; (Z)-non-2-enoic acid; Oprea1_323938; MLS001163802; SCHEMBL1873844; CTK1C1311; DTXSID50394183; HMS2873H18; 1658AJ; BDBM50178766; MFCD00846509; STK524333; AKOS005458227; MCULE-1772644300; SB36878; SMR000539218; FT-0701854; 2-Chloro-5,6,7,8,9,10-hexahydro-cycloheptabindole-6-carboxylic acid amide; 2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxylic acid amide
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
6-Methyl-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide
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Investigative | Compound Info | ||
| Synonyms |
SIRT1-IN-1; CHEMBL115600; SMR000041923; ChemDiv3_015530; Oprea1_169494; MLS000036457; SCHEMBL8244015; HMS1517B20; HMS2582N08; HMS3448P13; BDBM50178773; STL336698; AKOS021714064; MCULE-4334993191; HY-136199; CS-0120561; SR-01000001381; SR-01000001381-2; (6-Methyl-2,3,4,9-tetrahydro-1H-carbazol-1-yl)formamide
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| Activity |
IC50 ~ 100000 nM
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[2] | |||
| Compound Name |
N'-[(1Z)-(4-Hydroxy-3-methoxyphenyl)methylene]-2-methyl-3-furohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422360; ZINC249434; BDBM50081939; SR-01000079188; SR-01000079188-1
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| Activity |
IC50 = 103000 nM
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[3] | |||
| Compound Name |
2-Methyl-furan-3-carboxylic acid (3,4-dihydroxy-benzylidene)-hydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422359; ZINC249445; BDBM50081938
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| Activity |
IC50 = 109000 nM
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[3] | |||
| Compound Name |
N'-(2-Hydroxybenzoyl)-2-methylfuran-3-carbohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422380; BDBM50081944
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| Activity |
IC50 = 120000 nM
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[3] | |||
| Compound Name |
(2R,3R,4S,5R,13R,14S,15R,16R)-18-Bromo-3,4,8,10,14,15-hexahydroxy-8,10-dioxo-7,9,11,25,26-pentaoxa-1,17,19,22-tetraza-8lambda5,10lambda5-diphosphapentacyclo[18.3.1.12,5.113,16.017,21]hexacosa-18,20,22-trien-24-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3342441; BDBM50027372
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| Activity |
IC50 = 158000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Cyclic IDP ribose
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1161863; Cyclic Inosine 5'-Diphosphoribose; BDBM50027371; Cyclic Inosine 5''''-Diphosphoribose
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| Activity |
IC50 = 276000 nM
|
[4] | |||
| Compound Name |
2-Methyl-N'-[(1Z)-phenylmethylene]-3-furohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422361; ZINC249430; BDBM50081940; SR-01000079184; SR-01000079184-1
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| Activity |
IC50 = 296000 nM
|
[3] | |||
| Compound Name |
N'-[(1Z)-(2-Hydroxyphenyl)methylene]-2-methyl-3-furohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3422362; ZINC249436; BDBM50081941; SR-01000106968; SR-01000106968-1
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| Activity |
IC50 = 430000 nM
|
[3] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Flavonoids as inhibitors of human CD38. Bioorg Med Chem Lett. 2011 Jul 1;21(13):3939-42. | ||||
| REF 2 | Discovery of indoles as potent and selective inhibitors of the deacetylase SIRT1. J Med Chem. 2005 Dec 15;48(25):8045-54. | ||||
| REF 3 | Discovery of Potent Inhibitors of Schistosoma mansoni NAD+ Catabolizing Enzyme. J Med Chem. 2015 Apr 23;58(8):3582-92. | ||||
| REF 4 | Cyclic adenosine 5'-diphosphate ribose analogs without a "southern" ribose inhibit ADP-ribosyl cyclase-hydrolase CD38. J Med Chem. 2014 Oct 23;57(20):8517-29. | ||||
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