Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T08856 | Target Info | |||
| Target Name | Matrix metalloproteinase-8 (MMP-8) | ||||
| Synonyms |
PMNL-CL; PMNL collagenase; Neutrophil collagenase; CLG1
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | MMP8 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 100 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(biphenyl-3-ylamino)methylenediphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL55371; AC1NQQUY; (biphenyl-3-ylamino)methylenediphosphonic acid; BPH-218; NSC725581; BDBM50138040; ZINC13532369; NSC-725581; [(3-phenylanilino)-phosphonomethyl]phosphonic acid; [(3-phenylanilino)-phosphono-methyl]phosphonic acid; [(Biphenyl-3-ylamino)-phosphono-methyl]-phosphonic acid; (Biphenyl-3-yl)- aminomethylene-1,1-bisphosphonate (dihydrate); Phosphonic acid, [([1,1'-biphenyl]-3-ylamino)methylene]bis-
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|
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| Activity |
IC50 = 52000 nM
|
[1] | |||
| Compound Name |
N-Hydroxy-2-(4-methoxy-benzenesulfonyl)benzamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL575895; N-Hydroxy-2-(4-methoxy-benzenesulfonyl)benzamide
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|
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| Activity |
IC50 = 72000 nM
|
[2] | |||
| Compound Name |
Cis-2-aminocyclohexylcarbamoylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
cis-ACCP; cis-2-aminocyclohexylcarbamoylphosphonic acid; 777075-44-2; CHEMBL270083; SCHEMBL569075; C7H15N2O4P; CTK8E9417; MolPort-039-139-066; BDBM50234465; 1683AH; ZINC29134634
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|
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Cyclohexanamine;3-methylbutylcarbamoylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1160686
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|
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
N-(1-Benzylcarbamoyl-ethyl)-N''-hydroxy-2-isobutyl-malonamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL334065; BDBM50062460
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|
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| Activity |
Ki = 50000 nM
|
[5] | |||
| Compound Name |
2-Benzyl-N-hydroxy-3-morpholino-3-oxopropanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL117932; BDBM50062459; 2-Benzyl-N-hydroxy-3-morpholin-4-yl-3-oxo-propionamide
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| Activity |
Ki = 50000 nM
|
[5] | |||
| Compound Name |
trans-2-Aminocyclohexylcarbamoylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL270296; SCHEMBL4854279; BDBM50372742; ZINC29134636; [(1R,2R)-2-aminocyclohexyl]carbamoylphosphonic acid
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|
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| Activity |
IC50 = 50000 nM
|
[6] | |||
| Compound Name |
(Isopropylamino)carbonylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97034; Isopropylcarbamoylphosphonic Acid; BDBM50146799
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|
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| Activity |
IC50 = 50000 nM
|
[4] | |||
| Compound Name |
Chembl4210975
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456781
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|
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| Activity |
IC50 = 52100 nM
|
[7] | |||
| Compound Name |
Ethyl 2-benzyl-3-(hydroxyamino)-3-oxopropanoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL418619; BDBM50062473; 2-Benzyl-N-hydroxy-malonamic acid ethyl ester
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| Activity |
Ki = 52480.75 nM
|
[8] | |||
| Compound Name |
Chembl4211708
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456798
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|
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| Activity |
IC50 = 52500 nM
|
[7] | |||
| Compound Name |
Chembl4206886
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456777
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|
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| Activity |
IC50 = 52500 nM
|
[7] | |||
| Compound Name |
N*1*-Benzyl-2-(2-hydroxycarbamoyl-4-methyl-pentanoylamino)-succinamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL324522; BDBM50062472
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|
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| Activity |
Ki = 55000 nM
|
[5] | |||
| Compound Name |
Chembl4218730
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456797
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|
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| Activity |
IC50 = 55100 nM
|
[7] | |||
| Compound Name |
Chembl4203717
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456771
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|
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| Activity |
IC50 = 56100 nM
|
[7] | |||
| Compound Name |
[(Naphthalen-1-ylamino)-phosphonomethyl]phosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440429; SCHEMBL8333842; BDBM50442507
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|
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| Activity |
IC50 = 61000 nM
|
[1] | |||
| Compound Name |
5-Hydroxy-5-[2-(4-nitrophenyl)-2-oxoethyl]-1,3-diazinane-2,4,6-trione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2151351; BDBM50392698
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|
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| Activity |
IC50 = 63000 nM
|
[9] | |||
| Compound Name |
N-Hydroxy-4-methylbenzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
Benzenesulfonamide, N-hydroxy-4-methyl-; N-hydroxy-4-methylbenzene-1-sulfonamide; tosylhydroxylamine; N-Tosylhydroxylamine; N-hydroxy-4-methyl-benzenesulfonamide; Hydroxysulfonamide 58; ACMC-209djs; p-tolyl-N-hydroxysulfonamide; N-hydroxy-4-toluenesulfonamide; CHEMBL121559; SCHEMBL1832454; BDBM11377; CTK8B0907; DTXSID10435263; ANW-21830; MFCD11850835; ZINC13813791; AKOS015888649; MCULE-3823003338; SC-50302; DB-064280; CS-0068832; FT-0760726; V3581; A-3307
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|
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| Activity |
Ki = 64000 nM
|
[10] | |||
| Compound Name |
Chembl4212449
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456788
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|
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| Activity |
IC50 = 64500 nM
|
[7] | |||
| Compound Name |
4-Bromo-N-hydroxybenzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
p-Bromo-N-hydroxybenzenesulfonamide; Benzenesulfonamide, p-bromo-N-hydroxy-; 4-bromo-N-hydroxybenzene-1-sulfonamide; N-(p-bromobenzenesulfonyl)hydroxylamine; BRN 2645335; Hydroxysulfonamide 56; p-Bromobenzenesulfonhydroxamide; CHEMBL123404; SCHEMBL8229526; BDBM11375; CTK8H4740; DTXSID90941675; N-Hydroxy-p-bromobenzenesulfonamide; ZINC6093148; 4-Bromo-N-hydroxybenzenesulfonamide #
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|
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| Activity |
Ki = 69000 nM
|
[10] | |||
| Compound Name |
4-Chloro-N-hydroxybenzene-1-sulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
N-(p-chlorobenzenesulfonyl)hydroxylamine; 4-chloro-N-hydroxybenzenesulfonamide; NSC528513; Hydroxysulfonamide 55; CHEMBL301469; SCHEMBL5194625; BDBM11374; DTXSID10326460; ZINC1607221; 4-Chloro-N-hydroxy-benzenesulfonamide; NSC-528513; DS-014970
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|
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| Activity |
Ki = 70000 nM
|
[10] | |||
| Compound Name |
(Diethylamino)carbonylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97057; diethylcarbamoylphosphonic acid; Phosphonic acid, [(diethylamino)carbonyl]- (9CI); N-diethyl carbamyl phosphonate; SCHEMBL11592091; BDBM50146813
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| Activity |
IC50 = 70000 nM
|
[4] | |||
| Compound Name |
N-[(Hydroxyamino)carbonyl]-L-leucyl-Lphenylalanine methylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501715; BDBM50272134
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|
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| Activity |
IC50 = 70000 nM
|
[11] | |||
| Compound Name |
(Hydroxyamino)(4-iodophenyl)sulfone
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|
Investigative | Compound Info | ||
| Synonyms |
Hydroxysulfonamide 57; CHEMBL120934; SCHEMBL8229583; BDBM11376; ZINC5570003; AKOS024355469; N-hydroxy-4-iodobenzene-1-sulfonamide; MCULE-2099459518; ST50982751
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|
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| Activity |
Ki = 71000 nM
|
[10] | |||
| Compound Name |
(R)-2-(4-Fluorophenylsulphonamido-N-(pyridin-3-ylmethyl))-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL393793; BDBM50225398
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|
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| Activity |
IC50 = 71000 nM
|
[12] | |||
| Compound Name |
N-Hydroxybenzenesulfonamide
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|
Investigative | Compound Info | ||
| Synonyms |
Benzenesulfohydroxamic acid; Piloty's acid; Benzenesulfonamide, N-hydroxy-; Benzenesulphonohydroxamic acid; Benzsulfohydroxamic acid; Hydroxamic acid, benzsulfo-; N-(Phenylsulfonyl)hydroxylamine; Hydroxylamine, N-(phenylsulfonyl)-; UNII-C64L4UMH19; CHEMBL55310; C64L4UMH19; MFCD00025013; EINECS 209-973-8; N-Hydroxy-benzenesulfonamide; BRN 2257368; Benzenesulfohyd; piloty acid; BENZENESULFOHYDROXAMICACID; Hydroxysulfonamide 53; Hydroxyphenylsulfonamide; Benzenesulfhydroxamic acid; (hydroxyamino)phenylsulfone; C6H7NSO3; Benzenesulfonamide,N-hydroxy-; 4-11-00-00093 (Beilstein Handbook Reference); SCHEMBL184252; DTXSID4060521; BDBM11372; CTK5B0780; HMS3650A13; NSC45357; ZINC4284435; 1634AH; 7672AF; ANW-43953; NSC-45357; AKOS001139035; MCULE-1579584179; NE34189; VZ36592; AS-59127; ST50825041; SR-01000946758; SR-01000946758-1; Q27275238
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|
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| Activity |
Ki = 74000 nM
|
[10] | |||
| Compound Name |
2-(2-(4-Methoxyphenylsulfonyl)phenyl)acetic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL585376; BDBM50299069
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|
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| Activity |
IC50 = 74000 nM
|
[2] | |||
| Compound Name |
N-((S)-2-Benzyloxy-1-dimethylcarbamoyl-propyl)-N''-hydroxy-oxalamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL367331; BDBM50111985
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|
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| Activity |
Ki = 75000 nM
|
[13] | |||
| Compound Name |
N-(p-Fluorobenzenesulfonyl)hydroxylamine
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|
Investigative | Compound Info | ||
| Synonyms |
4-fluoro-N-hydroxybenzene-1-sulfonamide; Hydroxysulfonamide 54; CHEMBL332145; SCHEMBL2492594; BDBM11373; 4-fluoro-n-hydroxybenzenesulfonamide; N-Hydroxy-4-fluorobenzenesulfonamide
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|
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| Activity |
Ki = 75000 nM
|
[10] | |||
| Compound Name |
Benzenemethanesulfonamide, N-hydroxy-
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|
Investigative | Compound Info | ||
| Synonyms |
Hydroxysulfonamide 52; N-Benzylsulfonylhydroxylamin; CHEMBL333122; N-hydroxyphenylmethanesulfonamide; SCHEMBL10656290; BDBM11371; N-hydroxy-1-phenylmethanesulfonamide
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| Activity |
Ki = 76000 nM
|
[10] | |||
| Compound Name |
Chembl4211258
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456773
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|
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| Activity |
IC50 = 76500 nM
|
[7] | |||
| Compound Name |
Chembl4211189
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456774
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|
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| Activity |
IC50 = 77400 nM
|
[7] | |||
| Compound Name |
(R)-2-(N-((2-Fluoropyridin-3-yl)methyl)-4-methoxyphenylsulphonamido)-3-methylbutanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428554; BDBM50225403
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|
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| Activity |
IC50 = 78000 nM
|
[12] | |||
| Compound Name |
Cyclohexylmethylcarbamoylphosphonic Acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97951; SCHEMBL4859789; BDBM50146805; [(cyclohexylmethyl)amino]carbonylphosphonic acid
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|
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| Activity |
IC50 = 80000 nM
|
[4] | |||
| Compound Name |
Chembl4202989
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456792
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|
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| Activity |
IC50 = 84000 nM
|
[7] | |||
| Compound Name |
Chembl4211771
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456785
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|
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| Activity |
IC50 = 87500 nM
|
[7] | |||
| Compound Name |
N-Benzyl-3-(2-hydroxycarbamoyl-4-methyl-pentanoylamino)-succinamic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL326760; BDBM50062464
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|
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| Activity |
Ki = 88000 nM
|
[5] | |||
| Compound Name |
Chembl4206821
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456784
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| Activity |
IC50 = 89300 nM
|
[7] | |||
| Compound Name |
(Dibutylamino)carbonylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL96438; BDBM50146804
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| Activity |
IC50 = 90000 nM
|
[4] | |||
| Compound Name |
Chembl4211700
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456782
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| Activity |
IC50 = 90200 nM
|
[7] | |||
| Compound Name |
Chembl4203061
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456794
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| Activity |
IC50 = 92100 nM
|
[7] | |||
| Compound Name |
Ethyl 3-(hydroxyamino)-3-oxo-2-phenylpropanoate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL117316; BDBM50062454; N-Hydroxy-2-phenyl-malonamic acid ethyl ester
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| Activity |
Ki = 97723.72 nM
|
[8] | |||
| Compound Name |
2-[(4-Methoxyphenyl)methylthio]-6-methyl-1H-pyrimidin-4-one
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Investigative | Compound Info | ||
| Synonyms |
ML032; MLS000109390; CHEMBL500351; 2-[(4-methoxyphenyl)methylsulfanyl]-6-methyl-1H-pyrimidin-4-one; SMR000105333; SR-01000474780; CDS1_004684; CBMicro_030348; 6-methyl-2-(p-anisylthio)-1H-pyrimidin-4-one; Oprea1_680293; DivK1c_005724; cid_716696; SCHEMBL16743643; BDBM40478; CTK8J7376; HMS2282I24; ZINC8670459; AKOS000530959; MCULE-9257305475; BIM-0030343.P001; ST50101336; EC-000.1648; SR-01000474780-1; SR-01000474780-3; Q27164593; 2-[(4-methoxyphenyl)methylthio]-6-methylpyrimidin-4-ol; 2-(4-Methoxy-benzylsulfanyl)-6-methyl-3H-pyrimidin-4-one
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
[Phosphono-[4-(trifluoromethyl)anilino]methyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440440; BDBM50442517
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
[(3-Fluoroanilino)-phosphonomethyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440436; BDBM50442513
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Chembl4215193
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456799
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
[(2,4-Dichloroanilino)-phosphono-methyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL191613; BDBM50165966; 2,4-Dichloroanilinomethylenebisphosphonic acid; 2,4-DICHLOROPHENYLAMINOMETHYLENEBISPHOSPHONIC ACID; [(2,4-dichloro-phenyl)aminomethylene]-1,1-bisphosphonate; [(2,4-Dichloro-phenylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [[(2,4-dichlorophenyl)amino]methylene]bis-
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5S)-4-[2-(1-Adamantyl)ethyl]-5-butyl-1-[(2S)-1-(4-hydroxyphenyl)-3-[(2S)-2-[[(6R)-6-(naphthalen-2-ylmethyl)-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]propan-2-yl]piperazine-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593549; BDBM50104623
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| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(Propylamino)carbonylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL94346; BDBM50146797
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[(4-Cyanoanilino)-phosphonomethyl]phosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440437; BDBM50442516
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|
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Sodium hydrogen (butylamino)carbonylphosphonate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL97389
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]acrylamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3394285; SCHEMBL12425758; BDBM50140176; (E)-3-[4-(trifluoromethyl)phenyl]prop-2-enehydroxamic acid
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| Activity |
IC50 ~ 100000 nM
|
[16] | |||
| Compound Name |
Chembl4214716
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Investigative | Compound Info | ||
| Synonyms |
BDBM50456783
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Schembl21751149
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235912; BDBM50104619
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|
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| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(Cycloheptylamino)carbonylphosphonic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97614; SCHEMBL5886552; BDBM50146807
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|
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| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
(5S)-4-[2-(1-Adamantyl)ethyl]-5-[(4-hydroxyphenyl)methyl]-1-[(2R)-1-[(2S)-2-[[(6R)-6-[(4-hydroxyphenyl)methyl]-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-naphthalen-2-ylpropan-2-yl]piperazine-2,3-dione
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593550; BDBM50104622
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| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(3-Bromophenylamino)Methylenediphosphonic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL370662; BDBM50173799; [(3-Bromophenyl)amino]methylenebisphosphonic acid; [(3-bromoanilino)-phosphono-methyl]phosphonic acid; (3-bromo-phenyl)-aminomethylene-1,1-bisphosphonate; [(3-Bromo-phenylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [[(3-bromophenyl)amino]methylene]bis-
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(5S)-5-Benzyl-1-[(2R)-1-[(2S)-2-[[(6R)-6-benzyl-2,3-dioxopiperazin-1-yl]methyl]pyrrolidin-1-yl]-3-cyclohexylpropan-2-yl]-4-(2-phenylethyl)piperazine-2,3-dione
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593552; BDBM50104618
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| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(Hydroxysulfamoyl)dimethylamine
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Investigative | Compound Info | ||
| Synonyms |
Hydroxysulfonamide 51; CHEMBL330950; SCHEMBL6791061; BDBM11370; N-(Dimethylsulfamoyl)hydroxylamine
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
[Anilino(phosphono)methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440580; SCHEMBL7796889; N-phenylaminomethanediphosphonic acid; BDBM50442523; Phenylaminomethylenebisphosphonic acid; (PHENYLAMINO)METHYLENEDIPHOSPHONIC ACID
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
[2-Methyl-1-[[4-(5-methylthiophen-2-yl)phenyl]sulfonylamino]propyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752826; BDBM50500715
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
(2R)-N-Hydroxy-2-[[1-[2-[2-[2-[2-[4-[[[(2R)-1-(hydroxyamino)-3-methyl-1-oxobutan-2-yl]-(4-methoxyphenyl)sulfonylamino]methyl]triazol-1-yl]ethoxy]ethoxy]ethoxy]ethyl]triazol-4-yl]methyl-(4-methoxyphenyl)sulfonylamino]-3-methylbutanamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2064553; BDBM50389105
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
[(4-Hydroxyanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440438; SCHEMBL4088119; BDBM50442515
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1,1,1-Trifluoro-N-hydroxymethanesulfonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
Hydroxysulfonamide 47; CHEMBL331308; SCHEMBL8231627; BDBM11366; CTK1H6610; DTXSID10635307; Methanesulfonamide, 1,1,1-trifluoro-N-hydroxy-
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Cyclohexylcarbamoylphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL329784; (cyclohexylamino)carbonylphosphonic acid; SCHEMBL13986865; BDBM50146801
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
CID 78426619
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3235911; SCHEMBL20271444; BDBM50104621
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
(5S)-5-Benzyl-1-[(2R)-1-cyclohexyl-3-[(2S)-2-[[(6S)-2,3-dioxo-6-propylpiperazin-1-yl]methyl]pyrrolidin-1-yl]propan-2-yl]-4-(2-phenylethyl)piperazine-2,3-dione
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3593551; BDBM50104620
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
[1-[[4-(6-Fluoropyridin-3-yl)phenyl]sulfonylamino]-2-methylpropyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3752747; BDBM50500713
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
Chembl4202455
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456772
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Chembl4202528
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456800
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-Chloroanilinomethylenebisphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440579; BDBM50442521; ZINC59245747; N-(p-chlorphenyl)-aminomethanediphosphonic acid; (4-CHLOROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
(Sec-butylamino)carbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL97510; Phosphonic acid, [[(1-methylpropyl)amino]carbonyl]- (9CI); BDBM50146817
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[(4-Fluoro-3-nitroanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440434; BDBM50442511
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
2-[(4-Chlorophenyl)methylthio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
MLS000062185; CHEMBL473326; SMR000070991; 2-[(4-chlorobenzyl)thio]-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one; Oprea1_513869; Oprea1_558114; BDBM40467; cid_2047223; HMS2339I08; ML033; ZINC8602241; BDBM50031314; STL286652; AKOS001659025; CCG-317667; MCULE-1700867569; ST081503; SR-01000464438; SR-01000627583; SR-01000464438-1; SR-01000464438-2; SR-01000627583-2; SR-01000627583-3; Q27165053; 2-[(4-Chlorobenzyl)thio]-6,7-dihydro-5H-cyclopentapyrimidine-4-ol; 2-[(4-chlorobenzyl)thio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-one; 2-[(4-chlorobenzyl)sulfanyl]-3,5,6,7-tetrahydro-4H-cyclopenta[d]pyrimidin-4-one
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
N-Hydroxy-N-{1-(1-isobutyl-piperidin-4-ylidenemethyl)-2-[4-(2-methyl-quinolin-4-ylmethoxy)-benzenesulfonyl]-ethyl}-formamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL318252; SCHEMBL3882021; BDBM50146472
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Compound Name |
Chembl4207344
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456779
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
[1-[[4-[5-(Methoxymethyl)thiophen-2-yl]phenyl]sulfonylamino]-2-methylpropyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL3754314; BDBM50500719
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
[(3-Nitroanilino)-phosphono-methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL450938; SCHEMBL13458525; BDBM50173796; (3-NITROPHENYLAMINO)METHYLENEDIPHOSPHONIC ACID; [(3-Nitro-phenylamino)-phosphono-methyl]-phosphonic acid; Phosphonic acid, [[(3-nitrophenyl)amino]methylene]bis-
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Cyclopentylcarbamoylphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL316997; (cyclopentylamino)carbonylphosphonic acid; SCHEMBL4846602; CTK8I2608; BDBM50146816
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Benzyl 6-Benzyl-5,7-Dioxo-6,7-Dihydro-5h-[1,3]thiazolo[3,2-C]pyrimidine-2-Carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PD-503; CHEMBL409536; SCHEMBL5957461; PD503; BDBM50234334; ZINC29133346; DB08561; Q27097766
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
Lithium ethyl (cyclohexylamino)carbonylphosphonate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1627009
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
4-{[1-Methyl-2,4-Dioxo-6-(3-Phenylprop-1-Yn-1-Yl)-1,4-Dihydroquinazolin-3(2h)-Yl]methyl}benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496942; MMP Inhibitor, 5; SCHEMBL6244295; ZINC3815953; BDBM50265079; DB07827; DB-123234; SR-03000000793-1; Q27097037
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
[Phosphono-[3-(trifluoromethyl)anilino]methyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440435; BDBM50442514
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Hydroxysulfonamide 48
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL124237; BDBM11367; 1,1,1-trichloro-N-hydroxymethanesulfonamide
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[10] | |||
| Compound Name |
Chembl4214656
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456793
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Phenethylcarbamoylphosphonic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL24447; [(2-phenylethyl)amino]carbonylphosphonic acid; SCHEMBL13986851; BDBM50112446
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
Chembl4207416
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50456780
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Piperidin-1-ylcarbonylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL95068; SCHEMBL11749901; BDBM50146802
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[4] | |||
| Compound Name |
[(4-Fluoroanilino)-phosphonomethyl]phosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2440581; BDBM50442522
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
1-[2-[4-(4-Cyanophenyl)phenoxy]ethyl]-3-hydroxyurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL41928; BDBM50100898; N-{2-[(4''-cyano-1,1''-biphenyl-4-yl)oxy]ethyl}-N''-hydroxyurea
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 120000 nM
|
[20] | |||
| Compound Name |
N-[(2r)-2-(Hydroxycarbamoyl)-4-Methylpentanoyl]-L-Alanylglycinamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2372437; SCHEMBL9287740; BDBM50035235; Q27447213; N-[1-(Carbamoylmethyl-carbamoyl)-ethyl]-N''''-hydroxy-2-isobutyl-malonamide
Click to Show/Hide
|
||||
| Activity |
Ki = 121000 nM
|
[5] | |||
| Compound Name |
N-[(Hydroxyamino)carbonyl]-D-leucyl-Lphenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452082; BDBM50245247
Click to Show/Hide
|
||||
| Activity |
IC50 = 150000 nM
|
[11] | |||
| Compound Name |
1-(2-Hydroxycarbamoyl-4-methyl-pentanoyl)-pyrrolidine-2-carboxylic acid benzylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL440713; BDBM50062452
Click to Show/Hide
|
||||
| Activity |
Ki = 168000 nM
|
[5] | |||
| Compound Name |
Chembl4163839
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278363
Click to Show/Hide
|
||||
| Activity |
IC50 = 172800 nM
|
[21] | |||
| Compound Name |
Ethyl 2-(hydroxycarbamoyl)-4-phenylbutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116523; BDBM50062462; 2-Hydroxycarbamoyl-4-phenyl-butyric acid ethyl ester
Click to Show/Hide
|
||||
| Activity |
Ki = 189000 nM
|
[5] | |||
| Compound Name |
2-Hydroxycarbamoyl-4-methyl-pentanoic acid ethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL406023; BDBM50062476
Click to Show/Hide
|
||||
| Activity |
Ki = 190000 nM
|
[5] | |||
| Compound Name |
Ethyl 2-(hydroxycarbamoyl)-3-methylbutanoate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253470; BDBM50423425
Click to Show/Hide
|
||||
| Activity |
Ki = 190546.07 nM
|
[8] | |||
| Compound Name |
N-((R)-1-Benzylcarbamoyl-ethyl)-N''-hydroxy-2-isobutyl-malonamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL116588; BDBM50062465
Click to Show/Hide
|
||||
| Activity |
Ki = 194000 nM
|
[5] | |||
| Compound Name |
Chembl4160618
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278364
Click to Show/Hide
|
||||
| Activity |
IC50 = 198900 nM
|
[21] | |||
| Compound Name |
(1-Benzyloxycarbonylamino-2-phenyl-ethyl)-[2-[1-carbamoyl-2-(1H-indol-3-yl)-ethylcarbamoyl]-3-(2-trifluoromethoxy-phenylsulfanyl)-propyl]-phosphinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL323885; BDBM50138686
Click to Show/Hide
|
||||
| Activity |
Ki = 200000 nM
|
[22] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 12 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
[(2S)-3-[[(2S)-1-Amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-oxo-2-[2-(trifluoromethoxy)phenyl]sulfanylpropyl]-[(1R)-2-phenyl-1-(phenylmethoxycarbonylamino)ethyl]phosphinic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2153738; BDBM50393207
Click to Show/Hide
|
||||
| Activity |
Ki > 200000 nM
|
[23] | |||
| Compound Name |
Chembl4164016
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278389
Click to Show/Hide
|
||||
| Activity |
IC50 = 298500 nM
|
[21] | |||
| Compound Name |
D-Leucyl-L-phenylalanine methylamide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL510082; BDBM50245251
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[11] | |||
| Compound Name |
Z-L-Leu-L-Phe-OMe
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL452584; SCHEMBL7326037; BDBM50245249; N-benzyloxycarbonyl-L-leucyl-L-phenylalanine methyl ester; N-(Benzyloxycarbonyl)-L-leucyl-L-phenylalanine methyl ester; methyl (2S)-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-3-phenylpropanoate
Click to Show/Hide
|
||||
| Activity |
IC50 > 300000 nM
|
[11] | |||
| Compound Name |
Chembl4162521
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278366
Click to Show/Hide
|
||||
| Activity |
IC50 = 345800 nM
|
[21] | |||
| Compound Name |
1-(4-Phenoxyphenethyl)-3-hydroxyurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL197921; BDBM50175781
Click to Show/Hide
|
||||
| Activity |
IC50 > 380000 nM
|
[20] | |||
| Compound Name |
Chembl4171886
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278388
Click to Show/Hide
|
||||
| Activity |
IC50 = 401100 nM
|
[21] | |||
| Compound Name |
Chembl4167291
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278365
Click to Show/Hide
|
||||
| Activity |
IC50 = 483100 nM
|
[21] | |||
| Compound Name |
Chembl4175156
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278390
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[21] | |||
| Compound Name |
Chembl4170455
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278367
Click to Show/Hide
|
||||
| Activity |
IC50 > 500000 nM
|
[21] | |||
| Compound Name |
1-(4-Phenoxyphenethyl)-3-hydroxy-1-methylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200385; BDBM50175782
Click to Show/Hide
|
||||
| Activity |
IC50 = 1000000 nM
|
[20] | |||
| Compound Name |
N-{2-[(4'-Cyano-1,1'-biphenyl-4-YL)oxy]ethyl}-N'-hydroxy-N-methylurea
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL200435; BDBM50175780; DB06971; Q27095882; 1-{2-[(4'-cyanobiphenyl-4-yl)oxy]ethyl}-3-hydroxy-1-methylurea; N-{2-[(4''-cyano-1,1''-biphenyl-4-yl)oxy]ethyl}-N''-hydroxy-N-methylurea
Click to Show/Hide
|
||||
| Activity |
IC50 = 1200000 nM
|
[20] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Arylamino methylene bisphosphonate derivatives as bone seeking matrix metalloproteinase inhibitors. Bioorg Med Chem. 2013 Nov 1;21(21):6456-65. | ||||
| REF 2 | Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. | ||||
| REF 3 | Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem. 2008 Oct 1;16(19):8781-94. | ||||
| REF 4 | Carbamoylphosphonates, a new class of in vivo active matrix metalloproteinase inhibitors. 1. Alkyl- and cycloalkylcarbamoylphosphonic acids. J Med Chem. 2004 May 20;47(11):2826-32. | ||||
| REF 5 | Design and synthesis of malonic acid-based inhibitors of human neutrophil collagenase (MMP8). J Med Chem. 1998 Jan 29;41(3):339-45. | ||||
| REF 6 | Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic mat... J Med Chem. 2008 Mar 13;51(5):1406-14. | ||||
| REF 7 | Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation. Eur J Med Chem. 2017 Sep 29;138:979-992. | ||||
| REF 8 | Matrix metalloproteinases (MMPs): chemical-biological functions and (Q)SARs. Bioorg Med Chem. 2007 Mar 15;15(6):2223-68. | ||||
| REF 9 | Design, synthesis and biological evaluation of 5-hydroxy, 5-substituted-pyrimidine-2,4,6-triones as potent inhibitors of gelatinases MMP-2 and MMP-9. Eur J Med Chem. 2012 Dec;58:368-76. | ||||
| REF 10 | Carbonic anhydrase and matrix metalloproteinase inhibitors: sulfonylated amino acid hydroxamates with MMP inhibitory properties act as efficient inhibitors of CA isozymes I, II, and IV, and N-hydroxysulfonamides inhibit both these zinc enzymes. J Med Chem. 2000 Oct 5;43(20):3677-87. | ||||
| REF 11 | Peptidyl 3-substituted 1-hydroxyureas as isosteric analogues of succinylhydroxamate MMP inhibitors. Eur J Med Chem. 2008 May;43(5):1008-14. | ||||
| REF 12 | Novel fluorinated derivatives of the broad-spectrum MMP inhibitors N-hydroxy-2(R)-[[(4-methoxyphenyl)sulfonyl](benzyl)- and (3-picolyl)-amino]-3-methyl-butanamide as potential tools for the molecular imaging of activated MMPs with PET. J Med Chem. 2007 Nov 15;50(23):5752-64. | ||||
| REF 13 | Oxal hydroxamic acid derivatives with inhibitory activity against matrix metalloproteinases. Bioorg Med Chem Lett. 2002 Mar 25;12(6):933-6. | ||||
| REF 14 | Ranking the selectivity of PubChem screening hits by activity-based protein profiling: MMP13 as a case study. Bioorg Med Chem. 2009 Feb 1;17(3):1101-8. | ||||
| REF 15 | SAR Studies of Exosite-Binding Substrate-Selective Inhibitors of A Disintegrin And Metalloprotease 17 (ADAM17) and Application as Selective in Vitro Probes. J Med Chem. 2015 Aug 13;58(15):5808-24. | ||||
| REF 16 | Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid. Bioorg Med Chem. 2016 Feb 15;24(4):686-92. | ||||
| REF 17 | Fluorinated matrix metalloproteinases inhibitors--Phosphonate based potential probes for positron emission tomography. Bioorg Med Chem. 2016 Feb 15;24(4):902-9. | ||||
| REF 18 | A new class of highly potent matrix metalloproteinase inhibitors based on triazole-substituted hydroxamates: (radio)synthesis and in vitro and first in vivo evaluation. J Med Chem. 2012 May 24;55(10):4714-27. | ||||
| REF 19 | Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia si... J Biol Chem. 2007 Sep 21;282(38):27781-91. | ||||
| REF 20 | N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: mode of binding in a complex with MMP-8. Bioorg Med Chem Lett. 2006 Jan 1;16(1):20-4. | ||||
| REF 21 | A pentanoic acid derivative targeting matrix metalloproteinase-2 (MMP-2) induces apoptosis in a chronic myeloid leukemia cell line. Eur J Med Chem. 2017 Dec 1;141:37-50. | ||||
| REF 22 | Evaluation of P1'-diversified phosphinic peptides leads to the development of highly selective inhibitors of MMP-11. J Med Chem. 2004 Jan 15;47(2):325-36. | ||||
| REF 23 | Remarkable potential of the alpha-aminophosphonate/phosphinate structural motif in medicinal chemistry. J Med Chem. 2011 Sep 8;54(17):5955-80. | ||||
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