Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T08741 | Target Info | |||
| Target Name | Tyrosine-protein kinase CSK (CSK) | ||||
| Synonyms |
Protein-tyrosine kinase CYL; C-Src kinase
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| Target Type | Patented-recorded Target | ||||
| Gene Name | CSK | ||||
| Biochemical Class | Kinase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(S)-2-Amino-N-hydroxy-2-(4-hydroxyphenyl)acetamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL220129; Benzeneacetamide, alpha-amino-N,4-dihydroxy-, (alphaS)-; BDBM50200186
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| Activity |
IC50 = 57000 nM
|
[1] | |||
| Compound Name |
L-Tyrosine, hydrazide
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Investigative | Compound Info | ||
| Synonyms |
L-Tyrosine hydrazide; (S)-2-amino-3-(4-hydroxyphenyl)propanehydrazide; (2S)-2-amino-3-(4-hydroxyphenyl)propanehydrazide; CHEMBL220460; Tyrosine, hydrazide, L-; L-Tyrosinehydrazide; L-Tyrosinohydrazide; tyrosine hydrazide; tyrosine hydrazone; EINECS 231-631-1; NSC 337746; L-Tyrosine hydrazide, 98%; SCHEMBL4668353; CTK8B8588; DTXSID90884412; ZINC388235; KS-000012VN; 1933AC; ANW-60760; BDBM50200191; KM1782; MFCD00007609; AKOS016843145; 4-(2-???(2S)-2-aminoethyl)phenol; AC-24157; AS-67360; ST50825381; 2-Amino-3-(4-hydroxyphenyl)propanohydrazide #; T-9300
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| Activity |
IC50 = 75000 nM
|
[1] | |||
| Compound Name |
N~4~-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL4090364; KIN-281; BDBM50252338; STK542322; AKOS005471968; J3.639.819A; 2-(2,4,6-Trichlorostyryl)-N-[4-(diethylamino)-1-methylbutyl]quinazoline-4,6-diamine; N~4~-[5-(diethylamino)pentan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamine
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
Chembl4276946
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Investigative | Compound Info | ||
| Synonyms |
GTPL9965; compound 3a [Pipionne et al, 2018]; 1-[5-amino-4-(3,4-dichlorophenyl)-3-methyl-1H-pyrazol-1-yl]ethan-1-one
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| Activity |
IC50 ~ 100000 nM
|
[3] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(S)-N-Hydroxy-3-(4-hydroxyphenyl)-2-phenylpropanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL218593; BDBM50200199; ZINC35075540
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| Activity |
IC50 = 290000 nM
|
[1] | |||
| Compound Name |
(S)-2-Amino-N-benzyl-N-hydroxy-3-(4-hydroxyphenyl)propanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL373825; BDBM50200183
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| Activity |
IC50 = 291000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Design and evaluation of hydroxamate derivatives as metal-mediated inhibitors of a protein tyrosine kinase. J Med Chem. 2006 Dec 14;49(25):7532-9. | ||||
| REF 2 | Small molecules inhibit STAT3 activation, autophagy, and cancer cell anchorage-independent growth. Bioorg Med Chem. 2017 Jun 15;25(12):2995-3005. | ||||
| REF 3 | N-Acetyl-3-aminopyrazoles block the non-canonical NF-kB cascade by selectively inhibiting NIK. Medchemcomm. 2018 Apr 12;9(6):963-968. | ||||
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