Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T06320 | Target Info | |||
| Target Name | Galectin (LGALS) | ||||
| Target Type | Clinical trial Target | ||||
| Gene Name | NO-GeName | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4211695
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50451464
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|
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| Activity | Galectin 3 |
EC50 = 67700 nM
|
[1] | ||
| Compound Name |
(2S,3R,4S,5R,6R)-2-((2R,3S,4R,5R,6S)-6-(6-((2R,3S,4S,5R,6S)-3,4-Dihydroxy-6-(hydroxymethyl)-5-((2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-2-ylthio)hexa-2,4-diynylthio)-4,5-dihydroxy-2-(hydroxymethyl)-tetrahydro-2H-pyran-3-yloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL449603; BDBM50272380
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|
||||
| Activity | Galectin 3 |
IC50 = 160000 nM
|
[2] | ||
| Compound Name |
(2S,3R,4S,5R,6R)-2-((2R,3S,4R,5R,6S)-6-((1-((2S,3S,4S,5R,6S)-3,4-Dihydroxy-6-(hydroxymethyl)-5-((2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-2-yl)-1H-1,2,3-triazol-4-yl)methylthio)-4,5-dihydroxy-2-(hydroxymethyl)-tetrahydro-2H-pyran-3-yloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL508204; BDBM50272418
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|
||||
| Activity | Galectin 3 |
IC50 = 160000 nM
|
[2] | ||
| Compound Name |
(2S,3R,4S,5R,6R)-2-[(2R,3S,4R,5R,6R)-6-[6-[(2S,3S,4S,5R,6S)-3,4-Dihydroxy-6-(hydroxymethyl)-5-[(2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxyhexoxy]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2368599
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|
||||
| Activity | Galectin 3 |
IC50 = 163000 nM
|
[2] | ||
| Non Binders of This Target (in total, 36 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4207339
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|
Investigative | Compound Info | ||
| Synonyms |
BDBM50451462
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|
||||
| Activity | Galectin 3 |
EC50 = 205000 nM
|
[1] | ||
| Compound Name |
(2S,3R,4S,5R,6R)-2-((2R,3S,4R,5R,6S)-4,5-Dihydroxy-2-(hydroxymethyl)-6-((1-((2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yl)-1H-1,2,3-triazol-4-yl)methylthio)-tetrahydro-2H-pyran-3-yloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL502536; BDBM50272379
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|
||||
| Activity | Galectin 3 |
IC50 = 300000 nM
|
[2] | ||
| Galectin 1 |
IC50 = 600000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4S,5R,6R)-2-((2R,3S,4R,5R,6S)-6-(6-((2R,3S,4S,5R,6S)-3,4-Dihydroxy-6-(hydroxymethyl)-5-((2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-2-ylthio)hexa-2,4-diynylthio)-4,5-dihydroxy-2-(hydroxymethyl)-tetrahydro-2H-pyran-3-yloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL449603; BDBM50272380
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|
||||
| Activity | Galectin 1 |
IC50 = 300000 nM
|
[2] | ||
| Compound Name |
(2S,3R,4S,5R,6R)-2-((2R,3S,4R,5R,6S)-6-((1-((2S,3S,4S,5R,6S)-3,4-Dihydroxy-6-(hydroxymethyl)-5-((2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-2-yl)-1H-1,2,3-triazol-4-yl)methylthio)-4,5-dihydroxy-2-(hydroxymethyl)-tetrahydro-2H-pyran-3-yloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL508204; BDBM50272418
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|
||||
| Activity | Galectin 1 |
IC50 = 300000 nM
|
[2] | ||
| Compound Name |
(2S,3R,4S,5R,6R)-2-((2R,3S,4R,5R,6S)-4,5-Dihydroxy-2-(hydroxymethyl)-6-(prop-2-ynylthio)-tetrahydro-2H-pyran-3-yloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL502537; BDBM50272381
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|
||||
| Activity | Galectin 3 |
IC50 = 300000 nM
|
[2] | ||
| Galectin 1 |
IC50 = 600000 nM
|
[2] | |||
| Compound Name |
[(2S,3R,4R,5R,6R)-2-[3-[4-[3-[(2R,3S,4S,5R,6S)-3,4-Dihydroxy-6-(hydroxymethyl)-5-[(2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]sulfanylprop-1-ynyl]phenyl]prop-2-ynylsulfanyl]-3-hydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-4-yl] acetate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444523; BDBM50272383
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|
||||
| Activity | Galectin 3 |
IC50 = 300000 nM
|
[2] | ||
| Galectin 1 |
IC50 = 300000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4S,5R,6R)-2-((1-((2S,3S,4S,5R,6S)-3,4-Dihydroxy-6-(hydroxymethyl)-5-((2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-tetrahydro-2H-pyran-2-yl)-1H-1,2,3-triazol-4-yl)methylthio)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL505985; BDBM50272419
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|
||||
| Activity | Galectin 1 |
IC50 = 300000 nM
|
[2] | ||
| Galectin 3 |
IC50 = 600000 nM
|
[2] | |||
| Compound Name |
(E)-Methyl 2-phenyl-4-(beta-D-galactopyranosyl)-but-2-enoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL507820; BDBM50272206
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|
||||
| Activity | Galectin 1 |
IC50 = 313000 nM
|
[2] | ||
| Galectin 3 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
beta-Lactose
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|
Investigative | Compound Info | ||
| Synonyms |
(+)-Lactose; .beta.-Lactose; 4-(beta-D-Galactosido)-D-glucose; 4-O-beta-D-Galactopyranosyl-beta-D-glucopyranose; 4-O-beta-D-Galactopyranosyl-D-glucose; beta-D-Glucopyranose, 4-O-beta-D-galactopyranosyl-; beta-D-Lactose; D-(+)-Lactose; D-Glucose, 4-O-beta-D-galactopyranosyl; D-Lactose; Lactose; Lactose [JAN]; Milk sugar; Lactose anhydrous; Lactosum anhydricum; Lactobiose; Lactin; UNII-13Q3A43E0S; Saccharum lactin; Fast-flo Lactose; Aletobiose; Galactinum; Tablettose; Zeparox EP; Lactose Fast-flo; Pharmatose 21; 13Q3A43E0S; beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranose; MFCD00064521; Lactin (carbohydrate); Osmolactan; Super-Tab; Tablettose 70; Tablettose 80; Pharmatose 325M; Sorbalac 400; Flowlac 100; Pharmatosa DCL 21; EINECS 227-751-9; Galbeta1-4Glcbeta; Galb1-4Glcb; Lactose (8CI); PubChem18839; DSSTox_CID_3193; DSSTox_RID_76916; DSSTox_GSID_23193; CHEMBL417016; DTXSID2023193; DTXSID5058723; ZINC4095761; Tox21_301866; 6023AF; BDBM50370453; beta-D-Galp-(1->4)-beta-D-Glcp; beta-D-Gal-(1-->4)-beta-D-Glc; AKOS015950662; B-LACTOSE - MIN 70% B-ANOMER; NCGC00255383-01; .beta.-D-Gal-(1-->4)-.beta.-D-Glc; C01970; D-Glucose, 4-O-b-D-galactopyranosyl- (9CI); beta-D-galactopyranosyl-(1->4)-beta-D-glucose; A832404; Q127900; beta-Lactose, suitable for component for culture media; beta-D-Lactose, contains ca. 70% beta and ca. 30% alpha; UNII-3SY5LH9PMK component GUBGYTABKSRVRQ-DCSYEGIMSA-N; UNII-J2B2A4N98G component GUBGYTABKSRVRQ-DCSYEGIMSA-N; UNII-W8K377W98I component GUBGYTABKSRVRQ-DCSYEGIMSA-N; 60B85732-763B-4E21-BD67-6163315FD251; beta-Lactose, <=30% alpha-anomer basis, >=99% total lactose basis
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|
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| Activity | Galectin 3 |
IC50 = 800000 nM
|
[2] | ||
| Galectin 1 |
IC50 = 800000 nM
|
[2] | |||
| Compound Name |
5-(beta-D-Galactopyranosyl)-4-methyl-2-4-nitrobenzylaminothiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499072; BDBM50272303
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|
||||
| Activity | Galectin 3 |
IC50 = 2500000 nM
|
[2] | ||
| Galectin 1 |
IC50 = 2500000 nM
|
[2] | |||
| Compound Name |
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(3-(4-(3-((2R,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-ylthio)prop-1-ynyl)phenyl)prop-2-ynylthio)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500405; BDBM50272384
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|
||||
| Activity | Galectin 1 |
IC50 = 2500000 nM
|
[2] | ||
| Galectin 3 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
2-p-Anisamido-5-(beta-D-galactopyranosyl)-4-methylthiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500125; BDBM50272333
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|
||||
| Activity | Galectin 3 |
IC50 = 2500000 nM
|
[2] | ||
| Galectin 1 |
IC50 = 5000000 nM
|
[2] | |||
| Compound Name |
5-(beta-D-Galactopyranosyl)-4-methyl-2-benzylaminothiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL525202; BDBM50272302
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|
||||
| Activity | Galectin 3 |
IC50 = 2500000 nM
|
[2] | ||
| Galectin 1 |
IC50 = 5000000 nM
|
[2] | |||
| Compound Name |
2-Benzamido-5-(beta-D-galactopyranosyl)-4-methylthiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499073; BDBM50272304
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|
||||
| Activity | Galectin 3 |
IC50 = 2500000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
5-(beta-D-Galactopyranosyl)-4-methyl-2-(b-naphthyl)sulfonylaminothiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL502548; BDBM50272261
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|
||||
| Activity | Galectin 3 |
IC50 = 2500000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-((1-((2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yl)-1H-1,2,3-triazol-4-yl)methylthio)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL497324; BDBM50272420
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|
||||
| Activity | Galectin 3 |
IC50 = 2500000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(prop-2-ynylthio)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL443369; BDBM50272382; ZINC40828568
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|
||||
| Activity | Galectin 3 |
IC50 = 2500000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
5-(beta-D-Galactopyranosyl)-4-methyl-2-(2,5-dibromophenyl)sulfonylaminothiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499071; BDBM50272301
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|
||||
| Activity | Galectin 3 |
IC50 = 2500000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
2-p-Bromobenzamido-5-(beta-D-galactopyranosyl)-4-methylthiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL502805; BDBM50272334
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|
||||
| Activity | Galectin 3 |
IC50 = 2500000 nM
|
[2] | ||
| Galectin 1 |
IC50 = 2500000 nM
|
[2] | |||
| Compound Name |
5-(beta-D-Galactopyranosyl)-4-methyl-2-(4-tert-Butylphenyl)sulfonylaminothiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500420; BDBM50272300
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|
||||
| Activity | Galectin 3 |
IC50 = 5000000 nM
|
[2] | ||
| Galectin 1 |
IC50 = 5000000 nM
|
[2] | |||
| Compound Name |
(E)-Methyl 4-(beta-D-galactopyranosyl)-but-2-enoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL446968; BDBM50272205
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|
||||
| Activity | Galectin 3 |
IC50 = 5000000 nM
|
[2] | ||
| Galectin 1 |
IC50 = 5000000 nM
|
[2] | |||
| Compound Name |
5-(beta-D-Galactopyranosyl)-4-methyl-2-phenylacetamidothiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL502806; BDBM50272335
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|
||||
| Activity | Galectin 3 |
IC50 > 5000000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
5-(beta-D-Galactopyranosyl)-4-methyl-2-(2-chloro-phenyl)sulfonylaminothiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL502549; BDBM50272262
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|
||||
| Activity | Galectin 3 |
IC50 = 5000000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4R,5R,6S)-2-(Hydroxymethyl)-6-(2-(4-methoxyphenyl)allyl)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501197; BDBM50272208
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|
||||
| Activity | Galectin 3 |
IC50 = 5000000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
5-(beta-D-Galactopyranosyl)-2-methylcarbamate-4-methylthiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL499869; BDBM50272378
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|
||||
| Activity | Galectin 3 |
IC50 > 5000000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5R,6R)-2-Cinnamyl-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445870; BDBM50272204
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|
||||
| Activity | Galectin 3 |
IC50 > 5000000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
5-(beta-D-Galactopyranosyl)-4-methyl-2-(4-bromophenyl)sulfonylaminothiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL524363; BDBM50272260
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|
||||
| Activity | Galectin 3 |
IC50 = 5000000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
2-Acetamido-5-(beta-D-galactopyranosyl)-4-methylthiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL527113; BDBM50272336
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|
||||
| Activity | Galectin 3 |
IC50 = 5000000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
(2S,3R,4R,5R,6R)-2-((12S,14R,15R,16R,17R,E)-3-((E)-3-((2S,3R,4R,5R,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yl)prop-1-enyl)cinnamyl)-6-(hydroxymethyl)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL501196; BDBM50272207
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|
||||
| Activity | Galectin 1 |
IC50 = 5000000 nM
|
[2] | ||
| Galectin 3 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4R,5R,6S)-2-(Hydroxymethyl)-6-(2-(3-nitrophenyl)allyl)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL524323; BDBM50272258
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|
||||
| Activity | Galectin 1 |
IC50 = 5000000 nM
|
[2] | ||
| Galectin 3 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
Dimeric Galactoside
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL522064; BDBM50272417
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|
||||
| Activity | Galectin 1 |
IC50 = 5000000 nM
|
[2] | ||
| Galectin 3 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4R,5R,6S,E)-2-(Hydroxymethyl)-6-(prop-1-enyl)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500138; BDBM50272151
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|
||||
| Activity | Galectin 3 |
IC50 > 5000000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
5-(beta-D-Galactopyranosyl)-4-methyl-2-(4-methyl-phenyl)sulfonylaminothiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL502547; BDBM50272259
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|
||||
| Activity | Galectin 3 |
IC50 = 5000000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
5-(beta-D-Galactopyranosyl)-4-methyl-2-p-nitro-benzamidothiazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL500124; BDBM50272332
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|
||||
| Activity | Galectin 3 |
IC50 > 5000000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
1-((2S,3R,4R,5R,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yl)propan-2-one
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL453187; SCHEMBL1660605; 1-(beta-D-Galactopyranosyl)acetone; BDBM50255142; 1-[(2S,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]propan-2-one; 1-((2S,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)propan-2-one
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|
||||
| Activity | Galectin 3 |
IC50 = 5000000 nM
|
[2] | ||
| Galectin 1 |
IC50 > 5000000 nM
|
[2] | |||
| Compound Name |
Click to Show/Hide
|
Compound Info | |||
| Activity | Galectin 3 |
IC50 = 50000000 nM
|
[2] | ||
| Galectin 1 |
IC50 = 50000000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Binding of triazole-linked galactosyl arylsulfonamides to galectin-3 affects Trypanosoma cruzi cell invasion. Bioorg Med Chem. 2017 Nov 1;25(21):6049-6059. | ||||
| REF 2 | Synthesis of stable and selective inhibitors of human galectins-1 and -3. Bioorg Med Chem. 2008 Aug 15;16(16):7811-23. | ||||
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