Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T06020 | Target Info | |||
| Target Name | Neonatal Fc receptor (FCGRT) | ||||
| Synonyms |
Neonatal FcR; MHC class I family-like Fc receptor; IgG Fc fragment receptor transporter, alpha chain; FcRn; FCGRT
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| Target Type | Successful Target | ||||
| Gene Name | FCGRT | ||||
| Biochemical Class | Immunoglobulin | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 12 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[3-[[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-methyl-3-sulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]methyl]benzoyl]amino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL525088; BDBM50270955
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| Activity |
IC50 = 57000 nM
|
[1] | |||
| Compound Name |
Kiicspghfggmycqgk
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL503219; BDBM50270785
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| Activity |
IC50 = 64000 nM
|
[1] | |||
| Compound Name |
Fctghfgglypcngp
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL526683; BDBM50270794
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| Activity |
IC50 = 67000 nM
|
[1] | |||
| Compound Name |
(2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-methyl-3-sulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-piperidin-4-ylpropanoyl]amino]-3-phenylpropanoyl]amino]acetyl]-methylamino]acetyl]-methylamino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL525431; BDBM50270951
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| Activity |
IC50 = 85000 nM
|
[1] | |||
| Compound Name |
Rfctghfgglypc
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL505689; BDBM50270797
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| Activity |
IC50 = 87000 nM
|
[1] | |||
| Compound Name |
(2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-methyl-3-sulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]-methylamino]acetyl]-methylamino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL525232; BDBM50270953
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
Ctghfgglypc
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL444514; BDBM50270791
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| Activity |
IC50 = 110000 nM
|
[1] | |||
| Compound Name |
(2S)-1-[2-[[(2S)-4-Amino-2-[[(2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-5-carbamimidamido-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]-3-methyl-3-sulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-3-(4-nitrophenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoyl]amino]-4-oxobutanoyl]amino]acetyl]pyrrolidine-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL502881; BDBM50270935
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| Activity |
IC50 = 122000 nM
|
[1] | |||
| Compound Name |
(2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[4-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-methyl-3-sulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]phenyl]acetyl]amino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL508454; BDBM50270956
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| Activity |
IC50 ~ 125000 nM
|
[1] | |||
| Compound Name |
(2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[4-[[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-methyl-3-sulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]methyl]benzoyl]amino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL506848; BDBM50270954
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| Activity |
IC50 ~ 125000 nM
|
[1] | |||
| Compound Name |
(2S)-1-[2-[[(2S)-4-Amino-2-[[(2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-5-carbamimidamido-2-[[(2S)-2,5-diamino-5-oxopentanoyl]amino]pentanoyl]amino]-3-phenylpropanoyl]amino]-3-methyl-3-sulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-3-(4-hydroxy-2-nitrophenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoyl]amino]-4-oxobutanoyl]amino]acetyl]pyrrolidine-2-carboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL499946; BDBM50270936
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| Activity |
IC50 ~ 125000 nM
|
[1] | |||
| Compound Name |
(2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-methyl-3-sulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]amino]-3-(1H-pyrrol-3-yl)propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]-methylamino]acetyl]-methylamino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL510720; BDBM50270949
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|
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| Activity |
IC50 = 150000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 3 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Ctghfgglypcngp
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL525216; BDBM50270789
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|
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| Activity |
IC50 = 239000 nM
|
[1] | |||
| Compound Name |
(2R)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-[[(2S)-2-[[2-[[(2S,3R)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-3-phenylpropanoyl]amino]-3-methyl-3-sulfanylbutanoyl]amino]-3-hydroxybutanoyl]amino]acetyl]-methylamino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-phenylpropanoyl]amino]acetyl]amino]acetyl]amino]-4-methylpentanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-sulfanylpropanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL444490; BDBM50270824
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| Activity |
IC50 > 250000 nM
|
[1] | |||
| Compound Name |
Tghfgglyp
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL498954; BDBM50270792
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| Activity |
IC50 > 250000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Structure-activity relationships of a peptide inhibitor of the human FcRn:human IgG interaction. Bioorg Med Chem. 2008 Jun 15;16(12):6394-405. | ||||
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