Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T04689 | Target Info | |||
| Target Name | Neuronal acetylcholine receptor alpha-1 (CHRNA1) | ||||
| Synonyms |
CHNRA; Acetylcholine receptor subunit alpha; ACHRA
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| Target Type | Successful Target | ||||
| Gene Name | CHRNA1 | ||||
| Biochemical Class | Neurotransmitter receptor | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 4 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Nicotine
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Approved | Compound Info | ||
| Synonyms |
Habitrol; Micotine; NCT; NICOTINE AND SALTS; Nicoderm Patch; Nicotina [Italian]; Nicotine Patch; Nicotine [USAN]; Nicotine replacement patch; Nicotine solution; Nictoine patch; Nikotin [German]; Nikotyna [Polish]; Transdermal Nicotine; Nicotine [UN1654] [Poison]; ENT 3,424; Habitrol (TN); Nicorette (TN); Nicotine (USP); Nicotine (compounds related to); Nicotine [BSI:ISO]; L(-)-nicotine; Beta-Pyridyl-alpha-N-methyl pyrrolidine; (-)-Nicotine solution; (2S) 3-(1-Methyl-pyrrolidin-2-yl)-pyridine; (S)-(-)-NICOTINE, 3-[(2S)-1-METHYL-2-PYRROLIDINYL] PYRIDINE; (S)-(-)-Nicotine; (S)-3-(1-methylpyrrolidin-2-yl)pyridine; (S)-3-(N-methylpyrrolidin-2-yl)pyridine; (S)-Nicotine; 3-(2-(N-methylpyrrolidinyl))pyridine; 3-(N-Methylpyrollidino)pyridine; 3-(N-Methylpyrrolidino)pyridine; 3-[(2S)-1-methylpyrrolidin-2-yl]pyridine
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| Activity |
EC50 = 180000 nM
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[1] | |||
| Compound Name |
Hexahydropyrimidine2nitromethylene16chloro3pyrid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2270633; SCHEMBL888464; DTXSID80876386; BDBM50487992
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| Activity |
IC50 = 81000 nM
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[2] | |||
| Compound Name |
2-((S)-1-Methyl-pyrrolidin-2-yl)-furo[3,2-b]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL93883; SCHEMBL7850128; BDBM50290628; 2-[(2S)-1-methylpyrrolidin-2-yl]furo[3,2-b]pyridine
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| Activity |
EC50 ~ 100000 nM
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[1] | |||
| Compound Name |
Thiacloprid
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Investigative | Compound Info | ||
| Synonyms |
Calypso; (Z)-thiacloprid; (3-((6-Chloro-3-pyridinyl)methyl)-2-thiazolidinylidene)cyanamide; (E)-thiacloprid; UNII-DSV3A944A4; [3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene]cyanamide; Cyanamide, [3-[(6-chloro-3-pyridinyl)methyl]-2-thiazolidinylidene]-; CHEMBL451432; DSV3A944A4; {(2Z)-3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene}cyanamide; {3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene}cyanamide; Calypso 70WG; [3-(6-Chloro-3-pyridinylmethyl)-2-thiazolidinylidene]cyanamide; [3-[(6-chloro-3-pyridinyl)methyl]-2-thiazolidinylidene]cyanamide; Thiacloprid [ISO:BSI]; Cyanamide, (3-((6-chloro-3-pyridinyl)methyl)-2-thiazolidinylidene)-; HSDB 7268; (Z)-[3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene]cyanamide; DSSTox_CID_14961; DSSTox_RID_79228; DSSTox_GSID_34961; SCHEMBL26490; SCHEMBL26491; SCHEMBL237347; DTXSID7034961; CTK8G5807; HY-B1953; Tox21_300697; BDBM50251868; MFCD09028056; ZINC13828082; AKOS015897524; ZINC100057010; ZINC255976955; DB08620; CID 6011129; NCGC00164441-01; NCGC00164441-02; NCGC00164441-03; NCGC00164441-04; NCGC00254605-01; AS-35094; AT-19629; Thiacloprid 10 microg/mL in Acetonitrile; DB-017476; CS-0014056; FT-0657423; C18512; Thiacloprid, PESTANAL(R), analytical standard; 988T499; A802461; Q416283; J-002682; Q63408702; Thiacloprid, certified reference material, TraceCERT(R); N-(3-((6-Chloropyridin-3-yl)methyl)thiazolidin-2-ylidene)cyanamide; (E)-[3-[(6-chloropyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene]cyanamide; (E)-N-(3-((6-chloropyridin-3-yl)methyl)thiazolidin-2-ylidene)cyanamide; (Z)-3-(6-chloro-3-pyridylmethyl)-1,3-thiazolidin-2-ylidenecyanamide; (Z)-N-(3-((6-Chloropyridin-3-yl)methyl)thiazolidin-2-ylidene)cyanamide; [3-[(6-chloranylpyridin-3-yl)methyl]-1,3-thiazolidin-2-ylidene]cyanamide; N-(3-(6-chloro-pyridin-3-ylmethyl)-thiazolidin-2-ylidene)-cyanamide
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| Activity |
IC50 = 120000 nM
|
[2] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
ABT-418
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Discontinued in Phase 2 | Compound Info | ||
| Synonyms |
Abt-418; Abt 418; 147402-53-7; 3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole; CHEMBL274525; (S)-3-Methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole; (S)-3-methyl-5-(1-methylpyrrolidin-2-yl)isoxazole; C9H14N2O; Isoxazole, 3-methyl-5-((2S)-1-methyl-2-pyrrolidinyl)-; Isoxazole, 3-methyl-5-(1-methyl-2-pyrrolidinyl)-, (S)-; Isoxazole, 3-methyl-5-[(2S)-1-methyl-2-pyrrolidinyl]-; 3-methyl-5-[(2S)-1-methylpyrrolidin-2-yl]-1,2-oxazole; AC1L3OPH; SCHEMBL194161; DTXSID10163711; ILLGYRJAYAAAEW-QMMMGPOBSA-N; ZINC3786099; BDBM50035398
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| Activity |
EC50 = 411000 nM
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[1] | |||
| Compound Name |
(S)-2-Pyrrolidin-2-yl-furo[3,2-b]pyridine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL91005; SCHEMBL7842456; BDBM50290629; 2-[(2S)-pyrrolidin-2-yl]furo[3,2-b]pyridine; Furo[3,2-b]pyridine, 2-(2S)-2-pyrrolidinyl-
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| Activity |
EC50 > 1000000 nM
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[1] | |||
| References | Top | ||||
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| REF 1 | Novel 2-(2'-furo[3,2-b]pyridinyl) pyrrolidines: potent neuronal nicotinic acetylcholine receptor ligands. Bioorg Med Chem Lett. 1997 Nov 4;7(21):2703-8. | ||||
| REF 2 | Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors. J Agric Food Chem. 2000 Dec;48(12):6016-24. | ||||
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