Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T03500 | Target Info | |||
| Target Name | Matrix metalloproteinase-12 (MMP-12) | ||||
| Synonyms |
Macrophage metalloelastase; Macrophage elastase; MME; ME; HME
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|
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| Target Type | Clinical trial Target | ||||
| Gene Name | MMP12 | ||||
| Biochemical Class | Peptidase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 117 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Clodronate
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|
Approved | Compound Info | ||
| Synonyms |
Bonefos; Clodronsaeure; Dichloromethanediphosphonate; Dichloromethylenebisphosphonate; Methanedichlorodiphosphonate; Acide clodronique; Acido clodronico; Acidum clodronicum; Clodronic Acid; Dichloromethanediphosphonic acid; Dichloromethylene Biphosphonate; Dichloromethylene Diphosphonate; Dichloromethylidene diphosphonate; Liposomes containing clodronic acid; Methanedichlorodiphosphonic acid; Acid, Clodronic; Acid, Dichloromethanediphosphonic; Acide clodronique [INN-French]; Acido clodronico [INN-Spanish]; Acidum clodronicum [INN-Latin]; Biphosphonate, Dichloromethylene; Bonefos (TN); Clodron (TN); Diphosphonate, Dichloromethane; Diphosphonate, Dichloromethylene; Disodium, Clodronate; Loron (TN); Sodium, Clodronate; [dichloro(phosphono)methyl]phosphonic acid; Clodronic acid (USAN/INN); Clodronic acid [USAN:BAN:INN]; Dichlormethylen-bis(phosphonsaeure); Dichloromethylene-1,1-bisphosphonic acid; Dichloromethylene-1,1-diphosphonic acid; Phosphonic acid, (dichloromethylene)di-(8CI); (Dichloro-phosphono-methyl)-phosphonic acid; (Dichloromethylene)bisphosphonic acid; (Dichloromethylene)diphosphonic acid; (Lip-C); (dichloromethanediyl)bis(phosphonic acid)
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| Activity |
IC50 = 121000 nM
|
[1] | |||
| Compound Name |
Cis-2-aminocyclohexylcarbamoylphosphonic acid
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Investigative | Compound Info | ||
| Synonyms |
cis-ACCP; cis-2-aminocyclohexylcarbamoylphosphonic acid; 777075-44-2; CHEMBL270083; SCHEMBL569075; C7H15N2O4P; CTK8E9417; MolPort-039-139-066; BDBM50234465; 1683AH; ZINC29134634
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
(R)-2-(4-Fluoro-3,5-dimethylphenylamino)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1269994; SCHEMBL4738506; BDBM50329265; (2R)-2-(4-fluoro-3,5-dimethylanilino)-6-[(4-fluorophenyl)methylamino]-N-hydroxyhexanamide
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(S)-2-(4-Fluoro-3,5-dimethylbenzyl)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1760324; SCHEMBL3436885; BDBM50340754; (2S)-2-[(4-fluoro-3,5-dimethylphenyl)methyl]-6-[(4-fluorophenyl)methylamino]-N-hydroxyhexanamide
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(2R,3R)-4-(2-(3-Chlorophenyl)pyrrolidin-1-yl)-2,3-dihydroxy-4-oxo-N-(2-(thiophen-2-yl)ethyl)butanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL590343; SCHEMBL8217068; BDBM50309147
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| Activity |
Ki ~ 50000 nM
|
[4] | |||
| Compound Name |
(2R)-2-(4-Fluoro-3,5-dimethylphenoxy)-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012837; BDBM50379534
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(2S)-2-[(4-Fluoro-3,5-dimethylphenyl)methyl]-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2010824; BDBM50379535
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(2R)-2-(4-Fluoro-3,5-dimethylanilino)-6-[1-(4-fluorophenyl)propylamino]-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL2012836; BDBM50379536
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
(R)-2-(4-Fluoro-3,5-dimethylphenoxy)-6-(4-fluorobenzylamino)-N-hydroxyhexanamide
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1760322; BDBM50340768
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| Activity |
Ki ~ 50000 nM
|
[3] | |||
| Compound Name |
Cyclobutyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL251937; BDBM50227567
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| Activity |
IC50 = 51000 nM
|
[5] | |||
| Compound Name |
6-Mercapto-pyridine-2-carboxylic acid biphenyl-3-ylmethyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251426; BDBM50227601
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| Activity |
IC50 = 52000 nM
|
[5] | |||
| Compound Name |
3-Acetoxy-5-(biphenyl-4-yl)pentanoic acid
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL574445; SCHEMBL5694346; BDBM50300477; 3-acetyloxy-5-(4-phenylphenyl)pentanoic acid
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| Activity |
IC50 = 54400 nM
|
[6] | |||
| Compound Name |
2,4,5-Trifluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398450; BDBM50227548
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| Activity |
IC50 = 56000 nM
|
[5] | |||
| Compound Name |
4-(4,5-Dibromo-1H-pyrrol-2-yl)-1-methyl-1H-imidazo[4,5-c]pyridin-2-amine
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL394362; BDBM50215934
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| Activity |
IC50 = 56900 nM
|
[7] | |||
| Compound Name |
2,6-Difluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253375; BDBM50227604
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| Activity |
IC50 = 60000 nM
|
[5] | |||
| Compound Name |
1-Cinnamyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249249; BDBM50227597
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| Activity |
IC50 = 61000 nM
|
[5] | |||
| Compound Name |
Thiophen-3-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL398838; BDBM50227596
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| Activity |
IC50 = 62000 nM
|
[5] | |||
| Compound Name |
Perfluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL253820; BDBM50227562
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| Activity |
IC50 = 63000 nM
|
[5] | |||
| Compound Name |
[4-(Trifluoromethyl)phenyl]methyl 6-oxo-1H-pyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL1162966; BDBM50371234
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| Activity |
IC50 = 64000 nM
|
[5] | |||
| Compound Name |
4-Fluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253374; BDBM50227557
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|
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| Activity |
IC50 = 65000 nM
|
[5] | |||
| Compound Name |
Thiophen-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254039; BDBM50227537
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| Activity |
IC50 = 65000 nM
|
[5] | |||
| Compound Name |
3-Methylbut-2-enyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254627; BDBM50227565
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| Activity |
IC50 = 67000 nM
|
[5] | |||
| Compound Name |
Isopropyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL445939; BDBM50227603
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| Activity |
IC50 = 67000 nM
|
[5] | |||
| Compound Name |
Phenethyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL255051; BDBM50227541
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|
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| Activity |
IC50 = 68000 nM
|
[5] | |||
| Compound Name |
2-Chlorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399685; BDBM50227554
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| Activity |
IC50 = 68000 nM
|
[5] | |||
| Compound Name |
Pentyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL252326; BDBM50227593
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| Activity |
IC50 = 68000 nM
|
[5] | |||
| Compound Name |
2-Fluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253373; BDBM50227552
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|
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| Activity |
IC50 = 68000 nM
|
[5] | |||
| Compound Name |
Benzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL399070; SCHEMBL20083642; BDBM50227551; benzyl 6-oxo-1H-pyridine-2-carboxylate
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| Activity |
IC50 = 69000 nM
|
[5] | |||
| Compound Name |
6-Oxo-1,6-dihydro-pyridine-2-carboxylic acid 4-methyl-benzyl ester
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253801; BDBM50227586
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| Activity |
IC50 = 69000 nM
|
[5] | |||
| Compound Name |
3-Methoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252965; BDBM50227578
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| Activity |
IC50 = 69000 nM
|
[5] | |||
| Compound Name |
6-Mercapto-pyridine-2-carboxylic acid 3-methyl-benzyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254403; BDBM50227572
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| Activity |
IC50 = 70000 nM
|
[5] | |||
| Compound Name |
Cinnamyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254657; BDBM50227587
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| Activity |
IC50 = 70000 nM
|
[5] | |||
| Compound Name |
3-Phenoxybenzyl 6-mercaptopicolinate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL250069; BDBM50227575
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| Activity |
IC50 = 71000 nM
|
[5] | |||
| Compound Name |
But-2-ynyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254837; BDBM50227600
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| Activity |
IC50 = 71000 nM
|
[5] | |||
| Compound Name |
Cyclohexyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254838; BDBM50227583
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| Activity |
IC50 = 71000 nM
|
[5] | |||
| Compound Name |
Furan-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254821; BDBM50227529
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| Activity |
IC50 = 76000 nM
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[5] | |||
| Compound Name |
3-Methoxybenzyl 6-mercaptopicolinate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254406; BDBM50227568
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| Activity |
IC50 = 78000 nM
|
[5] | |||
| Compound Name |
4-Phenoxybutyl 6-mercaptopicolinate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254610; BDBM50227602
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| Activity |
IC50 = 78000 nM
|
[5] | |||
| Compound Name |
2-Phenoxyethyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL438519; BDBM50227595
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| Activity |
IC50 = 79000 nM
|
[5] | |||
| Compound Name |
6-Mercapto-pyridine-2-carboxylic acid 4-methyl-benzyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254404; BDBM50227582
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| Activity |
IC50 = 81000 nM
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[5] | |||
| Compound Name |
Benzyl 6-mercaptopicolinate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL402720; BDBM50227533
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| Activity |
IC50 = 82000 nM
|
[5] | |||
| Compound Name |
4-Phenoxybutyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL253372; BDBM50227559
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| Activity |
IC50 = 82000 nM
|
[5] | |||
| Compound Name |
3-(Trifluoromethyl)benzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL254006; BDBM50227549
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| Activity |
IC50 = 82000 nM
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[5] | |||
| Compound Name |
3-Phenylpropyl 6-mercaptopicolinate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL252523; BDBM50227542
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| Activity |
IC50 = 85000 nM
|
[5] | |||
| Compound Name |
Cyclohexyl 6-mercaptopicolinate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL442286; BDBM50227588
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| Activity |
IC50 = 87000 nM
|
[5] | |||
| Compound Name |
2-(2-(4-Methoxyphenylsulfonyl)phenyl)acetic Acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL585376; BDBM50299069
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| Activity |
IC50 = 89000 nM
|
[8] | |||
| Compound Name |
Thiophen-3-yl 6-mercaptopicolinate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL399999; BDBM50227561
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| Activity |
IC50 = 93000 nM
|
[5] | |||
| Compound Name |
4-(Trifluoromethyl)benzyl 6-mercaptopicolinate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL398662; BDBM50227544
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| Activity |
IC50 = 94000 nM
|
[5] | |||
| Compound Name |
Chembl4163839
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Investigative | Compound Info | ||
| Synonyms |
BDBM50278363
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| Activity |
IC50 = 95200 nM
|
[9] | |||
| Compound Name |
4-Methoxybenzyl 6-mercaptopicolinate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL399908; BDBM50227579
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| Activity |
IC50 = 96000 nM
|
[5] | |||
| Compound Name |
Naphthalen-2-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL253188; BDBM50227545
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| Activity |
IC50 = 97000 nM
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[5] | |||
| Compound Name |
6-Oxo-1,6-dihydro-pyridine-2-carboxylic acid biphenyl-3-ylmethyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL253835; BDBM50227553
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| Activity |
IC50 = 99000 nM
|
[5] | |||
| Compound Name |
4-(5-Bromo-4-methyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL571149; BDBM50301408; 4-(4-Methyl-5-bromo-1H-pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-(4,5-Dibromo-1H-pyrrol-2-yl)-N,1-dimethyl-1H-imidazo[4,5-c]pyridin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL230084; BDBM50215929
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| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-[3,5-Dibromo-4-[2-(trifluoromethyl)phenethyl]-1H-pyrrole-2-yl]-1H-imidazo[4,5-c]pyridine-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL572244; BDBM50301415; 4-(3,5-dibromo-4-(2-(trifluoromethyl)phenethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
5-Chloro-2-oxo-1,2,3,4-tetrahydroquinazoline-3-acetohydroxamic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL298647; BDBM50100095; 2-(5-Chloro-2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-N-hydroxy-acetamide
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| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
4-(5-Bromo-4-(3-phenylpropyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL583670; BDBM50301418; 4-[4-(3-Phenylpropyl)-5-bromo-1H-pyrrole-2-yl]-1H-imidazo[4,5-c]pyridine-2-amine
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-(4-Methylphenoxy)-N-(4-pyridinylmethyl)benzenecarboxamide
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Investigative | Compound Info | ||
| Synonyms |
MLS000755676; SMR000337350; 4-(4-methylphenoxy)-N-[(pyridin-4-yl)methyl]benzamide; 4-(4-methylphenoxy)-N-(pyridin-4-ylmethyl)benzamide; CHEMBL1427458; BDBM46421; cid_4358655; HMS2618P15; KS-00003O5G; ZINC4054502; AKOS005107358; MCULE-5269053313; MS-1279; 4-(4-methylphenoxy)-N-(4-pyridylmethyl)benzamide
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| Activity |
IC50 ~ 100000 nM
|
[12] | |||
| Compound Name |
1-[[2-(4-Chlorophenoxy)acetyl]amino]-3-(4-cyclohexylbutyl)thiourea
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2437163; BDBM50441574
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| Activity |
IC50 ~ 100000 nM
|
[13] | |||
| Compound Name |
4-(4-Benzyl-5-bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL579026; BDBM50301411; 4-(4-Benzyl-5-bromo-1H-pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
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| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-[4-[2-[(3S)-3-Hydroxy-1-azabicyclo[2.2.2]octan-3-yl]ethynyl]phenoxy]-N-methylbenzamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL1940296; BDBM50419619
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| Activity |
IC50 ~ 100000 nM
|
[14] | |||
| Compound Name |
(E)-N-Hydroxy-3-[4-(trifluoromethyl)phenyl]acrylamide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3394285; SCHEMBL12425758; BDBM50140176; (E)-3-[4-(trifluoromethyl)phenyl]prop-2-enehydroxamic acid
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| Activity |
IC50 ~ 100000 nM
|
[15] | |||
| Compound Name |
[(4S,5S)-2-(4-Nitro-phenyl)-5-vinyl-4,5-dihydro-oxazol-4-yl]-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364775; BDBM50152643
Click to Show/Hide
|
||||
| Activity |
Ki ~ 100000 nM
|
[16] | |||
| Compound Name |
4-(3,5-Dibromo-4-(3-phenylpropyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL583673; BDBM50301419
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-(3,5-Dibromo-4-(3-(trifluoromethyl)phenethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL571601; BDBM50301416
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-(4-Bromo-5-methyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL576790; BDBM50301403
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-(5-(Biphenyl-4-yl)-4-bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL569118; BDBM50301407
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-(3,4-Dibromo-5-methyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL578412; BDBM50301404
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-(3,5-Dibromo-4-(4-(trifluoromethyl)phenethyl)-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL571388; BDBM50301417
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-(4,5-Dibromo-1H-pyrrol-2-yl)-N,N-dimethyl-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230085; BDBM50215925
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
2,5-Difluorobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399304; BDBM50227547
Click to Show/Hide
|
||||
| Activity |
IC50 = 100000 nM
|
[5] | |||
| Compound Name |
trans-2-Aminocyclohexylcarbamoylphosphonic acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL270296; SCHEMBL4854279; BDBM50372742; ZINC29134636; [(1R,2R)-2-aminocyclohexyl]carbamoylphosphonic acid
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[17] | |||
| Compound Name |
4-(5-(Biphenyl-3-yl)-4-bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL570917; BDBM50301406
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-(4,5-Dibromo-3-phenethyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL582812; BDBM50301420
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-(4-Bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL231012; BDBM50215928; 4-(4-Bromo-1H-pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
Benzyl 6-Benzyl-5,7-Dioxo-6,7-Dihydro-5h-[1,3]thiazolo[3,2-C]pyrimidine-2-Carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
PD-503; CHEMBL409536; SCHEMBL5957461; PD503; BDBM50234334; ZINC29133346; DB08561; Q27097766
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[18] | |||
| Compound Name |
(5-Chloro-3,4-dihydro-1H-2,1,3-benzothiadiazine-3-acetohydroxamic acid)2,2-dioxide
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL299946; BDBM50100097; 2-(5-Chloro-2,2-dioxo-1,4-dihydro-2H-2lambda*6*-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamide
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[11] | |||
| Compound Name |
4-(5-Bromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL395799; BDBM50215930; 4-(5-Bromo-1H-pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-{[1-Methyl-2,4-Dioxo-6-(3-Phenylprop-1-Yn-1-Yl)-1,4-Dihydroquinazolin-3(2h)-Yl]methyl}benzoic Acid
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL496942; MMP Inhibitor, 5; SCHEMBL6244295; ZINC3815953; BDBM50265079; DB07827; DB-123234; SR-03000000793-1; Q27097037
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[19] | |||
| Compound Name |
4-(4-Bromo-5-phenyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL571814; BDBM50301405
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-(1H-Pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-ylamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230194; BDBM50215927; 4-(1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine; 4-(1H-Pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
4-(4-Benzyl-3,5-dibromo-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL572027; BDBM50301412; 4-(4-Benzyl-3,5-dibromo-1H-pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[10] | |||
| Compound Name |
4-(1-Methyl-4,5-dibromo-1H-pyrrole-2-yl)-1H-imidazo[4,5-c]pyridine-2-amine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL230196; BDBM50215932; 4-(4,5-dibromo-1-methyl-1H-pyrrol-2-yl)-1H-imidazo[4,5-c]pyridin-2-amine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 100000 nM
|
[7] | |||
| Compound Name |
Chembl4160618
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278364
Click to Show/Hide
|
||||
| Activity |
IC50 = 100100 nM
|
[9] | |||
| Compound Name |
Naphthalen-2-yl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251424; BDBM50227584
Click to Show/Hide
|
||||
| Activity |
IC50 = 101000 nM
|
[5] | |||
| Compound Name |
Hexyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249859; BDBM50227581
Click to Show/Hide
|
||||
| Activity |
IC50 = 105000 nM
|
[5] | |||
| Compound Name |
4-Methoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253172; BDBM50227538
Click to Show/Hide
|
||||
| Activity |
IC50 = 105000 nM
|
[5] | |||
| Compound Name |
Benzo[d][1,3]dioxol-5-ylmethyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL253189; BDBM50227540
Click to Show/Hide
|
||||
| Activity |
IC50 = 105000 nM
|
[5] | |||
| Compound Name |
4-Bromobenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254448; BDBM50227563
Click to Show/Hide
|
||||
| Activity |
IC50 = 105000 nM
|
[5] | |||
| Compound Name |
2,4,5-Trifluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250059; BDBM50227592
Click to Show/Hide
|
||||
| Activity |
IC50 = 106000 nM
|
[5] | |||
| Compound Name |
4-Phenoxybenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250070; BDBM50227532
Click to Show/Hide
|
||||
| Activity |
IC50 = 109000 nM
|
[5] | |||
| Compound Name |
Chembl4164016
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278389
Click to Show/Hide
|
||||
| Activity |
IC50 = 109100 nM
|
[9] | |||
| Compound Name |
Naphthalen-1-yl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399504; BDBM50227555
Click to Show/Hide
|
||||
| Activity |
IC50 = 111000 nM
|
[5] | |||
| Compound Name |
4-Fluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250057; BDBM50227527
Click to Show/Hide
|
||||
| Activity |
IC50 = 112000 nM
|
[5] | |||
| Compound Name |
4-Chlorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251081; BDBM50227556
Click to Show/Hide
|
||||
| Activity |
IC50 = 115000 nM
|
[5] | |||
| Compound Name |
Phenethyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252522; BDBM50227599
Click to Show/Hide
|
||||
| Activity |
IC50 = 117000 nM
|
[5] | |||
| Compound Name |
3-Phenoxybenzyl 6-oxo-1,6-dihydropyridine-2-carboxylate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254038; BDBM50227574
Click to Show/Hide
|
||||
| Activity |
IC50 = 118000 nM
|
[5] | |||
| Compound Name |
2,6-Difluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250058; BDBM50227531
Click to Show/Hide
|
||||
| Activity |
IC50 = 127000 nM
|
[5] | |||
| Compound Name |
3-(Trifluoromethyl)benzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254405; BDBM50227535
Click to Show/Hide
|
||||
| Activity |
IC50 = 134000 nM
|
[5] | |||
| Compound Name |
6-Mercapto-pyridine-2-carboxylic acid biphenyl-4-ylmethyl ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251425; BDBM50227590
Click to Show/Hide
|
||||
| Activity |
IC50 = 135000 nM
|
[5] | |||
| Compound Name |
Isopropyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL404205; BDBM50227591
Click to Show/Hide
|
||||
| Activity |
IC50 = 146000 nM
|
[5] | |||
| Compound Name |
3-((2-Phenethyl-2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251465; BDBM50227530
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
Naphthalen-1-yl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL251423; BDBM50227543
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
4-(4,5-Dihydrooxazol-2-yl)-1-phenethyl-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400851; BDBM50227577
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
1-Cyclohexenyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249860; BDBM50227560
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
4-(4,5-Dihydrooxazol-2-yl)-1-(3-phenylpropyl)-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249863; BDBM50227536
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
2-Bromobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399997; BDBM50227598
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
3-((2-Benzyl-2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400357; BDBM50227573
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
4-(4,5-Dihydrooxazol-2-yl)-1-hexyl-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249861; BDBM50227550
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
(E)-3-((2-Cinnamyl-2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL428762; BDBM50227546
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
4-(4,5-Dihydrooxazol-2-yl)-1-heptyl-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400850; BDBM50227570
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
5-(3-Pyridylmethyl)-1H-tetrazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399998; 3-(2H-tetrazol-5-ylmethyl)pyridine; BDBM50227558; AKOS000262059; 3-((2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
1-Benzyl-4-(4,5-dihydrooxazol-2-yl)-1H-1,2,3-triazole
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249862; BDBM50227566; J3.517.457E; 1-Benzyl-4-(2-oxazoline-2-yl)-1H-1,2,3-triazole
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
Cyclobutyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL252327; BDBM50227539
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
3-((2-(3-Phenylpropyl)-2H-tetrazol-5-yl)methyl)pyridine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL400358; BDBM50227594
Click to Show/Hide
|
||||
| Activity |
IC50 ~ 150000 nM
|
[5] | |||
| Compound Name |
3-Fluorobenzyl 6-mercaptopicolinate
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL254611; BDBM50227528
Click to Show/Hide
|
||||
| Activity |
IC50 = 151000 nM
|
[5] | |||
| Compound Name |
Chembl4162521
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50278366
Click to Show/Hide
|
||||
| Activity |
IC50 = 198300 nM
|
[9] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 17 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Chembl4202548
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
BDBM50455850
Click to Show/Hide
|
||||
| Activity |
IC50 = 230000 nM
|
[20] | |||
| Compound Name |
[(4S,5S)-2-(4-Bromo-phenyl)-5-vinyl-4,5-dihydro-oxazol-4-yl]-methanol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL181707; BDBM50152634
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[16] | |||
| Compound Name |
3,2-Diguanidinoneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
3,2'-diguanidinoneamine; CHEMBL215074; BDBM12005; Neamine guanidinylated deriv. 21
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[21] | |||
| Compound Name |
Neamine guanidinylated deriv. 29
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215715; BDBM12012; 1,3,2,6-Tetraguanidino-5,6,3,4-tetramethoxylneamine
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[21] | |||
| Compound Name |
(4S,5S)-2-p-Tolyl-5-vinyl-4,5-dihydro-oxazole-4-thiol
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL362099; BDBM50152637
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[16] | |||
| Compound Name |
Thioacetic acid S-[(4S,5S)-2-((E)-styryl)-5-vinyl-4,5-dihydro-oxazol-4-yl] ester
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL364212; BDBM50152631
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[16] | |||
| Compound Name |
Neamine guanidinylated deriv. 4
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL215269; 1,3,2,6-Tetraguanidinoneamine; BDBM11997; 1,3,2',6'-tetraguanidinoneamine
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[21] | |||
| Compound Name |
1,3,2-Triguanidinoneamine
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
1,3,2'-triguanidinoneamine; CHEMBL438810; BDBM12008; Neamine guanidinylated deriv. 23
Click to Show/Hide
|
||||
| Activity |
Ki > 300000 nM
|
[21] | |||
| Compound Name |
6-Methyl-2H-1,4-benzoxazin-3(4H)-one
Click to Show/Hide
|
Investigative | Compound Info | ||
| Synonyms |
6-methyl-2H-benzo[b][1,4]oxazin-3(4H)-one; 6-methyl-4H-1,4-benzoxazin-3-one; CHEMBL485691; 2H-1,4-Benzoxazine-3(4H)-one, 6-methyl-; 6-METHYL-4H-BENZO[1,4]OXAZIN-3-ONE; 6-Methyl-2H-1,4-benzoxazine-3(4H)-one; 6-methyl-2,4-dihydro-1,4-benzoxazin-3-one; SCHEMBL279594; CTK4I1476; DTXSID20192653; KS-00001W0X; ZINC3883825; 2427AE; BDBM50270676; MFCD01321311; SBB087684; STK317994; AKOS003392315; AB09061; CCG-321495; MCULE-8315381896; ST095737; 2H-1,4-Benzoxazin-3(4H)-one,6-methyl-; 6-Methyl-2H-1,4-benzooxazine-3(4H)-one; CS-0085207; EU-0063551; FT-0680323; 6-methyl-2H,4H-benzo[e]1,4-oxazin-3-one; A-8067; 3W-0266; 6-Methyl-2H-1,4-benzoxazin-3(4H)-one, 98%; 6-methyl-2H,4H-benzo[e]1,4-oxazaperhydroin-3-one; J-518885; 6-METHYL-3,4-DIHYDRO-2H-1,4-BENZOXAZIN-3-ONE
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| Activity |
IC50 = 355000 nM
|
[22] | |||
| Compound Name |
Chembl4170455
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Investigative | Compound Info | ||
| Synonyms |
BDBM50278367
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| Activity |
IC50 = 493200 nM
|
[9] | |||
| Compound Name |
Chembl4175156
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Investigative | Compound Info | ||
| Synonyms |
BDBM50278390
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| Activity |
IC50 = 493250 nM
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[9] | |||
| Compound Name |
Chembl4171886
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Investigative | Compound Info | ||
| Synonyms |
BDBM50278388
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| Activity |
IC50 > 500000 nM
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[9] | |||
| Compound Name |
Chembl4167291
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Investigative | Compound Info | ||
| Synonyms |
BDBM50278365
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| Activity |
IC50 > 500000 nM
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[9] | |||
| Compound Name |
8-Chloro-2-methyl-4H-thiochromeno[4,3-c]pyrazole
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL503690; SCHEMBL10368093; HMS1668P10; ZINC111396; BDBM50270674; CCG-245176; MCULE-2692189474; 8-chloro-2-methyl-2,4-dihydrothiochromeno[4,3-c]pyrazole
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| Activity |
IC50 = 1000000 nM
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[22] | |||
| Compound Name |
((4S,5S)-2-Phenyl-5-vinyl-4,5-dihydro-oxazol-4-yl)-methanol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL360509; BDBM50152639
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| Activity |
Ki > 2000000 nM
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[16] | |||
| Compound Name |
5-Methoxybenzimidazole
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Investigative | Compound Info | ||
| Synonyms |
5-methoxy-1H-benzo[d]imidazole; 5-Methoxy-1H-benzimidazole; 6-methoxy-1H-benzimidazole; 1H-Benzimidazole, 5-methoxy-; 6-methoxy-1h-benzoimidazole; MFCD00272526; 5-Methoxybenzimidazole, 97%; CHEMBL449325; EINECS 225-502-9; 5-Methoxybenzimazole; PubChem7662; 5-methoxybenzoimidazole; 5-methoxy-benzimidazole; ACMC-20am2i; 5-methoxy-1H-bezimidazole; 1H-Benzimidazole,6-methoxy-; SCHEMBL225931; 5-Methoxy-1H-benzimidazole #; 5-methoxy-1H-1,3-benzodiazole; CTK4J1024; DTXSID60197622; 1H-Benzo[d]imidazole, 5-methoxy; ALBB-022267; ZINC5424660; BDBM50270673; SBB086586; AKOS006243257; AKOS008967364; CS-W010985; DB04130; DS-4350; MCULE-8117732950; 2-(4-CYANOPHENYL)-13-DIOXOLANE; AK115930; SY042564; AB0032844; FT-0620563; R2781; ST50824121; X6271; Z-8187; 887M803; W-202866; Q27455905
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| Activity |
IC50 = 2000000 nM
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[22] | |||
| Compound Name |
6-(2-Methyl-1,3-thiazol-4-yl)-3,4-dihydro-1H-quinolin-2-one
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL485690; Maybridge1_001848; Oprea1_873512; MLS000851068; SCHEMBL7314031; HMS546L22; HMS2806P14; ZINC132405; BDBM50270675; AKOS001304252; CCG-234168; MCULE-9519526549; SMR000457311; 6-(2-methylthiazol-4-yl)-3,4-dihydroquinolin-2(1H)-one; 6-(2-methyl-1,3-thiazol-4-yl)-1,2,3,4-tetrahydro-2-quinolinone
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| Activity |
IC50 = 5000000 nM
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[22] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Platinum complexes can inhibit matrix metalloproteinase activity: platinum-diethyl[(methylsulfinyl)methyl]phosphonate complexes as inhibitors of matrix metalloproteinases 2, 3, 9, and 12. J Med Chem. 2007 Jul 26;50(15):3434-41. | ||||
| REF 2 | Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg Med Chem. 2008 Oct 1;16(19):8781-94. | ||||
| REF 3 | Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain. Bioorg Med Chem Lett. 2012 Mar 15;22(6):2242-6. | ||||
| REF 4 | The discovery of novel tartrate-based TNF-alpha converting enzyme (TACE) inhibitors. Bioorg Med Chem Lett. 2010 Feb 1;20(3):1189-93 | ||||
| REF 5 | Synthesis and evaluation of novel heterocyclic MMP inhibitors. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6864-70. | ||||
| REF 6 | The identification of beta-hydroxy carboxylic acids as selective MMP-12 inhibitors. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5760-3. | ||||
| REF 7 | Synthesis and matrix metalloproteinase (MMP)-12 inhibitory activity of ageladine A and its analogs. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4495-9. | ||||
| REF 8 | Design, synthesis, biological evaluation, and NMR studies of a new series of arylsulfones as selective and potent matrix metalloproteinase-12 inhib... J Med Chem. 2009 Oct 22;52(20):6347-61. | ||||
| REF 9 | A pentanoic acid derivative targeting matrix metalloproteinase-2 (MMP-2) induces apoptosis in a chronic myeloid leukemia cell line. Eur J Med Chem. 2017 Dec 1;141:37-50. | ||||
| REF 10 | Synthesis of novel ageladine A analogs showing more potent matrix metalloproteinase (MMP)-12 inhibitory activity than the natural product. Bioorg Med Chem Lett. 2009 Sep 15;19(18):5461-3. | ||||
| REF 11 | 2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-dioxo-1,4-dihydro-2H-2lambda6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as potent and selective peptide deformylase inhibitors. J Med Chem. 2001 Jun 7;44(12):1847-52. | ||||
| REF 12 | Selective non zinc binding inhibitors of MMP13. Bioorg Med Chem Lett. 2011 Jul 15;21(14):4215-9. | ||||
| REF 13 | Aggrecanase-2 inhibitors based on the acylthiosemicarbazide zinc-binding group. Eur J Med Chem. 2013 Nov;69:244-61. | ||||
| REF 14 | Lead optimisation of selective non-zinc binding inhibitors of MMP13. Part 2. Bioorg Med Chem Lett. 2012 Jan 1;22(1):271-7. | ||||
| REF 15 | Design and synthesis of an activity-based protein profiling probe derived from cinnamic hydroxamic acid. Bioorg Med Chem. 2016 Feb 15;24(4):686-92. | ||||
| REF 16 | Synthesis and evaluation of novel oxazoline MMP inhibitors. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4935-9. | ||||
| REF 17 | Carbamoylphosphonate matrix metalloproteinase inhibitors 6: cis-2-aminocyclohexylcarbamoylphosphonic acid, a novel orally active antimetastatic mat... J Med Chem. 2008 Mar 13;51(5):1406-14. | ||||
| REF 18 | Quinazolinones and pyrido[3,4-d]pyrimidin-4-ones as orally active and specific matrix metalloproteinase-13 inhibitors for the treatment of osteoarthritis. J Med Chem. 2008 Feb 28;51(4):835-41. | ||||
| REF 19 | Discovery and characterization of a novel inhibitor of matrix metalloprotease-13 that reduces cartilage damage in vivo without joint fibroplasia si... J Biol Chem. 2007 Sep 21;282(38):27781-91. | ||||
| REF 20 | Development of Thioaryl-Based Matrix Metalloproteinase-12 Inhibitors with Alternative Zinc-Binding Groups: Synthesis, Potentiometric, NMR, and Crystallographic Studies. J Med Chem. 2018 May 24;61(10):4421-4435. | ||||
| REF 21 | Selectively guanidinylated derivatives of neamine. Syntheses and inhibition of anthrax lethal factor protease. Bioorg Med Chem Lett. 2006 Oct 1;16(19):5183-9. | ||||
| REF 22 | Identification of MMP-12 inhibitors by using biosensor-based screening of a fragment library. J Med Chem. 2008 Jun 26;51(12):3449-59. | ||||
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