Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T02389 | Target Info | |||
| Target Name | HUMAN cysteinyl leukotriene receptor (CysLTR) | ||||
| Gene Name | CYSLTR1; CYSLTR2 | ||||
| Biochemical Class | G-protein coupled receptor 1 family | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 3 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
S136492
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|
Investigative | Compound Info | ||
| Synonyms |
(E)-2-(2-(quinolin-2-yl)vinyl)phenol; CHEMBL127545; 2-[(E)-2-(quinolin-2-yl)ethenyl]phenol; 143816-42-6; Quininib; 2-(2-(quinolin-2-yl)vinyl)phenol; (6E)-6-[(2E)-2-(1H-quinolin-2-ylidene)ethylidene]cyclohexa-2,4-dien-1-one; AC1OATYA; AC1NW9KR; Cambridge id 5719593; AC1NZV89; AC1Q791J; Quininib, > SCHEMBL10325190; CHEBI:133170; MolPort-001-824-964; MolPort-000-712-889; ZINC3882963; STL044348; BDBM50001270; 2-(2-Quinolin-2-yl-vinyl)-phenol; AKOS015955311; AKOS005697868; 2-[(E)-2-(quinolin-2-yl)vinyl]phenol
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
4-[(E)-2-(Quinolin-2-yl)ethenyl]phenol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL339304; 4-[2-(quinolin-2-yl)ethenyl]phenol; 4-((1E)-2-(2-quinolyl)vinyl)phenol; ImprimatinA3; NSC47971; 4-(2-Quinolin-2-yl-vinyl)-phenol; 2-(4-hydroxystyryl)quinoline; MLS000703752; DTXSID40421356; HMS2667C03; ZINC3953498; BDBM50230076; NSC-47971; SBB015339; STK830628; AKOS000267138; NE54144; Phenol, 4-[2-(2-quinolinyl)ethenyl]-; NS-03613; SMR000274117; 4-[(E)-2-(2-Quinolinyl)ethenyl]phenol #; ST50037900; EN300-36033; SR-01000484849; SR-01000484849-1
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| Compound Name |
2-[(E)-2-(2-Pyridinyl)vinyl]quinoline
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL127905; SCHEMBL22501436; ZINC6270035; BDBM50230048; 2-[(e)-2-(pyridin-2-yl)ethenyl]quinoline
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| Activity |
IC50 ~ 50000 nM
|
[1] | |||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Development of a novel series of styrylquinoline compounds as high-affinity leukotriene D4 receptor antagonists: synthetic and structure-activity studies leading to the discovery of (+-)-3-[[[3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl][[3- (dimethylamino)-3-oxopropyl]thio]methyl]thio]propionic acid. J Med Chem. 1992 Oct 16;35(21):3832-44. | ||||
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