Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T01865 | Target Info | |||
| Target Name | Plasmodium Hexose transporter 1 (Malaria ht1) | ||||
| Synonyms |
ht1; Putative sugar transporter; Hexose transporter
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| Target Type | Literature-reported Target | ||||
| Gene Name | Malaria ht1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 6 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(3R,4S,5R,6R)-6-(Hydroxymethyl)-4-(undec-10-enyloxy)-tetrahydro-2H-pyran-2,3,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL204300; BDBM50179102
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| Activity |
Ki = 53000 nM
|
[1] | |||
| Compound Name |
(3R,4S,5R,6R)-6-(Hydroxymethyl)-4-(5-phenylpentyloxy)-tetrahydro-2H-pyran-2,3,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL202645; BDBM50179108
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| Activity |
Ki = 64000 nM
|
[1] | |||
| Compound Name |
(3R,4S,5R,6R)-4-(5-(4-Butylphenyl)pentyloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-2,3,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL202600; BDBM50179099
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| Activity |
Ki = 81000 nM
|
[1] | |||
| Compound Name |
(3R,4S,5R,6R)-6-(Hydroxymethyl)-4-(8,8,9,9,10,10,11,11,12,12,13,13,13-tridecafluorotridecyloxy)-tetrahydro-2H-pyran-2,3,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL382864; BDBM50179095
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| Activity |
Ki = 130000 nM
|
[1] | |||
| Compound Name |
(3R,4S,5S,6R)-6-(Hydroxymethyl)-4-((Z)-20-((3S,4R,5R,6S)-2,3,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-4-yl)icos-10-enyl)-tetrahydro-2H-pyran-2,3,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203809; BDBM50179092
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|
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| Activity |
Ki = 140000 nM
|
[1] | |||
| Compound Name |
(3R,4S,5R,6R)-6-(Hydroxymethyl)-4-(8-phenyloctyloxy)-tetrahydro-2H-pyran-2,3,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL204221; BDBM50179106
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| Activity |
Ki = 148000 nM
|
[1] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 15 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
(3R,4S,5R,6R)-6-(Hydroxymethyl)-4-(octadecyloxy)-tetrahydro-2H-pyran-2,3,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL377704; BDBM50179096
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|
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| Activity |
Ki > 500000 nM
|
[1] | |||
| Compound Name |
(3R,4S,5R,6R)-6-(Hydroxymethyl)-4-(4,4,5,5,6,6,7,7,8,8,9,9,9-tridecafluorononyloxy)-tetrahydro-2H-pyran-2,3,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL204439; BDBM50179110; 3-O-(4,4,5,5,6,6,7,7,8,8,9,9,9-Tridecafluorononyl)-D-glucopyranose
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| Activity |
Ki > 500000 nM
|
[1] | |||
| Compound Name |
Methyl 16-((3R,4S,5R,6R)-2,3,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-4-yloxy)hexadec-8-ynoate
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203457; BDBM50179090
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|
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| Activity |
Ki > 500000 nM
|
[1] | |||
| Compound Name |
(3R,4S,5R,6R)-6-(Hydroxymethyl)-4-(tetradecyloxy)-tetrahydro-2H-pyran-2,3,5-triol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL204826; 3-O-Tetradecyl-D-glucopyranose; BDBM50179101
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|
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| Activity |
Ki > 500000 nM
|
[1] | |||
| Compound Name |
(2R,3S,4S,5R,6R)-2-(Hydroxymethyl)-6-(undec-10-enyloxy)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL248915; BDBM50216465
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|
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| Activity |
Ki > 500000 nM
|
[2] | |||
| Compound Name |
(3R,4S,5R,6R)-4-(7-(Allyloxy)heptyloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-2,3,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL204038; BDBM50179105
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|
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| Activity |
Ki > 500000 nM
|
[1] | |||
| Compound Name |
(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(undec-10-enyloxy)-tetrahydro-2H-pyran-3,4,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL250943; BDBM50216471
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|
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| Activity |
Ki > 500000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4R,5R)-2-((R)-1,2-Dihydroxyethyl)-5-(undec-10-enyloxy)-tetrahydrofuran-3,4-diol
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL249119; 10-Undecenyl beta-D-glucofuranoside; BDBM50216467
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| Activity |
Ki > 500000 nM
|
[2] | |||
| Compound Name |
(2R,3R,4R,5S)-2-((R)-1,2-Dihydroxyethyl)-5-(undec-10-enyloxy)-tetrahydrofuran-3,4-diol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL399874; 10-Undecenyl alpha-D-glucofuranoside; BDBM50216470
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| Activity |
Ki > 500000 nM
|
[2] | |||
| Compound Name |
(3R,4S,5R,6R)-4-(2-(Allyloxy)ethoxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-2,3,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL204636; BDBM50179104
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|
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| Activity |
Ki > 500000 nM
|
[1] | |||
| Compound Name |
(3R,4S,5R,6R,E)-4-(Hexadec-7-enyloxy)-6-(hydroxymethyl)-tetrahydro-2H-pyran-2,3,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL204151; BDBM50179107
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|
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| Activity |
Ki > 500000 nM
|
[1] | |||
| Compound Name |
(3R,4S,5S,6R)-6-(Hydroxymethyl)-4-(20-((3S,4R,5R,6S)-2,3,5-trihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-4-yl)icosyl)-tetrahydro-2H-pyran-2,3,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL203509; BDBM50179089
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|
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| Activity |
Ki = 540000 nM
|
[1] | |||
| Compound Name |
(3R,4S,5R,6R)-6-(Hydroxymethyl)-4-(2-(non-8-enyloxy)ethoxy)-tetrahydro-2H-pyran-2,3,5-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL381073; BDBM50179103
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|
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| Activity |
Ki = 590000 nM
|
[1] | |||
| Compound Name |
(3R,4R,5S)-5-((R)-2-Hydroxy-1-(undec-10-enyloxy)ethyl)-tetrahydrofuran-2,3,4-triol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249475; BDBM50216466
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|
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| Activity |
Ki = 1500000 nM
|
[2] | |||
| Compound Name |
(3R,4S,5S,6R)-6-((Undec-10-enyloxy)methyl)-tetrahydro-2H-pyran-2,3,4,5-tetraol
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|
Investigative | Compound Info | ||
| Synonyms |
CHEMBL249476; BDBM50216469
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|
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| Activity |
Ki = 2000000 nM
|
[2] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Probing structure/affinity relationships for the Plasmodium falciparum hexose transporter with glucose derivatives. Bioorg Med Chem Lett. 2006 Mar 1;16(5):1267-71. | ||||
| REF 2 | Interaction of O-(undec-10-en)-yl-D-glucose derivatives with the Plasmodium falciparum hexose transporter (PfHT). Bioorg Med Chem Lett. 2007 Sep 1;17(17):4934-7. | ||||
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