Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
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| Target ID | T01521 | Target Info | |||
| Target Name | Glutathione S-transferase omega-1 (GSTO-1) | ||||
| Synonyms |
SPG-R; S-(Phenacyl)glutathione reductase; Monomethylarsonic acid reductase; MMA(V) reductase; Glutathione-dependent dehydroascorbate reductase; Glutathione S-transferase omega 1-1; GSTTLP28; GSTO-1; GSTO 1-1
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| Target Type | Preclinical Target | ||||
| Gene Name | GSTO1 | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 2 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Rifampin
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Approved | Compound Info | ||
| Synonyms |
Abrifam; Archidyn; Arficin; Arzide; Benemicin; Benemycin; Dipicin; Doloresum; Eremfat; Famcin; Fenampicin; RFP; RMP; Ramp; Rifa; Rifadin; Rifadine; Rifagen; Rifaldazin; Rifaldazine; Rifaldin; Rifam; Rifamor; Rifampicin; Rifampicina; Rifampicine; Rifampicinum; Rifamsolin; Rifaprodin; Rifcin; Rifinah; Rifobac; Rifoldin; Rifoldine; Riforal; Rimactan; Rimactane; Rimactazid; Rimactizid; Rimazid; Rimycin; Sinerdol; Tubocin; Rifamicin AMP; Rifampicin SV; Rifampicine [French]; Rifampin [USAN]; Rifamycin AMP; Ba 41166; AZT + Rifampin; BA-41166E; Ba 41166/E; DRG-0109; Dione 21-acetate; L-5103; L-5103 Lepetit; Piperine & Rifampicin; R-Cin; R/AMP; Reserpine & Rifampicin; Rifadin (TN); Rifadin I.V; Rifampicin & EEP; Rifampicin & Propolis; Rifampicina [INN-Spanish]; Rifampicinum [INN-Latin]; Rifampin (USP); Rimactan (TN); Rimactane (TN); Rimycin (TN); Sinerdol (TN); Tubocin (TN); Rifadin I.V.; Rifampicin (JP15/INN); Rifampicin[INN:BAN:JAN]; Rifadin, Rimactane, Rifampicin, Rifampin; 1-b]furan-21-yl acetate; 3-(((4-Methyl-1-piperazinyl)imino)-methyl)rifamycin; 3-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV; 3-(4-Methylpiperazinyliminomethyl)-rifamycin SV; 3-(4-Methylpiperazinyliminomethyl)rifamycin SV; 3-([(4-Methyl-1-piperazinyl)imino]methyl)rifamycin SV; 3-[(4-Methyl-1-piperazinyl)iminomethyl]rifamycin SV; 3-[[(4-Methyl-1-piperazinyl)imino]-methyl]rifamycin; 8-(((4-Methyl-1-piperazinyl)imino)methyl)rifamycin SV; 8-(4-Methylpiperazinyliminomethyl) rifamycin SV; 8-[[(4-Methyl-1-piperazinyl)imino[methyl]rifamycin; 8-[[(4-Methyl-1-piperazinyl)imino]methyl]rifamycin sv; 8-[[(4-Methylpiperazinyl)imino]methyl]rifamycin sv; 8CI)
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| Activity |
IC50 = 75000 nM
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[1] | |||
| Compound Name |
Carnosic acid
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Investigative | Compound Info | ||
| Synonyms |
Salvin; UNII-LI791SXT24; LI791SXT24; 11,12-dihydroxyabieta-8,11,13-trien-20-oic acid; MFCD02259459; NSC694080; Carnosic acid from Rosmarinus officinalis; RoseOx; 11,12-dihydroxy-13-isopropylpodocarpa-8,11,13-trien-17-oic acid; Rosamox; Carnosic-acid; Carsonic acid; Carnosic acid; Deoxypicrosalvinic acid; PubChem13039; UPCMLD-DP056; CHEMBL484853; SCHEMBL9923661; UPCMLD-DP056:001; CTK8B3993; DTXSID20904450; BCPP000299; Carnosic acid, analytical standard; HY-N0644; ZINC3984016; ANW-43614; BDBM50371232; s3838; AKOS015901362; AC-6030; BCP9000491; CCG-207954; NSC-694080; SMP2_000204; NCGC00161623-01; AS-31052; NCI60_033653; SC-70968; BCP0726000155; C3477; CS-0009671; N2759; C21818; 650C097; Q412827; SR-05000002202; SR-05000002202-2; Carnosic acid, primary pharmaceutical reference standard; Carnosic acid from Rosmarinus officinalis, >=91%, powder; Carnosic acid, United States Pharmacopeia (USP) Reference Standard; Podocarpa-8,11,13-trien-17-oic acid, 11,12-dihydroxy-13-isopropyl-
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| Activity |
IC50 = 62000 nM
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[1] | |||
| Non Binders of This Target (in total, 2 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
DNCB
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Phase 2 | Compound Info | ||
| Synonyms |
1-Chloro-2,4-dinitrobenzene
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| Activity |
IC50 = 900000 nM
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[1] | |||
| Compound Name |
Sodium deoxycholate
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Investigative | Compound Info | ||
| Synonyms |
Deoxycholic acid sodium salt; Sodium desoxycholate; Deoxycholate sodium; Desoxycholate sodium; Sodium 7-deoxycholate; Deoxycholic acid, sodium salt; UNII-436LS6U35Y; 7-Deoxycholic acid sodium salt; 3-alpha,12-alpha-Dihydroxy-5-beta-cholan-24-oic acid sodium salt; 436LS6U35Y; MFCD00064139; NCGC00091038-01; ATX 101; Cholan-24-oic acid, 3,12-dihydroxy-, monosodium salt, (3a,5b,12a)-; DSSTox_CID_13389; DSSTox_RID_79069; DSSTox_GSID_33389; Sodium deoxycholic acid; Na-Desoxycholat; Na-Desoxycholat [German]; Sodiumdeoxycholate; CCRIS 655; Deoxycholic acid sodium salt monohydrate; Desoxycholic acid sodium salt; EINECS 206-132-7; sodium (3alpha,5beta,12alpha)-3,12-dihydroxycholan-24-oate; Dihydroxy 3-12 cholanate de Na [French]; Dihydroxy 3-12 cholanate de Na; Natrium-3-alpha,12-alpha-dihydroxycholanat [German]; deoxycholic acid sodium; Sodium 3-alpha,12-alpha-dihydroxy-5-beta-cholan-24-oate; Natrium-3-alpha,12-alpha-dihydroxycholanat; SCHEMBL37482; MLS002695906; 3alpha,12alpha-Dihydroxy-5beta-cholanic acid sodium salt; CHEMBL1365278; DTXSID5033389; HY-N0593A; Cholan-24-oic acid, 3,12-dihydroxy-, sodium salt (1:1), (3alpha,5beta,12alpha)-; Deoxycholic acid sodium salt hydrate; Tox21_111066; Tox21_200896; 5-beta-Cholan-24-oic acid, 3-alpha,12-alpha-dihydroxy-, sodium salt; SBB057910; AKOS002391107; AKOS017345123; CS-8046; Cholan-24-oic acid, 3,12-dihydroxy-, monosodium salt, (3alpha,5beta,12alpha)-; NCGC00258450-01; AC-24206; BP-31018; SMR001562102; Sodium deoxycholate, >=97% (titration); ST51007214; C11171; 68512-EP2275413A1; 68512-EP2308855A1; Deoxycholic acid sodium salt, for electrophoresis; Q-200935; Q25474151; Sodium 3-??,12-??-dihydroxy-5-??-cholan-24-oate; sodium 3alpha,12alpha-dihydroxy-5beta-cholan-24-oate; Sodium deoxycholate, Vetec(TM) reagent grade, >=97%; Sodium deoxycholate, BioXtra, >=98.0% (dry matter, NT); Sodium deoxycholate, Suitable for manufacturing of diagnostic kits and reagents
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| Activity |
IC50 = 1020000 nM
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[1] | |||
| References | Top | ||||
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| REF 1 | Reviewing Hit Discovery Literature for Difficult Targets: Glutathione Transferase Omega-1 as an Example. J Med Chem. 2018 Sep 13;61(17):7448-7470. | ||||
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