Target Poor or Non Binder(s) Information
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T00933 | Target Info | |||
| Target Name | Histone lysine demethylase PHF8 (PHF8) | ||||
| Synonyms |
ZNF422; PHD finger protein 8; KIAA1111
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| Target Type | Literature-reported Target | ||||
| Gene Name | PHF8 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Poor Binders of This Target (in total, 9 binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
3-[6-[Butyl(methyl)amino]hexanoyl-hydroxyamino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3590421; BDBM50095445
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| Activity |
IC50 = 58000 nM
|
[1] | |||
| Compound Name |
NCDM-82a
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3590427; BDBM50095447
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| Activity |
IC50 = 73000 nM
|
[1] | |||
| Compound Name |
3-[Hydroxy-[5-[methyl(pentyl)amino]pentanoyl]amino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3590426; BDBM50095446
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
4-(Isopropylamino)-4-oxobutanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164248; N-isopropylsuccinamic acid; 3-(propan-2-ylcarbamoyl)propanoic acid; NSC56468; 4-oxo-4-(propan-2-ylamino)butanoic acid; Butanoic acid, 4-[(1-methylethyl)amino]-4-oxo-; SCHEMBL94233; CTK2F3983; DTXSID20288540; ALBB-033190; ZINC1687428; BDBM50395081; MFCD02675045; NSC-56468; AKOS002675066; 4-Oxo-4-(isopropylamino)butanoic acid; MCULE-6515821068
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| Activity |
IC50 ~ 100000 nM
|
[2] | |||
| Compound Name |
3-[5-[Butyl(methyl)amino]pentanoyl-hydroxyamino]propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL3590418; BDBM50095443
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| Activity |
IC50 ~ 100000 nM
|
[1] | |||
| Compound Name |
N'1,N'1,N'4,N'4-Tetramethylsuccinohydrazide
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2164250; SCHEMBL584428; Succinic acid dimethyl hydrazide; BDBM50395077; AKOS002685593; MCULE-9315956570
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| Activity |
IC50 = 117000 nM
|
[2] | |||
| Compound Name |
Chembl4130224
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273478
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| Activity |
IC50 = 120000 nM
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[3] | |||
| Compound Name |
Chembl4126406
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273469
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| Activity |
IC50 = 126000 nM
|
[3] | |||
| Compound Name |
3-(10-Methylundecanoylhydroxyamino)propionic acid methyl ester
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2424810; BDBM50440291
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| Activity |
IC50 = 150000 nM
|
[4] | |||
| Click to Show/Hide the Information of All Poor Binders | |||||
| Non Binders of This Target (in total, 17 non binders) | Download | Top | |||
|---|---|---|---|---|---|
| Compound Name |
Amiodarone
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|
Approved | Compound Info | ||
| Synonyms |
Amidorone; Aminodarone; Amiobeta; Amiodarex; Amiodarona; Amiodarons; Amiodaronum; Amiohexal; Amjodaronum; Ancar; Aratac;Arycor; Braxan; Corbionax; Cordarex; Cordarone; Kordaron; Labaz; Ortacrone; Pacerone; Rytmarone; Sedacoron; Sedacorone; Tachydaron; ASTA Medica Brand of Amiodarone Hydrochloride; Alphapharm Brand of Amiodarone Hydrochloride; Amiodarone Base; Armstrong Brand of Amiodarone Hydrochloride; Berenguer Infale Brand of Amiodarone Hydrochloride; Betapharm Brand of Amiodarone Hydrochloride; Cordarone Intravenous; G Gam Brand of Amiodarone Hydrochloride; Hexal Brand of Amiodarone Hydrochloride; Leurquin Brand of Amiodarone Hydrochloride; Pharma Investi Brand of Amiodarone Hydrochloride; Sanofi Winthrop Brand of Amiodarone Hydrochloride; Wyeth Brand of Amiodarone Hydrochloride; Ethylaminoethoxy)benzoyl]benzofuran; L 3428; L3428; SKF 33134A; Amio-Aqueous IV; Amiodarona [INN-Spanish]; Amiodaronum [INN-Latin]; Aratac (TN); Arycor (TN); Atlansil (TN); Cordarone (TN); L-3428; Pacerone (TN); Pms-Amiodarone; SKF 33134-A; Amiodarone (USAN/INN); Amiodarone [USAN:BAN:INN]; Ketone, 2-butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl; Ketone, 2-butyl-3-benzofuranyl 4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl (7CI,8CI); (2-Butyl-3-benzofuranyl)(4-(2-(diethylamino)ethoxy)-3,5-diidophenyl)methanone; (2-butyl-1-benzofuran-3-yl)(4-{[2-(diethylamino)ethyl]oxy}-3,5-diiodophenyl)methanone; (2-butyl-1-benzofuran-3-yl)-[4-(2-diethylaminoethyloxy)-3,5-diiodophenyl]methanone; (2-butyl-1-benzofuran-3-yl){4-[2-(diethylamino)ethoxy]-3,5-diiodophenyl}methanone; (2-butylbenzofuran-3-yl)-[4-(2-diethylaminoethoxy)-3,5-diiodo-phenyl]-methanone; (2-{4-[(2-butyl-1-benzofuran-3-yl)carbonyl]-2,6-diiodophenoxy}ethyl)diethylamine; 2-Butyl-3-(3,5-diiodo-4-(2-diethylaminoethoxy)benzoyl)benzofuran; 2-Butyl-3-(3,5-diiodo-4-(beta-diethylaminoethoxy)benzoyl)benzofuran; 2-Butyl-3-(4'-beta-N-diethylaminoethoxy-3',5'-diiodobenzoyl)benzofuran; 2-Butyl-3-[3,5-diiodo-4-(2-di; 2-Butyl-3-benzofuranyl 4-(2-(diethylamino)ethoxy)-3,5-diiodophenyl ketone; 2-Butyl-3-benzofuranyl p-((2-diethylamino)ethoxy)-m,m-diiodophenyl ketone; 2-Butyl-3-benzofuranyl p-[(2-diethylamino)ethoxy]-m,m-diiodophenyl ketone; 2-n-Butyl-3',5'-diiodo-4'-N-diethylaminoethoxy-3-benzoylbenzofuran
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| Activity |
IC50 = 252000 nM
|
[3] | |||
| Compound Name |
Pyridine-2,4-dicarboxylic acid
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Investigative | Compound Info | ||
| Synonyms |
Pyridine-2,4-dicarboxylic acid; 499-80-9; 2,4-PYRIDINEDICARBOXYLIC ACID; Lutidinic acid; 2,4-Lutidinic acid; UNII-AFI29F0TVL; AFI29F0TVL; CHEBI:44737; EC 207-892-2; MJIVRKPEXXHNJT-UHFFFAOYSA-N; MFCD00149413; 2,4-Pyridinedicarboxylic acid hydrate, 99+%; 2,4-Pyridinedicarboxylicacid, hydrate (1:1); 4nrq; PD2; EINECS 207-892-2; NSC 403248; PubChem16314; 4-carboxypicolinic acid; 2vd7; 4ie0; 2w2i; pyridine carboxylate, 6a; AC1Q5UFW; ACMC-1BNB9; AC1L1V1N; 2,4-Pyridine-dicarboxylate; SCHEMBL72377; cid_10365; MLS000078055; GTPL8744
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| Activity |
IC50 > 250000 nM
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[4] | |||
| Compound Name |
2-(carboxymethylamino)-2-oxoacetic acid
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Investigative | Compound Info | ||
| Synonyms |
N-Oxalylglycine; 5262-39-5; Oxalylglycine; Oxaloglycine; 2-((Carboxymethyl)amino)-2-oxoacetic acid; UNII-VVW38EB8YS; N-(carboxycarbonyl)glycine; N-OXALYOLGLYCINE; VVW38EB8YS; 2-oxo-3-azaglutaric acid; CHEMBL90852; Glycine, N-(carboxycarbonyl)-; CHEBI:44482; OGA; C4H5NO5; 4idz; 4nrp; 2xml; 3hqr; N-oxalyl glycine, 1a; 2oq6; 1h2k; AC1MIVD0; Glycine,N-(carboxycarbonyl)-; SCHEMBL435820; BDBM26106; CTK8F0807; DTXSID20200601; MolPort-000-141-021; ZINC1534133; N-Oxalylglycine, > 4958AE
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| Activity |
IC50 > 250000 nM
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[4] | |||
| Compound Name |
Chembl4127515
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273471
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| Activity |
IC50 = 221000 nM
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[3] | |||
| Compound Name |
Chembl4129980
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273474
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| Activity |
IC50 = 240000 nM
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[3] | |||
| Compound Name |
Chembl4129830
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273477
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| Activity |
IC50 = 242000 nM
|
[3] | |||
| Compound Name |
Chembl4128613
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273470
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| Activity |
IC50 = 286000 nM
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[3] | |||
| Compound Name |
Chembl4128152
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273476
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| Activity |
IC50 > 300000 nM
|
[3] | |||
| Compound Name |
Chembl4126240
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Investigative | Compound Info | ||
| Activity |
IC50 = 307000 nM
|
[3] | |||
| Compound Name |
Chembl4127792
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273473
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| Activity |
IC50 = 377000 nM
|
[3] | |||
| Compound Name |
Chembl4126135
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Investigative | Compound Info | ||
| Synonyms |
BDBM50270475
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| Activity |
IC50 = 386000 nM
|
[3] | |||
| Compound Name |
Chembl4129540
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Investigative | Compound Info | ||
| Activity |
IC50 = 390000 nM
|
[3] | |||
| Compound Name |
Chembl4126951
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Investigative | Compound Info | ||
| Synonyms |
BDBM50273475
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| Activity |
IC50 = 397000 nM
|
[3] | |||
| Compound Name |
Chembl4127094
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Investigative | Compound Info | ||
| Synonyms |
BDBM50270479
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| Activity |
IC50 = 496000 nM
|
[3] | |||
| Compound Name |
(2R)-3-(Naphthalen-1-ylmethylsulfanyl)-2-(oxaloamino)propanoic acid
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030873; BDBM50383013
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
N-(Carboxycarbonyl)-S-(Naphthalen-2-Ylmethyl)-L-Cysteine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030872; BDBM50383012; Q27463093; MD3
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Compound Name |
N-(Carboxycarbonyl)-S-(3-Nitrobenzyl)-L-Cysteine
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Investigative | Compound Info | ||
| Synonyms |
CHEMBL2030869; BDBM50383011; Q27463094; MD5
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| Activity |
IC50 > 1000000 nM
|
[5] | |||
| Click to Show/Hide the Information of All Non Binders | |||||
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells. ACS Med Chem Lett. 2015 Apr 23;6(6):665-70. | ||||
| REF 2 | Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43. | ||||
| REF 3 | Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases. Bioorg Med Chem. 2018 Jul 15;26(11):2984-2991. | ||||
| REF 4 | Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity. J Med Chem. 2013 Sep 26;56(18):7222-31. | ||||
| REF 5 | Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase. J Med Chem. 2012 Mar 8;55(5):2173-84. | ||||
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