Target and Its Patented Drug(s)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T95558 | Target Info | |||
| Target Name | Diacylglycerol O-acyltransferase 2 (DGAT2) | ||||
| Synonyms | UNQ738/PRO1433; HMFN1045; Diglyceride acyltransferase 2 | ||||
| Target Type | Successful Target | ||||
| Gene Name | DGAT2 | ||||
| Biochemical Class | Acyltransferase | ||||
| UniProt ID | |||||
| Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
|---|---|---|---|---|---|
| World Intellectual Property Organization (WIPO) | |||||
| Patent ID | WO2013150416 | ||||
| Title | Diacylglycerol Acyltransferase 2 Inhibitors. | ||||
| Abstract | Derivatives of purine, 3H-imidazo[4,5-b]pyrimidine and 1H- imidazo[4,5-d]pyrazine of Formula I that inhibit the activity of the diacylglycerol acyltransferase 2 (DGAT2) and their uses in the treatment of diseases linked thereto in animals are described herein. | ||||
| Applicant(s) | Pfizer Inc | ||||
| Representative Drug(s) | D0L5DV | Drug Info | IC50 = 30000 nM | [1] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Acyltransferase inhibitors: a patent review (2010-present).Expert Opin Ther Pat. 2015 Feb;25(2):145-58. | ||||
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