Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T81780 Target Info
Target Name Ubiquitin-activating enzyme E1 (UBAE1)
Synonyms Ubiquitin-like modifier-activating enzyme 1; UBE1; Protein A1S9; A1S9T
Target Type Patented-recorded Target
Gene Name UBA1
UniProt ID
UBA1_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US10202389
Title Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
Abstract Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein Y isand W, Z, XY, RY1, RY2 and RY3 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.
Applicant(s) Millennium Pharmaceuticals, Inc.
Representative Drug(s) D0YE0V Drug Info IC50 < 10nM Click to Show More [1]
2 D0P3PT Drug Info IC50 < 10nM [1]
3 D0QQ3B Drug Info IC50 = 550 nM [1]
Patent ID US10202389
Title Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
Abstract Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein Y isand W, Z, XY, RY1, RY2 and RY3 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.
Applicant(s) Millennium Pharmaceuticals, Inc.
Representative Drug(s) D0YE0V Drug Info IC50 < 10nM Click to Show More [1]
2 D0P3PT Drug Info IC50 < 10nM [1]
3 D0QQ3B Drug Info IC50 = 550 nM [1]
Patent ID US10202389
Title Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme
Abstract Disclosed are chemical entities that inhibit ubiquitin-activating enzyme (UAE), each of which is a compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein Y isand W, Z, XY, RY1, RY2 and RY3 are defined herein; pharmaceutical compositions comprising the chemical entities; and methods of using the chemical entities. These chemical entities are useful for treating disorders, particularly cell proliferation disorders, including cancers.
Applicant(s) Millennium Pharmaceuticals, Inc.
Representative Drug(s) D0YE0V Drug Info IC50 < 10nM Click to Show More [1]
2 D0P3PT Drug Info IC50 < 10nM [1]
3 D0QQ3B Drug Info IC50 = 550 nM [1]
References  Top
REF 1 Pyrazolopyrimidinyl inhibitors of ubiquitin-activating enzyme. US10202389.

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