Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T78710 Target Info
Target Name Inward rectifier potassium channel Kir1.1 (KCNJ1)
Synonyms ROMK1; Potassium channel, inwardly rectifying subfamily J member 1; Inward rectifier K(+) channel Kir1.1; ATP-sensitive inward rectifier potassium channel 1
Target Type Patented-recorded Target
Gene Name KCNJ1
Biochemical Class Inward rectifier potassium channel
UniProt ID
KCNJ1_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2013062892
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Abstract The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir 1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D0A6EX Drug Info IC50 = 30 nM Click to Show More [1]
2 D05AJX Drug Info IC50 = 60 nM [1]
Patent ID WO2015017305
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Abstract The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D00WZH Drug Info IC50 = 6.7 nM Click to Show More [1]
2 D09KCN Drug Info IC50 = 9.6 nM [1]
3 D0N4DY Drug Info N.A. [1]
Patent ID WO2014150132
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Abstract The present invention provides compounds of Formula (I) and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir11) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D06FLB Drug Info IC50 = 10 nM Click to Show More [1]
2 D08UXR Drug Info IC50 = 93 nM [1]
3 D0X8YT Drug Info N.A. [1]
Patent ID WO2014085210
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Abstract The present invention provides compounds of Formula (I), and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D0M6JD Drug Info IC50 = 20 nM Click to Show More [1]
2 D07TUN Drug Info IC50 = 40 nM [1]
3 D0WP1P Drug Info N.A. [1]
Patent ID WO2014015495
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Abstract The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D0DG4A Drug Info IC50 = 3 nM Click to Show More [1]
2 D0O1RL Drug Info IC50 = 4 nM [1]
3 D0V0OD Drug Info IC50 = 10 nM [1]
4 D03PRT Drug Info N.A. [1]
Patent ID WO2013062900
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Abstract The present invention provides compounds of Formula I I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds act as diuretics and natriuretics and are valuable pharmaceutically active compounds for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension and conditions resulting from excessive salt and water retention.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D02HOM Drug Info IC50 = 20 nM Click to Show More [1]
2 D0TH5W Drug Info IC50 = 60 nM [1]
3 D00CMX Drug Info N.A. [1]
Patent ID WO2013039802
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Abstract This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D06TPB Drug Info IC50 <= 200 nM Click to Show More [1]
2 D07VUL Drug Info IC50 <= 200 nM [1]
3 D09WRT Drug Info N.A. [1]
Patent ID WO2013028474
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Abstract The present invention provides compounds of Formula Ia and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D0D7AI Drug Info IC50 = 60 nM Click to Show More [1]
2 D00SLD Drug Info IC50 = 90 nM [1]
3 D0ZX6S Drug Info N.A. [1]
Patent ID WO2012058134
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Abstract This invention relates to compounds having structural Formula (I); and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir 1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D0XM8F Drug Info IC50 = 12 nM Click to Show More [1]
2 D03TGG Drug Info IC50 = 20 nM [1]
3 D0RM6C Drug Info N.A. [1]
Patent ID WO2012058116
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Abstract This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kirl.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D0J9JB Drug Info IC50 = 17 nM Click to Show More [1]
2 D0CI2I Drug Info IC50 = 34 nM [1]
3 D0L8FE Drug Info N.A. [1]
Patent ID WO2010129379
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Abstract This invention relates to compounds having structural Formula I: and pharmaceutically acceptable salts thereof which are inhibitors of the Renal Outer Medullary Potassium (ROMK) channel (Kir1.1). The compounds of Formula I are useful as diuretics and natriuretics and therefore are useful for the therapy and prophylaxis of disorders resulting from excessive salt and water retention, including cardiovascular diseases such as hypertension and chronic and acute heart failure.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D0CC7A Drug Info IC50 = 6 nM Click to Show More [1]
2 D0DX8P Drug Info IC50 = 36 nM [1]
3 D02ZGO Drug Info N.A. [1]
Patent ID WO2014126944
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Abstract The present invention provides compounds of Formula(I) or a pharmaceutically acceptable salt thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure, kidney disease, edema, and conditions associated with excessive salt and water retention.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D0C4BJ Drug Info IC50 = 40 nM Click to Show More [1]
2 D08TDJ Drug Info N.A. [1]
Patent ID WO2014099633
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Abstract The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kirl.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and conditions associated with excessive salt and water retention.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D07CMZ Drug Info IC50 = 60 nM Click to Show More [1]
2 D00JVQ Drug Info N.A. [1]
United States Patent and Trademark Office (USPTO)
Patent ID US20140142115
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D03JCN Drug Info IC50 = 6 nM Click to Show More [1]
2 D0UY1A Drug Info IC50 = 36 nM [1]
3 D0WX4U Drug Info N.A. [1]
Patent ID US20140031349
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D06CGQ Drug Info IC50 = 3 nM Click to Show More [1]
2 D0F0TY Drug Info IC50 = 10 nM [1]
3 D0FC5J Drug Info IC50 = 30 nM [1]
4 D0TO9J Drug Info N.A. [1]
Patent ID US20140336177
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D0XK7H Drug Info IC50 = 40 nM Click to Show More [1]
2 D0CI6Y Drug Info N.A. [1]
Patent ID US20140309213
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D00ALX Drug Info IC50 = 18 nM Click to Show More [1]
2 D0EX9E Drug Info N.A. [1]
Patent ID US20140288042
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D01JCZ Drug Info IC50 = 39 nM Click to Show More [1]
2 D08HBF Drug Info N.A. [1]
Patent ID US20140275020
Title Inhibitors of The Renal Outer Medullary Potassium Channel.
Applicant(s) Merck Sharp & Dohme Corp
Representative Drug(s) D0E2WS Drug Info IC50 = 65 nM Click to Show More [1]
2 D0U0ZN Drug Info N.A. [1]
References  Top
REF 1 Inhibitors of the renal outer medullary potassium channel: a patent review.Expert Opin Ther Pat. 2015;25(9):1035-51.

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