| Patent(s) and the Corresponding Patented Drug(s) |
Top |
| World Intellectual Property Organization (WIPO) |
| Patent ID |
WO2014172315 |
| Title |
Methods of Treating Proliferative Disorders. |
| Abstract |
The invention is based on the discovery that elevated levels of oxidative stress shortly after administration of chemotherapeutic or radiation therapy in subjects having proliferative disorders is indicative of sensitivity to the administered chemotherapeutic or radiation therapy. Consequently, measurement of oxidative stress biomarker levels can inform whether a particular chemotherapeutic or radiation therapy is likely to be efficacious in treating a proliferative disorder before prolonged exposure to the therapy. This information allows a subject to avoid unnecessary and otherwise dangerous therapies and increases the likelihood that a selected therapeutic course will ultimately lead to treatment of a particular proliferative disorder. |
| Applicant(s) |
Rigas, Basil |
| Patent ID |
WO2014096864 |
| Title |
Enzyme Inhibitors. |
| Abstract |
The present subject matter relates generally to compounds having the formula (I): wherein each of X, Y, R1, R2, R3, R4, and n are as defined herein. Compounds of formula (I) may act as inhibitors of the thioredoxin reductase enzyme system. The subject matter also relates to use, formulation and preparation of the compounds. The compounds may be useful in the treatment of inflammatory and oxidative diseases and conditions. The compounds may also provide useful anti-proliferative and anti- apoptotic effects. |
| Applicant(s) |
University of Sunderland |
| Patent ID |
WO2014075574 |
| Title |
A Method of Using Binuclear Gold(I) Compounds for Cancer Treatment. |
| Abstract |
Provided herein is a method of treating cancer by the administration of binuclear gold(I) compounds in patients in need thereof. The pharmaceutical compounds possess anti-cancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growth in vivo. |
| Applicant(s) |
The University of Hong Kong |
| Patent ID |
WO2014075394 |
| Title |
Novel Gold(Iii) Complexes Containing N-Heterocyclic Carbene Ligand, Synthesis, and Their Applications In Cancer Treatment and Thiol Detection. |
| Abstract |
Provided herein is a method of synthesis of Au(III)-NHC complexes, a pharmaceutical composition comprises thereof. Also provided herein are the methods for the treatment and prevention of cancer/tumor in patients in need thereof by the administration of the Au(III)-NHC complexes. Also provided is method of detecting thiol in a biological system. The Au(III)-NHC complexes possess anticancer activity such as the induction of cell death, inhibition of cellular proliferation, inhibition of thioredoxin reductase activity, and inhibition of tumor growthin vivo. |
| Applicant(s) |
The University of Hong Kong |
| Patent ID |
WO2012050465 |
| Title |
Novel Esters of (Acyloxymethyl)Acrylamide, A Pharmaceutical Composition Containing Them, and Their Use As Inhibitors of The Thioredoxin - Thioredoxin Reductase System. |
| Abstract |
The subject of the present invention are novel esters of (acyloxymethyl)acrylamide, a pharmaceutical composition containing them and their use in the production of drugs for the prophylaxis or treatment of oncogenic diseases and diseases connected with increased cell proliferation. |
| Applicant(s) |
Inst Chemii Organicznej Polskiej Akademii Nauk |
| Patent ID |
WO2007103273 |
| Title |
Thioredoxin and Thioredoxin Reductase Inhibitors. |
| Abstract |
The present invention relates to sulfone derivatives and to their use as modulators of the thioredoxin/thioredoxin reductase redox system, including for the treatment and/or prevention of pathophysiological conditions mediated by thioredoxin/thioredoxin reductase, such as cancer, HIV/ AIDS, Alzheimer's disease, rheumatoid arthritis, and skin disorders. Also provided are pharmaceutical compositions comprising the inventive sulfones. |
| Applicant(s) |
Trustees of Boston University |
| Patent ID |
WO2007035641 |
| Title |
Palmarumycin Based Inhibitors of Thioredoxin and Methods of Using Same. |
| Abstract |
Embodiments of the present invention relate to inhibitors of thioredoxin. Certain embodiments relate to palmarumycin based compounds and methods of using the same. Such compounds may be useful in inhibiting the overexpression of thioredoxin, inhibiting tumor growth and treating cancer. |
| Applicant(s) |
Arizona Board of Regents, Acting On Behalf of the University of Arizona |
| Patent ID |
WO2006024770 |
| Title |
Phosphole Derivatives Complexed with Metals, and Pharmaceutical Uses Thereof. |
| Abstract |
The invention concerns pharmaceutical compositions comprising as active compound at least one compound of general formula (A), wherein: M represents a metal atom, and their uses in particular for preventing or treating pathologies associated with an excess activity of glutathion reductase and/or thioredoxin reductase. |
| Applicant(s) |
Centre Nat Rech Scient |
| Patent ID |
WO2004056361 |
| Title |
4-(1-(Sulfonyl)-1H-Indol-2-Yl)-4-(Hydroxy)-Cyclohexa-2,5-Dienone Compounds and Analogs Thereof As Therapeutic Agents. |
| Abstract |
This invention pertains to certain 4-(1-(sulfonyl)-1H-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds, and analogs thereof, including compounds of the following formula, which are, inter alia, antiproliferative agents, anticancer agents, and/or thioredoxin/thioredoxin reductase inhibitors: formula (I) wherein: Ar is a 1-(sulfonyl)-1H-indol-2-yl group; the bond marked alpha is independently: (a) a single bond; or: (b) a double bond; the bond marked gama is independently: (a) a single bond; or: (b) a double bond; the group -ORO is independently: (a) -OH; (b) an ether group (e.g., -OMe); or: (c) an acyloxy (i.e., reverse ester) group (e.g., -OC(=O)Me); each of R2, R3, R5, and R6, is independently a ring substituent and is: (a) H; (b) a monovalent monodentate substituent; or: (c) a ring substituent which, together with an adjacent ring substituent, and together with the ring atoms to which these ring substituents are attached, form a fused ring; and pharmaceutically acceptable salts, esters, amides, solvates, hydrates, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for example, in the treatment of proliferative conditions, (e.g., cancer), and/or conditions mediated by thioredoxin/thioredoxin reductase. |
| Applicant(s) |
Cancer Research Technology Limited |
| Patent ID |
WO2003004479 |
| Title |
4-Aryl Quinols and Analogs Thereof As Therapeutic Agents. |
| Abstract |
The present invention pertains to compounds of the formula (1), which are, inter alia, antiproliferative agents, anticancer agents, antimycobacterial agents, antituberculosis agents, and/or thioredoxin/thioredoxin reductase inhibitors: wherein: Q is =O or =N-S(=O)2-RQ;RQ is -H or optionally substituted C1-7alkyl, C3-20heterocyclyl, or C5-20aryl; Ar is optionally substituted C5-20aryl; Ro is an oxy substituent; the bond marked alpha is a single bond or a double bond; the bond marked is a single bond or a double bond; R3 and R5 are each independently ring substituents; R2 and R6 are each independently ring substituents; and pharmaceutically acceptable salts, esters, amides, solvates, hydrates, and protected forms thereof. The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, for example, in the treatment of proliferative conditions, (e.g., cancer), mycobacterial infections (e.g., tuberculosis), and/or conditions mediated by thioredoxin/thioredoxin reductase. |
| Applicant(s) |
Cancer Research Technology Limited |
| Patent ID |
WO2000050431 |
| Title |
Platinum (Ii) Compounds. |
| Abstract |
A compound which is a complex of formula (I) wherein each X, which may be the same or different, is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aryl, heterocyclyl, aralkyl, alkaryl, acyl, halogen, haloalkyl, haloaryl, hydroxyalkyl, hydroxyaryl, aminoalkyl, aminoaryl, primary, secondary or tertiary amine, hydrazine, alkylhydrazine, alkoxyl, alkylthio, aralkoxyl, nitrile, ester, amide, nitro, azide or aziridino, or is a covalently linked chain which is joined to at least one other complex of formula (I) so as to form a dimeric or oligomeric species, or a covalently linked moiety which provides recognition for a target receptor; and Y is alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, aralkyl, heterocyclyl, an inorganic oxyacid or inorganic oxyacid derivative, or a covalently linked chain which is joined to at least one other complex of formula (I) so as to form a dimeric or oligomeric species; or a pharmaceutically acceptable salt thereof, for use in a method of treatment of the human or animal body by therapy. |
| Applicant(s) |
Isis Innovation Limited |
| Patent ID |
WO2011134275 |
| Title |
Metal Complexes of Thiourea and Their Derivatives As Metal Delivering Anti-Cancer and Anti-Inflammatory Agents. |
| Abstract |
Disclosed are metal thiourea complexes comprising N-substituted thiourea ligands and sulfur-coordinated metal ions, and use of these metal thiourea complexes for delivering otherwise unstable or impermeable metal ions to mammalian cells, for inhibiting cancer cell growth and inflammation, and for inhibiting the activities of associated drug targets under in vitro and in vivo conditions. |
| United States Patent and Trademark Office (USPTO) |
| Patent ID |
US8617906 |
| Title |
Identification and Screening of Triptolide Target Molecules. |
| Representative Drug(s) |
D0CF4R |
Drug Info
|
N.A. |
[1] |
| Patent ID |
US8124651 |
| Title |
Palmarumycin Based Inhibitors of Thioredoxin and Methods of Using Same. |
| Patent ID |
US6673937 |
| Title |
Syntheses and Methods of Use of New Antimitotic Agents. |
| Patent ID |
US6552060 |
| Title |
Asymmetric Disulfides and Methods of Using Same. |
| Patent ID |
US20140256038 |
| Title |
Peptide-Bound Gold Metal Nano-Clusters As Cancer Cell Killing Agents. |
| Patent ID |
US20090264421 |
| Title |
Methods and Compositions for Treating Cancer. |
| Patent ID |
US20090232827 |
| Title |
Compositions and Methods of Use of Compounds To Increase Cancer Patient Survival Time. |
| Patent ID |
US2008045465 |
| Title |
Phosphole Derivatives Complexed with Metals, and Pharmaceutical Uses Thereof. |
| Patent ID |
US20050014801 |
| Title |
Benzoisoselenazole Derivatives with Anti-Inflammation, Antivirus and Antithrombosis Activity and Their Use. |
| Patent ID |
US20040116496 |
| Title |
AsymmetricPgDisulfides and Methods of Using Same. |
| Patent ID |
US20030176512 |
| Title |
Asymmetric Disulfides and Methods of Using Same. |
| Patent ID |
US9238659 |
| Title |
Method of Using Binuclear Gold (I) Compounds for Cancer Treatment. |
| Patent ID |
US8828984 |
| Title |
Gold(Iii) Complexes Containing N-Heterocyclic Carbene Ligand, Synthesis, and Their Applications In Cancer Treatment and Thiol Detection. |
| Patent ID |
US8722897 |
| Title |
Metal Complexes of Thiourea and Their Derivatives As Metal Delivering Anti-Cancer and Anti-Inflammatory Agents. |
| Patent ID |
US7307099 |
| Title |
4-(1-(Sulfonyl)-1H-Indol-2-Yl)-4-(Hydroxy)-Cyclohexa-2,5-Dienone Compounds and Analogs Thereof As Therapeutic Agents. |
| Patent ID |
US7144893 |
| Title |
4-Aryl Quinols and Analogs Thereof As Therapeutic Agents. |
| Patent ID |
US6372772 |
| Title |
Inhibitors of Redox Signaling and Methods of Using Same. |
| Patent ID |
US2004220236 |
| Title |
4-Aryl Quinols and Analogs Thereof As Therapeutic Agents. |
| China National Intellectual Property Administration (CNIPA) |
| Patent ID |
CN101921303 |
| Title |
Benzisoselenazolone Difluorocytidine Compound As Well As Preparation Method and Application Thereof. |
| Patent ID |
CN101781283 |
| Title |
Benzisoselenazolone Difluorocytidine Compound As Well As Preparation Method and Application Thereof. |
| Patent ID |
CN105001244 |
| Title |
Triazole Goldcompound As Well As Preparation Method and Application Thereof. |
| Patent ID |
CN103467516 |
| Title |
Golden Phosphorous Acetyletic Compound, and Preparation Method and Applications Thereof. |
