| Patent(s) and the Corresponding Patented Drug(s) |
Top |
| World Intellectual Property Organization (WIPO) |
| Patent ID |
WO2014053491 |
| Title |
Inhibitors of Histone Demethylases. |
| Abstract |
The present application discloses compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic dysregulation is involved in the pathogenesis, such as e.g. cancer. The present application also discloses pharmaceutical compositions comprising said compounds and the use of such compounds as a medicament. The compounds take the form (I). |
| Applicant(s) |
Epither Apeutics Aps |
| Representative Drug(s) |
D07CYB |
Drug Info
|
IC50 < 1000 nM |
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[1] |
|
2
|
D0U3KT
|
Drug Info
|
IC50 < 1000 nM
|
[1] |
| Patent ID |
WO2012007008 |
| Title |
Inhibitors of Hdme. |
| Abstract |
The present invention relates to compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic disregulation is involved in the pathogenesis, such as e.g. cancer. The present invention also relates to pharmaceutical compositions comprising said compounds and to the use of such compounds as a medicament. |
| Applicant(s) |
Epither Apeutics Aps |
| Representative Drug(s) |
D0BK5N |
Drug Info
|
N.A. |
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[1] |
|
2
|
D0Q5IR
|
Drug Info
|
N.A.
|
[1] |
|
3
|
D0Z2YB
|
Drug Info
|
N.A.
|
[1] |
| Patent ID |
WO2012007007 |
| Title |
Inhibitors of Hdme. |
| Abstract |
The present invention relates to compounds capable of modulating the activity of histone demethylases (HDMEs), which are useful for prevention and/or treatment of diseases in which genomic disregulation is involved in the pathogenesis, such as e.g. cancer. The present invention also relates to pharmaceutical compositions comprising said compounds and to the use of such compounds as a medicament. |
| Applicant(s) |
Epither Apeutics Aps |
| Representative Drug(s) |
D02FWO |
Drug Info
|
N.A. |
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[1] |
|
2
|
D04KUD
|
Drug Info
|
N.A.
|
[1] |
|
3
|
D0RP4W
|
Drug Info
|
N.A.
|
[1] |
|
4
|
D0UQ2R
|
Drug Info
|
N.A.
|
[1] |
| Patent ID |
WO2007104314 |
| Title |
Inhibition of Gascl. |
| Abstract |
The present invention provides a method of testing the ability of a test compound to bind to and optionally modulate the activity of a protein of the JMJD2 subfamily of Jumonji proteins. The method comprises incubating a test compound with a protein of the JMJD2 subfamily of Jumonji proteins, a co-factor of said protein and, optionally, a substrate for demethylation. The method of the invention can be used for screening large numbers of compounds to identify a group of compounds that are candidate compounds for clinical use for treatment of certain cancers especially prostate cancers. Other compounds that do not have activity in the screening assays can be eliminated from further consideration as candidate compounds. The method of the invention therefore has utility in the pharmaceutical industry. |
| Applicant(s) |
Kristian K?benhavns Universitet |
| Representative Drug(s) |
D0S8AZ |
Drug Info
|
N.A. |
[1] |
| United States Patent and Trademark Office (USPTO) |
| Patent ID |
US20130137720 |
| Title |
Histone Demethylase Inhibitors and Methods for Using The Same. |
| Representative Drug(s) |
D09NCT |
Drug Info
|
IC50 = 3400 nM |
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[1] |
|
2
|
D0L5RA
|
Drug Info
|
N.A.
|
[1] |
| Japan Patent Office (JPO) |
| Patent ID |
JP2011168581 |
| Title |
Preparation of Hydroxamic Acid Derivatives As Jhdm Inhibitors. |
| Representative Drug(s) |
D0MJ4L |
Drug Info
|
IC50 = 1000 nM |
[1] |
