Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T69612 Target Info
Target Name G protein-coupled receptor kinase 5 (GRK5)
Synonyms GPRK5; G protein-coupled receptor kinase GRK5
Target Type Patented-recorded Target
Gene Name GRK5
UniProt ID
GRK5_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US10023564
Title G protein-coupled receptor kinase 2 inhibitors and methods for use of the same
Abstract Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.
Applicant(s) THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Representative Drug(s) D00YYO Drug Info IC50 = 5000 nM Click to Show More [1]
2 D0U5IW Drug Info IC50 > 100000nM [1]
3 D05PTF Drug Info IC50 > 100000nM [1]
Patent ID US10023564
Title G protein-coupled receptor kinase 2 inhibitors and methods for use of the same
Abstract Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.
Applicant(s) THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Representative Drug(s) D00YYO Drug Info IC50 = 5000 nM Click to Show More [1]
2 D0U5IW Drug Info IC50 > 100000nM [1]
3 D05PTF Drug Info IC50 > 100000nM [1]
Patent ID US10023564
Title G protein-coupled receptor kinase 2 inhibitors and methods for use of the same
Abstract Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.
Applicant(s) THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Representative Drug(s) D00YYO Drug Info IC50 = 5000 nM Click to Show More [1]
2 D0U5IW Drug Info IC50 > 100000nM [1]
3 D05PTF Drug Info IC50 > 100000nM [1]
Patent ID US10023564
Title G protein-coupled receptor kinase 2 inhibitors and methods for use of the same
Abstract Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.
Applicant(s) THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Representative Drug(s) D00YYO Drug Info IC50 = 5000 nM Click to Show More [1]
2 D0U5IW Drug Info IC50 > 100000nM [1]
3 D05PTF Drug Info IC50 > 100000nM [1]
References  Top
REF 1 G protein-coupled receptor kinase 2 inhibitors and methods for use of the same. US10023564.

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