Target and Its Patented Drug(s)
| Target General Information | Top | ||||
|---|---|---|---|---|---|
| Target ID | T66665 | Target Info | |||
| Target Name | Prostaglandin G/H synthase 2 (COX-2) | ||||
| Synonyms | Prostaglandin-endoperoxide synthase 2; Prostaglandin H2 synthase 2; PHS II; PGHS-2; PGH synthase 2; Cyclooxygenase-2; COX2; COX-2 | ||||
| Target Type | Successful Target | ||||
| Gene Name | PTGS2 | ||||
| Biochemical Class | Paired donor oxygen oxidoreductase | ||||
| UniProt ID | |||||
| Patent(s) and the Corresponding Patented Drug(s) | Top | ||||
|---|---|---|---|---|---|
| World Intellectual Property Organization (WIPO) | |||||
| Patent ID | WO2014023643 | ||||
| Title | Multitarget Faah and Cox Inhibitors and Therapeutical Uses Thereof. | ||||
| Abstract | The invention provides novel multitarget inhibitors of the enzymes Fatty Acid Amide Hydrolase (FAAH), Cyclooxygenase-1 (COX-1) and/or Cyclooxygenase-2 (COX-2) having a specific carbamate moiety on the meta or ortho position of the A ring of a substituted biphenyl core and having an halogen in the ortho position of the B ring of the biphenyl core. The invention concerns also with therapeutical application of the multitarget inhibitors in particular in the prevention and treatment of cancer. | ||||
| Applicant(s) | Fondazione Istituto Italiano Di Tecnologia | ||||
| Representative Drug(s) | D0S8TB | Drug Info | IC50 = 430 nM | [1] | |
| References | Top | ||||
|---|---|---|---|---|---|
| REF 1 | Fatty acid amide hydrolase inhibitors: a patent review (2009-2014).Expert Opin Ther Pat. 2015;25(11):1247-66. | ||||
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