Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T62548 Target Info
Target Name Beta-adrenergic receptor kinase 1 (ADRBK1)
Synonyms GRK2; G-protein coupled receptor kinase 2; BetaARK1; Beta-ARK-1; Beta ARK1
Target Type Patented-recorded Target
Gene Name GRK2
Biochemical Class Kinase
UniProt ID
ARBK1_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US9493490
Title Boron-containing small molecules
Abstract This invention provides novel compounds of the following formula and pharmaceutical compositions containing such compounds.
Applicant(s) Anacor Pharmaceuticals, Inc.
Representative Drug(s) D0YB5B Drug Info IC50 > 20nM Click to Show More [1]
2 D0OE2R Drug Info IC50 > 20nM [1]
3 D04WNI Drug Info IC50 > 20nM [1]
4 D0ZS0I Drug Info IC50 > 30nM [1]
Patent ID US9493490
Title Boron-containing small molecules
Abstract This invention provides novel compounds of the following formula and pharmaceutical compositions containing such compounds.
Applicant(s) Anacor Pharmaceuticals, Inc.
Representative Drug(s) D0YB5B Drug Info IC50 > 20nM Click to Show More [1]
2 D0OE2R Drug Info IC50 > 20nM [1]
3 D04WNI Drug Info IC50 > 20nM [1]
4 D0ZS0I Drug Info IC50 > 30nM [1]
Patent ID US9493490
Title Boron-containing small molecules
Abstract This invention provides novel compounds of the following formula and pharmaceutical compositions containing such compounds.
Applicant(s) Anacor Pharmaceuticals, Inc.
Representative Drug(s) D0YB5B Drug Info IC50 > 20nM Click to Show More [1]
2 D0OE2R Drug Info IC50 > 20nM [1]
3 D04WNI Drug Info IC50 > 20nM [1]
4 D0ZS0I Drug Info IC50 > 30nM [1]
Patent ID US9493490
Title Boron-containing small molecules
Abstract This invention provides novel compounds of the following formula and pharmaceutical compositions containing such compounds.
Applicant(s) Anacor Pharmaceuticals, Inc.
Representative Drug(s) D0YB5B Drug Info IC50 > 20nM Click to Show More [1]
2 D0OE2R Drug Info IC50 > 20nM [1]
3 D04WNI Drug Info IC50 > 20nM [1]
4 D0ZS0I Drug Info IC50 > 30nM [1]
Patent ID US10023564
Title G protein-coupled receptor kinase 2 inhibitors and methods for use of the same
Abstract Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.
Applicant(s) THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Representative Drug(s) D0YD7S Drug Info IC50 = 5150 nM [2]
Patent ID US10023564
Title G protein-coupled receptor kinase 2 inhibitors and methods for use of the same
Abstract Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.
Applicant(s) THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Representative Drug(s) D0YD7S Drug Info IC50 = 5150 nM [2]
Patent ID US10023564
Title G protein-coupled receptor kinase 2 inhibitors and methods for use of the same
Abstract Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.
Applicant(s) THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Representative Drug(s) D0YD7S Drug Info IC50 = 5150 nM [2]
Patent ID US10023564
Title G protein-coupled receptor kinase 2 inhibitors and methods for use of the same
Abstract Disclosed herein are novel GRK2 inhibitors and methods for their use in treating or preventing heart disease, such as cardiac failure, cardiac hypertrophy, and hypertension. In particular, disclosed herein are compounds of Formula (I) and pharmaceutically acceptable salt thereof: wherein the substituents are as described.
Applicant(s) THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Representative Drug(s) D0YD7S Drug Info IC50 = 5150 nM [2]
References  Top
REF 1 Boron-containing small molecules. US9493490.
REF 2 G protein-coupled receptor kinase 2 inhibitors and methods for use of the same. US10023564.

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