Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T62266 Target Info
Target Name Indoleamine 2,3-dioxygenase 2 (IDO2)
Synonyms Indoleamine-pyrrole 2,3-dioxygenase-like protein 1; Indoleamine 2,3-dioxygenase-like protein 1; INDOL1; IDO-2
Target Type Patented-recorded Target
Gene Name IDO2
Biochemical Class Oxygenase
UniProt ID
I23O2_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2014186035
Title Inhibitors of The Kynurenine Pathway.
Abstract The present application provides novel inhibitors of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase, metabolites thereof, and phannaceutically acceptable salts or prodrugs thereof. Also provided are methods for preparing these compounds. A therapeutically effective amount of one or more of the compounds of formula (I) is useful in treating diseases resulting from dysregulation of the kynurenine pathway. Compounds of formula (I) act by inhibiting the enzymatic activity or expression of indoleamine 2,3-dioxygenase-1 and/or indoleamine 2,3-dioxygenase-2 and/or tryptophan 2,3-dioxygenase.
Applicant(s) CURADEV PHARMA PRIVATE LTD.
Representative Drug(s) D04BZI Drug Info IC50 < 200 nM Click to Show More [1]
2 D0F4VD Drug Info IC50 < 200 nM [1]
3 D0FF6H Drug Info IC50 < 200 nM [1]
4 D0RA7I Drug Info IC50 < 200 nM [1]
5 D04MIQ Drug Info IC50 < 1000 nM [1]
6 D05TIP Drug Info IC50 > 1000 nM [1]
7 D05ZGX Drug Info IC50 > 1000 nM [1]
8 D0HV0Y Drug Info IC50 < 1000 nM [1]
European Patent Office (EPO)
Patent ID EP2970173
Title Inhibitors of The Kynurenine Pathway.
Applicant(s) Curadev Pharma Private Ltd
Representative Drug(s) D0RA7I Drug Info IC50 < 200 nM Click to Show More [1]
2 D04MIQ Drug Info IC50 < 1000 nM [1]
References  Top
REF 1 Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32.

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