| Patent(s) and the Corresponding Patented Drug(s) |
Top |
| World Intellectual Property Organization (WIPO) |
| Patent ID |
WO1997006247 |
| Title |
Deubiquitinating Enzymes That Regulate Cell Growth. |
| Abstract |
The present invention relates to ubiquitin-specific thiol proteases or deubiquitinating enzymes, referred to as DUB (DeUBiquitinating) enzymes, of eukaryotic origin which are members of a superfamily of deubiquitinating enzymes and which comprise a new subfamily of deubiquitinating enzymes which are similar in size and amino acid sequence to one another. DUB enzymes of the present invention are of eukaryotic origin, such as vertebrate origin, including mammalian (e.g., murine, human) origin, as well as yeast origin. All DUB enzymes of the present invention are inducible by at least one cytokine. |
| Applicant(s) |
Dana-Farber Cancer Institute, Inc |
| Patent ID |
WO2012040527 |
| Title |
Deubiquitinase Inhibitors and Methods for Use of The Same. |
| Abstract |
Disclosed herein are methods of inhibiting a deubiquitinase (DUB), methods of treating pathogenic infections (e.g., viral, bacterial, and/or parasitic), methods of inhibiting cell proliferation, methods of treating a neurodegenerative disease, methods of treating one or more symptoms of a neurodegenerative disease or a genetic disorder, and compounds. |
| Applicant(s) |
The Regents of the University of Michigan |
| Representative Drug(s) |
D0EM8D |
Drug Info
|
N.A. |
[1] |
| Patent ID |
WO2011157982 |
| Title |
Fluorescent -Labelled Diubiquitin Substrate for A Deubiquitinase Assay. |
| Abstract |
There is described a substrate for measuring the activity of a deubiquitinating enzyme (DUB), comprising a diubiquitin molecule, wherein an ubiquitin monomer is labeled with a fluorescent label, as well as an assay for DUB enzymes using such substrates. |
| Applicant(s) |
Medical Research Council |
| Patent ID |
WO2011094545 |
| Title |
Compositions and Methods for Enhancing Proteasome Activity. |
| Abstract |
Proteinopathies result from the proteasome not acting efficiently enough to eliminate harmful proteins and prevent the formation of the pathogenic aggregates. As described herein, inhibition of proteasome-associated deubiquitinase Usp 14 results in increased proteasome efficiency. The present invention therefore provides novel compositions and methods for inhibition of Uspl4, enhancement of proteasome activity and treatment of proteinopathies. |
| Applicant(s) |
President and Fellows of Harvard College |
| Representative Drug(s) |
D04MQF |
Drug Info
|
N.A. |
[1] |
| Patent ID |
WO2003091411 |
| Title |
Semisynthetic Protein-Based Site-Directed Probes for Identification and Inhibition of Active Sites, and Methods Therefor. |
| Abstract |
A C-terminally modified Ubiquitin (Ub) derivative, ubiquitin vinyl sulfone (UbVS), which is specific for deubiquitinating enzymes (DUBs), was synthesized as an active site directed probe that irreversibly modifies a subset of Ub C-terminal hydrolases (UCHs) and Ub specific processing proteases (UBPs), is provided [125I]-UbVS modifies 6 of the 17 known and putative yeast deubiquitinating enzymes, namely Yuh1p, Ubp1p, Ubp2p, Ubp6p, Ubp12p and Ubp15p. In mammalian cells, a greater number of polypeptides is labeled, most of which are DUBs. An additional DUB that associates with the mammalian 26S proteasome, novel protein USP14, a mammalian homolog of yeast Ubp6p that is bound to the proteasome, is provided. |
| Applicant(s) |
President and Fellows of Harvard College |
| Patent ID |
WO201405952 |
| Title |
Inhibitors of The Usp1/Uaf1 Deubiquitinase Complex and Uses Thereof. |
| Representative Drug(s) |
D0EG8Y |
Drug Info
|
N.A. |
[1] |
| United States Patent and Trademark Office (USPTO) |
| Patent ID |
US20140370528 |
| Title |
Protease deubiquitinating inhibitor screening. |
| Representative Drug(s) |
D0HQ8X |
Drug Info
|
N.A. |
Click to Show More |
[1] |
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2
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D0PY0H
|
Drug Info
|
N.A.
|
[1] |
| Patent ID |
US8518660 |
| Title |
Di- and poly-ubiquitin deubiquitinase substrates and uses thereof. |
| Applicant(s) |
Chelur Dattananda Lifesensors, Inc |
| Patent ID |
US20040265931 |
| Title |
HAUSP-Mdm2 interaction and uses thereof. |
