Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T55703 Target Info
Target Name Plasma retinol-binding protein (RBP4)
Synonyms Retinol-binding protein 4; RBP4; RBP; Plasma retinol-binding protein(1-176); PRBP
Target Type Clinical trial Target
Gene Name RBP4
Biochemical Class Calycin family
UniProt ID
RET4_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US9777010
Title Substituted 4-phenylpiperidines, their preparation and use
Abstract The present invention provides a compound having the structure: whereinR1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; andB is a substituted or unsubstituted heterobicycle,wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.
Applicant(s) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Representative Drug(s) D05AIC Drug Info IC50 = 3.45 nM [1]
Patent ID US9434727
Title Substituted 4-phenylpiperidines, their preparation and use
Abstract The present invention provides a compound having the structure: whereinR1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; andB is a substituted or unsubstituted heterobicycle,wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.
Applicant(s) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Representative Drug(s) D0YU9U Drug Info IC50 = 16 nM Click to Show More [2]
2 D0K0IZ Drug Info IC50 = 21 nM [2]
3 D04BAA Drug Info IC50 = 833 nM [2]
Patent ID US9434727
Title Substituted 4-phenylpiperidines, their preparation and use
Abstract The present invention provides a compound having the structure: whereinR1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; andB is a substituted or unsubstituted heterobicycle,wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.
Applicant(s) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Representative Drug(s) D0YU9U Drug Info IC50 = 16 nM Click to Show More [2]
2 D0K0IZ Drug Info IC50 = 21 nM [2]
3 D04BAA Drug Info IC50 = 833 nM [2]
Patent ID US9434727
Title Substituted 4-phenylpiperidines, their preparation and use
Abstract The present invention provides a compound having the structure: whereinR1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; andB is a substituted or unsubstituted heterobicycle,wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.
Applicant(s) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Representative Drug(s) D0YU9U Drug Info IC50 = 16 nM Click to Show More [2]
2 D0K0IZ Drug Info IC50 = 21 nM [2]
3 D04BAA Drug Info IC50 = 833 nM [2]
Patent ID US8853215
Title Derivatives of N-acyl-N-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes
Abstract The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.
Applicant(s) Takeda Pharmaceutical Company Limited
Representative Drug(s) D0IV0E Drug Info IC50 = 3.8 nM Click to Show More [3]
2 D0D5AI Drug Info IC50 = 54 nM [3]
3 D01KKC Drug Info IC50 = 540 nM [3]
Patent ID US8853215
Title Derivatives of N-acyl-N-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes
Abstract The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.
Applicant(s) Takeda Pharmaceutical Company Limited
Representative Drug(s) D0IV0E Drug Info IC50 = 3.8 nM Click to Show More [3]
2 D0D5AI Drug Info IC50 = 54 nM [3]
3 D01KKC Drug Info IC50 = 540 nM [3]
Patent ID US8853215
Title Derivatives of N-acyl-N-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes
Abstract The present invention relates to a compound represented by the formula wherein each symbol is as defined in the present specification, which has a superior RBP4-lowering action and is useful as a pharmaceutical composition for the prophylaxis or treatment of a disease or condition mediated by an increase in RBP4.
Applicant(s) Takeda Pharmaceutical Company Limited
Representative Drug(s) D0IV0E Drug Info IC50 = 3.8 nM Click to Show More [3]
2 D0D5AI Drug Info IC50 = 54 nM [3]
3 D01KKC Drug Info IC50 = 540 nM [3]
Patent ID US8586571
Title Heterocyclic compound
Abstract The present invention relates to wherein each symbol is as defined in the specification. The compound of the present invention has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of disease and condition mediated by increased RBP4.
Applicant(s) Takeda Pharmaceutical Company Limited
Representative Drug(s) D0J9YV Drug Info IC50 = 20 nM Click to Show More [4]
2 D0I1LE Drug Info IC50 = 36 nM [4]
3 D08PYU Drug Info IC50 = 210 nM [4]
Patent ID US8586571
Title Heterocyclic compound
Abstract The present invention relates to wherein each symbol is as defined in the specification. The compound of the present invention has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of disease and condition mediated by increased RBP4.
Applicant(s) Takeda Pharmaceutical Company Limited
Representative Drug(s) D0J9YV Drug Info IC50 = 20 nM Click to Show More [4]
2 D0I1LE Drug Info IC50 = 36 nM [4]
3 D08PYU Drug Info IC50 = 210 nM [4]
Patent ID US8586571
Title Heterocyclic compound
Abstract The present invention relates to wherein each symbol is as defined in the specification. The compound of the present invention has a superior RBP4-lowering action, and is useful as a medicament for the prophylaxis or treatment of disease and condition mediated by increased RBP4.
Applicant(s) Takeda Pharmaceutical Company Limited
Representative Drug(s) D0J9YV Drug Info IC50 = 20 nM Click to Show More [4]
2 D0I1LE Drug Info IC50 = 36 nM [4]
3 D08PYU Drug Info IC50 = 210 nM [4]
Patent ID US10072016
Title Substituted 4-phenylpiperidines, their preparation and use
Abstract The present invention provides a compound having the structure: whereinR1, R2, R3, R4, and R5 are each independently H, halogen, CF3 or C1-C4 alkyl, wherein two or more of R1, R2, R3, R4, or R5 are other than H; R6 is H, OH, or halogen; andB is a substituted or unsubstituted heterobicycle,wherein when R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is H, R2 is CF3, R3 is H, R4 is CF3, and R5 is H, or R1 is Cl, R2 is H, R3 is H, R4 is F, and R5 is H, or R1 is CF3, R2 is H, R3 is F, R4 is H, and R5 is H, or R1 is CF3, R2 is F, R3 is H, R4 is H, and R5 is H, or R1 is Cl, R2 is F, R3 is H, R4 is H, and R5 is H, then B is other than or a pharmaceutically acceptable salt thereof.
Applicant(s) THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Representative Drug(s) D02TPQ Drug Info IC50 = 8 nM [5]
References  Top
REF 1 Substituted 4-phenylpiperidines, their preparation and use. US9777010.
REF 2 Substituted 4-phenylpiperidines, their preparation and use. US9434727.
REF 3 Derivatives of N-acyl-N-phenylpiperazine useful (inter alia) for the prophylaxis or treatment of diabetes. US8853215.
REF 4 Heterocyclic compound. US8586571.
REF 5 Substituted 4-phenylpiperidines, their preparation and use. US10072016.

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