Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T52447 Target Info
Target Name Rotamase D (PPID)
Synonyms Peptidylprolyl isomerase D; Peptidyl-prolyl cis-trans isomerase D; PPIase D; Cyclophilin-related protein; Cyclophilin-40; CYP40; CYP-40; 40 kDa peptidyl-prolyl cis-trans isomerase
Target Type Patented-recorded Target
Gene Name PPID
Biochemical Class Cis-trans-isomerase
UniProt ID
PPID_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US8901295
Title Inhibitors of cyclophilins and uses thereof
Abstract The present invention relates to a compound of formula (I): wherein: n is 0, 1 or 2;A is in particular CH or N;X is in particular CO, SO2, CS, and R1 is in particular H,R2 is a group of formula NR3R4 or OR5, R3 and R4 being in particular H, and R5 an alkyl group,R6 is in particular H or an alkyl group, andR7 is in particular an aryl group, for its use in the prevention and/or the treatment of viral pathologies or infections.
Applicant(s) Institut National de la Sante et de la Recherche Medicale (INSERM); Universite Montpellier 1; Universite Paris-EST Creteil val de Marne; Assistance Publique-Hopitaux de Paris; Centre National de la Recherche Scientifique
Representative Drug(s) D0M2OY Drug Info IC50 = 6200 nM Click to Show More [1]
2 D0KO5D Drug Info IC50 = 6200 nM [1]
3 D08YMT Drug Info IC50 = 11400 nM [1]
Patent ID US8901295
Title Inhibitors of cyclophilins and uses thereof
Abstract The present invention relates to a compound of formula (I): wherein: n is 0, 1 or 2;A is in particular CH or N;X is in particular CO, SO2, CS, and R1 is in particular H,R2 is a group of formula NR3R4 or OR5, R3 and R4 being in particular H, and R5 an alkyl group,R6 is in particular H or an alkyl group, andR7 is in particular an aryl group, for its use in the prevention and/or the treatment of viral pathologies or infections.
Applicant(s) Institut National de la Sante et de la Recherche Medicale (INSERM); Universite Montpellier 1; Universite Paris-EST Creteil val de Marne; Assistance Publique-Hopitaux de Paris; Centre National de la Recherche Scientifique
Representative Drug(s) D0M2OY Drug Info IC50 = 6200 nM Click to Show More [1]
2 D0KO5D Drug Info IC50 = 6200 nM [1]
3 D08YMT Drug Info IC50 = 11400 nM [1]
Patent ID US8901295
Title Inhibitors of cyclophilins and uses thereof
Abstract The present invention relates to a compound of formula (I): wherein: n is 0, 1 or 2;A is in particular CH or N;X is in particular CO, SO2, CS, and R1 is in particular H,R2 is a group of formula NR3R4 or OR5, R3 and R4 being in particular H, and R5 an alkyl group,R6 is in particular H or an alkyl group, andR7 is in particular an aryl group, for its use in the prevention and/or the treatment of viral pathologies or infections.
Applicant(s) Institut National de la Sante et de la Recherche Medicale (INSERM); Universite Montpellier 1; Universite Paris-EST Creteil val de Marne; Assistance Publique-Hopitaux de Paris; Centre National de la Recherche Scientifique
Representative Drug(s) D0M2OY Drug Info IC50 = 6200 nM Click to Show More [1]
2 D0KO5D Drug Info IC50 = 6200 nM [1]
3 D08YMT Drug Info IC50 = 11400 nM [1]
References  Top
REF 1 Inhibitors of cyclophilins and uses thereof. US8901295.

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