Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T50973 Target Info
Target Name Kynurenine 3-hydroxylase (KMO)
Synonyms Kynurenine 3monooxygenase; Kynurenine 3-monooxygenase
Target Type Clinical trial Target
Gene Name KMO
Biochemical Class Paired donor oxygen oxidoreductase
UniProt ID
KMO_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2013151707
Title Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions, and Methods of Use Thereof.
Abstract Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, pharmaceutical compositions comprising the same and methods of treating patients suffering from certain diseases and disord.
Applicant(s) Chdi Foundation, Inc
Representative Drug(s) D04BYB Drug Info 54.00% inhibition = 10000 nM Click to Show More [1]
2 D0BU9N Drug Info 98.60% inhibition = 10000 nM [1]
3 D0DB7W Drug Info 101.00% inhibition = 10000 nM [1]
4 D0FW5Q Drug Info 42.00% inhibition = 10000 nM [1]
5 D0G6DW Drug Info 52.50% inhibition = 10000 nM [1]
6 D0JZ9L Drug Info 100.60% inhibition = 10000 nM [1]
7 D0O8MJ Drug Info 15.40% inhibition = 10000 nM [1]
8 D0O9IS Drug Info 101.00% inhibition = 10000 nM [1]
9 D0UJ8Z Drug Info 96.70% inhibition = 10000 nM [1]
Patent ID WO2013033085
Title Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions, and Methods of Use Thereof.
Abstract Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of tre.
Applicant(s) Courtney, et al
Representative Drug(s) D0OM6D Drug Info 96% inhibition = 10000 nM Click to Show More [1]
2 D0R5HG Drug Info 98% inhibition = 10000 nM [1]
3 D0T8AS Drug Info 73% inhibition = 10000 nM [1]
Patent ID WO2013033068
Title Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions, and Methods of Use Thereof.
Abstract Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of tre.
Applicant(s) Courtney, et al
Representative Drug(s) D0XR0Z Drug Info IC50 = 12 nM Click to Show More [1]
2 D0MV3E Drug Info IC50 = 38 nM [1]
3 D0ZB9T Drug Info 105.5% inhibition = 10000 nM; IC50 = 500 nM [1]
4 D03ROY Drug Info 105.5% inhibition = 10000 nM; IC50 = 600 nM [1]
5 D01TDT Drug Info 100% inhibition = 10000 nM [1]
6 D0UF8Z Drug Info 47.70% inhibition = 10000 nM [1]
7 D0Z2JJ Drug Info 46% inhibition = 10000 nM; IC50 = 2130 nM [1]
8 D0ZY4T Drug Info 100.30% inhibition = 10000 nM [1]
Patent ID WO2013016488
Title Certain Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions, and Methods of Use Thereof.
Abstract Certain chemical entities are provided herein. Also provided are pharmaceutical compositions comprising at least one chemical entity and one or more pharmaceutically acceptable vehicle. Methods of tre.
Applicant(s) Dominguez, et al
Representative Drug(s) D06EDH Drug Info 100.65% inhibition = 10000 nM Click to Show More [1]
2 D0X5OC Drug Info 46.80% inhibition = 10000 nM [1]
Patent ID WO2008022286
Title Small Molecule Inhibitors of Kynurenine-3-Monooxygenase.
Abstract The present invention relates to compounds of Formula I below and their tautomers or pharmaceutically acceptable salts, compositions and methods of uses thereof.
Applicant(s) University of Maryland
Representative Drug(s) D0N9WZ Drug Info 73.61% inhibition = 10000 nM Click to Show More [1]
2 D0R3JM Drug Info 60.03% inhibition = 10000 nM [1]
Patent ID WO2015047978
Title Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions, and Methods of Use Thereof.
Abstract Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease.
Applicant(s) Chdi Foundation, Inc
Representative Drug(s) D0PI7V Drug Info 100.30% inhibition = 10000 nM [1]
Patent ID WO2011091153
Title Certain Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions, and Methods of Use Thereof.
Patent ID WO2010017179
Title Certain Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions, and Methods of Use Thereof.
United States Patent and Trademark Office (USPTO)
Patent ID US8710237
Title Small Molecule Inhibitors of Kynurenine-3-Monooxygenase.
Representative Drug(s) D0LM5V Drug Info 9% inhibition = 10000 nM Click to Show More [1]
2 D0P1BE Drug Info 24% inhibition = 10000 nM [1]
3 D0S0DL Drug Info 84% inhibition = 10000 nM [1]
4 D0VI4S Drug Info 64% inhibition = 10000 nM [1]
5 D0ZL9P Drug Info 52% inhibition = 10000 nM [1]
Patent ID US20120329812
Title Certain Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions, and Methods of Use Thereof.
Representative Drug(s) D00XMF Drug Info 74.53% inhibition = 10000 nM Click to Show More [1]
2 D03EYJ Drug Info 74.70% inhibition = 10000 nM [1]
3 D06KFU Drug Info 102.45% inhibition = 10000 nM [1]
4 D0Q7NM Drug Info 60.40% inhibition = 10000 nM [1]
5 D0TK3W Drug Info 101.21% inhibition = 10000 nM [1]
6 D0WL1Z Drug Info 84.50% inhibition = 10000 nM [1]
Patent ID US20120046324
Title Small Molecule Inhibitors of Kynurenine-3-Monooxygenase.
Representative Drug(s) D0N9WZ Drug Info 73.61% inhibition = 10000 nM Click to Show More [1]
2 D0R3JM Drug Info 60.03% inhibition = 10000 nM [1]
Patent ID US20130331370
Title Certain Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions, and Methods of Use Thereof.
Patent ID US20130029988
Title Certain Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions, and Methods of Use Thereof.
European Patent Office (EPO)
Patent ID EP2420494
Title Small Molecule Inhibitors of Kynurenine-3-Monooxygenase.
Representative Drug(s) D0N9WZ Drug Info 73.61% inhibition = 10000 nM Click to Show More [1]
2 D0R3JM Drug Info 60.03% inhibition = 10000 nM [1]
Patent ID EP252844)
Title Certain Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions, and Methods of Use Thereof.
Patent ID EP2331095)
Title Certain Kynurenine-3-Monooxygenase Inhibitors, Pharmaceutical Compositions, and Methods of Use Thereof.
References  Top
REF 1 Inhibitors of the kynurenine pathway as neurotherapeutics: a patent review (2012-2015).Expert Opin Ther Pat. 2016 Jul;26(7):815-32.

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