Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T47888 Target Info
Target Name Sphingosine-1-phosphate receptor 2 (S1PR2)
Synonyms Sphingosine 1-phosphate receptor Edg-5; S1PR2; S1P2; S1P receptor Edg-5; S1P receptor 2; Endothelial differentiation G-protein coupled receptor 5
Target Type Clinical trial Target
Gene Name S1PR2
Biochemical Class GPCR rhodopsin
UniProt ID
S1PR2_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
United States Patent and Trademark Office (USPTO)
Patent ID US9663511
Title Sphingosine 1-phosphate receptor antagonists
Abstract The present invention relates to sphingosine-1-phosphate (S1P) receptors and compounds of the general formula: that are useful in the treatment and prevention of conditions associated with such receptors. More specifically, the present invention relates to the synthesis and use of sphingosine 1-phosphate receptor 2 (S1P2) antagonists that are useful in the treatment of cancer, atherosclerosis, diabetic retinopathy, and other inflammatory diseases. Among these inflammatory diseases that could be treated with these S1P2 antagonist are those characterized by fibrosis including chronic lung disease, chronic kidney and liver disease, chronic heart disease, and skin diseases such as sclerosis/scleroderma. The S1P2 antagonists can also be used in the treatment of glioblastoma multiforme (brain cancer), pediatric neuroblastoma, and other cancers.
Applicant(s) Arroyo BioSciences, LLC
Representative Drug(s) D0QU9I Drug Info IC50 = 10 nM Click to Show More [1]
2 D0K4BI Drug Info IC50 = 11 nM [1]
3 D0J5YV Drug Info IC50 = 52 nM [1]
Patent ID US9663511
Title Sphingosine 1-phosphate receptor antagonists
Abstract The present invention relates to sphingosine-1-phosphate (S1P) receptors and compounds of the general formula: that are useful in the treatment and prevention of conditions associated with such receptors. More specifically, the present invention relates to the synthesis and use of sphingosine 1-phosphate receptor 2 (S1P2) antagonists that are useful in the treatment of cancer, atherosclerosis, diabetic retinopathy, and other inflammatory diseases. Among these inflammatory diseases that could be treated with these S1P2 antagonist are those characterized by fibrosis including chronic lung disease, chronic kidney and liver disease, chronic heart disease, and skin diseases such as sclerosis/scleroderma. The S1P2 antagonists can also be used in the treatment of glioblastoma multiforme (brain cancer), pediatric neuroblastoma, and other cancers.
Applicant(s) Arroyo BioSciences, LLC
Representative Drug(s) D0QU9I Drug Info IC50 = 10 nM Click to Show More [1]
2 D0K4BI Drug Info IC50 = 11 nM [1]
3 D0J5YV Drug Info IC50 = 52 nM [1]
Patent ID US9663511
Title Sphingosine 1-phosphate receptor antagonists
Abstract The present invention relates to sphingosine-1-phosphate (S1P) receptors and compounds of the general formula: that are useful in the treatment and prevention of conditions associated with such receptors. More specifically, the present invention relates to the synthesis and use of sphingosine 1-phosphate receptor 2 (S1P2) antagonists that are useful in the treatment of cancer, atherosclerosis, diabetic retinopathy, and other inflammatory diseases. Among these inflammatory diseases that could be treated with these S1P2 antagonist are those characterized by fibrosis including chronic lung disease, chronic kidney and liver disease, chronic heart disease, and skin diseases such as sclerosis/scleroderma. The S1P2 antagonists can also be used in the treatment of glioblastoma multiforme (brain cancer), pediatric neuroblastoma, and other cancers.
Applicant(s) Arroyo BioSciences, LLC
Representative Drug(s) D0QU9I Drug Info IC50 = 10 nM Click to Show More [1]
2 D0K4BI Drug Info IC50 = 11 nM [1]
3 D0J5YV Drug Info IC50 = 52 nM [1]
Patent ID US8975409
Title Phenyl derivative
Abstract The compound represented by the formula (I-1): wherein all the symbols have the same meanings as described in the specification, has two cyclic groups, particularly phenoxy groups at specific substitution positions and thus has high human S1P2 antagonistic activity. The compound may therefore be used as a therapeutic agent for S1P2-mediated diseases such as diseases resulting from vascular constriction, fibrosis and respiratory diseases.
Applicant(s) ONO Pharmaceutical Co., Ltd.
Representative Drug(s) D0C4AW Drug Info IC50 = 3 nM Click to Show More [2]
2 D0PW0R Drug Info IC50 = 6.2 nM [2]
3 D0T8FV Drug Info IC50 = 1200 nM [2]
Patent ID US8975409
Title Phenyl derivative
Abstract The compound represented by the formula (I-1): wherein all the symbols have the same meanings as described in the specification, has two cyclic groups, particularly phenoxy groups at specific substitution positions and thus has high human S1P2 antagonistic activity. The compound may therefore be used as a therapeutic agent for S1P2-mediated diseases such as diseases resulting from vascular constriction, fibrosis and respiratory diseases.
Applicant(s) ONO Pharmaceutical Co., Ltd.
Representative Drug(s) D0C4AW Drug Info IC50 = 3 nM Click to Show More [2]
2 D0PW0R Drug Info IC50 = 6.2 nM [2]
3 D0T8FV Drug Info IC50 = 1200 nM [2]
Patent ID US8975409
Title Phenyl derivative
Abstract The compound represented by the formula (I-1): wherein all the symbols have the same meanings as described in the specification, has two cyclic groups, particularly phenoxy groups at specific substitution positions and thus has high human S1P2 antagonistic activity. The compound may therefore be used as a therapeutic agent for S1P2-mediated diseases such as diseases resulting from vascular constriction, fibrosis and respiratory diseases.
Applicant(s) ONO Pharmaceutical Co., Ltd.
Representative Drug(s) D0C4AW Drug Info IC50 = 3 nM Click to Show More [2]
2 D0PW0R Drug Info IC50 = 6.2 nM [2]
3 D0T8FV Drug Info IC50 = 1200 nM [2]
References  Top
REF 1 Sphingosine 1-phosphate receptor antagonists. US9663511.
REF 2 Phenyl derivative. US8975409.

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