Patent(s) and the Corresponding Patented Drug(s) |
Top |
United States Patent and Trademark Office (USPTO) |
Patent ID |
US9353089 |
Title |
Compositions and methods for the treatment of malaria |
Abstract |
The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided. |
Applicant(s) |
Saint Louis University; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
Representative Drug(s) |
D0QX1S |
Drug Info
|
IC50 = 240 nM |
Click to Show More |
[1] |
2
|
D0H4IY
|
Drug Info
|
IC50 = 751 nM
|
[1] |
3
|
D03OLC
|
Drug Info
|
IC50 = 1010 nM
|
[1] |
Patent ID |
US9353089 |
Title |
Compositions and methods for the treatment of malaria |
Abstract |
The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided. |
Applicant(s) |
Saint Louis University; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
Representative Drug(s) |
D0QX1S |
Drug Info
|
IC50 = 240 nM |
Click to Show More |
[1] |
2
|
D0H4IY
|
Drug Info
|
IC50 = 751 nM
|
[1] |
3
|
D03OLC
|
Drug Info
|
IC50 = 1010 nM
|
[1] |
Patent ID |
US9353089 |
Title |
Compositions and methods for the treatment of malaria |
Abstract |
The present invention provides aminohydantoin anti-malarial agents. In some embodiments, these agents have the property of functions of targeting malarial aspartic proteases while at the same time having low activity against human BACE. Methods of employing such agents are also provided. |
Applicant(s) |
Saint Louis University; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences |
Representative Drug(s) |
D0QX1S |
Drug Info
|
IC50 = 240 nM |
Click to Show More |
[1] |
2
|
D0H4IY
|
Drug Info
|
IC50 = 751 nM
|
[1] |
3
|
D03OLC
|
Drug Info
|
IC50 = 1010 nM
|
[1] |