Target and Its Patented Drug(s)

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Target General Information
Patent(s) and the Corresponding Patented Drug(s)
References
Target General Information  Top
Target ID T34296 Target Info
Target Name Matrix metalloproteinase-13 (MMP-13)
Synonyms Matrix metalloproteinase 13; Collagenase-3; Collagenase 3
Target Type Clinical trial Target
Gene Name MMP13
Biochemical Class Peptidase
UniProt ID
MMP13_HUMAN
Patent(s) and the Corresponding Patented Drug(s)  Top
World Intellectual Property Organization (WIPO)
Patent ID WO2012080762
Title Novel Inhibitors of Matrix Metalloproteinases.
Abstract The present invention relates to compounds of general formula (I), salts or solvates thereof and pharmaceutical compositions containing same: wherein Z is N or CH or the Z(R1) part is replaced with a covalent bond, m and n is 0, 1, 2 or 3; HET is heteroaryl; X is CF3, halogen, CO-heterocyclyl, COOR3 or CONHR3; R1 is H, (CH2)o-aryl, (CH2)p-heteroaryl, (CH2)q-biphenyl; C(O)-R5; S(O)2-R6; R2 is H, aryl, heteroaryl, Y-(CH2)r-aryl, Y-(CH2)s-heteroaryl, where some of the above substituents may be substituted; Y is O or S; with the exclusion of the compound where HET is 1,3-thiazol, X is COOH, R1 is 4-fluorophenyl and R2 is benzyloxy. The invention also relates to the use of a compound of general formula (I), salts or solvates thereof for the use in the prevention or treatment of diseases where the activation of MMPs is involved in the pathomechanism. In this aspect the use of the above excluded compound is also inventive.
Applicant(s) Pharmahungary 2000 Kft
Representative Drug(s) D0X6GG Drug Info IC50 = 2500 nM Click to Show More [1]
2 D0O8RQ Drug Info N.A. [1]
China National Intellectual Property Administration (CNIPA)
Patent ID CN102036953
Title Arylsulfonamide-Based Matrix Metalloproteinase Inhibitors.
Representative Drug(s) D0LS4Y Drug Info IC50 = 80 nM Click to Show More [1]
2 D0A9ZW Drug Info IC50 = 510 nM [1]
3 D0S3PN Drug Info IC50 = 1400 nM [1]
References  Top
REF 1 Gelatinase inhibitors: a patent review (2011-2017).Expert Opin Ther Pat. 2018 Jan;28(1):31-46.

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