| Patent(s) and the Corresponding Patented Drug(s) |
Top |
| World Intellectual Property Organization (WIPO) |
| Patent ID |
WO2015040169 |
| Title |
Quinazoline Derivatives and Their Use As Dna Methyltransferase Inhibitors. |
| Abstract |
The present invention relates to compounds of the following formula (I): and pharmaceutically acceptable salts and solvates thereof, their methods of preparation, their use as a drug, notably in the treatment of cancer, and pharmaceutical compositions containing such compounds. |
| Applicant(s) |
PIERRE FABRE MEDICAMENT CENTER NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) |
| Representative Drug(s) |
D02VTV |
Drug Info
|
EC50 = 1100 nM |
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[1] |
|
2
|
D0F8AB
|
Drug Info
|
EC50 = 1100 nM
|
[1] |
|
3
|
D03LZO
|
Drug Info
|
EC50 = 2400 nM
|
[1] |
| Patent ID |
WO2014011573 |
| Title |
Oligonucleotide Inhibitors of Dna Methyltransferases and Their Use In Treating Diseases. |
| Abstract |
Modified oligonucleotides comprising CpG sites, wherein the cytosine is replaced by cytosine analogs are provided as well as methods of making the oligonucleotides and their use in inhibiting DNA Methyltransferase, inhibiting or reversing methylation of genes and in treating cancer, tumorigenesis and hyper-proliferative disorders. |
| Applicant(s) |
Metheor Therapeutics Corporation |
| Representative Drug(s) |
D0HA0J |
Drug Info
|
IC50 = 295 nM |
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[1] |
|
2
|
D0W9VZ
|
Drug Info
|
IC50 = 363 nM
|
[1] |
|
3
|
D0QY0N
|
Drug Info
|
IC50 = 1430 nM
|
[1] |
|
4
|
D02WRM
|
Drug Info
|
IC50 = 1940 nM
|
[1] |
| Patent ID |
WO2013062943 |
| Title |
New Compounds. |
| Abstract |
This invention relates to heteroaryl compounds, containing a purinyl moiety, that inhibit DNA methyltransferase (DNMT) activity - including DNMT1, DNMT3a, or DNMT3b - useful in the treatment of cancer and hyperproliferative diseases. |
| Applicant(s) |
Glaxosmithkline Intellectual Property (No.2) Limited |
| Representative Drug(s) |
D01LUJ |
Drug Info
|
IC50 = 3000 nM |
[1] |
